Trust Region Policy Learning for Adaptive Drug Infusion with Communication Networks in Hypertensive Patients by Mai The Vu, Seong Han Kim, Ha Le Nhu Ngoc Thanh, Majid Roohi, Tuan Hai Nguyen

“…Besides the various analyses such as normal condition (without CTD strategy), stability, and hybrid noise, a CTD analysis is implemented to illustrate the functionality of the system in a wireless manner and interruption in real-time feedback data.…”
Get full text

The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon by Lu Zou, Dan Cao, Qing Sun, Wenjun Yu, Bingzong Li, Guoqiang Xu, Liang Zhou

“…Biochemical experiments found that the CRBN-interacting protein KDM5C could stabilize CRBN and enhance the antileukemia effect of Len in an enzyme activity-independent manner. Furthermore, our studies revealed that the small-molecule compound MLN4924 could increase CRBN by elevating KDM5C.The combination of MLN4924 and Len can further increase the sensitivity of primary AML cells and AML cell lines to Len. …”
Get full text

Goat’s Milk Powder Enriched with Red (<i>Lycium barbarum</i> L.) and Black (<i>Lycium ruthenicum</i> Murray) Goji Berry Extracts: Chemical Characterization, Antioxidant Properties,... by Danijel D. Milinčić, Aleksandar Ž. Kostić, Steva Lević, Uroš M. Gašić, Dragana D. Božić, Relja Suručić, Tijana D. Ilić, Viktor A. Nedović, Bojana B. Vidović, Mirjana B. Pešić

“…GMLB and GMLR in a dose-dependent manner (0.3–5 mg/mL) showed a growth-promoting effect on probiotic strains. …”
Get full text

Investigating the role of urban furniture in improving the quality of urban environment (Case study: Bandar Abbas city) by Sepideh Raeisi Qanavati, Marzieh Moghli, Mohammad Ebrahim Afifi

“…The research questionnaire was created by a researcher whose validity was confirmed by experts in a formal and superficial manner. And its reliability was confirmed using Cronbach's alpha coefficient. …”
Get full text

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis by Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia

“…In the context of abundant fatty acids, niraparib elevated intracellular levels of fatty acids and lipid peroxidation, leading to subsequent tumor cell ferroptosis in a p53 and BRCA-independent manner. Notably, under niraparib exposure, a critical fatty acid transporter CD36 was dramatically upregulated in tumors, facilitating excessive uptake of fatty acids. …”
Get full text

Logics and Contradictions of Transalpine Transport within the Context of Political and Social Relations in Europe by Manfred Perlik

“…3 - Under what conditions may transport be reduced in a more comprehensive manner? Answers are given by analysing three fields relevant for traffic growth in their internal coherence: the political logic, the economic logic, and the logic of spatial development. …”
Get full text

Transverse Carpal Ligament and Forearm Fascia Release for the Treatment of Carpal Tunnel Syndrome Change the Entrance Angle of Flexor Tendons to the A1 Pulley: The Relationship bet... by Nazım Karalezli, Harun Kütahya, Ali Güleç, Serdar Toker, Hakan Karabörk, Tunc C. Ogun

“…We saw that the entrance angle increased in all of five fingers in an increasing manner from procedure 1 to 3, and it was seen that the maximal increase is detected in the middle finger from procedure 1 to procedure 2 and the minimal increase is detected in little finger. …”
Get full text

Rafraîchir les observatoires par le son by Cécile Regnault, Patrick Romieu

“…From the most notable disruptive innovations dating from the First World War to more seemingly mundane experiments such as the transistor, this article offers a theoretical and methodological look at sound observatories. …”
Get full text

Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity by Rui Ren, Xinyue Zhou, Tianyu Jia, Bin Wang, Ahui Liu, Min Gao, Ji Song, Liyan Wang, Yuanxue Jing, Liulin Yu, Haofei Shen, Xuehong Zhang

“…The activity against endometrial mesenchymal cells was significantly reduced by PFOS intervention, and the apoptosis flow assay results showed that PFOS significantly promoted cell death in a concentration-dependent manner. Transmission electron microscopy results revealed mitochondrial damage in the PFOS-intervened group, and WB results showed that the expression levels of endometrial tolerance-related proteins Homeobox A10 (HOXA10) and integrin beta3 (ITGB3) were decreased, and the expression level of Forkhead box O1 (FOXO1) protein was increased. …”
Get full text

W jaki sposób możemy wyrazić naszą troskę i odpowiedzialność za przyszłość naszej planety i zamieszkującej ją ludzkości? by Rafał Czekalski

“…Undoubtedly, something needs to be done, but can future generations be treated in the same manner as contemporary ones? This is a question that is very difficult to find a satisfactory answer for. …”
Get full text

Effect of Chromatin-Remodeling Agents in Hepatic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells In Vitro and In Vivo by Danna Ye, Tong Li, Philip Heraud, Rangsun Parnpai

“…We conclude that HDACis enhance hepatic differentiation in a time-dependent manner, while DNMTis do not induce the hepatic differentiation of rBM-MSCs in vitro. …”
Get full text

Synthesis and Validation of a Weatherproof Nursery Design That Eliminates Tropical Evening-Fever Syndrome in Neonates by Hippolite O. Amadi, Lawal I. Mohammed, Mohammed B. Kawuwa, Abdulquddus Oyedokun, Hajjah Mohammed

“…Lab-2 was a renovation of an existing room in a manner that could correct an existing nursery. Lab-1 was an entirely new building idea. …”
Get full text

Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans by Chih Jen Yang, Lyndsey E. Shorey-Kendrick, Cristina Puy, Ashley E. Benson, Phillip A. Wilmarth, Ashok P. Reddy, Keith D. Zientek, Kilsun Kim, Adam Crosland, Chaevien S. Clendinen, Lisa M. Bramer, Olivia L. Hagen, Helen H. Vu, Joseph E. Aslan, Owen J.T. McCarty, Joseph J. Shatzel, Brian P. Scottoline, Jamie O. Lo

“…Conclusion: Overall, our findings reveal that the addition of AF to plasma enhances coagulation in a manner dependent on phospholipids as well as the presence of proteases and other proteins that directly regulate coagulation. …”
Get full text

Kinetics of Mushroom Tyrosinase and Melanogenesis Inhibition by N-Acetyl-pentapeptides by Ching-Yi Lien, Ching-Yu Chen, Shih-Ting Lai, Chin-Feng Chan

“…The 4N-acetyl-pentapeptides were able to reduce the oxidation of L-DOPA by tyrosinase in a dose-dependent manner. Of the 4N-acetyl-pentapeptides, only Ac-P4 exhibited lag time (80 s) at a concentration of 0.5 mg/mL. …”
Get full text

PB: A Message Transmission Method Based on Area Layer Division in UAV Networks by Lisong Wang, Feifei Zhu, Qing Zhou, Kui Li, Liang Liu

“…Message transmission between area layers adopts a geographical routing manner, that is, messages are transmitted to the area layer closer to the ground station. …”
Get full text

A Novel Multivariate Spectral Local Quasilinearization Method (MV-SLQLM) for Modelling Flow, Moisture, Heat, and Solute Transport in Soil by Elias Mwakilama, Vusi Magagula, Duncan Gathungu

“…The MV-SLQLM uses a quasilinearization method (QLM) to linearize any nonlinear equations and then employs a local linearization method (LLM) to decouple the linearized system of PDEs to form a sequence of equations that are solved in a computationally efficient manner. The MV-SLQLM is thus an extension of the bivariate spectral local linearization method (BI-SLLM) that fails to deal with a 2D problem and is a modification of the MV-SQLM whose efficiency is compromised when operating on high dense solution matrices. …”
Get full text

Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. by Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan

“…Thus, we reveal that a satellite DNA-binding protein functions during embryogenesis to silence transposons, in a manner that is heritable across later stages of development.…”
Get full text

MEMBIASAKAN TRADISI AGAMA: ARAH BARU PENGEMBANGAN PENDIDIKAN AGAMA ISLAM DAN BUDI PEKERTI DI SMA NEGERI 3 YOGYAKARTA by Moch Fuad

“…The result of the research explains that: (1) the learning process of PAI based on culture and character of the nation in SMA Negeri 3 in Yogyakarta through integrated learning by teachers with students actualized on religious values and tolerance, including: the value of faith, the practice of worship to Allah, and social activities (2) that integrated learning by PAI teachers results in the cultural and character values that students exhibit in their religious and tolerant attitudes, such as the character of faith that is actualized in performing worship worship, manners in behavior and speech, peer empathy, (3) PAI learning process with model reform and material cotectualization (integrated domain) can improve the knowledge, attitude, and behavior of students through the cultivation of creative value and responsibility of students in their life, and (4) The practice of practicing the students' worship is shown Through the implementation of "worship maghdoh", such as: prayer, fasting, and reciting the Qur'an, and worship "ghoiru maghdoh" (social-community worship), such as: social-community activities, love environment, and tolerance. …”
Get full text

Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer by Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-Kong Chen, Hui-Min David Wang, Hurng-Wern Huang, Bin Huang

“…Cytotoxicity assays were used to measure the effects of arecoline on cell viability in a dose-dependent manner. In vitro and in vivo studies were conducted to evaluate the expression of the CYP26B1 splice variant. …”
Get full text

Evaluating the antagonist effect of naltrexone implant via opioid challenge tests with escalating doses of hydromorphone injection in former heroin dependent patients by Wei Qu, Xuyi Wang, Chongyang Dong, Tao Zhang, Shugui Yin, Zhijun Sun, Shiqiang Wang, Anni Guo, Wei Hao

“…The findings indicate that the NXT-IMP effectively blocks the agonistic effects of hydromorphone in a dose-dependent manner.…”
Get full text