Site-selective dimethylation of flavonoids using fusion flavonoid O-methyltransferases by Kyungha Lee, Seong Hee Bhoo, Sang-Won Lee, Man-Ho Cho

“…Most FOMTs methylate flavonoids in a regiospecific manner. Because of the regiospecific nature of FOMTs, the synthesis of polymethoxyflavonoids is accomplished by multiple O-methylation steps. …”
Get full text

EXTRAMURAL EDUCATION: A HISTORICAL PATH TO MOOC by M. A. Babaeva, A. F. Smyk

“…The authors propose to link the present and the near future of distance education in Russia with the phenomenon of MOOC since this format covers a large array of those wishing to get higher education and to improve their educational activities, and provides high-grade education in a cost-effective manner both for University and for a student. In conclusion the authors analyze the experience and prospects of using MOOC in Russian and foreign universities, discuss the features of the MOOC available at the Russian National platform of open education (NPOE) and their role in the educational process of the Russian universities (including distance learning).…”
Get full text

Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extra... by Yun Zuo, Jie Wang, Xiaoju Huang, Yuan Liu, Zhiwu Zeng, Ruiqing Xu, Yawen Chen, Kui Liu, Hongkang You, Jingang Wang

“…To assess the operational status of a grounding body in a timely manner, this paper proposes a multi-parameter pulsed eddy current (PEC) time-domain characteristic signal corrosion classification method for the detection of the state of a pole tower grounding body. …”
Get full text

Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor tissue and on the pro-inflammatory capacity of F. nucleatum. However, the exact manner in which F. nucleatum promotes inflammation in the tumor microenvironment and subsequent tumor promotion remains underexplored. …”
Get full text

Incorporation of recombinant proteins into extracellular vesicles by Lactococcus cremoris by Tina Vida Plavec, Kristina Žagar Soderžnik, Giulia Della Pelle, Špela Zupančič, Robert Vidmar, Aleš Berlec

“…However, our data suggests that L. cremoris NZ9000 genetically engineered to express recombinant proteins can produce EVs containing these proteins in scalable manner. As L. cremoris NZ9000 is considered safe bacterium, EVs from L. cremoris NZ9000 could have several advantages over EVs from other bacteria, implying possible biotechnological applications, e.g. in therapeutic protein delivery.…”
Get full text

Cayley–Purser secured communication and jackknife correlative classification for COVID patient data analysis by Ramesh Sekaran, Ashok Kumar Munnangi, Manikandan Ramachandran, Mohammad Khishe

“…The key objective of CPCSC-JCDC method is to collect the patient information through IoMT devices and send to the doctor in more secured manner. Initially in CPCSC-JCDC method, the patient data is collected. …”
Get full text

Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…Furthermore, LSEC abrogate killing of target cells, in an antigen-dependent manner, by previously activated effector CD8 T cells, and LSEC change the effector cell cytokine profile. …”
Get full text

Exercise-Induced Adaptations to the Mouse Striatal Adenosine System by Ella E. Bauer, Trevor J. Buhr, Carter H. Reed, Peter J. Clark

“…Therefore, long-term repeated bouts of exercise may subsequently generate plasticity in striatal adenosine systems in a manner that promotes dopaminergic activity. This study investigated the effects of long-term voluntary wheel running on adenosine 1 (A1R), adenosine 2A (A2AR), dopamine 1 (D1R), and dopamine 2 (D2R) receptor protein expression in adult mouse dorsal and ventral striatum structures using immunohistochemistry. …”
Get full text

Ultra-Low Static Power Circuits Addressing the Fan-Out Problem of Analog Neuron Circuits in Spiking Neural Networks by Jonghyuk Park, Woo Young Choi

“…The proposed circuits operate in a fully event-driven manner, resulting in a very low static power consumption. …”
Get full text

Cells Grouping Detection and Confusing Labels Correction on Cervical Pathology Images by Wenbo Pang, Yi Ma, Huiyan Jiang, Qiming Yu

“…Early screening can detect cervical precancerous lesions in a timely manner, thereby enabling the prevention or treatment of the disease. …”
Get full text

Limitations of Separating Athletes into High or Low-Risk Groups based on a Cut-Off. A Clinical Commentary by Justin M. Losciale, Linda K. Truong, Patrick Ward, Gary S. Collins, Garrett S. Bullock

“…# Key Results Cut-offs typically lack strong biologic plausibility to support them; and are typically derived in a data-driven manner and thus not generalizable to other samples. …”
Get full text

Integration of social work into specialist palliative home service by Janice Lee Wartchow, Stefan Bär, Bernd Alt-Epping, Christina Gerlach

“…Their perception of the SW profession determines the extent and manner of its integration into daily practices. Attributions on SW in SAPV as determined by nurses and physicians were social-medical knowledge, counselling, being a core competence in SAPV and similarities to the profession of psychologists. …”
Get full text

Pandemic-Induced changes in Travel Behaviour: Insights of Pandemic’s Lasting impacts on Lahore’s Urban Mobility by Hina Saleemi, Muhammad Momin Amer, Saadia Tabassum, Sadia Ismail

“…During the pandemic, public transportation utilization fell drastically, and this decline persisted long after restrictions were lifted. In the same manner, there was a decline in the use of carpooling and taxis, following a subsequent partial recovery. …”
Get full text

Injury mortality in South Africa: a 2009 and 2017 comparison to track progress to meeting sustainable development goal targets by Megan Prinsloo, Shibe Mhlongo, Rifqah A. Roomaney, Lea Marineau, Thakadu A. Mamashela, Bianca Dekel, Debbie Bradshaw, Lorna J. Martin, Carl Lombard, Rachel Jewkes, Naeemah Abrahams, Richard Matzopoulos

“…Age-standardised rates, 95% confidence intervals (CIs), and incidence rate ratios (IRRs) were calculated for manner of death rate comparisons and for age groups. …”
Get full text

miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…The miR-149 level in HUVECs was reduced by ox-LDL (100 μg/mL) incubation in a time-dependent manner. miR-149-mimic transfection markedly protected HUVECs from ox-LDL-induced injury, with increased cell viability and reduced caspase-3 activity. miR-149 mimics enhanced HUVEC autophagy, which was induced initially by ox-LDL. miR-149 mimics also markedly downregulated the expression of Akt, p-Akt, mTOR, and p-mTOR in ox-LDL-treated HUVECs. …”
Get full text

Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…In vitro, AGEs-modified bovine serum albumin upregulated RAGE expression of control VSMCs, and this was prevented by MET in an AMP kinase-dependent manner. Thus, experimental MetS induces RAGE upregulation and osteogenic transdifferentiation of aortic VSMCs curbed by oral treatment with MET.…”
Get full text

Carotid-cavernous fistula as an ophthalmic disease requiring interdisciplinary treatment by Wojciech Luboń, Małgorzata Luboń, Ewa Mrukwa-Kominek

“…The procedure was performed in a standard manner. Postoperatively, the patient’s general condition deteriorated, and ischemic stroke was diagnosed. …”
Get full text

Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis by Fujun Yu, Zhongqiu Lu, Bicheng Chen, Peihong Dong, Jianjian Zheng

“…In LX-2 cells, the reduction of lincRNA-p21 induced by TGF-β1 was in a dose- and time-dependent manner. lincRNA-p21 expression was reduced in liver tissues from patients with liver cirrhosis when compared with that of healthy controls. …”
Get full text

L’urbanité de l’héritage industriel by Zeila Tesoriere, Renzo Lecardane

“…From Chicago to Philadelphia, and not forgetting Rotterdam, many cities now envisage the rehabilitation of vast urban sectors in the same way, by converting their railway viaducts in the manner of the High Line. The importance of this operation allows us to consider deindustrialisation as a process capable of engendering a change in the urban territory through an approach at different scales and crossing over existing boarders.…”
Get full text

Chitosan oligosaccharides maintained postharvest quality and increased shelf life of mango by Nishat Nitu, Md. Sefat Ullah, Prianka Howlader, Md. Nazmul Mehedi, Habiba Meem, Santosh Bose

“…Originality/Value: COS 100mg/L have great potentiality to maintain postharvest quality and increase shelf life of mango which could be applied commercially for preservation of mango in an ecofriendly manner.…”
Get full text