Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…We found PrP carrying the disease-associated T182A mutation (Mut-PrP) was delivered to lysosomes in a Golgi-independent manner. Time-lapse live cell imaging revealed early formation and uptake of GFP-tagged Mut-PrP aggregates into LysoTracker labeled vesicles. …”
Get full text

Functional segregation and dynamic integration of the corticotectal descending signal in rat by Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira

“…The superior colliculus (SC) receives inputs from various brain regions in a layer- and radial subregion-specific manner, but whether the SC exhibits subregion-specific dynamics remains unclear. …”
Get full text

Changement climatique et ressource en eau en Himalaya by Joëlle Smadja, Olivia Aubriot, Ornella Puschiasis, Thierry Duplan, Juliette Grimaldi, Mickaël Hugonnet, Pauline Buchheit

“…In the Himalayas, where the increase in temperatures is higher than the world average, climate change is expected to impact water resources in a particularly significant manner. Whereas climate specialists using measurements and simulations play down this statement by underlining uncertainties and differences between the west and east of the range, the media and development agencies tend to paint a uniform picture of a water shortage now and in the future. …”
Get full text

Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…EFBL increased DA in a dose-dependent manner, remaining enhanced by 80 % over a period of 24 h and augmented NA by 54 % one hour after treatment. …”
Get full text

Role playing in human evolution: from life to art, and everything in between by Steven Brown

“…However, there are other means of acting in a similar manner to another person in which we do not impersonate them, but merely emulate their behavior. …”
Get full text

Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations by Zhifeng Zhang, Yuan Liu, Xuecong Ren, Hua Zhou, Kaishun Wang, Hao Zhang, Pei Luo

“…AE administration (10, 20, and 40 mg/kg) inhibited I/R-induced injury as indicated by decreasing myocardial infarct size, reducing of CK and LDH activities, and preventing ST-segment depression in dose-dependent manner. AE decreased cardiac tissue levels of proinflammatory factors TNF-α and IL-6 and attenuated leukocytes infiltration. …”
Get full text

m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways by Xi Wu, Shiyang Wang, Yuwei Pan, Mengzhen Li, Manyu Song, Hanfu Zhang, Min Deng, Xu Yang, Jiuzhi Xu, Shuo Zhang, Jinhua Zhang, Fengchao Wang, Maksim V. Plikus, Cong Lv, Lu Yu, Zhengquan Yu

“…Through multiomics analysis, PRRC2A directly targeted CSNK1E (encoding CK1ε), maintaining its RNA stability in an m6A‐dependent manner, and that elevated CK1ε can concomitantly result in activation of the WNT and YAP signaling pathways. …”
Get full text

Integrative model for disclosing the diagnosis to children and adolescents with HIV in San Luis Potosí by Rubén Romero Ortiz, Ismael García Cedillo, Rocío Angélica González-Romo

“…<br /><strong>Conclusions:</strong> The program allows the diagnosis to be disclosed in a comprehensive and safe manner, and improves communication between primary caregivers, patients, and health personnel.…”
Get full text

What if writing rock history was also writing with “ifs”? Or how Lester Bangs liked playing a trick on his reader’s perception of time by Maud Berthomier

“…However, from the beginning of his work, American rock critic Lester Bangs took a radically different look at the manner in which that history should be written. In his opinion, rock history did not necessarily have to be seen as an alternation between long periods of expectation and short heydays. …”
Get full text

Cambios en la producción y consumo de viandas en Cuba by Norma Helen Juárez

“…Using a ethno-ecological perspective, we identify how people classifyand name the different meats, according to their properties, uses and manners of preparation. The case study considers how the changes in the production patterns of Cuban economy in recent decades have impacted the quantities consumed daily of the different products.…”
Get full text

Regulatory, technical, and safety considerations for UAV-based inspection in chemical process plants: A systematic review of current practice and future directions by Sairul Safie, Raudhah Khairil

“…A narrative synthesis approach was used to summarize the findings of the studies in a descriptive manner. The implications of this review are significant, as they provide a comprehensive understanding of the benefits and limitations of using UAVs for inspection in chemical process plants. …”
Get full text

YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

“…Ythdf2 stabilized Cx3cl1 transcripts in an m6A-dependent manner, regulating the interplay between CD8+ T cells and the progression of liver malignancies. …”
Get full text

An RGB-D-Based Cross-Field of View Pose Estimation System for a Free Flight Target in a Wind Tunnel by Sheng Liu, Yuan Feng, Kang Shen, Yangqing Wang, Shengyong Chen

“…Based on all the input multimodal information, a so-called cross-FOV model is proposed to recognize the dominating sensor and accurately extract the foreground region in an automatic manner. Second, we develop an RGB-D-based pose estimation method for a single target, by which the 3D sparse points and the pose of the target can be simultaneously obtained in real time. …”
Get full text

Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use by J. M. J. Van den Bergh, E. L. J. M. Smits, M. Versteven, H. De Reu, Z. N. Berneman, V. F. I. Van Tendeloo, E. Lion

“…In view of the clinical use of DC vaccines, we evidence with a time- and cost-effective manner that clinical grade DC can be safely engineered to transpresent IL-15, hereby gaining the ability to transfer the immune-stimulating IL-15 signal towards antitumor immune effector cells.…”
Get full text

The Relationship between the Language of Interpretation and Mystical Experience in the Thought of Ibn Arabi and D. Suzuki by Alireza Shahmohamadi, Azim Hamzeian, Ghodratollah Khayatian, Jafar Fallahi

“…In this research, we examine the position of language and its functions in Ibn Arabi's mysticism and Zen and show in a descriptive-comparative manner what Ibn Arabi as representing Islamic mysticism and Suzuki as representing Zen have their views on. …”
Get full text

Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants by Tolmacheva Anna A., Rogozhin Eugene A., Deryabin Dmitry G.

“…Many plants stimulated violacein production by wild-type C. violaceum ATCC 31532 in a non-specific manner, and only the herb Bidens tripartita (three-lobe beggarticks) contained compounds that mimic acyl-homoserine lactone and operated as a QS agonist. …”
Get full text

Data Verification of Logical Pk-Anonymization with Big Data Application and Key Generation in Cloud Computing by Sindhe Phani Kumar, R. Anandan

“…The suggested artworks use a cloud-based gradual clustering device to cluster and refresh a large number of informational indexes in a useful manner. Purpose. Anonymization of data is done at the point of collection in order to safeguard the data. …”
Get full text

Phytochemical screening and phytotoxic activity of Pinus ponderosa (Dougl.) Lawson by Mouna Souihi, Marwa Khammassi, Habiba Kouki, Ismail Amri, Mohsen Hanana, Lamia Hamrouni, Yassine Mabrouk

“…The essential oil exhibited a significant inhibitory effect on seed germination and seedling growth in a dose-dependent manner. A low concentration of essential oil reduced the germination and seedling growth of all tested weeds. …”
Get full text

Accelerating charge estimation in molecular dynamics simulations using physics-informed neural networks: corrosion applications by Aditya Venkatraman, Mark A. Wilson, David Montes de Oca Zapiain

“…Lastly, even though developed for corrosion, these protocols are formulated in a phenomenon-agnostic manner, allowing application to various variable-charge interatomic potentials and related fields.…”
Get full text

Agent-Based Modeling of Harvest Decisions by Small Scale Forest Landowners in Maine, USA by Jessica E. Leahy, Erika Gorczyca Reeves, Kathleen P. Bell, Crista L. Straub, Jeremy S. Wilson

“…The multifaceted nature of landowner decisions drives a significant need to better understand decision-making processes, reactions to policy, and combined impacts on ecosystems in a comprehensive manner. Small-scale forests require an integrated approach to modeling the social and biophysical components comprehensively. …”
Get full text