Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations by Rafik Karaman, Alaa Qtait, Khulod Khayyat Dajani, Saleh Abu Lafi

“…In addition, a linear correlation of the calculated and experimental rate values has drawn credible basis for designing atenolol prodrugs that are bitterless, are stable in neutral aqueous solutions, and have the potential to release the parent drug in a sustained release manner. For example, based on the calculated B3LYP/6-31 G (d,p) rates, the predicted t1/2 (a time needed for 50% of the prodrug to be converted into drug) values for atenolol prodrugs ProD 1-ProD 2 at pH 2 were 65.3 hours (6.3 hours as calculated by GGA: MPW1K) and 11.8 minutes, respectively. …”
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Synthesis and release profile of ibuprofen-loaded zein and gelatin nanofiber scaffolds for potential transdermal application in burn wound treatment by umaima saleem memon, Murk saleem memon, Abdul Wahab Memon, Mehwish Shahzad, Murk Rehman, Farooq Ahmed, Zeeshan Khatri

“…The results indicate that the Ibuprofen is efficiently loaded onto the nanofibers, with a uniform distribution of the drug throughout the fiber matrix and ensures that the drug is released in a controlled and sustained manner, promoting effective wound healing.…”
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Device-Free Human Activity Recognition: A Systematic Literature Review by Majid Ghosian Moghaddam, Ali Asghar Nazari Shirehjini, Shervin Shirmohammadi

“…This mixed-method study assesses the quality of the reviewed papers and analyzes suggested HAR methods in both a scientometric and technical manner. The scientometric analysis investigates the trends of scientific publications in this field from the beginning of 2017 to the end of 2023 and reviews the types and distribution of publications among countries, universities, and media. …”
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A Computational Framework for Optimal Adaptive Function Allocation in a Human-Autonomy Teaming Scenario by Sooyung Byeon, Joonwon Choi, Inseok Hwang

“…The proposed optimal adaptive function allocation method is composed of three main elements: 1) analyze the teamwork to identify a set of all possible function allocations within a team construction, 2) numerically simulate the teamwork in temporal semantics to explore the interaction of the team with complex environments using the identified function allocations in a trial-and-error manner, and 3) optimize the adaptive function allocation with respect to a given situation such as physical conditions, available information resources, and human mental workload. …”
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ANALYSIS OF HIGH RISK FACTORS FOR NON-COMMUNICABLE DISEASE, STROKE IN THE SIDOARJO DISTRICT HEALTH SERVICE by Luluk Widarti, Muhammad Afif Hilmi Masyfahani, Dony Sulystiono, Kusmini Suprihatin, Hotmaida Siagian, Siti Maemonah

“…The results of the analysis of stroke risk factors are still high, so it is necessary to optimize advocacy and integrated partnerships in stroke prevention and control through promotive, preventive, curative, and rehabilitative activities in an integrated and sustainable manner.…”
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Reputation Detection for Information Diffusion in Social Network Systems by Yifeng Zhou, Fang Yu

“…., Twitter), the characteristic of the unidirectional relationship between agents and the decay property of diffusion will result in lacking direct interactions; therefore, interaction reputations will be difficult to be obtained by agents in a distributed manner. To solve this problem, a novel distributed reputation detection model following the pattern “from path to individual” (FPTI) is proposed, which can provide a new reputation factor as an alternative to interaction reputation in such environments. …”
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AN INVESTIGATION INTO CONTRACTORS’ EVALUATION OF RISKS ASSOCIATED WITH THE JBCC PRINCIPAL BUILDING AGREEMENT IN SOUTH AFRICA by Ayman Othman, Nishani Harinarain

“…The interviews were structured so that they were carried out in a free and unbiased manner and responding contractors were asked to complete a questionnaire. …”
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Application of EMD Technology in Leakage Acoustic Characteristic Extraction of Gas-Liquid, Two-Phase Flow Pipelines by Jian Ji, Yuxing Li, Cuiwei Liu, Dongxu Wang, Huafei Jing

“…When the liquid flow is maintained constant, the energy values of the IMF components change in a nonlinear manner when the gas flow rate increases. This verifies the feasibility of use of the acoustic wave sensing technology for leak detection in multiphase flow pipelines, which has important theoretical significance for promoting the development of safe and efficient operation in two-phase flow pipelines.…”
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Inhibitory Effect of <i>Moringa oleifera</i> Seed Extract and Its Behenic Acid Component on <i>Staphylococcus aureus</i> Biofilm Formation by Seoyoung Kim, Tae-Jong Kim

“…Although behenic acid did not affect cell growth, it inhibited biofilm formation in a concentration-dependent manner, up to 20 mg/L. The cell physiology changes caused by behenic acid are potentially unrelated to biofilm formation inhibition, as no correlation was noted between cell hydrophobicity, polysaccharide production, extracellular DNA production, or protein production and behenic acid concentration. …”
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Drawing the Map: Siting Architecture by Anne Bordeleau, Liana Bresler

“…If maps can successfully represent sets of complex interactions in an effective manner, they also have an objectifying tendency and are often criticized for being tools of domination as well for their propensity to stabilize space-time. …”
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Evolution and Influencing Factors of Township Spatial Form: A Two-Dimensional Perspective by Yanpeng Gao, Wenjun Chen

“…Clusters of rural settlements were formed in a north-south direction due to the topography and along the riverside in a band-like manner. From 2009‒2019, the integration level of the subdistrict improved and the scale and number of integration axis increased, forming a multicore tree-shaped structure. …”
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A comprehensive scoping review and meta-analysis of upper limb strength asymmetry by Ryan C. A. Foley, Danny H. Callaghan, Garrick N. Forman, Jeffrey D. Graham, Michael W. R. Holmes, Nicholas J. La Delfa

“…Results are compiled by exertion type and manner of asymmetry comparison (i.e. right/left, dominant/non-dominant). …”
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An Improved Deep Learning-Based Technique for Driver Detection and Driver Assistance in Electric Vehicles with Better Performance by Gunapriya Balan, Singaravelan Arumugam, Suresh Muthusamy, Hitesh Panchal, Hossam Kotb, Mohit Bajaj, Sherif S. M. Ghoneim, null Kitmo

“…As a part of this research, a driver identification system based on a deep driver classification model (deep neural network as DNN) with feature reduction techniques (random forest as RF and principal component analysis as PCA) is implemented to help automate and aid in crucial jobs such as the brake system in an efficient manner. Using task models, we simulate a low-cost driver assisted scheme in real time, where various scenarios are explored and the schedulability of tasks is established before implementing them in EV. …”
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Computationally-efficient rendering of diffuse reflections for geometrical acoustics based room simulation by Ewert Stephan D., Gößling Nico, Buttler Oliver, van de Par Steven, Hu Hongmei

“…Effects of scattering and multiple (inter-) reflections caused by larger geometric structures at walls, and by objects in the room are accounted for in a highly simplified manner. A single parameter is used to quantify deviations from an empty shoebox room. …”
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METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression by Chen Zhang, Tianpeng Yang, Hanbin Chen, Xiaofeng Ding, Huajian Chen, Zhenzhen Liang, Yinlong Zhao, Shumei Ma, Xiaodong Liu

“…In conclusion, our study suggests that METTL3 regulates the stability of SLC7A11 mRNA in an m6A/IGF2BP2-dependent manner and the ubiquitination of SLC7A11 protein through the m6A/YTHDF2/SOCS2 pathway, both of which require the m6A methyltransferase activity of METTL3. …”
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Fine-tuning a local LLaMA-3 large language model for automated privacy-preserving physician letter generation in radiation oncology by Yihao Hou, Yihao Hou, Christoph Bert, Christoph Bert, Christoph Bert, Ahmed Gomaa, Ahmed Gomaa, Ahmed Gomaa, Godehard Lahmer, Godehard Lahmer, Godehard Lahmer, Daniel Höfler, Daniel Höfler, Daniel Höfler, Thomas Weissmann, Thomas Weissmann, Thomas Weissmann, Raphaela Voigt, Raphaela Voigt, Raphaela Voigt, Philipp Schubert, Philipp Schubert, Philipp Schubert, Charlotte Schmitter, Charlotte Schmitter, Charlotte Schmitter, Alina Depardon, Alina Depardon, Alina Depardon, Sabine Semrau, Sabine Semrau, Sabine Semrau, Andreas Maier, Rainer Fietkau, Rainer Fietkau, Rainer Fietkau, Yixing Huang, Yixing Huang, Florian Putz, Florian Putz, Florian Putz

“…IntroductionGenerating physician letters is a time-consuming task in daily clinical practice.MethodsThis study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving manner within the field of radiation oncology.ResultsOur findings demonstrate that base LLaMA models, without fine-tuning, are inadequate for effectively generating physician letters. …”
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Transcriptomics and Physiological Analyses of Soybean Stay-Green Syndrome by Dagang Wang, Yanan Wang, Ruidong Sun, Yong Yang, Wei Zhao, Guoyi Yu, Yueying Wang, Feng Wang, Lin Zhou, Zhiping Huang

“…Transcriptomic analyses were performed in a tissue-specific manner to investigate differentially expressed genes (DEGs) in soybeans impacted by SGS and in those without SGS. …”
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Investigating the Effectiveness of the Interest Rate Monetary Policy Tool on Inflation Management in the Condition of the Banking System Imbalance and Analyzing the Imbalance Based... by Mohammad Shirijian, Mohammad Reza Farzin, Manijeh Hadinejad, Marjan Daman Keshideh

“…To answer this, first of all, the mechanisms of monetary policy transmission channels are elaborated in the condition of the banking system  soundness, and then by examining and explaining the reasons for creating imbalances in the banking system from the operational aspect and from the perspective of Islamic banking, the manner of disrupting the transmission channel mechanism of the monetary policy of the interest rate to the inflation rate when there is an imbalance in the banking network, and the final result of the quality of the application of this policy to the inflation variable in the mentioned conditions are theoretically analyzed.…”
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Understanding and addressing β-lactam resistance mechanisms in gram-negative bacteria in Lebanon: A scoping review by Yara Khachab, Mohamad Hodroj, Elie Salem Sokhn

“…To contribute to a complete understanding of the current state of antibiotic resistance in gram-negative strains, it was intended to collect and evaluate data on these organisms' resistance patterns in a comprehensive manner. Results: Several studies have emphasized the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in Lebanon, specifically noting Escherichia coli and Klebsiella pneumoniae as the most frequent culprits, with OXA-48 and NDM-1 being the primary carbapenemases discovered. …”
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A cross-sectional survey benchmarking the coverage and importance of obesity-related competencies in U.S. dietetic supervised practice programs by Rosanna P. Watowicz, Varsha Krishnan, W. Scott Butsch

“…The competencies most frequently reported as ‘very important’ were ‘perform effectively in an interprofessional team’ and ‘discuss obesity in a non-judgmental manner’. Lack of time in the curriculum was the most frequently reported barrier. …”
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