Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…We conclude that RGZ lowers blood pressure values by increasing the expression of RAS axis proteins ACE2 and AT2R, decreasing the levels of AngII and increasing levels of Ang-(1-7) in a PPARγ-dependent manner. The in silico analysis is a valuable tool to predict the interaction between PPARγ and RAS.…”
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The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells by Xiao Liang, Chang Xu, Wanchun Wang, Xiang Li

“…We here revealed the higher DNMT1 activity and expression, lower miR-34a expression with high methylation of its promoter, and stronger stemness of OSLCs, as manifested by elevated sphere and colony formation capacities; CD133, CD44, ABCG2, Bmi1, Sox2, and Oct4 protein amounts in vitro; and carcinogenicity in a nude mouse xenograft model, when compared to the parental U2OS cells. 5-Azacytidine (Aza-dC) repressed DNMT1 activation and upregulated miR-34a expression by promoter demethylation and suppressed the stemness of OSLCs in a dose-dependent manner. DNMT1 knockdown increased miR-34a and reduced the stemness of OSLCs. …”
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Effect of Cocoa (<i>Theobroma cacao</i>) Plantation Types on the Distribution of Anuran Communities in Ore, Ondo State, Nigeria by AB Onadeko

“…Farmers are encouraged to engage in intercropping (polyculture) especially with food and economic crops in a biodiversity friendly manner which could have similar characteristics of a natural ecosystem, thereby enhancing the  biological diversity of agro-ecosystems. © JASEM Keywords: Anuran, cocoa, pesticides, intercropped, biological diversity and agro-ecosystems …”
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Scenario-aware access control model by Dibin SHAN, Xuehui DU, Wenjuan WANG, Na WANG, Aodi LIU

“…Dynamic access control model is the theoretical basis for constructing a dynamic access control system for big data.However, most existing access control models can only fulfill dynamic access control in a single scenario and are unable to adapt to access control in multiple types of dynamic scenarios.These scenarios include changes in the contextual environment of big data, changes in entity relationships, and changes in the state of objects.To address these issues, an analysis was conducted based on the research of existing access control models and the dynamic factors of big data.Subsequently, scenario-aware access control (SAAC) model was proposed, which was based on dynamic factor conversion and scenario unified modeling.All types of dynamic factors were converted into basic elements such as attributes and relationships.Then, scene information was incorporated to model the various types of constituent elements in a unified manner.A big data dynamic access control model was constructed based on scene information to support multi-type dynamic factors and extended dynamic factors.The working framework of the SAAC model was designed, and the SAAC rule learning algorithm and SAAC rule execution algorithm were proposed corresponding to the workflow of the framework.This enabled the automatic learning of access control rules and dynamic access control decision-making.The security of the proposed model was analyzed and verified by introducing the non-transitive non-interference theory.To validate the effectiveness of the access control policy mining method of the proposed model, experimental comparisons were conducted between the SAAC model and baseline models such as ABAC-L, PBAC-X, DTRM, and FB-CAAC using four datasets.The experimental results demonstrate that the SAAC model and its strategy mining method outperforms the baseline models in terms of metrics such as area under the curve AUC, monotonicity, and steepness of the ROC curve.This verification confirms that the proposed model can support multiple types of dynamic factors and dynamic factor extensions, and that the combined effect of the access control rules obtained from its mining algorithm is relatively high.…”
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<i>Botrytis cinerea</i> PMT4 Is Involved in <i>O</i>-Glycosylation, Cell Wall Organization, Membrane Integrity, and Virulence by Verónica Plaza, Alice Pasten, Luz A. López-Ramírez, Héctor M. Mora-Montes, Julia Rubio-Astudillo, Evelyn Silva-Moreno, Luis Castillo

“…The phenotypic analysis showed that Δ<i>bcpmt4</i> null mutants exhibited significant changes in hyphal cell wall composition, including reduced mannan levels and increased amounts of chitin and glucan. …”
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Goal attainment scaling as an outcome measure for randomised controlled trials: a scoping review by Elaine Pascoe, Andrea Viecelli, Ruth Hubbard, Benignus Logan, Dev Jegatheesan

“…Outcome attainment was scored in various manners (self-report: 21%; observed: 26%; both self-report and observed: 8%; and not reported: 45%), and the calculation of GAS scores differed between trials (raw score: 21%; T score: 47%; other: 21%; and not reported: 66%).Conclusions GAS has been used as an outcome measure across a wide range of disciplines and trial settings. …”
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KAİDE MADDESİ İLE YUMUŞAK ASTAR MATERYALİ ARASINDAKİ BAĞLANMA DAYANIMINA YÜZEY İŞLEMLERİNİN ETKİSİ by Selin Tekin, Zeynep Yeşil Duymuş

“…Zamanla sertleşerek esnekliklerini yitirme, bakteri ve mantar kolonizasyonuna neden olma, porözite gösterme, su absorbe etme, renk değiştirme, protez kaidesinden ayrılma ve protezlerin kırılmaya karşı dayanıklılıklarını azaltma gibi klinik kullanım sürelerini sınırlayan önemli dezavantajlara sahiptirler. …”
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Elevational ranges of pioneer marsh species are site specific and likely shaped by different abiotic and biotic factors by Charlotte S. Steinigeweg, Ole J. Siebeneicher, Boris Schröder, Michael Kleyer, Kertu Lõhmus, Swantje Löbel

“…Zero‐inflated beta regression models demonstrated that species occurrence and cover are mediated by elevation in a species‐specific manner. The fast colonizer Salicornia procumbens occurred foremost at the lowest elevations, followed by the pioneer species Spartina anglica and Salicornia europaea. …”
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Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells by Rou-Yi Fang, Yueh-Wen Liu, Yih-Gang Goan, Jen-Jie Lin, Jui-Hsin Su, Wen-Tung Wu, Yu-Jen Wu

“…Furthermore, Western blot analysis was utilized to explore the underlying molecular mechanisms. In a dose-dependent manner, 4-carbomethoxyl-10-epigyrosanoldie E notably decreased the levels of matrix metalloproteinase-2 (MMP-2) and MMP-9, along with urokinase-type plasminogen activator (uPA), in both Cal-27 and Ca9-22 cell lines. …”
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Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i> by Qinghao Meng, Anna Hu, Weiyu Xiao, Robert P. Borris, Hyun-Min Kim

“…Moreover, the extracts induced apoptosis in the germline in a pCHK-1-independent manner. LC-MS analysis revealed 31 potential anti-tumor compounds, supporting the extract’s cytotoxic properties. …”
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Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…They inhibited biofilm formation and eradicated biofilms in a dose-dependent manner against MTCC 737 and MRSA 831, and they effectively eliminated MRSA persister cells, outperforming the reference antibiotic vancomycin. …”
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Equity and gender mainstreaming in public policy: A scoping review protocol. by Michelle Amri, Jinny Yang, Geneviève Jessiman-Perreault, Amne Haikal, Kathryn Barrett, Jesse B Bump

“…The inclusion criterion is that: (i) texts must provide information on how equity and/or gender has been considered by government officials in the development of public policy in a routine or systematic manner (e.g., descriptive, empirical); (ii) both texts produced by government or not (e.g., commentary about government action) will be included; (iii) there are no restrictions on study design or article type (i.e., commentaries, reports, and other documents, would all be included); and (iv) texts must be published in English due to resource constraints. …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. The depletion of ATP11B promoted CMTM6-mediated lysosomal degradation of PD-L1, thus reactivating the immune microenvironment and inducing an antitumor immune response. …”
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…Additionally, the Th17 cell percentages and IL-17A concentrations in spleen mononuclear cells (SMCs) from EAT-A mice decreased in a dose-dependent manner after DAPT treatment in vitro (all P<0.01). …”
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Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies by Gehad G. Mohamed, Walaa H. Mahmoud, Ahmed M. Refaat

“…The IR spectra revealed the binding of the azo ligand to the metal ions via two azo nitrogen atoms and protonated carboxylate O in a neutral tetradentate manner. Both IR and 1H NMR spectra documented the involvement of the carboxylate group without proton displacement. …”
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Effect of Cocoa (<i>Theobroma cacao</i>) Plantation Types on the Distribution of Anuran Communities in Ore, Ondo State, Nigeria by AB Onadeko

“…Farmers are encouraged to engage in intercropping (polyculture) especially with food and economic crops in a biodiversity friendly manner which could have similar characteristics of a natural ecosystem, thereby enhancing the  biological diversity of agro-ecosystems. © JASEM Keywords: Anuran, cocoa, pesticides, intercropped, biological diversity and agro-ecosystems …”
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A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer by Noriyuki Okonogi, MD, PhD, Hiroshi Tsuji, MD, PhD, Kana Kobayashi, MD, PhD, Mio Nakajima, MD, PhD, Shuri Aoki, MD, PhD, Takanobu Utsumi, MD, PhD, Hiroyoshi Suzuki, MD, PhD, Koichiro Akakura, MD, PhD, Tomohiko Ichikawa, MD, PhD, Hitoshi Ishikawa, MD, PhD

“…Ten patients were enrolled in each group, and the CIRT dose was increased in a stepwise manner if there were fewer than 4 cases of DLT. The initial CIRT dose was 36 Gy, followed by 40 Gy or 44 Gy. …”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…MR2938, a quinazolin-4(3H)-one derivative derived from the marine natural product penipanoid C, alleviated DSS-induced colitis in a dose-dependent manner. Herein, we aimed to investigate the impact of MR2938 on the gut microbiota in dextran sodium sulfate (DSS)-induced colitis in mice and to elucidate the role of the gut microbiota in the therapeutic mechanism of MR2938 for alleviating colitis. …”
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Impact of coronary bifurcation angle on the pathogenesis of atherosclerosis and clinical outcome of coronary bifurcation intervention-A scoping review. by Yoshinobu Murasato, Kyohei Meno, Takahiro Mori, Katsuhiko Tanenaka

“…However, the impact has not yet been fully elucidated due to a lack of statistical power or different manner of the assessment of BA.<h4>Objectives</h4>To analyze the published studies on coronary artery BA, the modalities used for assessment, and the impact of BA on interventions and attempt to define the pre-procedural protocols.…”
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Psychotropic medications: a descriptive study of prescription trends in Tabriz, Iran, 2021–2022 by Mostafa Farahbakhsh, Ali Fakhari, Ali Azimian, Amin Khameneh, Mahsa Matinkia, Ehsan Aghajani

“…Prescription analysis is critical for evaluating and improving medical care in a cost-effective manner. This study examined prescription patterns for psychotropic drugs in outpatient settings to improve the understanding of medication utilization in a variety of patients. …”
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