Sleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1 by Andrew J. Hill, Bryan Robinson, Jesse G. Jones, Paul W. Sternberg, Cheryl Van Buskirk

“…We show that SISS-1 overexpression induces sleep in an EGFR-dependent, sleep neuron-dependent manner. We find that SISS-1 undergoes stress-responsive shedding by the ADM-4/ADAM17 metalloprotease, and that the ADM-4 site of action depends on the tissue specificity of the stressor. …”
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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

“…Interestingly, SMARCA4 deficient cells, intrinsically vulnerable to replication stress, exhibited exacerbated DNA damage upon combined ATRi and PARPi treatment in a Mre11- and Mus81-mediated manner. In vivo, combined treatment with intermittent ATRi and continuous PARPi showed greater inhibition of tumor growth than ATRi alone in SMARCA4-deficient lung adenocarcinoma xenograft models. …”
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Low-Resolution Target Detection with High-Frequency Information Preservation by Feng Zhang, Hongyang Bai, Wenlong Yin, Ze Li, Hailong Ma, Lei Chen

“…It is composed of two key components: (1) the decoupled high-frequency learning component, which extracts the high-frequency information along the vertical and horizontal directions separately, and (2) the dilated frequency-aware channel correlation component, which decomposes the input feature map into multiple smaller ones in a dilated manner, concatenates them by channel, and then correlates the combined channels in the frequency space. …”
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament by Emmajay Sutherland, Christopher J. Harding, Tancrède du Monceau de Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster

“…The enzyme exhibits promiscuity, processing various cyclic dipeptides as substrates in a distributive manner. The reaction is optimal at high pH and involves the formation of a radical intermediate. …”
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Physicochemical Characterization of Star Anise Silver Nanoparticles Incorporated Chitosan Biomaterial for Absorb Water and Cure Wounds by M. Prabhahar, Gomathi Kannayiram, S. Prakash, M. Saravanakumar, Sangeetha Krishnamoorthi, S. Sendilvelan, P. Rahul Senthan, T. S. Ashikmon, M. Karthik, Haiter Lenin

“…The anti-inflammatory assay suggests that nanoparticles prevent the aggregation of proteins in a dose-dependent manner. IC50 was found to be 20 μg/ml. The synthesized nanoparticle was incorporated into the chitosan biomaterial and characterized by various physicochemical parameters such as differential scanning calorimetry, scanning electron microscopy, FTIR, and thermogravimetric analysis. …”
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Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Viv... by Najia Xu, Mokarram Hossain, Lixin Liu

“…After adhesion in the lumen, many leukocytes crawl to optimal sites at endothelial junctions and transmigrate to extravascular tissue in a Mac-1-dependent manner. The signalling mechanisms that regulate postadhesion steps of intraluminal crawling, transmigration, and chemotaxis in tissue remain incompletely understood. …”
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Early Differentiation of Human CD11c+NK Cells with γδ T Cell Activation Properties Is Promoted by Dialyzable Leukocyte Extracts by Dalia Ramírez-Ramírez, Eduardo Vadillo, Lourdes Andrea Arriaga-Pizano, Héctor Mayani, Sergio Estrada-Parra, Marco Antonio Velasco-Velázquez, Sonia Mayra Pérez-Tapia, Rosana Pelayo

“…Thus, by direct effect on progenitor cells and through activation and remodeling of the supporting hematopoietic microenvironment, DLE may contribute a robust innate immune response by promoting the emerging lymphopoiesis of functional CD11c+ NK cells in a partially TLR-related manner. Unraveling the identity and mechanisms of the involved DLE components may be fundamental to advance the NK cell-based therapy field.…”
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Network Diffusion Framework to Simulate Spreading Processes in Complex Networks by Michał Czuba, Mateusz Nurek, Damian Serwata, Yu-Xuan Qiu, Mingshan Jia, Katarzyna Musial, Radosław Michalski, Piotr Bródka

“…For instance, by utilising these advancements, one can model structures such as social networks in a much more refined manner, which is particularly relevant in simulations of the spreading processes. …”
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The impact of digital transformational leadership on digital intensity among primary healthcare entities: a moderated mediation model by Magdalena Kludacz-Alessandri, Liliana Hawrysz, Katarzyna Żak, Wei Zhang

“…Abstract Background Uncertain times require healthcare entities to demonstrate strong leadership, develop digitalisation, and respond to change in a creative and flexible manner. Based on emerging new institutional theory, we developed and tested a model of how digital transformational leadership (DTL) affects digital intensity (DI) among healthcare entities through the mediating role of organisational agility (OA). …”
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A Role of Fluoride on Free Radical Generation and Oxidative Stress in BV-2 Microglia Cells by Xi Shuhua, Liu Ziyou, Yan Ling, Wang Fei, Guifan Sun

“…Activities of NOS in cells and medium significantly increased with fluoride concentrations in a dose-dependent manner. NT concentrations also increased significantly in 10 and 50 mg/L NaF-treated cells compared with the control cells. …”
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Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…EIF3J-AS1 may function in an estrogen-independent manner and could be inhibited by the compound FDI-6. …”
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Hierarchical Spatial Clustering in Multihop Wireless Sensor Networks by Zhidan Liu, Wei Xing, Yongchao Wang, Dongming Lu

“…The resource-limited sensor nodes usually transmit the sensing readings to Sink node collaboratively in a multihop manner to conserve energy. In this paper, we consider the problem of spatial clustering for approximate data collection that is feasible and energy-efficient for environment monitoring applications. …”
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Ultra-Low Temperature Coefficient of Capacitance (Tcc) of the SrSnO3-Based Electrical Components by Abdul-Majeed Azad, Toh Yen Pang, Mohammad A. Alim

“…These ac electrical data were found to exhibit relaxation in more than one complex plane formalisms in a simultaneous manner. The magnitude of the terminal capacitance was found to be in a narrow window of 3 pF to 6 pF possessing very weak temperature dependence. …”
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The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment by Tian Lan, Fengwei Gao, Yunshi Cai, Yinghao Lv, Jiang Zhu, Hu Liu, Sinan Xie, Haifeng Wan, Haorong He, Kunlin Xie, Chang Liu, Hong Wu

“…Mechanistically, circPETH-147aa, encoded by circPETH in an m6A-driven manner, promotes PKM2-catalyzed ALDOA-S36 phosphorylation via the MEG pocket. …”
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Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats by V. Gayathri, S. Ananthi, Hannah R. Vasanthi

“…ENO pretreatment showed a significant ameliorative action on elevated lipids and lipoproteins in a dose-dependent manner when compared to standard. Altogether, the results prove that Nerium oleander flowers are not toxic at the tested doses and exhibit antilipimic activity.…”
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A lack of meaningful human control for automated vehicles: pressing issues for deployment and regulation by Simeon C. Calvert, Arkady Zgonnikov

“…Workshop participants agreed that meaningful human control has an essential role to play to address the identified issues by ensuring that humans can adequately interact with ADS and that ADS are designed in a manner that ensures safe and responsible deployment with clear fail-safes and redundancy mechanisms. …”
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Landscape risk analysis of the 2003 Barkal-Rangamati (5.7 Mw) earthquake in Bangladesh using geospatial techniques and people’s perceptions by Biswajit Nath, Tania Sultana Shifa, Sumon Miah, Bo Zhong, Junjun Wu, Aixia Yang, Shukla Acharjee, Ramesh P. Singh

“…Our detailed results will ultimately help the planners to assess better the changing state of 2003 Barkal-Rangamati earthquake-prone areas in a sustainable manner.…”
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Airspace closures due to reentering space objects by Ewan Wright, Aaron Boley, Michael Byers

“…However, over 2300 rocket bodies are already in orbit and will eventually reenter in an uncontrolled manner. Airspace authorities will face the challenge of uncontrolled reentries for decades to come.…”
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TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells by Wenyi Gu, Jiezhong Chen, Lei Yang, Kong-Nan Zhao

“…We observed that both interleukin-4 and interferon-γ increased CD40 expression in these hematological cells in a dose-dependent manner, although the concentration required for interleukin-4 was significantly higher than that for interferon-γ. …”
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Philosophical biography : some problems of conceptualization by Irina Polyakova

“…It shows that philosophical biography has a variety of features, which limit the applications of chronology, rubrication and other principles of organizing in a linear manner the material of a biography. In this context such notions as “life-course”, “trajectory”, and “life-course trajectory” are analyzed; and the grounds of the unity of biographical content are revealed.This article claims that the unity of biographical content is determined by the author’s philosophical worldview. …”
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