Immunogenicity and vaccine efficacy of Actinobacillus pleuropneumoniae-derived extracellular vesicles as a novel vaccine candidate by Su Hyun Park, Yun Hye Kim, Hyeon Jin Lee, Jeong Moo Han, Byoung-Joo Seo, Gyeong-Seo Park, Chonghan Kim, Young Bae Ryu, Woo Sik Kim

“…Additionally, APP-EVs induced dendritic cell (DC) maturation in a Toll-like receptor 4 (TLR4)-dependent manner without cytotoxicity. APP-EVs predominantly elicited Th1-mediated IgG responses in immunized mice without significant liver and kidney toxicity. …”
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Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane by Ruilin Hu, Penghui Fan, Yiding Wang, Jin Shan, Luyi Jing, Wei Xu, Fan Mo, Mixia Wang, Yan Luo, Ying Wang, Xinxia Cai, Jinping Luo

“…Isoflurane caused an inhibition of spike firing rate in hippocampal CA1 neurons, while inducing low-frequency oscillations in CA1, thus enhancing the low-frequency power of local field potentials. In this manner, the spike firing rate and the power of local field potentials in CA1 could characterize the degree of isoflurane anesthesia. …”
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Pharmacological effects of purple basil extract on ısolated mouse bladder functions and underlying molecular mechanisms by Naciye YAKTUBAY DÖNDAŞ, Beyza Nur ARSLAN

“…PBE reversed these effects of the respective agents in a statistically significant manner. In contrast, verapamilsignificantly decreased the contractile responses of the respective tissues compared to the control, whereas PBE potentiated this inhibitory effect of verapamil. …”
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OPTIMIZING PROPERTY VALUATION: A SYSTEMATIC APPROACH FOR SELECTING COMPARABLE SALES BASED ON SIMILARITY AND RELIABILITY CRITERIA IN THE MARKET COMPARISON APPROACH by Francesca Salvo, Daniela Tavano

“…It operates on the premise that the market assigns a property’s price in a manner akin to how it prices comparable properties. …”
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Modulatory effects of cinnamomi cortex and its components epicatechin and linalool on skin circadian rhythms by Ji-Young Kim, Juyeon Lee, Soo-Hyeon Lee, Eui-Man Jung, Kyung-Ha Lee

“…Gene expression analysis revealed that CC extract, EC, and LO altered the mRNA and protein levels of clock genes in a time-dependent manner. During molecular docking simulations, both EC and LO exhibited strong binding affinities for RORA, a key nuclear receptor involved in circadian regulation. …”
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Undesirable Postoperative Anesthesia Outcomes at Two National Referral Hospitals: A Cross-Sectional Study in Eritrea by Yonatan Mehari Andemeskel, Traudl Elsholz, Ghidey Gebreyohannes, Eyasu H. Tesfamariam

“…The prevalence were computed in two manners, prevalence of those with ‘at least a little bit’ outcomes, which was computed to see the total occurrence of these outcomes, and prevalence of those having ‘more than moderate’ outcomes to see the severe experience of these outcomes. …”
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Design of an integrated model with temporal graph attention and transformer-augmented RNNs for enhanced anomaly detection by Sai Babu Veesam, Aravapalli Rama Satish, Sreenivasulu Tupakula, Yuvaraju Chinnam, Krishna Prakash, Shonak Bansal, Mohammad Rashed Iqbal Faruque

“…We employ a Multimodal Variational Autoencoder-MVAE that fuses video, audio, and motion sensor information in a manner resistant to noise and missing samples. To address the challenge of having a few labeled anomalies, we apply the Prototypical Networks to perform few-shot learning and enable generalization based on a few examples. …”
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DESCARTES’ COMPREHENSION OF HUMAN NATURE IN «DISCOURSE ON THE METHOD» by A. M. Malivskyi

“…The condition of realization the designated purpose is to solve the following problems: 1) To Define the diversity of Descartes position on the issue of essentiality to the true knowledge of human nature; 2) To find out the manner influence of methodology of understanding the mathematical truth to the way of interpretation of human nature; 3) To clarify the question of Descartes awareness of boundaries rationalist methodology in understanding of human nature. …”
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Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia by Ling Zhao, Qiwei Liao, Yueting Zhang, Shufen Tan, Shuqing Li, Tingyu Ke

“…Diabetes and cerebral ischemia increased retinal VEGF expression in a step-wise manner, while additional ischemic PC reduced retinal VEGF expression. …”
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Phosphate-sensing mechanisms and functions of phosphate as a first messenger by Yuichi Takashi

“…Our previous data indicated that high extracellular phosphate phosphorylates FGF receptor 1 (FGFR1) in an unliganded manner, and its downstream intracellular signaling pathway regulates the expression of GALNT3. …”
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Food manipulation and processing in wild western gorillas of Central African Republic: implications for studying behavioural variability by Shelly Masi, Ellen JM Meulman, Françoise Aubaile, Sabrina Krief, Angelique Todd, Emanuelle Pouydebat

“…Whereas traditional ethnographic approaches may help to identify some of this variation, more fine-scaled quantification of manipulative actions may be required to detect such behavioral variation in a more systematic and detailed manner. In this regard, relative to other great apes, gorillas are interesting because, like humans, they possess an elongated thumb that enables precision grips and finer manipulative actions, particularly important for bimanual coordination. …”
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Expectorant Effects of <i>Atractylodes japonica</i> Koidz. ex Kitam Root Extracts on Particulate Matter-Induced Pulmonary Injury in Mice by Junho Lee, Sana Mansoor, Jeongjun Lee, Hunsuk Chung, Young-Sam Kwon, Khawaja Muhammad Imran Bashir, Jae-Suk Choi, Sae-Kwang Ku

“…The results revealed that AJ significantly alleviated PM_2.5-induced pulmonary injuries, mucus overproduction, and respiratory acidosis in a dose-dependent manner. Notably, body surface redness was reduced by up to 55% at a concentration of 100 mg/kg compared to the control. …”
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Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract by Shahla Korani, Khodabakhsh Rashidi, Mona Hamelian, Ali R. Jalalvand, Ahmad Tajehmiri, Mitra Korani, Thozhukat Sathyapalan, Amirhossein Sahebkar

“…The Au NPs showed cell viability in a dose-dependent manner, and this technique was found to be nontoxic. …”
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Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. by Shridhar Bale, Jean-Philippe Julien, Zachary A Bornholdt, Christopher R Kimberlin, Peter Halfmann, Michelle A Zandonatti, John Kunert, Gerard J A Kroon, Yoshihiro Kawaoka, Ian J MacRae, Ian A Wilson, Erica Ollmann Saphire

“…Analysis of dsRNA binding by dot-blot and isothermal titration calorimetry reveals that multiple copies of MARV VP35 RBD can indeed bind the dsRNA sugar-phosphate backbone in a cooperative manner in solution. Further, MARV VP35 RBD can also cap the ends of the dsRNA in solution, although this arrangement was not captured in crystals. …”
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Quantum many-body scars with unconventional superconducting pairing symmetries via multibody interactions by Shohei Imai, Naoto Tsuji

“…These findings open up the possibility of realizing nonequilibrium unconventional superconductivity in a long-lived manner protected against thermalization.…”
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Play Therapy in Children with Autism Diagnosis: An Investigation into the Trainers’ Opinions by Meliha Uzun, Baki Yılmaz

“…In addition, it is very important to cooperate with families ensuring that they also actively participate in the education process to continue education in a coordinated manner.…”
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Estimating Potential for Drug Budget Reallocation Following Expiration of Exclusivity of Pharmaceutical Products by Samira Toghanian, John Moshtaghi-Svensson, Maria Papageorgiou, Kristin Kittelsen, Christiaan Dolk, Markus Hultstrand, Stina Salomonsson

“…**Background:** The prioritization of public funds in an equitable and ethically sound manner along with efficient budget allocation are key challenges for governments and budget holders. …”
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A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyr... by Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

“…Although B16BL6 melanoma cells showed insufficient sensitivity to the cytotoxicity assay, the siRNA-mediated knockdown of the transcription factor NRF2 (NFE2L2) repressed the expression of cytoprotective factors, thereby augmenting the cytotoxicity of all six leukoderma-inducing phenols tested in a tyrosinase-dependent manner, indicating enhanced sensitivity to <i>o</i>-quinone metabolites. …”
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Low-Frequency Admittance of Capacitor with Working Substance “Insulator–Partially Disordered Semiconductor– Insulator” by N. A. Poklonski, I. I. Anikeev, S. A. Vyrko

“…The partially disordered semiconductor of the working substance of the capacitor can be, for example, a highly defective crystalline silicon containing point t-defects randomly (Poissonian) distributed over the crystal in charge states (−1), (0), and (+1), between which single electrons migrate in a hopping manner. It is assumed that the electron hops occur only from t-defects in the charge state (−1) to t-defects in the charge state (0) and from t-defects in the charge state (0) to t-defects in the charge state (+1).In this work, for the first time, the averaging of the hopping diffusion coefficients over all probable electron hopping lengths via t-defects in the charge states (−1), (0) and (0), (+1) in the covalent crystal matrix was carried out. …”
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Survey on intellectual property protection for deep learning model by Xinya WANG, Guang HUA, Hao JIANG, Haijian ZHANG

“…With the rapid development of deep learning technology, deep learning models have been widely used in many fields such as image classification and speech recognition.Training a deep learning model relies on a large amount of data and computing power, thus selling the trained model or providing specific services (DLaaS, e.g.) has become a new business.However, the commercial interests of model trainers and the intellectual property rights of model developers may be violated if the model is maliciously stolen.With deep neural network watermarking becoming a new research topic, multimedia copyright protection techniques were used for deep learning model protection.Numerous methods have been proposed in this field and then a comprehensive survey is needed.the existing deep neural network watermarking methods were elaborated and summarized and the future research directions of this field were discussed.The overall framework of neural network watermarking was presented, whereby the basic concepts such as classification model and model backdoor were introduced.Secondly, the existing methods were divided into two types according to the mechanism of watermark embedding, one is to embed the watermark bits into the carrier of internal information of the network, and the other one uses the established backdoor mapping as the watermark.These two existing deep neural network watermarking methods were analyzed and summarized, and attacks to the watermarks were also introduced and discussed.By analyzing the white-box and black-box conditions in watermarking scenario, it comes to the conclusion that the model is difficult to be effectively protected when it is distributed in the white-box manner, and the neural network watermark defenses in the black-box distribution and black-box verification are both worthy for further research.…”
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