Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…We have applied peptide microarrays, multiparameter FACS (fluorescence-activated cell analysis) analysis, cellular/molecular immunological technology, advanced microscopic imaging, and transgenic mouse models of solid cancers, to study the interaction between BG34-200 carbohydrate ligand and CD11b protein and the resulting immunological changes in the context of solid cancers, including osteosarcoma, advanced melanoma, and pancreatic ductal adenocarcinoma (PDAC).Results Our results show that BG34-200 can bind directly to the activated CD11b on its I (or A) domain, at previously unreported peptide residues, in a multisite and multivalent manner. This engagement significantly impacts the biological function of tumor-associated inflammatory monocytes (TAIMs) in osteosarcoma, advanced melanoma, and PDAC backgrounds. …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…Our findings demonstrated the significant ability of morin to decrease the production of IL-1β, IL-18, and IL-6 in a dose-dependent manner (<i>p</i> < 0.05), as well as suppress NSCLC cell migration and invasion. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…HDAC7 could modulate astrocytic uptake and lysosomal degradation of tau proteins through a transcriptional factor EB (TFEB) acetylation-dependent manner. Specifically, deacetylation of TFEB at K310 site by HDAC7 prevented TFEB nuclear translocation with reduced lysosomal biogenesis and tau clearance in astrocytes, whereas inhibiting HDAC7 restored astrocytic TFEB acetylation level at K310 with improved tau pathology and cognitive functions in PS19 mice. …”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

“…Thus, this pathway acts in an opposite manner compared with the canonical RIG-I pathway, which plays essential roles in antiviral innate immune response later in infection. …”
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A dual-band microwave sensor for glucose measurements utilizing an enclosed split ring metamaterial-based array by Abhishek Kandwal, Ziheng Ju, Louis W.Y. Liu, Rohit Jasrotia, Choon Kit Chan, Zedong Nie, Ali M. Almuhlafi, Hamsakutty Vettikalladi

“…At 9.2 GHz, there was no significant resonant frequency shift with varying glucose concentrations, but the magnitude of the reflection coefficient changed with the glucose concentration nonlinearly in an amount-dependent manner, with a sensitivity of 16.6 dB per unit glucose concentration within the clinical diabetic range. …”
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Utilization of personal protective equipment and the hygiene sanitation practices of farmers in the application of pesticides by G. Fizulmi, H. Agustina

“…In a cross-program and cross-sector manner, agricultural extension workers can explain how to wear protective equipment and use pesticides correctly, while health educators can promote pesticide exposure pathways and preventive measures for pesticide-related diseases. …”
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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…This study employed the widely recognized and commonly used technique of defining the review's scope in a focused manner by first identifying the population, intervention, comparison, and outcome. …”
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Adolescent HIV prevent and care framework: A global scoping review protocol- BSGH 006. by Gamji Rabiu Abu-Ba'are, Osman Wumpini Shamrock, Darcey Rodriguez, George Rudolph Kofi Agbemedu, LaRon E Nelson

“…Additionally, a search will be conducted for grey literature using Global Index Medicus (WHO), MedNar (Deep Web Technologies), and Central Register of Controlled Trials (Cochrane). …”
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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Methods We have performed meta-analyses of new and previously published scRNA-seq datasets for mouse and human prostate tissues to identify and compare cell populations across datasets in a uniform manner. Using random matrix theory to denoise datasets, we have established reference cell type classifications for the normal mouse and human prostate and have used optimal transport to compare the cross-species transcriptomic similarities of epithelial cell populations. …”
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Analysis of Acoustic Surface Wave Focused Unidirectional Interdigital Transducers Using Coupling-of-Mode Theory by Guopeng Hui, Tinglun Ao, Haotian Liu, Minglei Li, Chen Chen

“…The proposed EWC-FEFUDT may provide an alternative method for cell or droplet separation in an efficient manner.…”
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Intra-operative nasal compression after lateral osteotomy to minimize post-operative Peri-orbital ecchymosis and edema by L. Sowerby, L. M. Kim, W. Chow, C. Moore

“…Although the effect may be variable to some degree, this is an intervention with no additional risks involved and thus can be used in a safe manner.…”
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The role of health literacy in intervention studies targeting children living with overweight or obesity and their parents—a systematic mixed methods review by Heidi Holmen, Heidi Holmen, Tone Nygaard Flølo, Tone Nygaard Flølo, Christine Tørris, Astrid Torbjørnsen, Kari Almendingen, Kirsti Riiser, Kirsti Riiser

“…Future research should focus on integrating health literacy into weight management interventions in a systematic and theory-driven manner, ensuring that these interventions are tailored to the specific needs of children and their families and can sustain behavior change over time.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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VIRTUALIZATION OF IDENTITY IN THE CONTEXT OF SELF-REALIZATION OF A PERSONALITY by Y. V. Lyubiviy, R. V. Samchuk

“…McDonnell, N. Wildman, S. Muncer, G. M. Murtagh, S. Nettleton, O. Ollinaho, N. …”
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Water homeostasis gene expression in the kidney of broilers divergently selected for water conversion ratio by Kentu Lassiter, Loujain Aloui, Elizabeth S. Greene, Marciela Maqaeda, Travis Tabler, Sami Dridi, Robert F. Wideman, Jr., Sara Orlowski, Walter G. Bottje

“…In Exp. 2, target genes were regulated in environment and/or line-dependent manner. The renal expression of heat shock proteins 70 and 90, AVP receptor 2 (AVPR2), AGT, renin, AT1/2, and AQP1was significantly upregulated in HS compared to TN birds, however AVPR2 expression was significantly higher in HWE compared to MRB birds. …”
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Expert decision-making in clinicians: An auto-analytic ethnographic study of operational decision-making in urgent care. by Nicola Irvine, Robert Van Der Meer, Itamar Megiddo

“…Expert solutions generated in this manner are pragmatic rather than optimal, context dependent, and seek to achieve goals which vary from moment-moment. …”
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MATHEMATICAL RATIONALE FOR CREATING AN APPLICATION FOR CONDUCTING RANDOM MEETINGS «COFFEE BREAK» by Vadym Ziuziun, Daniil Osoka

“…This study’s findings lay the groundwork for a new tool that encourages in-person interactions, enabling individuals to expand their social networks in a balanced and purposeful manner.…”
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Comparison of Medical Students&rsquo; Peer Evaluation and Teaching Staff Evaluation of Community Health Projects: Perceptions and Experiences by Mahmoud MA, Almutairi ZS, Mahmoud AM, Alanazi HB, Abdulrahman SM, Bin Abdulrahman KA

“…Both groups evaluated the project’s level of innovation and the clarity of its target audience in a comparable manner. The analysis of the Full Project Level indicated no substantial disparity between medical students and Staff, as evidenced by the p-value of 0.920.Conclusion: This study validates that peer evaluation of student projects is equally practical as evaluation conducted by faculty members. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Histological and TUNEL detection in the liver demonstrated that the 14 °C and 7 °C cold stress caused severe morphological damage and cell apoptosis in a time-dependent manner. DEGs in the biosynthesis of fatty acids (<i>Acsbg2, Acsl3, Acsl4, Acsl5, Mcat,</i> and <i>Acacb</i>), as well as unsaturated fatty acids (<i>Hsd17b12</i>, <i>Elovl7</i>, <i>Scd</i>, and <i>Baat</i>), starch and sucrose metabolism (<i>Pgm1</i>, <i>Pgm2</i>, and <i>Treh</i>), and apoptosis (<i>Ddit3</i>, <i>Gadd45a</i>, <i>Lmnb1</i>, <i>Tuba1c</i>, <i>Tnf</i>, <i>Tnfsf10</i>, <i>Fos</i>, <i>Itpr1</i>, and <i>Ctso</i>) were discovered in the transcriptome under cold stress. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…In contrast, a small number of extensively instrumented research sites would enable community-based experiments in an unprecedented manner, thereby facilitating a deeper understanding of complex, non-linear processes modulated by scale-dependent feedback and multiscale spatiotemporal heterogeneity. …”
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Effect of Construction Waste as a Fine Aggregate on Properties of Concrete. by Sempala, Ronald

“…In order to continue all development efforts with the least possible harm to the environment and to obtain all the infrastructure needed to provide services and convenience in an affordable and environmentally friendly manner, research in this sector and successful outcomes are very essential. …”
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