Xanthoxyletin blocks the RANK/RANKL signaling pathway to suppress the growth of human pancreatic cancer cells by Zhang Xin, Li Luming, Wu Yan

“…The administration of pancreatic cancer cells with xanthoxyletin diminished the viability of Capan-2 cells in a concentration-dependent manner and led to a significant decline in RANK, RANKL, and OPG expression. …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…From our results we found CGA7 treatment induces cell death in a dose and time dependent manner in different cancer cell lines. Further, CGA7 induced apoptosis was characterized by DNA fragmentation, PARP-1 cleavage, caspase-9 activation, and down regulation of Bcl-2, an anti-apoptotic protein and up regulation of pro-apoptotic protein BAX. …”
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Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth by Chu-Wen Li, Xiao-Li Wu, Xiao-Ning Zhao, Zu-Qing Su, Hai-Ming Chen, Xiu-Fen Wang, Xiao-Jun Zhang, Hui-Fang Zeng, Jian-Nan Chen, Yu-Cui Li, Zi-Ren Su

“…Results indicated that oral administration of ERP (120, 240, and 480 mg/kg) significantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, inhibited carrageenan-induced neutrophils recruitment, and reduced carrageenan-induced paw edema, in a dose-dependent manner. Histopathologically, ERP (480 mg/kg) abated inflammatory response of the edema paw. …”
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“Pretty as a peach” by Nicola Jones, Sandra Pitcher

“…This paper uses the example of the Sunday Times and City Press newspapers’ coverage of Oscar Pistorius’ arrest and bail application in February 2013 to demonstrate how two of South Africa’s most widely read traditional Sunday newspapers represented Pistorius in the same manner as You magazine, South Africa’s most widely read English tabloid style magazine. …”
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Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting by Dimitri Perivoliotis, Dimitri Perivoliotis, Kayla Knopp, Kayla Knopp, Shannon Remick, Allie Kaigle, Allie Kaigle, Christopher S. Stauffer, Christopher S. Stauffer, Chandra Khalifian, Chandra Khalifian, Tamara R. Wachsman, Bettye E. Chargin, Andrew W. Bismark, Andrew W. Bismark, Al Alam, Al Alam, Leslie Morland, Leslie Morland, Leslie Morland

“…Mostly derived from our experience conducting clinical trials of MDMA-AT for PTSD in VHA, we present specific and practical suggestions for optimizing set and setting from both the participant’s and clinician’s perspective in a manner that both leverages the opportunities of such settings and adapts to their challenges. …”
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Refleksi sosial dalam antologi cerpen Kita Susah Tidur sejak Dilahirkan karya Aksan Taqwin Embe by Nurkalina Pratiwi Suganda, Tedi Permadi, Yostiani Noor Asmi Harini

“…Twelve stories are delivered in a light and simple manner, and the topics discussed in each story reflect the circumstances that occur in the real world. …”
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L’insécurité foncière dans et autour des Aires Protégées de Madagascar : un obstacle à surmonter pour la conservation de la biodiversité et le développement rural by Sigrid Aubert, Saholy Rambintsaotra, Jules Razafiarijaona

“…Recognition of and/or the granting of real rights to the local populations, in a manner registered by forest management, appears to be a means of encouraging subsequent territorial and social accountability; one of the conditions associated with the maintenance of ecosystem services.…”
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Wear Prediction and Visual Decision Support of Drop Forged Rivetless Chain for Conveyors by Liu Manxian, Xu Zijia, Shen Xujia, Li Xiaodong, Zhang Zhijun, Yang Yi

“…The wear condition can be presented in a three-dimensional and dynamic manner to quickly and accurately locate the wear chain by a visual simulation method. …”
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A Rational Model for Agroecology as a Science by Luis Fernando Gómez-Echeverri, Leonardo Alberto Ríos-Osorio, María Luisa Eschenhagen-Durán

“…However, any of them can explain its change or difference with its rival theories in a rational manner that allows assessment of its success. As a result, the aim of this study was to propose a rational model of scientific change based on main and auxiliary hypotheses. …”
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YgaE Regulates Out Membrane Proteins in Salmonella enterica Serovar Typhi under Hyperosmotic Stress by Min Wang, Ping Feng, Xun Chen, Haifang Zhang, Bin Ni, Xiaofang Xie, Hong Du

“…Altogether, our results implied that YgaE regulates out membrane proteins in a time-dependent manner under hyperosmotic stress in S. Typhi.…”
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Delay/Disruption Tolerant Networking Performance Characterization in Cislunar Relay Communication Architecture by Ding Wang, Ethan Wang, Ruhai Wang

“…We present a performance characterization of the concatenations of different CLAs and the associated data transport protocols in an experimental manner. The performance of different concatenations is compared over a typical primary and secondary cislunar relay architecture. …”
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Microbial Biomass as a Bioresource of Functional Food Ingredients: A Review by Elena M. Serba, Tatyana V. Yuraskina, Liubov V. Rimareva, Polina Yu. Tadzibova, Elena N. Sokolova, Galina S. Volkova

“…Most studies concentrated on the chitin-glucan-mannan complex of cell walls and protoplasmic biovaluable protein. …”
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Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway by Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong Ma

“…These effects on apoptosis and insulin were reversed by FLZ in a dose-dependent manner. FLZ treatment also increased forkhead box O1 protein phosphorylation and reduced its nuclear location. …”
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Mesenchymal Stem Cells in Oriented PLGA/ACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model by Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo

“…In vitro, we found that the scaffolds not only guided seeded cells to proliferate in an aligned manner but also exhibited high biomechanical strength. …”
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Risk Analysis and Control Measures for Slurry Shield Tunneling Diagonally under an Urban River Embankment by Yu Liang, Xiangyu Chen, Junsheng Yang, Linchong Huang

“…Furthermore, based on settlement monitoring data, the driving velocity of the shield should be reasonably adjusted in a timely manner to avoid disturbing the fine sand stratum below the embankment.…”
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Connectivity, Information Jumps, and Market Stability: An Agent-Based Approach by Khaldoun Khashanah, Talal Alsulaiman

“…The results show that the simulated market is driven to instability in a similar manner to patterns observed in a crisis where all agents become homogeneous in information awareness of events. …”
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What makes the difference? Social media platforms and party characteristics as contextual factors for political parties’ use of populist political communication by Magin Melanie, Larsson Anders Olof, Skogerbø Eli, Tønnesen Hedvig

“…Which parties used populist communication the most depended on the platform, and it was not always the populist Progress Party [Fremskrittspartiet] that communicated in the most populist manner. Parties located towards the fringes of the political party spectrum used more populist communication. …”
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Igf2/H19 Imprinting Control Region (ICR): An Insulator or a Position-Dependent Silencer? by Subhasis Banerjee, Alan Smallwood, Scott Lamond, Stuart Campbell, Geeta Nargund

“…The imprinting control region (ICR) located far upstream of the H19 gene, in conjunction with enhancers, modulates the transcription of Igf2 and H19 genes in an allele-specific manner. On paternal inheritance, the methylated ICR silences the H19 gene and indirectly facilitates transcription from the distant Igf2 promoter, whereas on the maternal chromosome the unmethylated ICR, together with enhancers, activates transcription of the H19 gene and thereby contributes to the repression of Igf2. …”
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Coordination Reactions and Noncovalent Interactions of Polyamines with Nucleotides in Binary Systems and with Nucleotides and Copper(II) Ion in Ternary Systems by Lechoslaw Lomozik, Anna Gasowska, Grzegorz Krzysko, Romualda Bregier-Jarzebowska

“…The mode of coordination in the complex is realised mainly through the phosphate groups of the nucleotide with involvement of the endocyclic nitrogen atoms in a manner which depends upon the steric conditions and in particular on the number of the methylene groups in the polyamine molecule.…”
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A Unified Elastoplastic Model of Unsaturated Soils Considering Capillary Hysteresis by Tiantian Ma, Changfu Wei, Pan Chen, Huihui Tian, De'an Sun

“…The new model has a hierarchical structure, and, depending upon application, it can describe the stress-strain relation and the soil-water characteristics in a coupled or uncoupled manner.…”
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