Ginseng exhibits adaptogenic-like activity in mice exposed to hypoxic-anoxic stress through activation of antioxidant/BDNF protective mechanisms and inhibition of pro-inflammatory... by James Olukayode Oni, Divine Oluwaferanmi Oyenekan, Yetunde Olamide Olayemi, Osarugue Christabel Irabor, Precious Ogbuji, McCarthy Oritseweyinmi Tova, Paul Ademola Adeleke, Gbemisayo Adetomiwa Abbas, Solomon Umukoro

“…The neurobehavioral changes (motor functions, memory, anxiety, catalepsy, depression, and muscle strength) were evaluated afterwards. …”
Get full text

Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…If possible, we will also compare interventions from the different categories (eg. cardiovascular, resistance, motor-coordinative, multicomponent or mind-body exercise) as a network analysis and report the influence of moderator variables. …”
Get full text

Effect of maturity status on lower-limb strength testing reliability in academy football players from an elite professional club by Maxime Violin, Abd-elbasset Abaïdia, Guillaume Rave, Sébastien Ratel

“…In this sense, it is possible to suggest that pre-pubertal players exhibit lower scores of test-retest reliability during poly-articular movements than their older counterparts because of their poorer motor coordination due to immaturity of cerebellum. …”
Get full text

Yishenyangsui granule for degenerative cervical myelopathy: a randomized, double-blind, placebo-controlled trial with long-term follow-up by He Yin, Xin Chen, Zhiwei Liu, Zhiwei Liu, Bo Xu, Zhefeng Jin, Yan Liu, Baoyu Qi, Bin Tang, Ping Wang, Fanping Xu, Xu Wei, Jie Yu, Liguo Zhu, Liguo Zhu

“…Furthermore, improvements in motor function of upper/lower extremities, sensory function of upper extremities, reading ability, and recreation domain scores were also significantly superior in the Yishenyangsui granule group compared to the placebo group (P < 0.05). …”
Get full text

Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson’s disease: study protocol for a randomised contro... by Hang Su, Xiaoyu Jiang, Limin Wang, Linlin Zhang, Qing Wang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Xinjie Qu, Haihao Cao, Wenyu Sun, Guoming Chen, Huifen Liu, Jiahui Jiang, Hongyan Bi

“…Phyphox APP, CRST, CPET, UPDRS(II, III) were used to evaluate tremor, aerobic capacity, and motor function in groups.Discussion We are investigating the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD. …”
Get full text

Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients by Sisi Zheng, Mingkang Song, Nan Song, Hong Zhu, Xue Li, Dongqing Yin, Shanshan Liu, Yan Zhao, Meng Fang, Yanzhe Ning, Hongxiao Jia

“…Notably, a significant negative correlation was observed between the 'Self' factor of the CDS and the FC within the somatosensory-motor network. Conclusion Overall, disrupted FC of large-scale brain networks may contribute to understanding neurobiological underpinnings in DPRD. …”
Get full text

Estudio psicométrico del cuestionario de intenciones emprendedoras en jóvenes mexicanos - Psychometric study of the entrepreneurial intentions questionnaire in Mexican youth by Ignacio Norambuena, Felipe Quintano, Leonor Riquelme, José Sepúlveda, Cristina Tavera, Selene Pérez, Crisóforo Álvarez, Roque López

“…Introducción/objetivo: el emprendimiento se ha consolidado como un motor clave para el crecimiento personal y el desarrollo económico en distintos ámbitos. …”
Get full text

A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome by Sujie Xiong, Guangyao Hu, Yao Zhou, Fei Sun, Yanlin Ma

“…Cytoplasmic dyneins transport cargo towards the minus end of microtubules and are thus termed the “retrograde” cellular motor. Mutations in DYNC2H1 are the main causative mutations of short rib-thoracic dysplasia syndrome type III with or without polydactyly (SRTD3). …”
Get full text

NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Progressive degeneration of midbrain dopaminergic neurons (mDANs) and nigrostriatal projections results in severe motor symptoms. While the preferential loss of mDANs has not been fully understood yet, the cell type-specific vulnerability has been linked to a unique intracellular milieu, influenced by dopamine metabolism, high demand for mitochondrial activity, and increased level of oxidative stress (OS). …”
Get full text

Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…In contrast, deleting Nprl2 from inhibitory neurons led to increased motor learning, hyperactive behavior, in addition to social and learning deficits. …”
Get full text

Role of Epidural Electrode Stimulation in Three Patients with Incomplete AIS D Spinal Cord Injury by Yu-Chen Chen, Xiang-Ling Huang, Hung-Yu Cheng, Ciou-Chan Wu, Ming-Yung Wu, Lian-Cing Yan, Shin-Yuan Chen, Sheng-Tzung Tsai, Shinn-Zong Lin

“…One participant achieved a full motor score, whereas the others’ scores increased by 19 and 7 points. …”
Get full text

Early Detection and Intervention of Preschool-Aged Children Using Android-Based Monitoring during the COVID-19 Pandemic in Central Java by Triwiji Lestari, Elisa

“…Alarming statistics from the Indonesian Ministry of Health reveal that 16% of Indonesian toddlers, amounting to 0.4 million children, experience developmental delays, encompassing fine and gross motor skills, hearing impairments, reduced cognitive abilities, and speech delays. …”
Get full text

Traumatic Bladder Ruptures: A Ten-Year Review at a Level 1 Trauma Center by John Barnard, Tyler Overholt, Ali Hajiran, Chad Crigger, Morris Jessop, Jennifer Knight, Chad Morley

“…Mean age was 41 years, mean BMI was 24.8 kg/m2, 95% were Caucasian, and 55% were female. Motor vehicle collision (MVC) was the most common mechanism, representing 45% of total injuries. …”
Get full text

START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Secondary outcomes will focus on motor function, mobility, quality of life, activity level, heart rate, blood pressure, and performance-based measures.DiscussionThe study's strengths include its foundation in previous usability analyses, which informed refinements to the START program. …”
Get full text

Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…Results TTC staining, behavioral experiments, and pathological assessments reveal intranasal delivery of hMSC-L and hMSC-M significantly reduces the infarct volume of mice with cerebral ischemia, improves neurological function scores, and promotes motor function recovery. Higher concentrations of hMSC-M contributed a more pronounced effect on neuropathological improvements in ischemic mice. …”
Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…We present a turnkey iPSC-based model of the NMJ employing channelrhodopsin-2 expression within the motor neuron (MN) population driving muscle contraction in response to blue light. …”
Get full text

Enhancement of Executive Functions but Not Memory by Multidomain Group Cognitive Training in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Multicenter Randomiz... by Elke Kalbe, Ann-Kristin Folkerts, Anja Ophey, Carsten Eggers, Saskia Elben, Karina Dimenshteyn, Patricia Sulzer, Claudia Schulte, Nele Schmidt, Christian Schlenstedt, Daniela Berg, Karsten Witt, Lars Wojtecki, Inga Liepelt-Scarfone

“…Regression analyses revealed cognitive baseline levels, education, levodopa equivalent daily dose, motor scores, and ApoE status as significant predictors for CT success. …”
Get full text

Modelo de aprendizaje para la selección de un proyecto diseño-construcción (llave en mano) en el sector público A learning model for design-build project selection in the public se... by Alfonso Bastias, Keith R Molenaar

“…Este modelo se ajusta a parámetros y funciones a través del empleo de inteligencia artificial, como principal motor de conocimiento. Este enfoque puede ser adaptado a muchas aplicaciones de apoyo a la toma de decisiones en la industria del diseño y construcción.…”
Get full text

Ultrasound investigation at examination of gastro-intestinal tract at combined trauma by A. S. Yermolov, O. A. Alekseyechkina, Ye. S. Vladimirova, G. P. Titova, V. M. Abuchina

“…In the second group at the 3rd day after surgery disorder of motor and evacuatory function of GIT was found. At US control in 11 patients with small intestine mesentery trauma signs of dynamic ileus were revealed, in 4 of them after resection of intestinal segment signs of mesenteric circulation disorder at the early postoperative period were found out. …”
Get full text

CLN6‐related continuum phenotype caused by aberrant splicing by Federica Invernizzi, Barbara Castellotti, Chiara Reale, Celeste Panteghini, Isabel Colangelo, Roberta Solazzi, Francesca Ragona, Lucio Giordano, Jessica Galli, Davide Rossi Sebastiano, Gianluca Marucci, Valeria Cuccarini, Giuseppe Didato, Cinzia Gellera, Barbara Garavaglia, Tiziana Granata, Laura Canafoglia

“…Abstract Neuronal ceroid lipofuscinoses (NCLs) are genetically heterogeneous neurodegenerative disorders, characterized by progressive cognitive and motor decline, epilepsy, visual impairment, and shortened life‐expectancy. …”
Get full text