Putative evolution of Myxococcus fulvus 124B02 plasmid pMF1 from a chromosomal segment in another Myxococcus species by Shruti Jain, Gaurav Sharma

“…We further reported that all pMF1 plasmid genes depict homology with Myxococcus stipitatus CYD1 draft genome (contig 28) and a chromosomal segment of M. stipitatus DSM14675 in a syntenic manner, implying the presence of plasmid-like structure in M. stipitatus CYD1, integrated into its chromosome. …”
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Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro by Meng-Xi Li, Zhen Zhang, Yue Zhang, Fan-Ru Zhao, Yu-Fan Li, Yu-Fei Dang, Yang-Yang Yue, Li Li

“…RESULTS: Treatment with SCF-II decreased HCEC viability in a dose-dependent manner. A concentration below 10 µmol/L did not present obvious cell toxicity, and survival rates were more than 70% at 48h. …”
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Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models by Tomofumi Watanabe, Takuya Sadahira, Yusuke Tominaga, Yuki Maruyama, Naoya Nagasaki, Takanori Sekito, Kohei Edamura, Toyohiko Watanabe, Motoo Araki, Masami Watanabe

“…Intravesical instillation of AA increased the urinary frequency and decreased the mean voided volume (VV) in a concentration-dependent manner, with statistical significance at a concentration of 1.0% (urinary frequency; p=0.0007, mean VV; p=0.0032, respectively) compared with PBS. …”
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Preparation and Protective Performance of High-Reflection and High-Thermal Insulation Laser Protection Coatings by LI Shuwen, WU Lingfeng, YANG Guanjun, CHEN Lin

“…Laser weapons have entered the actual combat application stage， and the research on anti-laser protection for air and space weapons is becoming increasingly urgent.Prolonged high-energy laser irradiation leads to problems such as reduced metal reflectance，mass loss of ablated layer of the ablative layer and insufficient heat insulation toughness.Based on this，a composite laser protection strategy based on the principles of reflection and heat insulation was proposed.In this study， by adjusting spraying power， spraying distance and other parameters， supersonic flame spraying technology and plasma spraying technology were used to prepare NiCoCrAlTaY bond coating and yttria-stabilized zirconia(YSZ) top coating double-layer coatings， to explore the influence of surface roughness and porosity on reflectivity， and to investigate the laser protection performance of the coatings.Results showed that the larger the spraying power or spraying distance， the more obvious the layer effect， and the more cross-sectional pores were observed in the coating.The surface roughness of the coating decreased first and then increased with the increase in spraying distance.When the secondary reflection structure was removed， the coating surface had Ra＝1.8 μm.When Ra＝0.5 μm， the wedge-shaped structure of the coating increased the reflectivity by about 2.4%compared to that of the coating when Ra＝1.8 μm.It was pointed out that the layered pores were key to the high-reflection wedge structure， the spherical voids were the laser absorption points，and the process parameter of 14.7%porosity (39 kW，100 mm) was the best.In the laser ablation experiment，with the increase in laser power density， the cracks in the coating gradually increased until holes were ablated.The line ablation rate increased approximately in a parabolic manner.With low laser power density (<3 800 W/cm2)， the surface structure changed slightly； as the power increased， the surface cracks increased and deepened， and the petal-like structure in the recondensing zone increased.With high laser power density (>8 050 W/cm2)， partial peeling and ablation of the coating surface caused the coating to fail.…”
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CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against Escherichia coli by Thushari Gunawardana, Khawaja Ashfaque Ahmed, Kalhari Goonewardene, Shelly Popowich, Shanika Kurukulasuriya, Ruwani Karunarathana, Lisanework E. Ayalew, Ashish Gupta, Betty Lockerbie, Marianna Foldvari, Suresh K. Tikoo, Philip Willson, Susantha Gomis

“…Overall, the present study revealed that CpG-ODNs orchestrate immunological niches in neonatal chickens in a dose-dependent manner that resulted in differential protection against E. coli infection, thus supporting a cause and effect relationship between CpG-ODN-induced immune enrichment and the antibacterial immunity.…”
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A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. by Nadeene E Riddick, Emilia A Hermann, Lamorris M Loftin, Sarah T Elliott, Winston C Wey, Barbara Cervasi, Jessica Taaffe, Jessica C Engram, Bing Li, James G Else, Yingying Li, Beatrice H Hahn, Cynthia A Derdeyn, Donald L Sodora, Cristian Apetrei, Mirko Paiardini, Guido Silvestri, Ronald G Collman

“…SIVsmm primary isolates infected both homozygous mutant and wild-type PBMC in a CCR5-independent manner in vitro, and Envs from both CCR5-null and wild-type infected animals used CXCR6, GPR15 and GPR1 in addition to CCR5 in transfected cells. …”
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MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Results Our investigation revealed that exposure to ox-LDL led to a downregulation in miR-125b-5p, while upregulating the expression of tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), TLR4, p-p65 and p-IkBa in HUVECs in a dose-dependent manner. We confirmed TNFSF4 as a direct target of miR-125b-5p. …”
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Charakter prawny rady społecznej w samodzielnym publicznym zakładzie opieki zdrowotnej by Michał Gornowicz

“…De lege lata, the current manner of legal shaping of social councils makes it a facade, deprived of any authority enabling effective implementation of statutory objectives accompanying their establishment within the broadly understood social control of independent public healthcare institutions. …”
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…ROCK1/ROCK2-deficient primary hepatocytes demonstrated increased susceptibility to both caspase-3–mediated apoptosis and caspase-3–independent forms of cell death in a cell intrinsic manner. Conclusions:. ROCK signaling plays a critical role in mediating hepatocyte cell survival pathways in response to liver injury.…”
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Gemelos digitales pulmonares by Ana Fernández-Tena, Carlos Arnedo, Guillaume Houzeaux, Beatriz Eguzkitza

“…Abstract: The development of lung digital twins (DTs) represents a significant advance in personalized medicine, providing a virtual framework that replicates the structure, function, and pathology of the respiratory system in an individualized manner. DTs integrate clinical data, high-resolution images, and mathematical models to simulate respiratory mechanics, gas diffusion, and fluid dynamics in real time. …”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…The ability of nanoherbal formulations to deliver drugs to tumor cells in an improved permeability and retention manner, such as, cancer therapy while minimizing tissue damage, has been largely practiced in many laboratories. …”
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Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck by Doriana Iancu, Ana Fulga, Doina Vesa, Iuliu Fulga, Dana Tutunaru, Andrei Zenovia, Alin Ionut Piraianu, Elena Stamate, Corina Sterian, Florentin Dimofte, Mihail Alexandru Badea, Alin Laurentiu Tatu

“…In addition, immune-deficient patients with early-stage disease had a 21-month median survival rate that changed to11 months for advanced-stage cases. In a similar manner, immunocompetent patients with early-stage cancer had a significantly better median survival than those withadvancedstages,43 versus 18months. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…We found that ibrutinib, in a dose-dependent manner, decreased brain endothelial cell–cell adhesion over 24 h, without affecting endothelial cell viability (p < 0.005). …”
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Parkinson’s disease and other movement disorders in the context of the SARS-COV-2 pandemic by R. Kaladytė Lokominienė

“… Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is able to invade the human nervous system and can cause headache, nausea, vomiting, febrile seizures, encephalopathy, encephalitis, ataxia or psychiatric disorders, as well as quantitative disturbances of smell and taste which are observed both during the course of Parkinson’s disease and other alpha-synucleinopathies, only in slowly progressive and irreversible manner. The penetration of SARS-CoV-2 into the brain damaged by Parkinson’s disease can enhance the clinical burden of movement disorder and increase the deficit for substitutional dopaminergic therapy. …”
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Vermicomposting of coir pith and cow manure: Influence of initial total phenolic content on earthworms’ performance by Kanokwan Pundee, Saengchai Akeprathumchai, Sudarut Tripetchkul

“…Earthworm mortality and weight loss increased as initial TPC of materials increased in a concentration dependent manner. High performance liquid chromatography (HPLC) results showed that the total numbers of water-soluble phenolics of coir pith and cow manure were, respectively, 17 and 16 out of which 5 and 4 were unique to coir pith and cow manure, respectively. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…Cell viability was reduced in a dose-dependent manner, with only the highest doses causing a cytotoxic effect associated with caspase 3/7 activation. …”
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Postcards from Inside the Practices by Alicia Lazzaroni, Antonio Bernacchi, Enrique Espinosa Pérez, Lydia Maria Arantes, Michele Avis Feder-Nadoff

“…Instead, their panel was designed to explore making-knowledge with others in a manner that is improvisatory, non-authoritative, and open to the silence of gestures and quiet exchange. …”
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Respectful maternity care and associated factors among mothers who gave birth at public health institutions in Debre Tabor town, Northwest Ethiopia: a mixed-methods study by Tadesse Ayana Fentie, Abayneh Aklilu Solomon, Mihretu Molla Enyew, Meseret Mekuriaw Beyene, Ayalew Kassie Melese, Alamirew Enyew Belay, Gebrie Getu Alemu

“…BackgroundRespectful maternity care is care organized for and provided to all women in a manner that maintains their dignity, privacy, and confidentiality, ensures freedom from harm and mistreatment, and enables informed choice and continuous support during labor and childbirth. …”
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Potential and actual evapotranspiration and Landsat derived indices by P. Kumar, D. Deka, A. Yadav, Ashwani ., M. Kumar, J.P. Das, A. Singh, A. Gurjar

“…Accurately estimating the rate of evapotranspiration is crucial for understanding fluctuations in water availability and effectively managing water resources in a sustainable manner. The study aims to examine the correlation between actual evapotranspiration and potential evapotranspiration by assessing the linkages with vegetation and snow cover in an ecologically fragile located in the northwestern Himalaya.MATERIALS AND METHODS: The present study uses remote sensing Landsat satellite data series to map vegetation cover and snow cover in the area. …”
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Restraint stress effects on glutamate signaling protein levels in the rats’ frontal cortex: Does β1 adrenoceptor activity matter? by Agnieszka Zelek-Molik, Anna Gądek-Michalska, Michał Wilczkowski, Adam Bielawski, Katarzyna Maziarz, Grzegorz Kreiner, Irena Nalepa

“…These results suggest that decreased Fyn kinase activity, indicated by phosphorylation at Y530, underlies the stress-evoked downregulation of GluN2B in the FC in a manner independent of β1AR activity.…”
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