Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies by Lucía Campos-Prieto, Aitor García-Rey, Eddy Sotelo, Ana Mallo-Abreu

“…Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of chemical libraries with high diversity in a time-efficient and environmentally sustainable manner. In this review, we focus on central nervous system (CNS) disorders, particularly Alzheimer's disease, Parkinson's disease, schizophrenia, depression, and epilepsy, where MCRs have contributed to the development of promising ligands in recent years. …”
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(Un)homely Dwellings: The Usher House and the Collyer Mansion by Theodora Tsimpouki

“…On the contrary, they become paradigms of dwelling with alertness in the Heideggerian sense, the embodiment of an escapist mentality in a culture driven by mundane prosperity and social compliance.…”
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BUSINESS-RELATED TERMINATION OF EMPLOYMENT CONTRACT IN VIEW OF JUDICIAL PRACTICE by Damir Juras, Anamarija Buzolić Mrklić

“…The court cannot valuate a validity of economic, technical or organizational changes’ implementation because it falls within autonomous authority of the employer, but the court is empowered to determine whether the reasons for business-related dismissal of a worker were justified and whether the employer terminated the employee’s employment contract in the manner prescribed by law.…”
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Self-Adaptive Firefly-Algorithm-Based Unified Power Flow Controller Placement with Single Objectives by Selvarasu Ranganathan, S. Rajkumar

“…The selection of positions for unified power flow controller (UPFC) placement in transmission network is an essential factor, which aids in operating the system in a more reliable and secured manner. This paper focuses on strengthening the power system performance through UPFC placement employing self-adaptive firefly algorithm (SAFA), which selects the best positions along with parameters for UPFC placement. …”
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Bayesian and Frequentist Estimation of Stress-Strength Reliability from a New Extended Burr XII Distribution by Varun Agiwal, Shikhar Tyagi, Christophe Chesneau

“… In this article, we propose and study a new three-parameter heavy-tailed distribution that unifes the Burr type XII and power inverted Topp-Leone distributions in an original manner. This unification is made through the use of a simple 'shift parameter'. …”
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Yoruba Festival and the Dramatist: Satire as Spine in Soyinka’s A Dance of the Forests by Olusegun i Olu-Osayomi

“…By vigorously exploiting African (Yoruba) experience, festival motif, and satiric modes, in a manner relevant to the moral development of his world, it will be seen that Soyinka, succeeds in laying the foundation for a truly Nigerian national literature and it is, in fact, on this that his strengths as a satirist playwright lie …”
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Editorial: Relaunching Cultural Science by Hartley John

“…Each volume of the relaunched Cultural Science Journal will be cumulative over the year, so that work will be published in a timely manner once it is reviewed, revised and accepted, without having to wait for an issue. …”
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The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging by Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD

“…Using luciferase-expressing cell lines, we showed that HPCD lowers the BLI signal in a concentration-dependent manner. Flow cytometry revealed that HPCD resulted in reduced cellular accumulation of d -luciferin, and mass spectrometry revealed d -luciferin HPCD species, confirming a direct interaction. …”
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Model of effective leadership in public administration by Janez Stare

“…Leaders as individuals are defined in this manner by their inherited qualities and the personality-trait development they have either received or actually achieved themselves. …”
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The mitochondria as a potential therapeutic target in cerebral I/R injury by Susu Fang, Susu Fang, Wenzhou Huang, Wenzhou Huang, Xinhui Qu, Xinhui Qu, Wen Chai

“…Among patients with ischemic stroke, the primary treatment goal is to reduce acute cerebral ischemic injury and limit the infarct size in a timely manner by ensuring effective cerebral reperfusion through the administration of either intravenous thrombolysis or endovascular therapy. …”
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Customer Churn Modeling via the Grey Wolf Optimizer and Ensemble Neural Networks by Maryam Rahmaty, Amir Daneshvar, Fariba Salahi, Maryam Ebrahimi, Adel Pourghader Chobar

“…In recent years, many methods have been developed including data mining for predicting the customer churn and manners that customers are likely to behave in the future and therefore, taking action early to prevent their leaving. …”
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Memory Map: A Multiprocessor Cache Simulator by Shaily Mittal, Nitin

“…Although, it is very important to select a correct memory configuration, it might be equally imperative to choreograph the data flow between various levels of memory in an optimal manner. Memory map is a multiprocessor simulator to choreograph data flow in individual caches of multiple processors and shared memory systems. …”
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Advanced MicroCT Analysis of Lacustrine Carbonate Reservoirs for Fluid Flow Simulation by Olga M. O. Araújo, Alessandra Silveira Machado, Davi F. Oliveira, Ricardo Tadeu Lopes

“…MicroCT is a powerful tool for visualizing the internal structure of materials, enabling 3D visualization and quantitative analysis of complex pore networks in a non-destructive manner. Lacustrine carbonate rocks, such as coquinas, are important hydrocarbon reservoirs, often found in oil fields. …”
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Endoscopy by Nonphysicians by Elaine R Gossman

“…A focus on preventive care in a cost-effective manner is a high priority. The Kaiser Permanente northwest region (covering northwest Oregon and southwest Washington) serves nearly one-half of a million members. …”
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Isaiah 3:16–23: Dress, pride, ostentatious items or syncretism? by Paul Nyarko-Mensah, Dirk J. Human

“…Isaiah rebuked the women for their pride in appearance, suggesting that their sin was a haughty spirit, expressed through their manner of walking and the use of luxurious items. …”
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Lamb Waves in a Functionally Graded Composite Plate with Nonintegral Power Function Volume Fractions by Xiaoshan Cao, Zhen Qu, Junping Shi, Yan Ru

“…The numerical results reveal that the dispersion properties in some regions are changed by the graded property, the phase velocity varies in a nonlinear manner with the gradient coefficient, nondispersion frequency exists in the first mode, and the set of cutoff frequencies is a union of two series of approximate arithmetic progressions. …”
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Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord–Derived Mesenchymal Stem Cell–Mediated Rheumatoid Arthritis Therapy by Guangyang Liu, Herui Wang, Chenliang Zhang, Xin Li, Yi Mi, Yaoyao Chen, Liqiang Xu, Li Miao, Haomiao Long, Yongjun Liu

“…Previous in vitro studies indicate that TNF-α secreted by T cells can activate NF-κB in human MSCs, thereby triggering the immunoregulatory capacity of MSCs in a manner dependent on tumor necrosis factor receptor 1 (TNFR1). …”
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Deciphering In Vitro and In Vivo Pharmacological Properties of Seed and Fruit Extracts of Flacourtia jangomas (Lour.) Raeusch by Farhana Alam Ripa, Fowzia Alam, Fahmida Haque Riya, Yesmin Begum, Sharmin Akter Eti, Nusratun Nahar, Zebunnesa Ahmed, Sabrina Sharmin

“…All samples notably reduced blood glucose levels in the oral glucose tolerance test in a dose-responsive manner, and SFJC exhibited a considerable hypoglycemic impact (7.38 ± 0.44 mmoles/L at 600 mg/kg). …”
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Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…Etoposide inhibited replication of EV71 A, B, C, and CVA16 viruses in a concentration-dependent manner in a variety of cell lines with minimal cytotoxicity. …”
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Internal Combustion Engine Modeling Framework in Simulink: Gas Dynamics Modeling by Bradley Thompson, Hwan-Sik Yoon

“…The framework allows engine component blocks to be connected in a physically representative manner in the Simulink environment, reducing model build time. …”
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