Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries by Olivia Lenoir, François Gaillard, Hélène Lazareth, Blaise Robin, Pierre-Louis Tharaux

“…This was associated with a renal increase in the expression of the oxidative stress marker, nitrotyrosine. Conclusions. Genetic Hmox1 partial deficiency is sufficient to sensitize mice to the development of diabetic glomerular microvascular lesions. …”
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Frequency of Antibiotic-Resistant Bacteria isolated from the Kınalıada Coastal Areas of the Sea of Marmara, Türkiye by Pelin Saliha Çiftçi Türetken, Gülşen Altuğ, Selma Dilara Karaman Baş

“…The frequency of bacterial antibiotic resistance in aquatic ecosystems is a micro-marker of human activity. The frequency of antibiotic-resistant bacteria was investigated in surface water samples collected from the coastal areas of Kınalıada Island in the Sea of Marmara between 2018 and 2019. …”
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Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway by Ximei Shen, Beibei Fan, Xin Hu, Liufen Luo, Yuanli Yan, Liyong Yang

“…GPR40 was involved in metformin reversing metabolic inflammation key marker TLR4 activation-mediated β-cell injury. Furthermore, downstream signaling protein PLC-IP3 of GPR40 was involved in the protective effect of metformin on meta-inflammation, and the above process of metformin was partially regulated by AMPK activity. …”
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A Neovascularized Left Atrial Mass by Rania Hammami, Leila Abid, Souad Mallek, Ilyes Kharrat, Mariem Ellouz, Mourad Hentati, Imed Frikha, Samir Kammoun

“…The cardiac auscultation, revealed an irregular rhythm with diastolic murmur at the apex. The electrocardiogram showed an atrial fibrillation. …”
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ADAM-multi: software to simulate complex breeding programs for animals and plants with different ploidy levels and generalized genotypic effect models to account for multiple allel... by Thinh Tuan Chu, Thinh Tuan Chu, Just Jensen

“…While the bi-allelic state of marker loci is due to the common choice of genotyping technology of single nucleotide polymorphism (SNP) chip, the assumption may not hold for the linked QTL. …”
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Peculiarities of the molecular composition of heterochromatin associated with pronucleoli in mouse embryos by I. O. Bogolyubova, Z. K. Sailau, D. S. Bogolyubov

“…Intriguingly, these zones contain not only tri-methylated histone Н3K9me3 as an epigenetic mark of repressed chromatin but also acetylated histone H4K5ac, a well-known marker of active chromatin. Immunocytochemical data suggest that the molecular composition of this ‘ring heterochromatin’ in mouse embryos changes during the realization of embryonic genome activation events, as well as during artificial suppression of transcription. …”
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Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional stud... by Hongjuan Wei, Xin Chang, Jin Wang

“…Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variability, and cranial ultrasound abnormalities (CUAs) remains unclear.ObjectiveThe primary aim of this study was to explore the impact of RDW-CV on CUAs in neonatal hyperbilirubinemia and to elucidate the potential clinical implications of this relationship.MethodsThis retrospective cross-sectional study included 503 cases of neonatal hyperbilirubinemia at gestational age ≥35 weeks with available RDW-CV and CUS screening data at Nanjing Lishui People's Hospital. …”
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Urinary Concentrations of Steroids in Bulls under Anabolic Treatment by Revalor-XS® Implant by Giancarlo Biancotto, Roberto Stella, Federica Barrucci, Francesca Lega, Roberto Angeletti

“…To control the food chain and guarantee consumers’ health, there is a need of highly sensitive analytical methods for the identification of marker residues of such treatments. In the present study, a group of bulls (n=16) received trenbolone acetate (200 mg) and estradiol (40 mg) by a commercial ear implant during a time range of 71 days, and a second group (n=16) was kept for control. …”
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A daily rhythm of cell proliferation in a songbird brain by Vladimira Hodova, Valentina Maresova, Rebecca Radic, Lubica Kubikova

“…We injected the birds with the cell proliferation marker 5-ethynyl-2´-deoxyuridine (EdU; thymidine analog), quantified the number of dividing cells in the neurogenic ventricular zone (VZ), and measured mRNA expression of clock genes as well as genes indicating cell proliferation or apoptosis. …”
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Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway by Wedad S. Sarawi, Hala A. Attia, Afraa Alzoubi, Nour Alanazi, Raeesa Mohammad, Rehab A. Ali

“…TAM caused inflammation in the liver tissue as indicated by higher levels of tumor necrosis factor-α and interleukin-6 as well as increased expression of CD68; a phagocytic Kupffer’s cells marker. Additionally, the protein expression analysis revealed a high expression of pyroptotic markers including NLRP3-inflammasome, caspase-1, and gasdermin D. …”
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Opportunistic Infections in Patients with HTLV-1 Infection by Toshiki Tanaka, Toshio Sekioka, Masakatsu Usui, Shinsaku Imashuku

“…In HTLV-1-positive patients, an increase in the CD4+CD25+ T cell subset may have its value as a prognostic marker.…”
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CMS systems in rapeseed and their use in the breeding of domestic hybrids by I. N. Anisimova, A. G. Dubovskaya

“…Mitochondrial CMS genes associated with nap, pol, ogu and Nsa sterility types as well as nuclear Rf genes for pollen fertility restoration were identified. Molecular marker systems for identification of CMS-inducing and male fertility restoring genes were developed. …”
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Identification and Characterization of Novel Perivascular Adventitial Cells in the Whole Mount Mesenteric Branch Artery Using Immunofluorescent Staining and Scanning Confocal Micro... by Chandra Somasundaram, Rahul K. Nath, Richard D. Bukoski, Debra I. Diz

“…We now show that ANNIES express the neurite growth marker, growth associated protein-43(Gap-43), palladin, and the calcium sensing receptor (CaSR), that senses changes in extracellular Ca(2+) and participates in vasodilator mechanisms. …”
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GRAMMAR-Lambda Delivers Efficient Understanding of the Genetic Basis for Head Size in Catfish by Yunfeng Zhao, Jin Gao, Hong Feng, Li Jiang

“…These findings contribute to our understanding of the genetic architecture of head size and will support marker-assisted breeding in aquaculture, also reflecting the potential application of the GRAMMAR-Lambda method in genetic studies of complex traits.…”
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Exploring the Active Constituents of <i>Andrographis paniculata</i> in Protecting the Skin Barrier and the Synergistic Effects with Collagen XVII by Heng Xu, Shiying Lan, Simin Lin, Anjing Wang, Yuanlin Luo, Jing Wang, Zhenzhong Yang

“…Notably, the combined treatment with andrographolide and collagen XVII enhanced the viability of UVB-damaged epidermal stem cells, increased the expression of stemness markers integrin β1 and p63, and decreased the expression of the differentiation marker keratin 10. …”
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miR-203 Expression in Exfoliated Cells of Tongue Coating Represents a Sensitive and Specific Biomarker of Gastroesophageal Reflux Disease by Xiuli Yan, Shengliang Zhu, Hui Zhang

“…These results suggest that miR-203 may be a useful diagnostic marker for discriminating GERD from Ctrls. Conclusions. miR-203 testing may assist in the diagnosis of patients with symptoms suggestive of GERD.…”
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Repurposing Drugs in Controlling Recurrent Platinum-Resistant Clear-Cell Ovarian Cancer by Woraporn Sinsuwan, Phawit Norchai

“…Two months after therapy, a computerized tomography (CT) scan revealed a conflict between a decline in tumor marker levels (CA 125, CA 19-9) and an increase in the number of lymph nodes. …”
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The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…The endothelium is the major regulator of vascular homeostasis, and endothelial cell dysfunction (ED) is considered an early marker for atherosclerosis. Thus, it is speculated that changes in DNA methylation within endothelial cells may, in part, be causal in ED, leading to atherosclerosis and CVD generally. …”
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Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 by Dongli Huang, Yuan He

“…PurposeThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a crucial lipid marker associated with various cardiovascular diseases. …”
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Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology by Shen Y, Leng L, Hu Y

“…The frequency of occurrence is on the rise, but there is a lack of certain indicators for the timely detection and recognition of illnesses.Methods: By virtue of scRNA-seq, this research has analyzed single-cell transcriptome data from samples taken from groups with septic death and systemic inflammatory response syndrome so as to identify the unique markers and patterns in immune response.Results: By revealing the status of twelve cell clusters of four major cell types in blood samples through UMAP cell clustering and the differences of major cell populations between the dead and SIRS patients, the results have elucidated the components of different cells and their marker genes in two disease states, and the response mechanism beneficial to disease diagnosis in blood samples.Conclusion: By establishing a theoretical framework centered on cellular and molecular regulation, the study has introduced a novel approach for diagnosing and treating sepsis death group and SIRS patients early, as well as differentiating and preventing these conditions.Keywords: sepsis, SIRS, single cell sequencing, biomarkers, single cell transcriptome…”
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