Potential Use of C60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer by Abdulmalik Altaf, Hibah Aldawsari, Zainy M. Banjar, Daisuke Iohara, Makoto Anraku, Kaneto Uekama, Fumitoshi Hirayama

“…C60/HP-β-CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner. The IC50 values of the C60/HP-β-CyD nanoparticles was 10 μM for HeLa cells and 60 μM for A549 cells at an irradiation level of 35 mW/cm2. …”
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‘Over-hopefulness and getting-on-ness’: Ruskin, Nature, and America by Sara Atwood

“…Ruskin’s understanding of the natural world was connected by ‘all manner of strange intellectual chords and nerves with the pathos and history of this old English country of ours; and on the other side, with the history of the European mind from earliest mythology down to modern rationalism and ir-rationalism’ (36.533). …”
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Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer by Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Abdellatif Bouazzaoui, Shaaban K. Osman, Issa Saad Al-Moraya, Abdulaziz M. Saleh Showail, Mansour Alsharidah, Ashraf Aboelela, Osamah Al Rugaie, Tarek M. Faris, Hesham M. Tawfeek

“…In vitro cytotoxicity testing showed the AgNPs-PVP exhibited antiproliferation properties in PC3 in a dose-dependent manner. In addition, when compared to control cells, AgNPs-PVP has lower TNF-α with a significant value (∗p<0.05); the value reached 16.84 ± 0.71 pg/ml versus 20.81 ± 0.44 pg/ml, respectively. …”
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Fast Simulation and Chaos Investigation of a DC-DC Boost Inverter by Rachid Dhifaou, Houda Brahmi

“…First, we develop a like-discrete integration process that permits precise results in a very fast manner. For one switching period, we compute only two or a maximum of three breaking points depending on whether we treat a continuous conduction mode (CCM) or a discontinuous conduction mode (DCM) of the inductor current. …”
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Le site d’Azrou Iklane : un exemple d’usage de l’imagerie numérique pour l’étude et la préservation de l’art rupestre saharien by Gwenola Graff, Martin Loyer, Abdelhadi Ewague, Romain Simenel, Maxence Bailly

“…This model was then enriched with the survey of the engravings carried out in a vector format drawing (done with machine intelligence), a photographic coverage using Gigapixel, the virtual visits and 360° images in the manner of Google Street View. Using the data acquired, a geographical information system is now being elaborated, The Moroccan heritage services were keen supporters of this project which was an original one for the country and one that satisfied local demands for a better preservation and interpretation of the fragile engravings. …”
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Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques by Nico A Flierman, Sue Ann Koay, Willem S van Hoogstraten, Tom JH Ruigrok, Pieter Roelfsema, Aleksandra Badura, Chris I De Zeeuw

“…We found that single-unit DN neurons modulated spiking activity over the entire time course of the task, and that their activity often bridged temporally separated intra-trial events, yet in a heterogeneous manner. To better understand the heterogeneous relationship between task structure, behavioral performance, and neural dynamics, we constructed a behavioral, an encoding, and a decoding model. …”
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The Prospects of Russia and India Jointly Leading a New Non-Aligned Movement by A. Korybko, V. M. Morozov

“…The neorealist school of International Relations Theory preaches the need to pursue national interests, which sometimes align with others', and it is argued in the article that it is with this idea in mind that both countries have a motivation to jointly improve their strategic positions relative to the People's Republic, albeit in a non-hostile manner that avoids the risk of inadvertently triggering a security dilemma and reversing the recent gains made in Eurasian integration.Two articles published by Russia's Valdai Club in 2019 indicated the possibility of creating a new Non-Aligned Movement, with the most recent one proposing that it be jointly led by Russia and India in order to advance the aforementioned neo-realist objective of balancing China. …”
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NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB by Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He

“…LPS was found to increase the NRF2 expression and the nuclear abundance of NRF2 in gEECs in a dose-dependent manner. NRF2 knockout (KO) not only increased the expression of LPS-induced proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) but also increased the expression of TLR4, p-IκBα/IκBα, and p-p65/p65 proteins. …”
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Migrated intra-uterine device to infra-umbilical skin: a rare case report by Nigat Amsalu Addis, Yared Alem Sibhat, Yohannis Derbew Molla, Wasihun Nigdu Mengestu, Abebe Sinknew Seid, Michael Argaw Damite, Misganaw Abere Worku

“…Removal of misplaced IUD with completely non-invasive manner makes this case special in addition to the unique site of migration to the infra-umbilical skin. …”
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Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Results Our results demonstrate that 125I seeds effectively inhibited tumor growth in the rabbit VX2 tumor model and promoted the apoptosis of CCA cells in vitro in a dose-dependent manner. Molecular analyses indicate a marked increase in reactive oxygen species (ROS) levels following treatment with 125I seeds, suggesting the involvement of ROS-mediated apoptosis in the therapeutic mechanism. …”
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Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells by Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

“…Knockdown of caspase-8 by CRISPR/Cas9 based gene editing reduced the sensitivity of tumor cells to apoptosis and pyroptosis.Conclusions Our study presented a novel mechanism in which hyperthermia synergized with chemotherapy in promoting apoptosis and pyroptosis in a caspase-8 dependent manner.…”
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Nutritional and Sensory Properties of Formulated Biscuits Supplemented with Vernonia amygdalina Del Leaves And Heteroclarias Spp Viscera Oil by Omolola Soji-Omoniwa, Omolade Bosede Olugbenga, Phoebe Adedamola Adewuyi, Olatunji Peter Ajao, Daniel Olasunkanmi Awe, Pelumi Zecharaiah Olawale, Khadijah Adedolapo Badmos, Jubril Akinpelumi Omotosho

“…Carbohydrate was significantly lower (p &lt; 0.05) in BWVF- 1 g, BWVF- 2 g and BWVF- 3 g in a dose dependent manner compared to the CB, while percentage crude protein, lipid and ash contents increased significantly (p &lt; 0.05) compared to CB. …”
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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro by Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock

“…Rozanolixizumab was also able to mediate antibody bipolar bridging (ABB), a phenomenon that led to a reduction of labeled FcγRI from the surface of human macrophages in an FcRn-dependent manner. However, the presence of exogenous human IgG, even at low concentrations, was able to prevent both binding and ABB events. …”
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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope by Ling Guo, Nivedita Khobragade, Spencer Kieu, Suleman Ilyas, Preston N. Nicely, Emmanuel K. Asiedu, Fabio V. Lima, Caroline Currie, Emileigh Lastowski, Gaurav Choudhary

“…Methods Approximately 6000 PCG recordings with the corresponding echocardiogram‐based estimated pulmonary artery systolic pressure values, as well as ≈169 000 PCG recordings without associated echocardiograms, were used for training a deep convolutional network to detect pulmonary artery systolic pressures ≥40 mm Hg in a semisupervised manner. Each 15‐second PCG, recorded using a digital stethoscope, was processed to generate 5‐second mel‐spectrograms. …”
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Construction and Release Characteristics of 3D Printed Spaced Multi-layer Structure of Lutein Emulsion Gel by Shuai DENG, Minghui ZHAO, Chunxue HAO, Ming LI, Dajing LI, Lei FENG, Zhongyuan ZHANG, Yayuan XU

“…In this study, 3D printing technology with double nozzles was applied to print lutein emulsion gels (lutein-loaded layer) and corresponding unloaded emulsion gels in an interlaced manner. The preparation parameters of lutein-loaded and unloaded emulsion gels were screened by evaluating the rheological properties and 3D printing characteristics. 3D printed gel systems with different intervals of multilayers structures were constructed to explore the effects of the number of spacer layers and the positioning of empty layers in spaced multi-layer structures on the release characteristics and bioaccessibility of lutein. …”
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Expression and Secretion of CXCL-8 and CXCL-10 From <emph>Mycobacterium Bovis</emph> BCG-Infected Human Epithelial Cells: Role of IL-4

“…In addition, IL-4 decreased CXCL-8 (in a graded and significant manner) but not CXCL-10 secretion. These results were further confirmed, since a significant reversion was obtained with a neutralizing antibody to human IL-4, whereas an isotype-matched control antibody had no significant effect on CXCL-8 secretion. …”
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A Hybrid Method for Short-Term Host Utilization Prediction in Cloud Computing by Jing Chen, Yinglong Wang

“…However, it is very difficult to accurately predict host utilization in a timely manner because host utilization varies very quickly and exhibits strong instability with many bursts. …”
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Selection of Production Strategies for New Energy Vehicles: An Analysis of the Impact of Government Intervention Policies by Yingxi Ge, Kehong Chen

“…However, excessively high subsidies may lead the firm to revert to fuel vehicle production. (3) Tax policies influence production strategies in a manner similar to subsidy policies. (4) When government intervention is weak and competition between fuel vehicles and new energy vehicles is intense, subsidy policies are more effective; however, when competition is less intense, tax policies may be more beneficial. …”
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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…In addition, the therapeutic effects of BA-LP showed a dose-dependent manner. Western blot analysis indicated that the anti-inflammatory action of BA could be attributed to the inhibition of the TLR4-NFκBp65 and JNK-ERK signaling pathways. …”
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IMPEMENTASI SISTEM EVALUASI DIRI DALAM PENCAPAIAN MUTU LULUSAN SD ASSALAM BANDUNG by Hidayat Aji Permana, Muhamad Arif Nugraha, Neng Vera Fachriyah, Tatang Muh Nasir, Abdul Azis Hatala

“…The quality compliance plan is implemented in every aspect that involves all components in a comprehensive manner. The whole series of implementation of direct mentoring quality fulfillment at TPMPS is then evaluated to see the effectiveness of the implementation of learning. …”
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