Function of nodal cilia in left-right determination: Mechanical regulation in initiation of symmetry breaking by Takanobu A. Katoh

“…Immotile cilia at the periphery of the node mechanically sense the direction of leftward nodal flow in a manner dependent on the polarized localization of Pkd2, which is localized on the dorsal side of cilia. …”
Get full text

In vitro triazophos suppresses innate and cell-mediated immune responses of lymphoid organs in snakehead fish, Channa punctatus by Rakesh Kumar Chandra, Ajay Kumar Bhardwaj, Neha Gupta, Devendra Kumar Patel, Manish Kumar Tripathi

“…Additionally, triazophos suppressed the phagocytosis by lymphoid organ cells in a dose-dependent manner. Residual pesticides present in aquatic bodies pose a critical problem and understanding their role in modulating the physiological responses of aquatic organisms is essential. …”
Get full text

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity by Shayla R. Mosley, Angie Chen, David N.W. Doell, Siwon Choi, Courtney Mowat, Felix Meier-Stephenson, Vanessa Meier-Stephenson, Kristi Baker

“…Sequencing indicates that MSI cyDNA is enriched in microsatellites, which, upon DC uptake, induce anti-tumor immunity in a manner consistent with clinical MSI CRCs. DNA-damaging therapies also modulate cyDNA stimulation capacity, with radiation inducing larger cyDNA sizes and increased mitochondrial DNA content. …”
Get full text

Identification of nine mammal monosaccharides by solid-state nanopores by Yunze Sun, Zhuang Mi, Xiaoyu Chen, Jian-Jun Li, Jun Lu, Xinyan Shan, Xinghua Lu, Yuguang Du

“…Inspired by this, it is potential to sequence glycans in the similar manner. Herein, SiNx nanopores were used to identify nine common monosaccharides in mammals. …”
Get full text

Economic and Sensitivity Analyses of Controllable Queues With Customer Feedback and Impatience Using Markovian Modeling by Shreekant Varshney, Mankumar Acharya, Zala Jenishkumar Kanjibhai, Mukesh Pushkarna, Walid El-Shafai, Ievgen Zaitsev

“…In comparison to conventional models, this approach combines customer impatience, feedback procedure, and working vacation into the statistical modeling of queues in a novel manner. These aspects contain enormous potential for practical applications but require additional evaluation from an operational or customer service perspective through dynamic investigation. …”
Get full text

Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response by Xuan Le, Gérrard Eddy Jai Poinern, Nurshahidah Ali, Cassandra M. Berry, Derek Fawcett

“…It is believed that by engineering a well-defined nanometre scale surface topography, it should be possible to induce appropriate surface signals that can be used to manipulate cell function in a similar manner to the extracellular matrix. Therefore, there is a need to investigate, understand, and ultimately have the ability to produce tailor-made nanometre scale surface topographies with suitable surface chemistry to promote favourable biological interactions similar to those of the extracellular matrix. …”
Get full text

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders by I. De Toma, L. Manubens Gil, S. Ossowski, M. Dierssen

“…Epigenetic treatments act in a context specific manner, targeting different regions based on cell and state specific chromatin accessibility, facilitating the establishment of the lost balance. …”
Get full text

Gust Mitigation of Micro Air Vehicles Using Passive Articulated Wings by Adetunji Oduyela, Nathan Slegers

“…Birds and insects naturally use passive flexing of their wings to augment their stability in uncertain aerodynamic environments. In a similar manner, micro air vehicle designers have been investigating using wing articulation to take advantage of this phenomenon. …”
Get full text

Application of marketing tools in establishing loyalty in customers of PEKAO S.A. BANK 1st Branch in Rzeszów by Wiesław Szopiński

“…The conducted empirical studies allowed to identify marketing tools and manner of its use which would determine a proper condition of services at the Bank, in comparison to the competition. …”
Get full text

The survival of B cells is compromised in kidney disease by Doureradjou Peroumal, Chetan V. Jawale, Wonseok Choi, Hossein Rahimi, Danielle Antos, De-dong Li, Shuxia Wang, Godhev K. Manakkat Vijay, Isha Mehta, Raymond West, Muthusamy Thangaraju, Thomas D. Nolin, Jishnu Das, John F. Alcorn, Partha S. Biswas

“…Uremic toxin hippuric acid drives loss of mitochondrial membrane potential, leading to increased apoptosis of GC B cells in a G-protein–coupled receptor 109A dependent manner. Finally, GC B cells and antibody titer are diminished in mice with kidney disease following influenza virus infection, a major cause of mortality in individuals with renal disorders. …”
Get full text

Compressive Fracture of Brittle Geomaterial: Fractal Features of Compression-Induced Fracture Surfaces and Failure Mechanism by L. Ren, L. Z. Xie, C. B. Li, J. Wang

“…No remarkable differences between the fractal dimensions of the compression-induced and tension-induced fracture surfaces may indicate that compressive fracture may occur, at least on the investigative scale of this work, in a similar manner to tension fracture.…”
Get full text

The Local, The Global, or Somewhere in Between? by Peter J. Verdin

“…Aspects of such imaginaries are observable through the various forms of expressive culture that festivals celebrate and the manner that such content is (re)presented, promoted, and consumed at such events. …”
Get full text

PRELIMINARY STUDY ON DRIED GREEN BOTTLE FLY LUCILIA CAESAR “RESOURCE SAVING/DIVERSIFICATION” by Людмила Анатольевна Надточий, Кифлом Негаси Тсиге, Мохамед Саид Булькран, Алёна Владиславовна Проскура, Мариам Башировна Мурадова

“…Based on the proximate analyses, the crude protein content of ground green bottle fly larvae paste had significantly increased from 45.20 to 64.95 % after defatting. In similar manner, the ash and moisture content of the samples also increased to 7.10 and 4.95 % respectively. …”
Get full text

The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells by Sera Oh, Eun Sook Hwang

“…T-Bet simultaneously modulates IL-2 and Th2 cytokines in an IFN-γ-independent manner, resulting in an attenuation of Th2 cell development. …”
Get full text

Structure Characterization and Antioxidant Activity of a Novel Polysaccharide from <i>Bacillus natto</i> Fermented Millet Bran by Hanzhuo Zhang, Xia Fan, Wenjie Zhao, Fanqiang Meng, Fengxia Lu, Zhaoxin Lu, Haizhen Zhao

“…In addition, the antioxidant assays indicated that FMBP-1 possessed certain capacities for scavenging free radicals and reducing power, and this was in a concentration-dependent manner. This research will provide fundamental data regarding the structure–activity relationship of millet bran polysaccharides and provide a theoretical foundation for the high-value utilization of millet bran within the food and pharmaceutical industries.…”
Get full text

Expert advice from ResearchMatch volunteers: Recruitment Innovation Center use cases and innovation by Maeve Tischbein, Sarah K. Cook, Cathy Shyr, Katelyn Benhoff, Amna Baig, Kaysi Quarles, Leslie R. Boone, Loretta M. Byrne, Mariela Rodriguez, Terri Edwards, Consuelo H. Wilkins, Paul A. Harris

“…For this to occur, streamlined mechanisms are needed to connect the populations potentially impacted by a given study or health topic with research teams in order to inform trial design in a meaningful and timely manner. To address this need, we developed an innovative mechanism called the “ResearchMatch Expert Advice Tool” that quickly obtains volunteer perspectives from populations with specific health conditions or lived experiences using the national recruitment registry, ResearchMatch. …”
Get full text

Deception defense method against intelligent penetration attack by Jinyin CHEN, Shulong HU, Changyou XING, Guomin ZHANG

“…The intelligent penetration attack based on reinforcement learning aims to model the penetration process as a Markov decision process, and train the attacker to optimize the penetration path in a trial-and-error manner, so as to achieve strong attack performance.In order to prevent intelligent penetration attacks from being maliciously exploited, a deception defense method for intelligent penetration attack based on reinforcement learning was proposed.Firstly, obtaining the necessary information for the attacker to construct the penetration model, which included state, action and reward.Secondly, conducting deception defense against the attacker through inverting the state dimension, disrupting the action generation, and flipping the reward value sign, respectively, which corresponded to the early, middle and final stages of the penetration attack.At last, the three-stage defense comparison experiments were carried out in the same network environment.The results show that the proposed method can effectively reduce the success rate of intelligent penetration attacks based on reinforcement learning.Besides, the deception method that disrupts the action generation of the attacker can reduce the penetration attack success rate to 0 when the interference ratio is 20%.…”
Get full text

Orthodontic retainers: are they all the same? by Telma Martins de ARAUJO, Paula Paes FERREIRA, Izabelle Alice Pinheiro Barros LISBOA, Carlos Jorge VOGEL, Carolina Ribeiro STARLING

“…The retention protocol must be performed in an individualized and planned manner, taking the initial dental positions as a reference. …”
Get full text

A Multi-granularity Decomposition Mechanism of Complex Tasks Based on Density Peaks by Ziling Pang, Guoyin Wang, Jie Yang

“…There are many algorithms for solving complex problems in supervised manner. However, unsupervised tasks are more common in real scenarios. …”
Get full text

Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective by V. Lahera, V. Cachofeiro, G. Balfagon, J.L. Rodicio

“…Many studies showed local extra-adrenal production of aldosterone in brain blood vessel, and the heart, which contribute in an important manner to the pathological actions of this mineralocorticoid.Several studies such as RALES, EPHESUS, 4E and others, recently showed that mineralocorticoid-receptor (MR) antagonists, alone or in combination with ACE inhibitors or ARBs, reduced the risk of progressive target organ damage and hospitalization in patients with hypertension and heart failure. …”
Get full text