Dual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficienc... by Laura Tomasello, Antonina Coppola, Giuseppe Pizzolanti, Giuseppe Pizzolanti, Carla Giordano, Giorgio Arnaldi, Valentina Guarnotta

“…After 12 months of DR-HC treatment, a significant increase in CD4+ T cells (p = 0.012), PD-L1 (p = 0.003), and IDO (p < 0.001) and a decrease in CD8+ T cells (p < 0.001), IL-6 (p = 0.003), IL-17A (p = 0.0014), COX-2 (p < 0.001), HSP-70 (p = 0.005), and TXN-1 (p = 0.0008), as well as a significantly higher conversion in the CD4+/CD8+ ratio (p = 0.033), were observed compared to conventional GCs.ConclusionsThe switch from conventional GCs to DR-HC treatment altered the T lymphocyte phenotype and CD4+/CD8+ ratio in a Treg-independent manner, inducing significant improvements in the immune and inflammatory profile in PAI.…”
Get full text

Přítel příteli, bratr bratru, muž muži. Jan, František, Josef a Alois Vojtěch Šemberovi ve své vzájemné korespondenci by Zuzana Čevelová, Jana Straníková

“…Jahrhundert, als das bei den amtlichen und institutionellen Quellen der Fall ist. Die Briefe der Männer aus 19. Jahrhundert zeigen oft, dass sie sein Interesse nicht nur an die Öffentlichkeit orientierten, sondern sich sehr viel auch in dem privaten Raum seiner Fami- lie und Haushalt engagierten. …”
Get full text

Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Finally, IR of ALI-PBEC had a marked effect on organoid formation capacity, which was markedly impaired following IR in a dose-dependent manner. Conclusion In conclusion, epithelial progenitor cell function as assessed by organoid formation capacity is strongly reduced by IR and persists for at least 7 days. …”
Get full text

Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model by Blanca Martínez Soriano, Antonio Güemes, Guillermo Pola, Azucena Gonzalo, Pilar Palacios Gasós, Ana C. Navarro, Roberto Martínez-Beamonte, Jesús Osada, José J. García

“…Regarding the parameters of oxidative stress, MDA modifies in a significant manner within the group of animals that continue with the diet and take melatonin (p=0.004). …”
Get full text

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study by Sudeshna Das, Yao Ge, Yuting Guo, Swati Rajwal, JaMor Hairston, Jeanne Powell, Drew Walker, Snigdha Peddireddy, Sahithi Lakamana, Selen Bozkurt, Matthew Reyna, Reza Sameni, Yunyu Xiao, Sangmi Kim, Rasheeta Chandler, Natalie Hernandez, Danielle Mowery, Rachel Wightman, Jennifer Love, Anthony Spadaro, Jeanmarie Perrone, Abeed Sarker

“…Our modular framework generates individual summaries followed by an aggregated summary to answer medical queries from large amounts of user-generated social media data in an efficient manner. We compared the performance of a quantized large language model (Nous-Hermes-2-7B-DPO), deployable in low-resource settings, with GPT-4. …”
Get full text

Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…Furthermore, our data demonstrate that the combined knockdown of FBXO4 and E6AP not only rescues the protein levels of E6 but also induces high levels of cell death in a p53-dependent manner in the HPV-positive cervical cancer cell line, HeLa. …”
Get full text

Monetary Fines in EU Mergers: In Need for More Regulation by Nora Memeti

“…Here it is relevant to inquire in what manner the EC imposes fines and why it occasionally mirrors the fining guidelines applicable to other pillars of EU Competition Law. …”
Get full text

Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription by Lipeng Pei, Yan Zhu, Wenpeng Li, Bin Xu, Jingli Sun

“…Results Treatment of Celastrol inhibited cell viability in a dose-dependent manner, and caused cell cycle arrest, accompanied by the downregulation of CDK2 and cyclin E expression and the upregulation of p21. …”
Get full text

Study of the Shock Absorption Effectiveness of Air Cushions by Jacek Roguski, Leszek Jurecki, Ryszard Łyszczek, Krzysztof Cygańczuk

“…Safety air cushions are designed to slow the body down in a controlled manner by spreading kinetic energy over a larger surface area and for a longer period of time, which reduces the risk of serious injury. …”
Get full text

Tuning Electrical Conductivity and Ultrafast Optical Nonlinearity of Reduced-GO Films Ablated by Femtosecond Laser Direct Writing by Youliang Tao, Xuefeng Zhang, Han Wang, Zhongquan Nie, Deng Pan

“…The results show that the behavior of ONL is reversed whenever GO is reduced in a controlled manner. More interestingly, the higher the ablation laser power is, the stronger the optical nonlinearity of r-GO is. …”
Get full text

Reliability and Validity of the ActivForce Digital Dynamometer in Assessing Shoulder Muscle Force across Different User Experience Levels by Christos Karagiannopoulos, Sean Griech, Brian Leggin

“…Its low-cost and electronic accessibility features may promote better compliance for clinicians using dynamometry to objectively assess and store muscle force data in a cost-effective manner. # Level of Evidence 3…”
Get full text

Relationships between structural stigma, societal stigma, and minority stress among gender minority people by Kristen D. Clark, Mitchell R. Lunn, Jae M. Sevelius, Carol Dawson-Rose, Sandra J. Weiss, Torsten B. Neilands, Micah E. Lubensky, Juno Obedin-Maliver, Annesa Flentje

“…The application of this variable should be investigated further to explore its association with health outcomes and to inform efforts to reduce health equity barriers experienced by GM people through addressing structural stigma in a manner inclusive of societal stigma.…”
Get full text

Differential impact of TIM-3 ligands on NK cell function by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert L Ferris, Tullia C Bruno, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lawrence P Kane, Pragati Upadhyay, Jennifer L Anderson, Onyedikachi Victor Onyekachi, Lidia M R B Arantes

“…Among the four putative TIM-3 ligands, galectin-9 most consistently suppresses NK cell-mediated cytotoxicity and proliferation through TIM-3 and CD44 signaling, respectively, but promotes IFN-γ release in a TIM-3-dependent manner. Among patients with HNSCC, an elevated intratumoral TIM-3+ NK cell gene signature associates with worse outcomes, specifically in those with human papillomavirus (HPV)+ disease, potentially attributable to higher galectin-9 levels in HPV+ versus HPV− patients.Conclusions Our findings underscore the complex functional impact of TIM-3 ligand signaling, which is consistent with recent clinical trials suggesting that targeting TIM-3 alone is suboptimal as an immunotherapeutic approach for treating malignancies.…”
Get full text

Investigating the preventive effects of pulsed electromagnetic fields on glucocorticoid-induced osteoporosis in rats by Shuai Ding, Guangquan Zhang, Yanzheng Gao, Zhiqiang Hou, Fuqiang Shao

“…Subsequently, the rats were exposed to PEMF for 4 h daily, with the duration varying from 1 to 8 weeks. (2) Adhering to the injection schedule of the PEMF group, the MPSL group (consisting of 24 rats) was administered LPS and MPSL, omitting PEMF stimulation. (3) The PS group (n = 24) was administered injections of 0.9% saline solution in an identical manner and at the same time intervals as the other two groups. …”
Get full text

Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice by Kazuki Harada, Eiji Wada, Yuri Osuga, Kie Shimizu, Reiko Uenoyama, Masami Yokota Hirai, Fumihiko Maekawa, Masao Miyazaki, Yukiko K. Hayashi, Kazuaki Nakamura, Takashi Tsuboi

“…Results: AVP induced the increase in intracellular Ca2+ levels and GLP-1 secretion from GLUTag cells in a V1aR and V1bR-dependent manner. AVP receptor-deficient mice, particularly V1aR−/−V1bR−/− mice, demonstrated impaired secretion of GLP-1 and peptide YY secreted by enteroendocrine L cells. …”
Get full text

Time Course of Acute Hip Adduction Range of Motion Changes Following Foam Rolling by Anthony D’Amico, Kevin Silva, Joseph Gallo

“…# Background With the increased popularity of foam rolling (FR), it is important to establish the exact manner in which the practice is useful. # Purpose The purpose of this study was to examine the impact of FR the iliotibial (IT) band on hip adduction range of motion (ROM) and the short-term time course of any ROM changes that may occur…”
Get full text

Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…In this study, we developed a model of septic shock with a clinically relevant bacteria (Klebsiella pneumoniae) that provides standard supportive care including mechanical ventilation, invasive hemodynamic monitoring, volume resuscitation, vasopressors, antibiotics, and steroids. In a dose-dependent manner, we observed that this model closely emulates the hemodynamic, end-organ dysfunction, and cellular and soluble responses associated with human sepsis. …”
Get full text

Supporting complex skill learning with digital tools in tertiary education: educator’s perspective by Bernarda Letnar, André Klostermann, Mirko Schmidt

“…Educators were presented with a video of a student performing a sports skill in suboptimal manner to prompt a discussion on their approach to optimize student’s movement. …”
Get full text

RETRACTED: Melanin Produced by Bordetella parapertussis Confers a Survival Advantage to the Bacterium during Host Infection by Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Fuminori Sugihara, Yasuhiko Horiguchi

“…Taken together, our findings indicate that melanin produced by B. parapertussis in a BvgAS-independent manner confers a survival advantage to the bacterium during host infection. …”
Get full text

MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…Through miRNA gene chips analysis, 40 differential genes were screened. mmu-miR-146b-5p could directly and negatively regulate the expression and translocation of HMGB1, inhibit the expression of inflammatory mediators, and might participate in the NF-κB signaling pathway in a HMGB1-dependent manner under C. albicans infection. Conclusion: mmu-miR-146b-5p may play an anti-inflammatory role in treating C. albicans infection and provide a novel target for it.…”
Get full text