Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…Despite the success of these drugs, a substantial proportion of patients do not benefit. Targeting multiple inhibitory pathways simultaneously to augment anti-tumor immunity has proven to be a promising approach. …”
Get full text

Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction by Joselle Cook, Steven Song, Anthony Ventimiglia, Carol Luhrs

“…This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. Through incidental discovery during a delayed hemolytic transfusion reaction workup, EMPs were found in the liver, spleen, and possibly the lung. …”
Get full text

Missense variants at the p.Arg225 residue in ARHGEF40 identified in individuals with multiple congenital anomalies and developmental delay by Melanie P. Napier, Erin Ryan, Adi Reich, Joshua A. Suhl, Diane Masser-Frye, Marilyn Jones, Celese Beaudreau, Nathaniel Robin, Dana Goodloe, Leandra Folk, Michelle M. Morrow, Deanna Alexis Carere

Get full text

Sample Size Calculation for Controlling False Discovery Proportion by Shulian Shang, Qianhe Zhou, Mengling Liu, Yongzhao Shao

“…The false discovery proportion (FDP), the proportion of incorrect rejections among all rejections, is a direct measure of abundance of false positive findings in multiple testing. …”
Get full text

Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

Get full text

An Application of Subgroup Discovery Algorithm on the Case of Decentralization and Quality of Governance in EU by Lan Umek

“…The degree of decentralization is measured from a fiscal and political point of view, and the quality of governance by multiple indicators and citizen opinions. The paper presents a subgroup discovery algorithm which is capable of analysing two sets of several variables, and uses it for the analysis of EU countries. …”
Get full text

MATRIX: a platform for cultivation profiling and bioactive discovery in natural product research by Zeinab G. Khalil, Thulasi Sritharan, Angela A. Salim, Robert J. Capon

“…The 24-well format supports the simultaneous study of multiple microbial strains and conditions, allowing the discovery of novel bioactive compounds. …”
Get full text

Improving students' critical thinking ability through the inquiry learning model and discovery learning by Rizka Andhika Putra, Tati Cimari

“…The instrument in the research was multiple choice complex questions that measured students' critical thinking skills. …”
Get full text

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. …”
Get full text

Discovery and Detailed Study of the M31 Classical Nova AT 2023tkw: Evidence for Internal Shocks by Judhajeet Basu, Ravi Kumar, G.C. Anupama, Sudhanshu Barway, Peter H. Hauschildt, Shatakshi Chamoli, Vishwajeet Swain, Varun Bhalero, Viraj Karambelkar, Mansi Kasliwal, Kaustav K. Das, Igor Andreoni, Avinash Singh, Rishabh Singh Teja

Get full text

An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers of Pheretima by Ye Shang, Suyi Liu, Chunxiao Liang, Kunze Du, Shujing Chen, Jin Li, Hua Jin, Yanxu Chang

“…The fingerprint and network pharmacology-based strategy was proved to be a powerful strategy for the discovery of efficiency related Q-markers of Pheretima.…”
Get full text

A Comprehensive Machine Learning Approach for COVID-19 Target Discovery in the Small-Molecule Metabolome by Md. Shaheenur Islam Sumon, Md Sakib Abrar Hossain, Haya Al-Sulaiti, Hadi M. Yassine, Muhammad E. H. Chowdhury

Get full text

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

Get full text

Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery by Wanli Ma, Xinyi Liu, Ran Yu, Jiannan Song, Lina Hou, Ying Guo, Hongwei Wu, Dandan Feng, Qi Zhou, Haibo Li

Get full text

Accelerating the design and discovery of tribocorrosion-resistant metals by interfacing multiphysics modeling with machine learning and genetic algorithms by Yucong Gu, Kaiwen Wang, Zhengyu Zhang, Yi Yao, Ziming Xin, Wenjun Cai, Lin Li

Get full text

Miniaturization and characterization of patient derived hepatocellular carcinoma tumor organoid cultures for cancer drug discovery applications by David A. Close, Paul A. Johnston

“…Complimenting cell viability readouts with multiple HCI parameters including morphological features and dead cell staining improved the analysis of drug impact and enhanced the value that could be extracted from these more physiologically relevant three-dimensional HCC organoid cultures.…”
Get full text

Coordinate Descent-Based Sparse Nonnegative Matrix Factorization for Robust Cancer-Class Discovery and Microarray Data Analysis by Melisew Tefera Belachew

Get full text

Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

Get full text

Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. …”
Get full text

Multiple Sclerosis and Obesity: Possible Roles of Adipokines by José de Jesús Guerrero-García, Lucrecia Carrera-Quintanar, Rocío Ivette López-Roa, Ana Laura Márquez-Aguirre, Argelia Esperanza Rojas-Mayorquín, Daniel Ortuño-Sahagún

“…Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. …”
Get full text