Deepfake detection method based on patch-wise lighting inconsistency by Wenxuan WU, Wenbo ZHOU, Weiming ZHANG, Nenghai YU

“…The rapid development and widespread dissemination of deepfake techniques has caused increased concern.The malicious application of deepfake techniques also poses a potential threat to the society.Therefore, how to detect deepfake content has become a popular research topic.Most of the previous deepfake detection algorithms focused on capturing subtle forgery traces at pixel level and have achieved some results.However, most of the deepfake algorithms ignore the lighting information before and after generation, resulting in some lighting inconsistency between the original face and the forged face, which provided the possibility of using lighting inconsistency to detect deepfake.A corresponding algorithm was designed from two perspectives: introducing lighting inconsistency information and designing a network structure module for a specific task.For the introduction of lighting task, a new network structure was derived by designing the corresponding channel fusion method to provide more lighting inconsistency information to the network feature extraction layer.In order to ensure the portability of the network structure, the process of feature channel fusion was placed before the network extraction information, so that the proposed method can be fully planted to common deepfake detection networks.For the design of the network structure, a deepfake detection method was proposed for lighting inconsistency based on patch-similarity from two perspectives: network structure and loss function design.For the network structure, based on the characteristic of inconsistency between the forged image tampering region and the background region, the extracted features were chunked in the network feature layer and the feature layer similarity matrix was obtained by comparing the patch-wise cosine similarity to make the network focus more on the lighting inconsistency.On this basis, based on the feature layer similarity matching scheme, an independent ground truth and loss function was designed for this task in a targeted manner by comparing the input image with the untampered image of this image for patch-wise authenticity.It is demonstrated experimentally that the accuracy of the proposed method is significantly improved for deepfake detection compared with the baseline method.…”
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Collagen-1 and elastin expression in cervical tissue: A comparison across cervical elongation, pelvic organ prolapse, and combined conditions by Anis Widyasari, Gatut Hardianto, Etty Hari Kusumastuti, Eighty Mardiyan Kurniawati

“…Two experienced pathologists conducted the analyses in a blinded manner to ensure objective evaluation. Results: Statistical analysis using the Kruskal-Wallis test revealed significant differences in the expression of Collagen-1 across the four groups (CE, POP, CE with POP, and control). …”
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Problems of abuse of law when applying to the European Court of Human Rights by V. V. Lazariev, I. A. Lohvynenko

“…It is noted that the European Court of Human Rights considers that this concept should be understood in its ordinary meaning, namely, as the fact of exercise of a right by a subject of law outside its intended purpose in a manner which causes prejudicial damage. The author identifies the approaches to understanding the abuse of law which are used by the European Court of Human Rights in its work. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Animal experiments revealed that antiplatelet pharmacological agents and genetic knockout of platelets potentiated the antitumour effect of the PD-L1 mAb treatment in a CD8 + T cell dependent manner. Conclusions Our data suggest that PD-L1 positive platelets suppress CD8 + T cell immunity. …”
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Dynamic Expression of HDAC3 in db/db Mouse RGCs and Its Relationship with Apoptosis and Autophagy by Yuhong Fu, Ying Wang, Xinyuan Gao, Huiyao Li, Yue Yuan

“…In this study, we examined the morphological and immunohistochemical changes of HDAC3, Caspase3, and LC3B in a sequential manner by characterizing the process of retinal ganglion cell variation. …”
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Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. by Judith A Smith, Mike Khan, Diogo D Magnani, Jerome S Harms, Marina Durward, Girish K Radhakrishnan, Yi-Ping Liu, Gary A Splitter

“…Purified TcpB, a protein recently identified to modulate microtubules in a manner similar to paclitaxel, also induced UPR target gene expression and resulted in dramatic restructuring of the ER. …”
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Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats by Ayşe Er, Enver Yazar

“…Hovewer, investigation is need that especially dose-depended manner effects of macrolide antibiotics on immunosystem.…”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…Data from these publications were extracted and the overall findings were summarized in a narrative manner. The variations in microbial communities and immune responses of periodontitis and peri-implantitis are explored. …”
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Using unmanned aerial vehicles to estimate body volume at scale for ecological monitoring by Thomas C. Stone, Katrina J. Davis

“…Our method accurately estimates individual body volume of pinnipeds in a time‐ and cost‐effective manner while minimising disturbance. While the approach is applied to pinnipeds here, the method could be adapted to further taxa that are otherwise challenging to obtain direct measurements from. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Accordingly, the CBF prevented LRP oxidation in a concentration-dependent manner. This formula is not toxic in mice (LD₅₀ > 2000 mg/kg body weight). …”
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Immunomodulatory effects of thymol and cinnamaldehyde in chicken cell lines by C. Shen, L.G. Christensen, S.Y. Bak, N. Christensen, K. Kragh

“…Epithelial integrity of LMH cells (as assessed by TEER) was increased by TCB (10 ng/ml) after 4 h incubation, versus untreated controls, and phagocytic capacity of HD-11 cells was increased, in a dose-dependent manner (P<0.05). In HD-11 cells, TCB (10 ng/ml) downregulated the relative expression of pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8 and the transcription factor cyclooxygenase-2 and upregulated expression of anti-inflammatory IL-10, versus untreated controls (P<0.05). …”
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The Effects of Nebulized Inhaled Triptolide on Airway Inflammation in a Mouse Model of Asthma by Yafang Miao, Li Wei, Hao Chen, Zeming Zhang, Li Han

“…Inhalation of nebulized triptolide can play a role in suppressing airway inflammation with inflammatory cytokines and transcriptional factors reduced and CD4+Th17+ T cells dampened, also in a manner less than injected dexamethasone.…”
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Enhanced Disc Herniation Classification Using Grey Wolf Optimization Based on Hybrid Feature Extraction and Deep Learning Methods by Yasemin Sarı, Nesrin Aydın Atasoy

“…The aim of this study was to classify lumbar disc herniations in a computer-aided, fully automated manner using magnetic resonance images (MRIs). Methods: This study presents a hybrid method integrating residual network (ResNet50), grey wolf optimization (GWO), and machine learning classifiers such as multi-layer perceptron (MLP) and support vector machine (SVM) to improve classification performance. …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…The levels of both CXCL8 mRNA and its protein IL-8 in cancer cells under conditions of glucose deficiency were increased in an NF-κB-dependent manner. Supplementary IL-8 stimulated TAMs to synthesize CLU, and CLU counteracted oxidative stress in HNSCC cells under conditions of glucose deficiency. …”
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F. NIETZSCHE’S POŽIŪRIS Į TIESĄ: MIRTINAS ĮKANDIMAS? by Aivaras Stepukonis

“…In Nietzsche’s thought, there may be observed a threefold turning away from the traditionally affirmative conception of truth: (1) the reduction of thinking and knowing to the physiological processes of the body and its changing corporeal states; (2) the exposure of many time-honored truths as mere superstitions expedient to factual human communities in dealing with reality in a practical, yet oversimplified and distorted manner; (3) the devaluation and/or disvaluation of truth as something useless or even detrimental to life. …”
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Patients' perceived needs of osteoarthritis health information: A systematic scoping review. by Louisa Chou, Lisa Ellis, Michelle Papandony, K L Maheeka D Seneviwickrama, Flavia M Cicuttini, Kaye Sullivan, Andrew J Teichtahl, Yuanyuan Wang, Andrew M Briggs, Anita E Wluka

“…Also, patients wanted this information to be delivered in a clear manner from multiple sources of health information. …”
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Comparison of anonymization techniques regarding statistical reproducibility. by David Pau, Camille Bachot, Charles Monteil, Laetitia Vinet, Mathieu Boucher, Nadir Sella, Romain Jegou

“…<h4>Methods</h4>The French data protection authority (CNIL) defines anonymization as a processing activity that consists of using methods to make impossible any identification of people by any means in an irreversible manner. To answer project's objective, a series of analyses were performed on a cohort, and reproduced on four sets of anonymized data for comparison. …”
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The Impact of 3S2E Nursing Management on the Psychological Status of Respiratory Function and Quality of Life of Patients with Severe Pneumonia in the ICU by Yaoyao Xu, Xia Li, Qin Yang, Xiuxian Ma

“…The observation class added 3S2E manner in addition to ordinary breastfeeding, whereas the control class received treatment in the usual nursing mode. …”
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Isolation, characterization and control of Botrytis spp. pathogenic on strawberry in Iran by Fatemeh Maghsoodi, Parissa Taheri, Saeed Tarighi

“…The EO obtained from F. gummosa at 125, 250, 500, 750 and 1000 μg mL−1 concentrations showed significant antifungal effect on mycelial growth of B. cinerea and B. pelargonii in a dose dependent manner. Also, the EO at all concentrations tested strongly inhibited spore germination of B. cinerea and B. pelargonii. …”
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A cross-lagged analysis of the relationship between marital quality and depression among the older adults: gender effects of socioeconomic status by Bi-Ji Fang, Kai-Seng Leong, Hong-Xiu Tan

“…Regarding the moderating role of socioeconomic status, it was observed that among the older adult women, socioeconomic status exerted a moderating influence on the impact of depression on marital quality (β = 0.05, p &lt; 0.05), whereas among the older adult men, their socioeconomic status failed to display a significant moderating effect (β = 0.02, p &gt; 0.05). In a contrasting manner, for the older adult men, the socioeconomic status played a moderating role in the effect of marital quality on depression (β = −0.05, p &lt; 0.01), while for the older adult women, it did not exhibit a moderating effect (β = −0.01, p &gt; 0.05).ConclusionThere exists a reciprocal causal nexus between the marital quality and depression among the older adults. …”
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