Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite by Musarat Amina, Nawal M. Al Musayeib, Nawal A. Alarfaj, Maha F. El-Tohamy, Gadah A. Al-Hamoud

“…Polymeric bionanocomposite exerted significant cytotoxicity against human lung carcinoma cell lines in a concentration-dependent manner with an IC50 value of 42.7 ± 0.25 μg mL−1. …”
Get full text

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…Moreover, the total levels of GRK2, not only in the brain, but also in peripheral blood samples, are increased in a manner inversely correlated with the patient's cognitive levels. …”
Get full text

Adaptive CNN Ensemble for Complex Multispectral Image Analysis by Syed Muslim Jameel, Manzoor Ahmed Hashmani, Mobashar Rehman, Arif Budiman

“…The proposed ensemble approach in the DEC module (individual spectral band handling by the individual classifier of the ensemble) contributes the diversity to the ensemble system in the simple yet effective manner. The results have shown the effectiveness and proven the diversity of the proposed framework to adapt the new spectral band during online image classification. …”
Get full text

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. by Karen S Kelly-Spratt, Kay E Gurley, Yutaka Yasui, Christopher J Kemp

“…Thus, p19(Arf) inhibits the growth rate of tumors in a p53-independent manner. Through its regulation of p53, p19(Arf) also suppresses malignant conversion and metastasis. p53 expression was upregulated in papillomas from wild-type but not p19( Arf)-null mice, and p53 mutations were more frequently seen in wild-type than in p19( Arf)-null carcinomas. …”
Get full text

Information support for administrative and jurisdictional activities of the state border guard service of Ukraine in relation to proceedings on administrative offences by Kushnir I.

“…The methodological basis of the study is formed by a set of philosophical, general scientific, sectoral and special scientific methods (dialectical, communicative, structural and functional, formal and logical, hermeneutical), which, when applied in a comprehensive manner, made it possible to achieve the purpose of the study. …”
Get full text

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.…”
Get full text

Calibration of ionization chamber in megavoltage x-ray field of medical linear accelerator by Pham Hong-Lam, Hoang Thanh-Phi-Hung, Sunjun Jin, Bui Duy-Linh, Nguyen Tuan-Khai, Bui Van-Loat, Le Tuan-Anh, Nguyen Huu-Quyet, Pham Duc-Khue, Phan Viet-Cuong, Phan Tien-Dung, Pham Quang-Trung, Tran Hoai-Nam, Le Ngoc-Thiem

“…Whereas, absorbed doses to water at a depth of 10 cm below the water surface were measured using the same ionization chamber (referred to as IC-1) in two different manners (i.e., applying the old beam quality correction factor kQ0 from the old IAEA/TRS-398 protocol, referred to as D1-old10 and using the new one, kQ from the updated protocol, referred to as D1-new10. …”
Get full text

Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…We conclude that oncogenic PIK3CA H1047R corrupts information transfer in a growth factor-dependent manner and suggest new opportunities for tuning of receptor-specific PI3K pathway outputs for therapeutic benefit.…”
Get full text

ASSESSMENT OF ENVIRONMENTAL IMPACT OF ENERGY FACILITIES IN THE ISLAMIC REPUBLIC OF IRAN BY METHOD OF BUILDING COMPOSITE THREE-DIMENSIONAL MODELS by M. A. Mehdizadeh

“…This enables rendering a prompt decision on the measures minimizing unfavorable impact on the population and environment.Altering the point of topographical survey while synchronizing the scales, the researcher can place the designed project within any territory and analyze the necessary parameters for each variant.The author considers the presented in such a manner technique worth productive implementing while analyzing environmental impact of both operating and projected industrial facilities (industrial and agricultural enterprises, thermal and nuclear electric-power plants etc.).…”
Get full text

Flavour deconstructing the composite Higgs by Sebastiano Covone, Joe Davighi, Gino Isidori, Marko Pesut

“…At the TeV scale, the gauge groups SU(2) R and U(1) B−L are assumed to act in a non-universal manner on light- and third-generation fermions, while the Higgs emerges as a pseudo Nambu-Goldstone boson of the spontaneous global symmetry breaking Sp(4) → SU(2) L × SU 2 R 3 $$ \textrm{SU}{(2)}_R^{\left[3\right]} $$ , attributed to new strong dynamics. …”
Get full text

iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer by María del Moral-Martinez, Paula Sánchez-Uceta, Ruben Clemente-Gonzalez, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Huda Khaldy, David Lopez-Perez, Javier Arnedo, Jorge Casado, Luis Martínez-Heredia, Angel Carazo, Josefa León

“…We have recently reported that PARP-1 influences tumor progression in CRC through the regulation of CSCs in a p53-dependent manner. In this study, we propose that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) could act as a mediator. …”
Get full text

Phase Transformation, Microstructures, and Mechanical Properties of α + β Two-Phase Titanium Alloy Deposited Metal by Surfacing Welding by Naiwen Fang, Ruisheng Huang, Kai Xu, Tianli Zhang, Pengbo Wu, Yiming Ma, Hao Cao, Jian Qin, Jipeng Zou

“…The results showed that primary α phase began to appear at grain boundaries when the deposited metal was heated to 890.5°C, and microstructures were all composed of coarse β columnar grains after the temperature was raised to 1 190.2°C; with the increase of cooling rate during the cooling process, temperature for starting new phase transformation decreased from 943.7°C to 811.1°C, and temperature for ending the transformation increased gradually from 708.0°C to 736.2°C; when cooled to room temperature at a rate of 1°C/s, microstructures consisted of α phase; at a rate of 15°C/s, acicular α′ martensite appeared in the microstructures; at 100°C/s, the microstructures were completely comprised by acicular α′ martensite; when the cooling rate was low, V element would be slightly precipitated from αgb into the matrix; when cooling turned faster, V element had no time to enter the matrix by diffusion, so it became uniformly distributed; as the cooling rate getting faster, lamellar microstructures became thinner gradually, and microhardness of the deposited metal was improved in a gradual manner.…”
Get full text

Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model by Hossein Rahavi, Seyed Mahmoud Hashemi, Masoud Soleimani, Jamal Mohammadi, Nader Tajik

“…AT-MSCs inhibited splenocytes proliferative response to specific (islet lysate) and nonspecific (PHA) triggers in a dose-dependent manner (P<0.05). Decreased production of proinflammatory cytokines, such as IFN-γ, IL-2, and IL-17, and increased secretion of regulatory cytokines such as TGF-β, IL-4, IL-10, and IL-13 by stimulated splenocytes were also shown in response to islet lysate or PHA stimulants (P<0.05). …”
Get full text

Airborne Ultrafine Particle and Acute Physiological Effects during Maximal Aerobic Power Test by Angelo Rodio, Francesco Misiti, Alessandro Zagaglia, Luca Stabile, Giorgio Buonanno, Luigi Fattorini

“…Methods Male recreational cyclists performed tests in a manner randomized crossover in two environmental conditions: low (environmental noise exposure) and high ultrafine particle concentration. …”
Get full text

Double disaggregation of the decline of terrestrial water storage for a highly cultivated dryland partially covered by glaciers by Zongxia Wang, Suxia Liu

“…Besides the Tianshan Mountains, TWS also declined significantly downstream where it should have increased given the substantive glacier meltwater supply from upstream, implying that the evolution of TWS in NSTM has probably deviated from natural manners. Pixel-wise internal disaggregation indicated that groundwater storage was the predominant hydrological component leading to TWS depletion in most of the NSTM except for glacier-covered areas. …”
Get full text

Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism by Lu Wang, Lu Wang, Menghan Xi, Menghan Xi, Wei Cao, Haiyan Qin, Di Qin, Shuai Chen, Siyuan Zhou, Yujun Hou, Ying Chen, Xianjun Xiao, Qianhua Zheng, Dehua Li, Ying Li

“…Our results indicate that miR-205-5p, significantly upregulated in fecal and colonic tissues of EA-treated constipated mice, promotes intestinal motility in a microbiome-dependent manner. Specifically, EA promoted the growth of Lactobacillus reuteri, enriched in the feces of constipation-recovered mice, through host-derived miR-205-5p regulation. …”
Get full text

An Efficient Network Based on Conjugate Gradient Optimization and Approximate Observation Model for SAR Image Reconstruction by Song Zhou, Jing Chen, Zao Wang, Yuhao Wang, Pin Wen

“…However, due to the computation of the large-scale matrix, the optimal searching in an iterative manner will involve tremendous computational complexity with slow convergence, which will prevent deep learning algorithms from being efficiently applied for SAR imaging. …”
Get full text

The Politics of Knowledge Production and Decolonisation: An Appraisal of Mahmood Mamdani’s Contributions by Sifiso Ndlovu

“…From the vantage point of the present, Mahmood Mamdani, is one of the scholars who have given an account of colonial rule, its main characteristics and consequences of colonial conquests in a telling manner that renders transparent how the universalising structure of political modernity produced the colonised as subjects of difference. …”
Get full text

Digitalized co-production of emergency response: ICT-enabled dispatch and coordination of volunteers at the emergency site by Sofie Pilemalm, Anna Follin, Erik Prytz

“…However, to make most use of their capabilities, they need to be dispatched to the emergency site in an effective manner and coordinated on-site. The purpose of this study is to present a requirements specification and initial design proposal for ICT-enabled dispatch of volunteers as first responders as part of emergency response digitalized co-production initiatives. …”
Get full text

The returning dead: unconventional inhumations in Medieval Lithuania by Gintautas Vėlius

“…The great number of so-called unconventional inhumations in medieval Lithuania depict the permanent co-existence of both pagan post-existential concepts and rituals and the new Christian ones; such manner of beliefs is significant for a religiously syncretic society. …”
Get full text