Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22 by Fang Li, Xin Li, Guiyan Liu, Chong Gao, Xiaofeng Li

“…In vitro, IL-22 induced significantly the expression of RANKL mRNA in cultured FLSs in a dose-dependent manner, whereas this induction was significantly reduced in FLSs derived from CIA rats transplanted with MSCs (normal controls: F=79.33, P<0.001; CIA controls: F=712.72, P<0.001; and CIA-MSC rats: F=139.04, P<0.001). …”
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Anti-Inflammatory Effects of Cerium Dioxide Nanoparticles on Peritonitis in Rats Induced by Staphylococcus epidermidis Infection by Yan Li, Hongmei Sun, Zhiqi Yin, Xuexi Guo, Jun Yan

“…The ELISA results showed that compared with the control group, the TNF-α in the peritoneal lavage fluid and serum of the model group increased in a time-dependent manner (all P<0.05); however, there was no significant change in the CeO2 group (P>0.05); at the same time in the CeO2 + model group, the TNF-α content was significantly reduced (all P<0.05). …”
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Adrenoleukodystrophy: Symptoms, Treatment and Newborn Screening. Literature Review and Clinical Case by Laura Regelskytė, Rūta Praninskienė

“…It is inherited through the X chromosome in a recessive manner. Due to the ABCD1 gene mutation, there is a disorder of peroxisomes, thus very long-chain fatty acids are not degraded properly. …”
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An Interactive Pain Application (MServ) Improves Postoperative Pain Management by Richard Gordon-Williams, Andreia Trigo, Paul Bassett, Amanda Williams, Stephen Cone, Martin Lees, Brigitta Brandner

“…We recruited 234 patients to a prospective cohort study into sequential groups in a nonrandomised manner, one day after major thoracic or urological surgery. …”
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ANÁLISE POSTURAL DO SETOR DE EMBALAGENS SECUNDÁRIAS E EXPEDIÇÃO DE UM FRIGORÍFICO TÍPICO DA INDÚSTRIA SUINÍCOLA DO BRASIL by Wemerton Luís Evangelista, Laureilton José Almeida Borges

“…Outras posturas que merecem atenção são aquelas provenientes das atividades de retirar o pacote com carne da esteira no setor de embalagens secundárias, e as de bater caixa, de montar paletes e puxar paleteira para o interior das carretas, envolvidas no processo de expedição. …”
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Implementation outcomes of HIV self-testing in low- and middle- income countries: A scoping review. by Adovich S Rivera, Ralph Hernandez, Regiel Mag-Usara, Karen Nicole Sy, Allan R Ulitin, Linda C O'Dwyer, Megan C McHugh, Neil Jordan, Lisa R Hirschhorn

“…Both quantitative and qualitative results were extracted and synthesized in a narrative manner.<h4>Results and discussion</h4>Most (75%) of the 206 included articles focused on implementation in Africa. …”
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Some issues of global problems in the changing system of values of the modern world by Natalia Hrushchynska

“…The modern world transforms a person's way of life, forms of communication, changes the characteristics of relationships, views on the same things, manners of communication, and ultimately, values. …”
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ANALYSIS OF RELATIONSHIP BETWEEN FLEXIBLE WORK ARRANGEMENTS, WORK LIFE BALANCE AND EMPLOYEES’ EFFICIENCY: EVIDENCE FROM BOSNIA AND HERZEGOVINA’S (BiH) IT SECTOR by Ognjen Riđić, Adnan Avdibegović, Senad Bušatlić

“…The study was conducted in a cross-sectional time manner in the period June-July 2016. A modified, 18 questions, primary quantitative survey instrument with a 5-point Likert scale was conducted on 503 Bosnian IT employees. …”
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Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…Results showed that PAPP-A significantly stimulated the expression of MCP-1, TNF-α, and IL-6 at both transcriptional and translational levels in a dose-dependent and time-dependent manner. The secretion of these inflammatory cytokines by macrophages was also increased after PAPP-A treatment. …”
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Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica. by Simran Preet, Sanjay Bharati, Geeta Shukla, Ashwani Koul, Praveen Rishi

“…<h4>Methods/principal findings</h4>In the present study, cryptdin-2 exhibited potent in-vitro amoebicidal activity against E. histolytica in a concentration dependent manner at a minimum amoebicidal concentration (MAC) of 4 mg/L. …”
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Pneumothorax, Pneumomediastinum, and Cervical and Facial Massive Emphysema Secondary to Colonoscopy: A Rare Complication of Colonoscopy by Ruben Daniel Perez Lopez, Julian Vargas Flores, Lenin de Jesus Orbe Garibay, Hugo Fernando Narvaez Gonzalez

“…The purpose of presenting this case is for the doctor who performs these interventions to suspect this complication in a timely manner, not delaying the diagnosis and carrying out an urgent therapeutic approach as in this case with exploratory laparotomy, finding the perforation site and carrying out the corresponding surgical management. …”
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Challenges in Bootstrapping a Start-Up Venture: Keenga Research Turning the Tables on Venture Capitalists by Prescott C. Ensign, Anthony A. Woods

“…Can the concept be developed and brought to market in a timely manner? Will the product generate revenue? How? When? …”
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Antiviral Activity of Plant‐Based Additives Against African Swine Fever Virus (ASFV) in Feed Ingredients by Thi Ngoc Ha Lai, Thi Bich Ngoc Trinh, Thi Tam Than, Nguyen Tuan Anh Mai, Niku Moussavi Biuki, Bernhard Eckel, Viktor P. L. Eckel, Thi Lan Nguyen, Van Phan Le

“…Conclusions All additives, OAB, Phyto.A04 and Phyto.B, were able to inactivate ASFV in a dose‐dependent manner, as confirmed by cell culture and PCR methods. …”
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CRIMEA AND THE POLITICS OF LEGITIMACY IN INTERNATIONAL RELATIONS by A. A. Vlasov, A. V. Brega

“…However, if Russia’s criticism of Ukraine continues in a rationally legal manner, Russia should also insist, within the same rational-legal logic, on material reparation of the consequences, which may cause Ukrainian blockade of the peninsula.…”
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The finding and researching algorithm for potentially oscillating enzymatic systems by T. N. Lakhova, F. V. Kazantsev, S. A. Lashin, Yu. G. Matushkin

“…Using the method described in the article, we present and analyze, in a step-by-step manner, first the structural models (graphs) of gene networks and then the reconstruction of the mathematical models and computational experiments with them. …”
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Impact of national e-commerce demonstration city pilot policy on urban carbon emission efficiency: From the perspective of soft and hard environments by YUE Li, WANG Xinran

“…It is recommended to advance the construction of pilot cities in an orderly manner, establish industrial e-commerce ecosystem, reinforce the coordinated optimization of soft and hard environments, and develop e-commerce according to local conditions.…”
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Human Islet Amyloid Polypeptide Fibril Binding to Catalase: A Transmission Electron Microscopy and Microplate Study by Nathaniel G. N. Milton, J. Robin Harris

“…Human IAPP fibrils are toxic in a similar manner to Alzheimer's amyloid-β (Aβ) and prion protein (PrP) fibrils. …”
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Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling. by Xiu-Ying He, Yui-Si Yang, Yue-Xiang Zheng, Qing-Jie Xia, Hong-Zhou Yu, Xiao-Ming Zhao, Ting-Hua Wang

“…<h4>Results</h4>In present study, we found that SCU and lidocaine suppressed the proliferation and migration, and induced the apoptosis of human glioma cell lines, including U251 and LN229 cells, in a dose-dependent manner in vitro. Moreover, the combination of SCU and lidocaine further restrained the proliferation and migration ability of U251 and LN229 cells, while induced their apoptosis in vitro. …”
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Mechanical properties and piecewise constitutive model of fine sandstone in mining area of western China by Qing Wang, Dongxiao Zhang, Fei Han, Yongqiang Zhao, Pengfei Zhang, Feng Xiong

“…The results indicate that (1) the cumulative ringing counts and cumulative energy of the AE increase in a stepwise manner with an increase in the cyclic loading and unloading times. …”
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Misinterpretation of Psychiatric Illness in Deaf Patients: Two Case Reports by Ethan Anglemyer, Craig Crespi

“…Symptoms such as auditory hallucinations are not brought up in the same manner and are thought to be a visual construct interpreted by the patient as a vocal expression. …”
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