A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal by Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock

“…Localized destruction of the endothelial monolayer was achieved in a consistent manner with a 3.4 mm diameter/concave profile cryoprobe and represents a potentially useful approach to remove dysfunctional corneal endothelial cells from corneas with endothelial dysfunction.…”
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Anthelmintic Activity of Crude Extract and Essential Oil of Tanacetum vulgare (Asteraceae) against Adult Worms of Schistosoma mansoni by Loyana Silva Godinho, Lara Soares Aleixo de Carvalho, Clarissa Campos Barbosa de Castro, Mirna Meana Dias, Priscila de Faria Pinto, Antônio Eduardo Miller Crotti, Pedro Luiz Silva Pinto, Josué de Moraes, Ademar A. Da Silva Filho

“…Quantitative analysis on the schistosomes tegument showed that TV caused changes in the numbers of tubercles of S. mansoni male worms in a dose-dependent manner. The findings suggest that T. vulgare is a potential source of schistosomicidal compounds.…”
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Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

“…Herein, using carotid arterial ligation models, we found that ethanol extract from A. cinnamomea (EEAC) significantly inhibited neointimal hyperplasia in a dose-dependent manner, accompanied with the reduced expression of activated p65 and inflammatory cytokines. …”
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Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes by Mark Wulczynski, Stephen P. J. Brooks, Judy Green, Fernando Matias, Martin Kalmokoff, Julia M. Green-Johnson, Sandra T. Clarke

“…Conclusions These findings indicate that including GS can influence microbiota and immune-related parameters, in a sex dependent manner. This shows that environmental enrichment strategies need to be clearly reported in publications to properly evaluate and compare experimental results, especially with respect to the use of chewable EE in the context of studies examining diet, microbiome and immune parameters.…”
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Detailed Nonlinear Modeling and High-Fidelity Parallel Simulation of MMC With Embedded Energy Storage for Wind Farm Grid Integration by Bingrong Shang, Ning Lin, Venkata Dinavahi

“…Since the sequential data processing manner of the central processing unit (CPU) is prone to an extremely long simulation following an increase of component quantity with even one order of magnitude, the massively concurrent threading of the GPU is exploited. …”
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CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway by Jinchuan Yan, Yunjie Yin, Wei Zhong, Cuiping Wang, Zhongqun Wang

“…Data shows that the CD137 expression can be stimulated by TNF-α in a time-dependent manner in mouse VSMCs. Knockdown of TRAF6 by siTRAF6 significantly attenuated agonist-CD137mAb induced increase of NF-κB p65 and NFATc1 in VSMCs. …”
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Ethical Considerations in Protecting the Marine Environment from the Effects of Oil Pollution and Its Support by International Law by Rafa Zaati Abadee, Reza Nikkhah Saranghi, Siamak Jafarzadeh

“…Material and Methods: This study used reliable sources and international scientific articles in the field of environmental ethics and the support of international laws for the marine environment from oil pollution in a descriptive and review manner. Conclusion: The results of this study showed that it is not possible to define a specific and unified ethical framework for protecting the marine environment. …”
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Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells by A. Mastrofrancesco, M. Alfè, E. Rosato, V. Gargiulo, C. Beatrice, G. Di Blasio, B. Zhang, D. S. Su, M. Picardo, S. Fiorito

“…Euro 5 particle exposure increased the mRNA expression of MMP-2, -7, and -9 in SSc fibroblasts in a dose dependent manner and only at the highest concentration in normal cells. …”
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»Ogni sorte de gradi, & di armonia«. Aspekte des Paradoxen in Jacobus Gallus’ Motette Mirabile mysterium by Markus Roth

“…The interpretative commentary deals with some parallel cases in cinquecento madrigals and concepts of paradoxical rhetoric and mannerism.…”
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Pterostilbene antagonizes homocysteine-induced oxidative stress, apoptosis and lipid deposition in vascular endothelial cells by Qiao Jiang, Li Wang, Xu Si, Yuanyuan Bian, Weijia Zhang, Huijun Cui, Hailong Gui, Ye Zhang, Bin Li, Dehong Tan

“…Pte inhibited Hcy-induced Akt dephosphorylation, increased p53, and decreased the Bcl-2/Bax ratio and caspase-9/caspase-3 activation in a dose-dependent manner. LY294002 pretreatment partially reversed the protective effect of Pte by blocking the PI3K/Akt pathway. …”
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Post-mortem and histological lesions in the European minks (Mustela lutreola) induced by spontaneous infection with coronavirus SARS-CoV-2 by I. A. Subbotina, I. N. Gromov

“…All this together will allow veterinary specialists not only to quickly and timely diagnose the disease in the population of fur animals (European mink), but also to take necessary therapeutic and preventive measures in a timely manner, to select the most effective means for symptomatic and pathogenetic therapy as well as the most rational and effective substances and disinfection procedures.…”
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High-Throughput Sequencing Reveals Diverse Sets of Conserved, Nonconserved, and Species-Specific miRNAs in Jute by Md. Tariqul Islam, Ahlan Sabah Ferdous, Rifat Ara Najnin, Suprovath Kumar Sarker, Haseena Khan

“…A group of plant microRNAs are evolutionarily conserved; however, others are expressed in a species-specific manner. Jute is an agroeconomically important fibre crop; nonetheless, no practical information is available for microRNAs in jute to date. …”
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Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis by Zhihong Hu, Xixi Hou, Yongjing Ren, Ziyuan Wu, Dong Yan, Hong Chen, Lan Wang

“…Moreover, compound c13 significantly inhibited the colony formation ability of Hela cells in a dose-dependent manner, accompanied by morphological changes in HeLa cells. …”
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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1 by Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran

“…Treatment of immortalized human hepatocyte-like cells (imHC) with domperidone could inhibit DENV production and NS1 secretion in a dose-dependent manner following infection with DENV serotype 2. These inhibitory effects were mediated by reduction in viral RNA replication and viral E and NS1 protein expression, but not by interference with virus entry into cells or NS1 oligomerization. …”
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Inhibitory Effect of r-Hirudin Variant III on Streptozotocin-Induced Diabetic Cataracts in Rats by Xiaojian Gong, Qiuyan Zhang, Shuhua Tan

“…As a result, rHV3 drops treatment significantly increased the activities of SOD and GSH-Px in the lens in a dose-dependent manner, whereas AR activity and MDA level in the lens were dramatically decreased. …”
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Characteristics and treatment modes of industrial wastewater in new energy vehicles industrial park by LI Dian, WANG Xun, LIU Yingming

“…Each region needed to conduct water quality and quantity analysis in advance based on the current situation and development plans of the park, and dispose key pollutants in a targeted manner. At the same time, more consideration should be given to investment promotion, enterprise wastewater supervision, and wastewater treatment fees in the park.…”
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Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition by Jonathan W. Nyce

“…The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues. In a manner comparable to animal models of MKD, the reconstitution of protein geranylgeranylation blocked the autoinflammatory reaction caused by systemic G6PD inhibition. …”
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Climate change and water resources in the Himalayas by Joëlle Smadja, Olivia Aubriot, Ornella Puschiasis, Thierry Duplan, Juliette Grimaldi, Mickaël Hugonnet, Pauline Buchheit

“…In the Himalayas, where the increase in temperatures is higher than the world average, climate change is expected to impact water resources in a particularly significant manner. Whereas climate specialists using measurements and simulations play down this statement by underlining uncertainties and differences between the west and east of the range, the media and development agencies tend to paint a uniform picture of a water shortage now and in the future. …”
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Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis. by Carissa Chan, Eduardo A Groisman

“…DnaK-dependent reduction in protein synthesis is critical for survival against Mg2+ starvation because inhibiting protein synthesis in a dnaK-independent manner overcame the 10,000-fold loss in viability resulting from DnaK truncation. …”
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Key Intelligent Pesticide Prescription Spraying Technologies for the Control of Pests, Diseases, and Weeds: A Review by Kaiqiang Ye, Gang Hu, Zijie Tong, Youlin Xu, Jiaqiang Zheng

“…The advancement of these technologies will enhance agricultural productivity in a more efficient, environmentally sustainable manner.…”
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