Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…Owing to the size effect, the NF-k and NF-c release up to 50% of the drug in a sustained manner till 50 h showing twofold higher concentration than the control where it released 25%. …”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Mechanically, GADD45B-facilitated inflammation was directly mediated by p38 phosphorylation, while GADD45B interacted with FOS to promote cellular senescence in a p38 phosphorylation-independent manner. Furthermore, Gadd45b deficiency remarkably alleviated inflammation and senescence of lungs in CS-exposed mice, as well as improved emphysema and lung function. …”
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Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells by Liza U. Ljungberg, Mulugeta M. Zegeye, Caroline Kardeby, Knut Fälker, Dirk Repsilber, Allan Sirsjö

“…Overall, our data indicate that IL6 acts in an autocrine manner to regulate basal cellular functions, such as cell cycle regulation, signaling, and cellular movement, and suggests that the autocrine functions of IL6 in human endothelial cells are mediated via IL6 classic signaling.…”
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CpG Oligodeoxynucleotides Inhibit RANKL-Induced Osteoclast Formation by Upregulating A20 Deubiquitinase in RAW 264.7 Cells by Seong-Kyu Kim, Jung-Yoon Choe, Ki-Yeun Park

“…CpG-ODN increased A20 gene and proteins in time-dependent manner. A20 expression under costimulation with CpG-ODN and RANKL was more decreased than under stimulation with RANKL alone. …”
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STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…Signal transducer and activator of transcription 3 (STAT3) regulates gene expression in a cell-specific, cytokine-dependent manner, involving multiple immune responses. This study proposes the positive correlation between the prevalence of STAT3 rs744166 risky allele “A” with the severity of disease in a cohort of 94 CD patients. …”
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A contentious intervention to support the medical workforce: a case study of the policy of introducing physician associates in the United Kingdom by Martin McKee, Louella K. Vaughan, Giuliano Russo

“…The name soon changed, to physician associate, and the range of roles and responsibilities expanded greatly, although in a largely unregulated manner; by 2024, some were undertaking complex procedures or managing undifferentiated patients in primary care. …”
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The Double-Edged Sword of Third-Party Resources: Examining Use and Financial Burden of Extracurricular Tools in Medical Students [version 2; peer review: 1 approved, 2 approved wit... by Dimitrios Papanagnou, Saaniya Farhan, Andres Fernandez, Meryem Guler, Drake Kienzle, Faizaan Siddique

“…Studies suggest third-party resources are used in a task-dependent manner with a supplemental role to lectures during the preclinical years and a primary role for United States Medical Licensing Examination (USMLE) preparation during clinical years. …”
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“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…To increase acceptability of such treatments, clinicians should ensure patients are aware of mpox symptom management options, including pain relief; acknowledge and address patient concerns upfront and within the context of non-stigmatising care; and communicate offers in a consistent and supportive manner in line with locally approved eligibility criteria and protocols at the time.…”
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Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation by Huanjin Song, Hao Wu, Jun Dong, Sihua Huang, Jintao Ye, Ruoxi Liu

“…Western blot analysis showed that EA reduced MTA1 expression in a dose-dependent manner in MH7A cells. Then, TNF-α-treated MH7A cells were incubated with EA alone or together with MTA1 overexpression plasmid (pcDNA-MTA1), and we found that EA inhibited proliferation, inflammation cytokine levels, and oxidative stress marker protein levels and promoted apoptosis in MH7A cells, while MTA1 overexpression abolished these effects. …”
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Aplikasi Peran Pendidikan Etika Politik Pada Fenomena Politik Identitas di Pemilu 2024 by Husein Maruapey, Herli Andani, Shifa Nursahwa, Halimatu Sa’diah, Nur Santi Paujiah

“…Agar menjadi warga negara yang baik kita harus menyaring segala berita yang ada, untuk terhindar dari politik identitas yang bersifat diskriminasi hingga radikalisasi. …”
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Bathymetry estimation for coastal regions using self-attention by Xiaoxiong Zhang, Maryam R. Al Shehhi

“…We trained the model using the collected dataset in an end-to-end manner. We validated the robustness and effectiveness of our model by conducting extensive experiments, including pre-seen and un-seen regions bathymetric estimations. …”
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Le « jonglage » des visiteurs entre œuvres et cartels : de l’étude d’un comportement à l’application d’un principe muséographique. by Anne-Sophie Grassin

“…These writings offer a set of information distributed in a homogeneous, constant and hierarchical manner from the particular to the general: the nominative, descriptive, explanatory and contextual information is articulated to serve the work exhibited nearby. …”
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Pore Structure and Fractal Characteristics of Inter-Layer Sandstone in Marine–Continental Transitional Shale: A Case Study of the Upper Permian Longtan Formation in Southern Sichua... by Jianguo Wang, Jizhen Zhang, Xiao Xiao, Ya’na Chen, Denglin Han

“…It also attempts to combine high-pressure mercury intrusion analysis and gas adsorption experiments to describe the structural and fractal characteristics of pores at different scales in a segmented manner. The findings reveal that the sandstone type of the Longtan Formation is mainly lithic sandstone. …”
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SVM directed machine learning classifier for human action recognition network by Dharmanna Lamani, Pramod Kumar, A Bhagyalakshmi, J. Maria Shanthi, Lakshmana Phaneendra Maguluri, Mohammad Arif, C Dhanamjayulu, Sathish Kumar. K, Baseem Khan

“…This generated input is then supplied into HARNet, which processes spatial and motion information in a single stream in an effective manner, maximizing the benefits of both types of cues. …”
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Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

“…Conclusions Our findings unveil DAPK1-215 as a molecular brake on DAPK1 expression, influencing cancer cell migration and invasion in a context-dependent manner. These results highlight the potential of DAPK1-215 as an important regulator of malignant progression and as a prognostic marker in liver cancer.…”
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Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, E. E. Uldanova, E. А. Chuyko, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…Our new findings indicate that calsyntenin-2 regulates neuronal hippocampal density in subfield-specific manner, suggesting that the CA1 neuronal subpopulation may represent a cellular target for earlylife preventive therapy of ASD.…”
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Modified GIC Estimation Using 3‐D Earth Conductivity by Anna Kelbert, Greg M. Lucas

“…This modest modification to the simpler local field formulation approach avoids real‐time integration of geoelectric fields along power lines while taking the realistic 3‐D Earth into account in a rigorous manner. Once implemented, the method provides a power grid operator with the benefits of convenience and computational speed for a first look real‐time operational GIC hazard assessment. …”
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Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis by Quan Nha Hong, Esther McSween-Cadieux, Maxime Guillette, Luiza Maria Manceau, Jingjing Li, Vera Granikov, Marie-Pascale Pomey, Marie-Pierre Gagnon, Saliha Ziam, Christian Dagenais, Pierre Dagenais, Alain Lesage, Thomas G. Poder, Martin Drapeau, Valéry Ridde, Julie Lane

“…Abstract Background The COVID-19 pandemic necessitated the rapid availability of evidence to respond in a timely manner to the needs of practice settings and decision-makers in health and social services. …”
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Systematic comparison of quantity and quality of RNA recovered with commercial FFPE tissue extraction kits by Sukoluhle Dube, Sharefa Al-Mannai, Li Liu, Sara Tomei, Satanay Hubrack, Shimaa Sherif, Ayesha Jabeen, Eiman I. Ahmed, Apryl Sanchez, William Mifsud, Davide Bedognetti, Wouter Hendrickx, Christophe M. Raynaud

“…The slices were distributed in a systematic manner to prevent any biases. Each of the 7 commercially available RNA extraction kits were used according to manufacturer's instructions, with each sample being tested in triplicate resulting in a total of 189 extractions. …”
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The mediating effect of clinical belongingness on the relationship between anxiety and professional identity in nursing interns: a cross-sectional study by Junhao Zhang, Lijia Wang, Xue Yang, Yuwei Yang, Xuehua Wu, Huaping Huang, Guirong Li

“…Accordingly, nursing educators and managers should screen and channel the mental health problems of nursing interns in a timely manner, improving their clinical belonging, which will help improve PI and ultimately improve the stability of the nursing workforce.…”
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