Effects of Polygonatum sibiricum Polysaccharides (PSP) on Human Esophageal Squamous Cell Carcinoma (ESCC) via NF-κB Signaling Pathway by Weizheng Zhou, Jiang Hong, Ji Zhu, Xiaowei Wang

“…PSP significantly inhibited the proliferation of Eca109 cells (p<0.05) on a time- and dose-dependent manner; the apoptosis rates of Eca109 cells in experimental groups were significantly increased after 48 h of culture (p<0.05); PSP significantly reduced the migration and invasion ability of Eca109 cells (p<0.05); RT-PCR results showed that the expression of IL-10 in Eca109 cells increased significantly after treatment with PSP (p<0.05), while the expression of IL-1, IL-6, TNF-α, and TGF-β decreased significantly (p<0.05). …”
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Shaping ability of NiTi reciprocating file systems R-motion and waveOne gold in mesial canals of mandibular molars; micro CT study by Mona Alsulaiman, Loai Alsofi, Mey A. Alhabib

“…Thus, RM is recommended for its ability to balance effective canal shaping with structural preservation in a conservative manner.…”
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Ecological validity and inclusivity in heritage bilingualism research: Examining objective and subjective Spanish proficiency assessments and language experience factors by Alicia Luque, Alicia Luque, Alicia Luque, Bryan Koronkiewicz, Bernard Issa, Mandy Faretta-Stutenberg, Harriet Wood Bowden

“…By critically evaluating the reliability and validity of existing objective and subjective proficiency assessments alongside HL experience factors, our study aims to shed light on the best practices of assessing language proficiency among bilingual individuals, specifically HSs of Spanish in the US, in an ecologically valid and inclusive manner.…”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…., SOD2, Heme oxygenase-1, and EGR-1) while increasing GDF15 mRNA expression via EGR-1 regulation in a dose- and time-dependent manner. Furthermore, urinary GDF15 levels were positively associated with urinary MEOHP and MEHP metabolites in the biopsy cohort (p = 0.0007 and 0.011, respectively) and with urinary oxidative stress marker 8-OHdG, aggressive marker VEGF, and CCL2/MCP-1 levels in the prostatectomy cohort (p = 0.0004, 0.006, and 0.0034, respectively). …”
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The Importance of Physiochemical Processes in Decarbonisation Technology Applications Utilizing the Subsurface: A Review by Ieva Kaminskaite, Sandra Piazolo, Andy R. Emery, Nicholas Shaw, Quentin J. Fisher

“…Using the subsurface in a safe manner requires a fundamental understanding of the physiochemical processes which occur when decarbonising technologies are implemented and operated. …”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…Experimental validation showed that quercetin inhibited the growth of TC cells in a dose-dependent manner. Protein results indicated that quercetin downregulated SPP1 mRNA and protein expression. …”
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Slight thermal stress exerts genetic diversity selection at coral (Acropora digitifera) larval stages by Cristiana Manullang, Nozomi Hanahara, Ariyo Imanuel Tarigan, Yuko Abe, Mao Furukawa, Masaya Morita

“…The genomic regions under higher and lower Tajima’s D were not broadly shared among control and head conditions, implying that selective pressures operated in distinctive manners. Many larval protein-coding sequences were identified in this genomic region, and the codon evolution of many of these genes showed signs of positive selection. …”
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Triple Endobutton with Coracoacromial Ligament Transfer: A Modified Technique for Fixation of Acromioclavicular Joint Dislocation by Vikas Kesari, Jatin Prakash, Jyoti Garg, Divesh Jalan, Karan Maggo, Naval Bhatia

“…An Endobutton loaded with No. 2 FiberWire was passed under the coracoid and the medial clavicle tunnel in a retrograde manner. ACJ was then reduced and the No. 2 FiberWire was tied over the Endobutton on the clavicle. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…We ensured the unbiased nature of our assessment by conducting morphological evaluations with two independent observers in a blinded manner. We identified elevated expression of ATF3 in both human sporadic AAD tissues and mouse AAD models. …”
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Insulin treatment lowered blood glucose in a dose-dependent manner. In addition, both doses of insulin lowered lipids and increased body fat percentage. …”
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Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…This algorithm integrates multiple aspects of human communication, including posture modelling, voice modulation, greet- ings mannerisms, eye contact management, gestural communication and interactive responsiveness. …”
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Postharvest wounding treatment influences flavone production and biological activities of the hairy root cultures of Scutellaria baicalensis by Hyeon Ji Yeo, Su Young Shin, Sang Un Park, Chang Ha Park

“…We found that the levels of these flavones in S. baicalensis hairy roots increased after 6, 12, 24, 48, 72, and 96 h of exposure in a time-dependent manner. In particular, the highest production of three flavones was reported after exposure to 96 h of wounding stress. …”
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Influence of Inflammatory Cytokines IL-1β and IFNγ on Sarcoplasmic Aggregation of p62 and TDP-43 in Myotubes by Bryony McCord, Richard M. Day

“…IL-1β increased p62 protein expression in an autophagy-independent manner. None of the cytokine treatments affected TDP-43 protein expression, size, or frequency of TDP-43 aggregates or localization, suggesting IL-1β and IFNγ may influence TDP-43 processing in human skeletal muscle cells. …”
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mHealth knowledge and usage in maternal healthcare delivery: perspectives and experiences of healthcare practitioners in Ghana by Edward Kwabena Ameyaw, Padmore Adusei Amoah, Pascal Agbadi, Aikins Amoako Asiama

“…Interventions aimed at enhancing mHealth integration should address these factors in a context-specific manner.…”
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Intrauterine fetal growth restriction in sheep leads to sexually dimorphic programming of Preadipocytes' differentiation potential by Michell Goyal, Rosa I. Luna Ramirez, Sean W. Limesand, Ravi Goyal

“…Thus, we hypothesized that growth restriction differentially programs gene expression and genetic pathways in perirenal preadipocytes, which reduces their differentiation potential in male fetuses in a sexually dimorphic manner. We created FGR by exposing pregnant sheep to ambient hyperthermia. …”
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Copper Does Not Induce Tenogenic Differentiation but Promotes Migration and Increases Lysyl Oxidase Activity in Adipose-Derived Mesenchymal Stromal Cells by Marta Milewska, Anna Burdzińska, Katarzyna Zielniok, Katarzyna Siennicka, Sławomir Struzik, Piotr Zielenkiewicz, Leszek Pączek

“…Furthermore, the exposition to the CuSO4 significantly increased directed migration of human ASCs in a dose-dependent manner. Conclusion. Copper sulfate supplementation can have a beneficial effect on tendon regeneration not by inducing tenogenic differentiation, but by improving the recruitment of MSCs to the site of injury, where they can secrete growth factors, cytokines and chemokines, and prevent the effects of oxidative stress at the site of inflammation, as well as improve the stabilization of collagen fibers, thereby accelerating the process of tendon healing.…”
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O conceito de Estado-Nação by Vítor Neto

“…En effet, nous assistons à la perte de l'un des symboles du pouvoir politique national : la monnaie nationale cèdera bientôt la place à l'euro. …”
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Osobnost a dílo Matouše Radouše a tvorba renesančních epitafů v Chrudimi by Ondřej Jakubec, Radka Milotová

“…We can observe how compositions of Matouš Radouš's epitaphs reflect the figural canon and the patterns of international Mannerism, transmitted especially by graphics. Nevertheless, the character of Radouš represents a typical local “shift” from the exclusive court art and the art of a rather low formal quality. …”
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Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans. by Alison M Day, Min Cao, Alessandra da Silva Dantas, Olga Ianieva, Carmen Herrero-de-Dios, Alistair J P Brown, Janet Quinn

“…Notably, we find Ssk1 regulates Hog1 in a two-component independent manner by functioning to promote interactions between the Ssk2 and Pbs2 kinases. …”
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Application Effect of Transparent Supervision Based on Informatization in Prevention and Control of Carbapenem-Resistant Klebsiella pneumoniae Nosocomial Infection by Xiaoqin Wu, Quansheng Lu, Guo Feng, Hongxia Kan, Liran Shi

“…Transparent supervision of CRKP-infected patients was conducted daily from January to December 2020, which resulted in the following: (a) the infection rate of CRKP decreased in a fluctuating manner, and the actual value of hydrocarbon alkene use rate was basically the same as the predicted value with an overall decreasing trend; (b) after the intervention, hand hygiene compliance rate increased from 53.30% to 70.24% (P<0.001) and the ATP qualified rate increased from 53.77% to 92.24% (P<0.001); (c) the fitted value of the ARIMA model was in good agreement with the actual value. …”
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