Efficacy and safety of the metformin-mazindol anorectic combination in rat by Argüelles-Tello Federico, Roa-Coria José Eduardo, Zúñiga-Romero Ángel, Huerta-Cruz Juan Carlos, Quiñonez-Bastidas Geovanna Nalley, Flores-Murrieta Francisco Javier, Rocha-González Héctor Isaac, Reyes-García Juan Gerardo

“…An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. …”
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Domates (Solanum lycopersicum L.)’te Fungisit Stresine Karşı Kitosanın Etkisi by Halil İbrahim Öztürk, Hüseyin Bulut

“…Domates yetiştiriciliğinde verim kayıplarına neden olan önemli faktörlerden birisi mantar hastalıklarıdır. Bu hastalıklarla mücadelede en hızlı ve etkili çözüm olarak fungisitler kullanılmaktadır. …”
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The Problem of Obtaining Evidence from EU Countries While Achieving the “Crime Does Not Pay” Goal by Šalčius Marijus, Molienė Reda

“…In the context of the European Union’s efforts to fight crime in a comprehensive manner and in line with the European Commission’s Communication of 2008, that confiscation and recovery of proceeds are a powerful means for fighting organized crime effectively and its commitment to support the development of confiscation-related legislative and non-legislative measures1, alternative legal instruments to achieve the “crime does not pay” objective are also being developed, where obtaining evidence from other Member States is also a key issue. …”
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Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves by Onoja Samuel O., Nnadi Charles O., Udem Samuel C., Anaga Aruh O.

“…It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg−1 bm. …”
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Developing a Clustering-Based Empirical Bayes Analysis Method for Hotspot Identification by Yajie Zou, Xinzhi Zhong, John Ash, Ziqiang Zeng, Yinhai Wang, Yanxi Hao, Yichuan Peng

“…As crash data often contain underlying heterogeneity that, in essence, can make them appear to be generated from distinct subpopulations, methods are needed to select similar sites in a principled manner. To overcome this possible heterogeneity problem, EB-based HSID methods that use common clustering methodologies (e.g., mixture models, K-means, and hierarchical clustering) to select “similar” sites for building SPFs are developed. …”
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The Influence of Mg2+ Ions on the In Vitro Efficacy of Chitosan-Titanium Dioxide Nanotubes (CTNTs) Scaffolds by Siew Shee Lim, Shui Wei Kho, Nehemiah Li Heng Ang, Cheng Heng Pang, Hwei-San Loh

“…Fluorescence-based staining, cell viability, and alkaline phosphatase assays indicated that the adsorbed Mg2+ ions onto CTNTs scaffolds aided in promoting higher proliferation and early differentiation of MG63 cells than scaffolds without Mg2+ ions in a concentration-dependent manner. Based on current results, CTNTs scaffolds with Mg2+ ions may be a potential biomaterial for bone regeneration.…”
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Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci) by Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón

“…The enzyme reduced H2O2 in a NADPH-dependent manner, although with low catalytic efficiency. In the presence of thioredoxin, mitochondrial TGR showed a thioredoxin peroxidase-like activity. …”
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Exploration of Resident Satisfaction and Willingness in the Renovation of a Typical Old Neighborhood by Wenjun Peng, Yanyan Huang, Changquan Li, Yilin Wang

“…Residents over 61 years old or those who held real estate certificates had a strong willingness to renovate and tended to accept a unified management manner after the renovation of the old neighborhood. …”
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Parasitic contamination of soil and vegetable crops irrigated with raw wastewater: A case study from Al-Far’a, Palestine by Sameer Qorom, Taleb. M Abu-Sharar, Randa N Albdaiwi

“…Farmers' awareness of the manner of parasite transmission and adherence to safety regulations should be among them.…”
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Design and Application of Water Conservancy Model Management Service Platform by TIAN Maochun, ZOU Xianyong, YANG Yue, HE Qilian

“…The current water conservancy model cannot realize unified access and use,and the computing efficiency of multiple users,models,and schemes is low.In addition,the ability of sharing applications deeply bound with the system is weak.Therefore,the model fails to meet the requirements of intelligent water conservancy and digital twin watershed construction.In view of this,this paper designs a water conservancy model management service platform and applies it to practice.First,different types of water conservancy models are integrated,and their service interfaces are standardized,so as to uniformly receive model calculation service parameters and data in different formats and then convert them into required formats through platform adaptation,which avoids the problem of difficult unified invocation caused by differences in the interfaces of each model.Second,model computing resources are deployed and managed in a unified manner,and model calculation requests are distributed to different servers for calculation through task scheduling,so as to improve the resource utilization rate and reduce calculation time.Finally,a water conservancy model management service platform is developed,which integrates model management,model service,and model assembly functions,so as to provide the application system with model computing service.The application of multiple projects shows that the platform can integrate and share the resources of water conservancy models,give full play to the smart function,and provide support for the construction of intelligent water conservancy and digital twin watersheds.…”
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EU, Eastern Europe and Values Imperialism by S. White

“…Article also points out several cases when the EU intervened directly in the domestic affairs of the Eastern Europe countries in a manner that was not always compatible with the provisions on state sovereignty: a 'European Instrument for Democracy and Human Rights', launched in 2006, interventions ofEU representatives in the work of local courts and organisation of exit polls, which could be used to discredit the official election results and in this way to undermine the position of local governments. …”
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ANALYSIS ON FATIGUE CRACK INITIATION LIFE OF COUPLER KNUCKLE OF RAILWAY HEAVY-HAUL WAGON by TIAN XiaoChen, ZHU Tao, WANG Chao, YIN MinXuan, XU JingTao, XIAO ShouNe, YANG GuangWu, YANG Bing

“…In order to accurately analyze the fatigue crack initiation life of heavy-haul wagon coupler knuckle, an analysis manner of fatigue crack initiation life based on the separated body model is proposed. …”
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Waterloo in Vanity Fair or the Art of not Representing War by Marianne Camus

“…But more often he prefers the indirect or refracted manner (to use the mirror image he liked so much). …”
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SDZ MRL 953, A Novel Synthetic Lipid a Analogue, Induces Tolerance to the Lethal Effects of Endotoxin and Enhances Nonspecific Immunity by Charles Lam, Eberhard Schütze, Emmanuel Quakyi, Ekke Liehl, Peter Stütz

“…The analogue protected mice against a lethal dose of LPS or infections in a time- and dose-dependent manner. Maximum effects were observed in animals pretreated with SDZ MRL 953 on three consecutive days before the LPS challenge or microbial inoculation. …”
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Representation of Fictional Characters with Disabilities in Selected Crime Novels of Oͅládèͅjoͅ Òkédìjí by Oͅlálérè Adéyeͅmí

“…The findings of the study showed that Òkédìjí represents the blind and cognitively impaired persons in a positive manner through his modes of projected characterization. …”
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Optimal Molecular Methods in Detecting p190BCR-ABL Fusion Variants in Hematologic Malignancies: A Case Report and Review of the Literature by Rebecca J. Sonu, Brian A. Jonas, Denis M. Dwyre, Jeffrey P. Gregg, Hooman H. Rashidi

“…Incorporating NGS methods in an algorithmic manner into the standard diagnostic PCR-based approach for BCR-ABL1 will aid in minimizing false negative results.…”
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Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage by Kazumori Arai, Tomohiro Iwasaki, Chinatsu Tsuchiya, Akihiro Sonoda

“…A further comparison of this case with an IMAC with nongastric lineage suggested the following probabilities: (1) ANX A2 likely contributes to STAS in a manner that is dependent on its subcellular localization. (2) Both the subcellular localization of ANX A2 and the detachment site depend on tumor cell characteristics, including the biomarker immunophenotype.…”
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Proliferation and TH1/TH2 Cytokine Production in Human Peripheral Blood Mononuclear Cells after Treatment with Cypermethrin and Mancozeb In Vitro by Rajesh Mandarapu, Rajanna Ajumeera, Vijayalakshmi Venkatesan, Balakrishna Murthy Prakhya

“…Mancozeb induced dose-dependent increases in lymphocyte proliferation, inhibition of production of TNFα and the TH2 cytokines IL-6 and IL-10, and an increase in IFNγ (TH1 cytokine) production (at least 2-fold compared to control); mancozeb also induced inhibition of IL-4 (TH2) and stimulated IL-2 (TH1) production, albeit only in dose-related manners for each. In contrast, cypermethrin exposure did not cause significant effects on proliferation or cytokine profiles. …”
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Magnetic Flux Emergence and Solar Eruptions in Partially Ionized Plasmas by Georgios Chouliaras, V. Archontis

“…In both cases, new flux ropes (FR) are formed due to reconnection between emerging field lines, and they eventually erupt in an ejective manner toward the outer solar atmosphere. We are witnessing three major eruptions in both simulations. …”
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Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells by Jean Paul Dzoyem, Shashank Reddy Pinnapireddy, Hugues Fouotsa, Jana Brüßler, Frank Runkel, Udo Bakowsky

“…Compared to the untreated control, guttiferone E-loaded liposomes significantly reduced the nitric oxide production and the activity of COX in a concentration-dependent manner. Conclusion. This study indicates that liposomes can be an alternative to overcome the water insolubility issue of the bioactive guttiferone E.…”
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