Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer by Linsheng Xu, Linsheng Xu, Bingde Hu, Jingli He, Xin Fu, Na Liu

“…Experimental assays, including CCK8 and wound-healing, demonstrated that intratumor microbiome-derived butyrate enhances the proliferation and migration of HCT15 cells in a time- and concentration-dependent manner. Cell survival analysis further indicated that butyrate treatment significantly increased the IC50 value, suggesting heightened drug resistance in HCT15 cells. …”
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A clean energy Korea by 2035: Transitioning to 80% carbon-free electricity generation by Won Young Park, Yong Hyun Song, Nikit Abhyankar, Hee Seung Moon, Umed Paliwal, Eunsung Kim, Nina Khanna, Sanghyun Hong, James Hyungkwan Kim, Kenji Shiraishi, Jiang Lin, Seung Wan Kim, Amol Phadke

“…We find that accelerated renewable energy deployment by 2035 is achievable in a cost-effective and reliable manner, offering substantial economic, environmental, and energy security benefits. …”
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Quantitative proteomics and targeted metabolomics reveal the role of Cassia siamea L. extract in the response to high-fat diet-induced obesity in Drosophila by Ananya Dechakhamphu, Nattapong Wongchum, Theeraphan Chumroenphat, Alongklod Tanomtong, Sirithon Siriamornpun

“…In vitro, CSE significantly inhibited pancreatic lipase activity (IC50 = 67.73±3.24 µg/mL) in a noncompetitive manner. In a high-fat diet-fed Drosophila model, CSE supplementation (10 mg/mL) reduced lipase activity and triglyceride levels and improved body weight, suggesting antiobesity and potential antidiabetic effects. …”
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Effects of soil water on fungal community composition along elevational gradients on the northern slope of the Central Kunlun Mountains by Yongguang Zhang, Yongguang Zhang, Chaonan Li, Zhihao Zhang, Chenhong Li, Bo Zhang, Hongchen Jiang, Waqar Islam, Xiangzhen Li, Fanjiang Zeng

“…Variations in ecological processes may be linked to changes in key environmental factors that influence soil fungal communities in an elevation-dependent manner. These findings can enhance our ability to predict soil fungal diversity patterns and their responses to climate change in the ecosystems of the northern slope of the Central Kunlun Mountain.…”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…PI3K inhibitor reversed increased granzyme B synthesis upon IFN-α costimulation in a dose-dependent manner. Conclusion: In summary, elevated serum level of IFN-α was responsible for increased secretion of granzyme B and enhanced cytotoxicity of CD8+T cells in SLE and this process may be related to PI3K pathway. …”
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Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…A xenogeneic SLE model was utilized to study their in vivo combination.ResultsIn a dose-dependent manner, ruxolitinib addition synergizes with UCB-Tregs to suppress SLE-PBMC proliferation, inhibit CD8+ T cells, and reduce phosphorylation of STAT3/STAT5/AKT in CD8+ T cells. …”
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Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…Increased levels of CXCR4 and PD‐L1 expression, in a dose‐ and time‐dependent manner upon cisplatin treatment, were observed in GC cells (p < 0.05). …”
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Peculiarities of Forming the Methodology for Investigating Criminal Offenses against the Authority of State Agencies in the Law Enforcement Sphere by V. O. Gusieva

“…It has been established that the specified group of criminal offenses includes: 1) interference in the activities of a law enforcement officer; 2) the threat of murder, bodily injury or destruction or damage to property in a generally dangerous manner in respect to an official or his relatives or in respect to a citizen performing public duties, used to terminate the activities of a citizen performing public duties or to change its nature in the interests of the person who makes threats; 3) unauthorized appropriation of powers combined with the commission of any socially dangerous actions. …”
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Comparison of Statistical, Graphical, and Wavelet Transform Analyses for Rainfall Trends and Patterns in Badulu Oya Catchment, Sri Lanka by Ashika M. Ruwangika, Anushka Perera, Upaka Rathnayake

“…The results reveal that the nonparametric Mann–Kendall test is powerful to produce the statistically significant rainfall trends in qualitative and quantitative manner. Mann–Kendall analysis shows a positive trend to Ledgerwatte Estate in monthly (3.7 mm in February and 7.4 mm in October), seasonal (6.9 mm in the 2ndintermonsoon), and annual (3 mm annually) scales. …”
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Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinic... by Muhittin CALIM, Serdar YESILTAS, Mustafa GUNAY, Ismail SUMER, Sedat AKBAS

“…These patients were then randomly assigned in a double-blind manner to two groups: one receiving paracetamol (n=32), and the other receiving ibuprofen (n=32). …”
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The Efficacy of Fecal Microbiota Transplantation in Experimental Autoimmune Encephalomyelitis: Transcriptome and Gut Microbiota Profiling by Sanwang Wang, Hongliang Chen, Xin Wen, Jingjing Mu, Mingyue Sun, Xiaowen Song, Bin Liu, Jinbo Chen, Xueli Fan

“…Altogether, FMT may selectively regulate gene expression to improve inflammation and maintain the stability of the intestinal environment in a gut microbiota-dependent manner.…”
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Maternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity by Shuangyi Zhao, Zhimin Chen, Huina Liu, Xinyan Wang, Xiuru Zhang, Huirong Shi

“…Results: Maternal HSD significantly altered lung transcriptomes in a sex-specific manner. Male offsprings showed increased susceptibility to fibrosis, as confirmed by histological and molecular analyses, including elevated expression of α-SMA, collagen I, Fn1, and TGF-β. …”
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Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

“…In the first phase, various MDTs’ case discussions about oncological situations and their decisions regarding possible therapy trials were recorded in a structured manner. In the second phase, the actual inclusion rates of patients in therapy trials and reasons for non-inclusion were examined. …”
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Potential of Regional Ionosphere Prediction Using a Long Short‐Term Memory Deep‐Learning Algorithm Specialized for Geomagnetic Storm Period by Jeong‐Heon Kim, Young‐Sil Kwak, YongHa Kim, Su‐In Moon, Se‐Heon Jeong, JongYeon Yun

“…To test and verify the predictive performance and the usability of the LSTM model for geomagnetic storms developed in this manner, we created and diagnosed the 0.5, 1, 2, 3, 6, 12, and 24‐h predictive LSTM models. …”
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High-Intensity Focused Ultrasound (HIFU) Focal Therapy for Localized Prostate Cancer with MRI-US Fusion Platform by Chi-Hang Yee, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Chi-Fai Ng, Chi-Kwok Chan, See-Ming Hou

“…HIFU focal therapy was performed in the conventional manner in the beginning 50% of the series, whereas the subsequent cases were performed with MRI-US fusion platform. …”
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F. NIETZSCHE’S POŽIŪRIS Į TIESĄ: MIRTINAS ĮKANDIMAS? by Aivaras Stepukonis

“…In Nietzsche’s thought, there may be observed a threefold turning away from the traditionally affirmative conception of truth: (1) the reduction of thinking and knowing to the physiological processes of the body and its changing corporeal states; (2) the exposure of many time-honored truths as mere superstitions expedient to factual human communities in dealing with reality in a practical, yet oversimplified and distorted manner; (3) the devaluation and/or disvaluation of truth as something useless or even detrimental to life. …”
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Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus by Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song

“…Meanwhile, it could significantly enhance the formation of ALP and calcium nodules in ASCs-T2DM, increase the expression of osteogenesis-related genes in vitro, and promote the healing of calvarial defects of T2DM rat in a concentration-dependent manner. 5-az intervention indicated that the reduction of the methylation level in Calca target fragment of ASCs-T2DM indeed escalated the gene expression, which may be related to DNMT1. …”
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Teaching methods for critical thinking in health education of children up to high school: A scoping review. by Anna Prokop-Dorner, Aleksandra Piłat-Kobla, Magdalena Ślusarczyk, Maria Świątkiewicz-Mośny, Natalia Ożegalska-Łukasik, Aleksandra Potysz-Rzyman, Marianna Zarychta, Albert Juszczyk, Dominika Kondyjowska, Agnieszka Magiera, Małgorzata Maraj, Dawid Storman, Sylwia Warzecha, Paulina Węglarz, Magdalena Wojtaszek-Główka, Wioletta Żabicka, Małgorzata M Bała

“…Many educational interventions did not address the development of critical thinking skills in a comprehensive manner, and the significance of critical thinking varied greatly. …”
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Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation by Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

“…Conclusion In patients with MD and RA, circulating apoCIII levels were positively associated with glycoproteins and negatively with hsCRP, in a TG-independent manner. Our results suggest that apoCIII is associated with the low-grade inflammatory profile represented by glycoproteins, independent of triglyceride levels. …”
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The New York Times on The NATO bombing of FR Yugoslavia in 1999 by Savić Aleksandra

“…Additionally, beyond the stereotypical depiction of the military attacks themselves, the relationship between the two opposing sides is portrayed in a clichéd and simplified manner. A negative attitude towards an entire nation, its past, and its main characteristics is used to justify increasingly inhumane targets for NATO bombs. …”
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