Disparities in the Diagnosis of Hypertrophic Obstructive Cardiomyopathy: A Narrative Review of Current Literature by Joseph Burns, Philippe Jean-Pierre

“…HOCM is a frequently implicated cause of sudden cardiac death (SCD) in young athletes. In this manner, this condition has the capacity for tremendous emotional, social, financial, and medical burdens for families and communities across the country. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…Implementation of the developed clinical guidelines can help to establish a diagnosis in a timely manner, which will lead to an improvement in the quality of medical care for patients with achalasia.…”
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex by A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova

“…All isoforms are highly regulated and included in the PBAF complex in a mutually exclusive manner. Two of the PHF10 isoforms (PHF10-P) are expressed at a high level in neuronal and myeloid progenitors and are necessary for cell proliferation. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…The applications, characteristics, and existing challenges are summarized in combination with our lab experiences in this field in an effort to help gene-editing technology better serve humans in a regulated manner. Current preclinical and clinical trials have demonstrated initial safety and efficacy of PSC gene editing; however, for better application in clinical settings, additional investigation is warranted.…”
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A pilot study on diabetes detection using handheld fundus camera and mobile app development by Hamada R. H. Al-Absi, Gilbert Njihia Muchori, Saleh Musleh, Syed Abdullah Basit, Mohammad Tariqul Islam, Younss Ait Mou, Tanvir Alam

“…We invited participants from the community to share their demographic information, history of diabetes, and captured their retinal fundus images using the oDocs Nun IR handheld non-mydriatic fundus camera in a non-invasive manner (no dilation is required). Subsequently, we developed a deep learning model for early diagnosis of diabetes based on fundus image only. …”
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Multiplex Network Embedding Model with High-Order Node Dependence by Nianwen Ning, Qiuyue Li, Kai Zhao, Bin Wu

“…In the intralayer embedding phase, we present a symmetric graph convolution-deconvolution model to embed high-order proximity information as the intralayer embedding of nodes in an unsupervised manner. In the interlayer embedding phase, we estimate the local structural complementarity of nodes as an embedding constraint of interlayer dependence. …”
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Thermal and morphological properties of human erythrocytes from patients afflicted with type 1 diabetes mellitus by Péter Gaszler, Dénes Lőrinczy, Dávid Szatmári, Beáta Bódis, Katalin Türmer

“…The comparison of the RBCs from diabetic and non-diabetic patients was classified by the HbA1c, showing that the conditions in diabetes caused atypical cell morphology and then, in a casedependent manner, increased or decreased the thermal stability of cytoplasm or the cell membrane, respectively. …”
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Clinical Pregnancy and Miscarriage Rates in relation to Vitamin D Supplementation among women with Hyper Androgenic PCOS: A prospective study by Sherif Sobhy Menshawy Khalifa, Wael Gaber Eldamaty, Ahmed Tharwat Abo Dakika, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Hassan Elfiky, Ghada Adel Hegazy

“…Our results indicate that women who have enough 25(OH)D are far more likely to get clinically pregnant than those who had deficiency of 25(OH)D.Conclusion More research is necessary to determine whether vitamin D supplementation can increase pregnancy rates in a simple and economical manner. In our study population, there was a significant prevalence of 25(OH)D deficit or insufficiency. …”
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Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro by Renlei Feng, Hongli Liu, Yunqing Chen

“…Interestingly, in TGF-β1-stimulated cardiac fibroblasts, baricitinib decreased the expressions of Col1, Col3, α-SMA, Fn, MMP9, and TIMP1 in a dose-dependent manner (From 10 to 2000 nM), also exhibited a dose-dependent impact on the expressions of p-STAT3 and TGF-βRII. …”
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Global Geomagnetic Perturbation Forecasting Using Deep Learning by Vishal Upendran, Panagiotis Tigas, Banafsheh Ferdousi, Téo Bloch, Mark C. M. Cheung, Siddha Ganju, Asti Bhatt, Ryan M. McGranaghan, Yarin Gal

“…Such quick inferences at high temporal cadence and arbitrary spatial resolutions may ultimately enable accurate forewarning of dB/dt for any place on Earth, resulting in precautionary measures to be taken in an informed manner.…”
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Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells. by Napat Armartmuntree, Yingpinyapat Kittirat, Bundit Promraksa, Watcharin Loilome, Hasaya Dokduang, Anchalee Techasen, Pahol Sansomchai, Malinee Thanee, Thomas O'Connor, Phutthida Kongthitilerd, Sureerat Padthaisong

“…TC treatments reduce CCA cell viability, inhibiting growth and inducing apoptosis in a dose-dependent manner. The Bax/Bcl-2 ratio increases, signifying a pro-apoptotic shift. …”
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The Experience of Embodiment Scale: An examination of its psychometric properties in women from the Republic of Cyprus. by Viren Swami, Christophe Maïano, Marios Argyrides, Elly Anastasiades

“…Our work highlights important psychometric issues relating to the manner in which the EES should (or could) be conceptualised and modelled, which should be considered more fully in future work.…”
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Development of a Bipolar Radio-frequency Power Supply for Structures of Lossless Ion Manipulations by Qing LIU, Run-ze XU, Yun-jing ZHANG, Ling-feng LI, Peng LI

“…This RF power supply can support the TW-SLIM platform in an efficient manner and is highly valuable for developing compact portable research equipment based on SLIM.…”
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Building a Framework for Visual Question Answering Systems by Maya Abu Hamoud, Wasim Safi

“…The significance of these systems lies in their ability to interpret and analyze images in a manner similar to human comprehension, making them applicable to a wide range of critical fields. …”
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Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis by Tao Jiang, Jinhong Xu, Yang Lu, Xiaojin Chen, Yongxia Li

“…The inflammatory factor tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) in a dose-dependent manner were decreased. In addition, hematoxylin-eosin staining showed that liver tissue damage and inflammatory cell infiltration in mice were significantly reduced with increasing doses. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…The phagocytosis degree of RAW 264.7 macrophage varied with the concentration gradient of MOMP in a time-dependent manner. MOMP could increase the expression levels of MCP-1, IL-10, NOD2, and RIP2 and decrease the expression levels of FOXO1 and coronin-1 in cell culture supernatants. …”
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Evaluating the Combined Effects of Transverse Pitch Ratio and Flow Arrangement on the Thermo-Hydraulic Performance of a Novel Inclined Delta Winglet by Hüseyin Zahit Demirağ

“…In accordance with the objective of this investigation, the combined effects of the positioning of the NIDW in common-flow-down (NIDW-CFlowD) and common-flow-up (NIDW-CFlowU) orientations together with two transverse pitch ratios [Pt=0.333 and 0.166] are investigated and the resulting data are presented in a comparative manner. The angle of attack [α=30°] and the angle of inclination [β=30°] of the NIDW are kept constant. …”
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The Effects of Alpha Interferon on the Development of Autoimmune Thyroiditis in the NOD H2h4 Mouse by Yael Oppenheim, Grace Kim, Yoshiyuki Ban, Pamela Unger, Erlinda Concepcion, Takao Ando, Yaron Tomer

“…This may imply that αIFN induces thyroiditis in a non-genetically dependent manner, and this would not be detected in a genetically susceptible mouse model if the effect were small. …”
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Clonidine Use for the Treatment of Nightmares in Posttraumatic Stress Disorder by Jill S. Bange, Kelly E. Melvin

“…Current proposed mechanisms of action for clonidine’s ability to control nightmare symptoms in PTSD include that clonidine may alter the proportions of REM and non-REM sleep in a dose-dependent manner or that clonidine may play a role in memory consolidation. …”
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Alleviating the IL-1β-stimulated extracellular matrix degradation in osteoarthritis, and chondrocyte inflammation by Morinda officinalis polysaccharide via the SIRT6/NF-κB pathway... by Dongfang Zhao, Shuqin Xing, Jiao Qi, Zhiqiang Wei, Jianghai Huang, Jigao Sun, Xinzhu Wen, Yafei Wang

“…MOP counteracted these effects by mitigating IL-1β-induced cell damage, preventing ECM degradation, and reducing inflammatory factor secretion, in a dose-dependent manner. Furthermore, IL-1β treatment suppressed SIRT6 expression, whereas MOP upregulated it. …”
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