Taguchi Grey relational analysis (GRA) based multi response optimization of flammability, comfort and mechanical properties in station suits by Hafsa Jamshaid, Awais Ahmad Khan, Rajesh Kumar Mishra, Naseer Ahmad, Vijay Chandan, Viktor Kolář, Miroslav Müller

“…Therefore, it is essential to balance these multi responses in a scientific manner. This study explores the multi-response optimization of fiber blend composition and knitted structures on the responses like flammability, comfort, and serviceability/mechanical properties, for the development of fire-resistant fabrics. …”
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Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway by Xiaocen Chang, Yuyan Zhao, Lei Guo

“…We reported the first evidence that orexin-A stimulated p70S6K and 4EBP1 in human H295R adrenocortical cells in a concentration and time-dependent manner. 10−6 M orexin-A treatment for 1 hour was the most potent. …”
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Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells by Zhongyan Zhao, Zhiyu Xu, Tao Liu, Shixiong Huang, Huai Huang, Xiaoyun Huang

“…Taken together, UK treatment reduced LPS-induced neuroinflammation and oxidative stress in a dose-dependent manner, which might be a potential treatment of migraine.…”
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Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury by Mohammad Yassin Zamanian, Niloofar Taheri, Maria Jade Catalan Opulencia, Dmitry Olegovich Bokov, Sharif Y. Abdullaev, Mohammadreza Gholamrezapour, Mahsa Heidari, Gholamreza Bazmandegan

“…However, when treatment is provided in a timely manner, there is a significant window of opportunity to avoid a few of the serious effects. …”
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A distinct double-ring LH1–LH2 photocomplex from an extremophilic phototroph by Kazutoshi Tani, Kenji V. P. Nagashima, Risa Kojima, Masaharu Kondo, Ryo Kanno, Issei Satoh, Mai Kawakami, Naho Hiwatashi, Kazuna Nakata, Sakiko Nagashima, Kazuhito Inoue, Yugo Isawa, Ryoga Morishita, Shinichi Takaichi, Endang R. Purba, Malgorzata Hall, Long-Jiang Yu, Michael T. Madigan, Akira Mizoguchi, Bruno M. Humbel, Yukihiro Kimura, Yutaka Nagasawa, Takehisa Dewa, Zheng-Yu Wang-Otomo

“…The additional LH1-B797 BChls a are located in such a manner that they facilitate exciton transfer from monomeric BChls in LH2 to the dimeric BChls in LH1. …”
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“The Road of War” and “The Path of Peace”: William Morris’s Representation of Violence by Eleonora Sasso

“…Through the regression to a primitive level of personality, I suggest, Morris attempts to arouse a sense of rejection, in order to progress to the dream of order which News from Nowhere extols, with important political solutions which permit to live safely in an organizational manner with others.…”
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Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine by Shiqi Zhang, Emmanouil Ntasis, Sarah Kabtni, Jaap van den Born, Gerjan Navis, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…Irrespective of glucose concentrations L-carnosine prevented toxicity in a dose-dependent manner, only if it was present during the FeCl3 challenge. …”
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Analysis of the Impact of Big Data on E-Commerce in Cloud Computing Environment by Rongrui Yu, Chunqiong Wu, Bingwen Yan, Baoqin Yu, Xiukao Zhou, Yanliang Yu, Na Chen

“…This method can avoid the disadvantages of the traditional e-commerce, where large-scale data cannot be processed in a timely manner, realize the value of mining data behind, and realize the precision marketing of e-commerce enterprises.…”
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Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model by Meijiao Yu, Meijiao Yu, Yu Chen, Yu Chen, Sishi Dong, Sishi Dong, Zhongxin Chen, Zhongxin Chen, Xuelian Jiang, Xuelian Jiang, Yufei Wang, Yufei Wang, Linglin Zhang, Linglin Zhang

“…The growth of S. mutans and the biofilm formation were inhibited by SFN in a dose-dependent manner through suppressing the synthesis of extracellular polysaccharide (EPS) and acid production, as well as decreasing the acid tolerance. …”
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Intimate Partner Violence from Schema Therapy Perspective by Ayse Gokcen Gundogmus, Suheyla Dogan Bulut, Yasir Safak

“…Considering that personality traits are more frequently detected in cases of domestic violence, the use of schema therapy, which integrates many therapeutic techniques into a therapy model (especially in a problematic area with multi-faceted manner such as violence), is promising even though there are few studies on the effectiveness of schema therapies in couples. …”
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Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model by Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda

“…Moreover, dequalinium inhibited hOCT2-mediated transport of platinum anti-cancer agents (cisplatin and oxaliplatin) in a concentration-dependent manner. Our study is the first to demonstrate the construction of a novel machine learning-based QSAR model for hOCT2 inhibitors and identify a novel hOCT2 inhibitor among FDA-approved drugs using this model.…”
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Cadmium Uptake and Distribution in Fragrant Rice Genotypes and Related Consequences on Yield and Grain Quality Traits by Adam Sheka Kanu, Umair Ashraf, Zhaowen Mo, Issaka Fuseini, Lamin R. Mansaray, Meiyang Duan, Shenggan Pan, Xiangru Tang

“…The results showed that, with increased levels of soil Cd toxicity, Cd uptake in roots and distribution to other organs increased in dose dependent manner. Uptake and accumulation were higher in roots than in shoots with the highest uptake in both roots and shoots observed in Meixiangzhan 2, followed by Nongxiang 18, Basmati, Xiangyaxiangzhan, and Guixiangzhan cultivars. …”
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Virtual Force-Based Swarm Trajectory Design for Unmanned Aerial Vehicle-Assisted Data Collection Internet of Things Networks by Xuanlin Liu, Sihua Wang, Changchuan Yin

“…The sense-collect-interchange-explore (SCIE) protocol is proposed to regulate UAV actions, ensuring synchronization and adaptability in a distributed manner. To maintain real-time monitoring while reducing data transmission, we introduce status freshness, which is an extension of age of information (AoI) and allows negative values to reflect the swarm’s predictive capabilities. …”
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PTEN depletion reduces H3K27me3 levels to promote epithelial-to-mesenchymal transition in epithelial colorectal cancer cells. by Ahmed H Ghobashi, Jane W Kimani, Christopher A Ladaika, Heather M O'Hagan

“…Interestingly, PTEN KD reduced the global levels of trimethylation of histone 3 at lysine 27(H3K27me3) in an EZH2-phosphorylation-dependent manner. Additionally, EZH2 phosphorylation at serine 21 reduced the interaction of EZH2 with another polycomb repressive complex 2 (PRC2) component, suppressor of zeste 12 (SUZ12), suggesting that the reduced H3K27me3 levels in PTEN KD cells were due to a disruption of the PRC2 complex. …”
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Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria by Teresa Krakauer

“…Pathogens, PAMPs, and DAMPs activate TLRs and intracellular inflammasomes, inducing apoptotic and inflammatory caspases in a context-dependent manner to promote various forms of cell death to eliminate pathogens. …”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…Furthermore, TRIM8 was shown to reduce the expression of the PEDV N protein in a dose-dependent manner. Mechanistically, TRIM8 inhibits the expression of PEDV N through K48-linked ubiquitin proteasome degradation. …”
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In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice by Hana Biruk, Biruk Sentayehu, Yonatan Alebachew, Wondmagegn Tamiru, Abebe Ejigu, Solomon Assefa

“…Moreover, the 80% methanol extract showed a significant p<0.001 attenuation of anemia associated with infection in a dose-dependent manner. The aqueous extract, on the other hand, exhibited a percent inhibition of 51.1% at the highest dose (400 mg/kg/day). …”
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Dose and time dependent cytotoxicity of Blepharis maderaspatensis (L) against various human cancer cell lines by Bhutkar Pratima Milind, V. Suganthi, Bhutkar Milind Vishnu

“…Results: Ethanolic extract of B. maderaspatensis was effective cytotoxic agent against all the tested cancer cell lines in dose and time-dependent manner. Cytotoxicity was maximum against A375 (melanoma) (IC50: 21.46μg/ml), followed by HT29 (colon cancer) cell lines (IC50: 32.66μg/ml). …”
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Uncovering the whole genome silencers of human cells via Ss-STARR-seq by Xiusheng Zhu, Lei Huang, Chao Wang, Guoli Li, Biao Deng, Dashuai Kong, Xiaoxiao Wang, Rongrong Chang, Yi Gu, Qiuhan Wen, Siyuan Kong, Yuwen Liu, Yubo Zhang

“…In this study, we applied Ss-STARR-seq to human cell lines K562, LNCaP, and 293 T, and identified 134,171, 137,753, and 125,307 silencers on a genome-wide scale, respectively, these silencers function in various cells in a cell-specific manner. Silencers exhibited a substantial enrichment of transcriptional-inhibitory motifs, including REST, and demonstrated overlap with the binding sites of repressor transcription factors within the endogenous environment. …”
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Tissue-specific resistance and susceptibility to the tomato brown rugose fruit virus (ToBRFV) conferred by Solanum pennellii loci by Edan Rochsar, Shai Torgeman, Kfir Bandel, Amnon Koren, Chen Klap, Aviv Dombrovsky, Dani Zamir

“…Conclusion Taken together, S. pennellii loci conferring resistance and susceptibility act in a tissue-specific manner and are modified by genetic background.…”
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