Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…Stroke patients were older on average (78.94 vs. 77.28 years, p-value<0.0001) with significantly higher risk-adjusted inpatient mortality (7.14% vs. 2.09%, p-value<0.0001), emergency room visits (79.97% vs. 46.34%, p-value<0.0001), and average LOS measures (overall: 10.20 vs. 6.83 days, p<0.0001; cardiovascular-related: 8.35 vs. 5.90 days, p-value<0.0001). …”
Get full text

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Background While major advances have been made in improving the quality of life and survival of children with most forms of medulloblastoma (MB), those with MYC-driven tumors (Grp3-MB) still suffer significant morbidity and mortality. There is an urgent need to explore multimodal therapeutic regimens which are effective and safe for children. …”
Get full text

Outcome and prognostic value of N‐terminal pro‐brain natriuretic peptide and high‐sensitivity C‐reactive protein in mildly dilated cardiomyopathy vs. dilated cardiomyopathy by Jiayu Feng, Pengchao Tian, Lin Liang, Yuyi Chen, Yunhong Wang, Mei Zhai, Yan Huang, Qiong Zhou, Xuemei Zhao, Lang Zhao, Boping Huang, Liyan Huang, Yuhui Zhang, Jian Zhang

“…Compared with DCM, patients with baseline MDCM had lower composite risks of all‐cause mortality, heart transplantation, and heart failure rehospitalization [adjusted hazard ratio (HR) 0.63, 95% confidence interval (CI) 0.43–0.93, P = 0.019]. …”
Get full text

The incidence of incomplete abortion and the prevalence of abortion-related morbidity in South African public hospitals, 2018 by D N Conco, J Levin, B Komane, K Blanchard, T Bessenaar, N G Nkosi, S Fonn

“…Globally, unsafe abortions remain a persistent, yet preventable, cause of maternal mortality. South Africa (SA) is internationally recognised for its progressive reproductive rights framework, supported by its Constitution and laws. …”
Get full text

Socio-Demographic and Lifestyle Factors Influencing Adherence to AntiHypertensive Treatment in a Rural Area of Ludhiana, India by Sangeeta Girdhar, ,Mahesh Satija, Daljit Kaur, .Anurag Chaudhary

“…Improving adherence will not only reduce complications and mortality among patients but also improve their quality of life and reduce financial burden. …”
Get full text

Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…This study used the TMB algorithm from the FDA-approved test supporting solid tumor CDx and composite mortality variable validated against the national death index: real-world overall survival (rwOS). …”
Get full text

Deep Neck Infections: The Effectiveness of Therapeutic Management and Bacteriological Profile by Geanina Bandol, Mihail Dan Cobzeanu, Mihaela Moscalu, Octavian Dragos Palade, Liliana Moisii, Florentina Severin, Emilia Patrascanu, Florin Mocanu, Andrei Ionut Roman, Bogdan Mihail Cobzeanu

“…<i>Conclusions</i>: Deep neck infection has a complex pathology, whose therapeutic management remains a challenge in order to reduce the length of hospitalization and mortality.…”
Get full text

A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis by Ruidong Mo, Zhenglan Zhang, Yanmei Zhou, Yue Wang, Pengbo Yin, Chenxi Zhang, Haoshuang Fu, Cong Qian, Xiaogang Xiang, Rongkun Yin, Qing Xie

“…Conclusion In HBV-ACLF and AD patients, lower serum apoAI levels suggest greater disease severity and 90-day mortality risk. For predicting the short-term prognosis of these patients, the new Lip-ACLF score might serve as a potential model.…”
Get full text

Epidemiology, Risk Factors, and Predictors of Disability in a Cohort of Jordanian Patients with the First Ischemic Stroke by Majdi Al Qawasmeh, Belal Aldabbour, Aiman Momani, Deema Obiedat, Kefah Alhayek, Raid Kofahi, Ahmed Yassin, Khalid El-Salem

“…The mean admission NIHSS score was 7.94, and on discharge was 5.76. In-hospital mortality was 2.81%, while 50% of patients had a favorable outcome on discharge (mRS score between 0-2). …”
Get full text

The impact of COVID-19 pandemic on sleep duration and mental health among middle school students: a 3-year cross-sectional survey by Kai-yun Dou, Ru-bao Dong, Chun-long Gan

“…Changes in daily life and teaching methods, along with the high initial mortality rate of COVID-19, have had varying degrees of negative impact on the mental health (MH) of adolescents.PurposesThis study aimed to explore the impact of the COVID-19 pandemic status on the sleep duration (SD) and MH of adolescents, investigate the relationship between SD and MH in middle school students, and evaluate the protective effect of SD on MH.MethodsUsing a convenient sampling method, 6 junior high schools and 3 senior high schools in Guiyang City, China, were selected. …”
Get full text

Compassion fatigue and associated factors among nurses working in Jimma Zone public hospitals, southwest Ethiopia: A facility based cross-sectional study. by Duguma Debela Ganeti, Bikila Dereje Fufa, Ebissa Bayana Kebede, Sheka Shemsi Seid, Birhanu Wogane Ilala, Nuritu Bacha Benti, Yeshitila Belay Belachew

“…<h4>Background</h4>Nurses are at risk of developing compassion fatigue, which has negative impacts on their well-being, quality care and leads to patient mortality and a financial burden on the healthcare system. …”
Get full text

HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…Clusters will be matched based on ICU size (fewer or more than 20 beds), region, and average 2023 mortality. The primary outcome is the proportion of HCPs with burnout between intervention and control clusters at the end of the intervention. …”
Get full text

Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

“…Competing risk analysis, with persistent disability (mRS score 3–5) as the primary risk and ICU-death as the competing risk, revealed that chronic alcohol consumption was the sole significant variable associated with persistent disability at 90 days (cause-specific hazard ratio 4.26, 95%CI 1.83–9.91), whereas the remaining variables were associated with mortality. Conclusions In adults with severe pneumococcal meninigitis, intracranial complications were independently associated with a higher risk of poor functional outcome, in the form of persistent disability or death. …”
Get full text

Navigating Emergency Management of Cancer Patients: A Retrospective Study on First-Time, End-Stage, and Other Established Diagnoses in a High Turnover Emergency County Hospital by Mihaela Corlade-Andrei, Radu-Alexandru Iacobescu, Viorica Popa, Alexandra Hauta, Paul Nedelea, Gabriela Grigorasi, Monica Puticiu, Roxana Elena Ciuntu, Andreea Ivona Sova, Diana Cimpoesu

“…Risk analysis was performed to understand these patients’ care needs (such as medical care, surgical care, specialty consults, intensive care, ward admission, and other hospital transfers) and immediate care outcomes (such as in-hospital mortality and home discharge). <i>Results</i>: 2318 patients with cancer requested emergent care (patient presentation rate of 3.08%), of which 444 (19.15%) were diagnosed for the first time, and 616 (26.57%) were at the end-stage. …”
Get full text

Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves by Letiele Bruck de Souza, Amanda Leitão Gindri, Thainara de Andrade Fortes, Thais Felli Kubiça, Jefferson Enderle, Rafael Roehrs, Sidnei Moura e Silva, Vanusa Manfredini, Elton Luís Gasparotto Denardin

“…Results show that the C. nutans extract leaves used to prevent PQ damage were effective in reducing flies’ mortality and improving locomotor capacity. Conclusion. …”
Get full text

Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…Intestinal parasitic infections are most common and prevalent among children and accounts for great morbidity and mortality. Objective. This research is aimed at studying the prevalence and related risk factors of parasitic infections among private school-going pupils of Dharan Submetropolitan City. …”
Get full text

The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study by M. L. Tang, Y. Q. Zhou, A. Q. Song, J. L. Wang, Y. P. Wan, R. Y. Xu

“…Previous studies reported that overweight older adults had a lower mortality after cardiovascular diseases attack, indicating being thinner might not always be better. …”
Get full text

Dietary β-Mannanase Affects the Growth, Antioxidant, and Immunes Responses of African Catfish, Clarias gariepinus, and Its Challenge Against Aeromonas hydrophila Infection by Ibrahim Adeshina, Bilal Ahamad Paray, Eijaz Ahmed Bhat, Shahid Sherzada, Olaolu O. Fawole, Dalhatu J. Bawa, Thais Pereira da Cruz, Lateef O. Tiamiyu

“…In addition, fish-fed diets comprising 6000 TMU β-mannanase/kg diet showed the lowest rates of fish mortality (7.5%) (p <0.05). Therefore, feeding African catfish, Clarias gariepinus, β-mannanase enhanced growth performance, increased activity of digestive enzymes, gut morphology, enhanced generation of short-chain fatty acids, digesta potential of hydrogen (pH), and improved antioxidant profiles and immunity at the optimum dose of 5800 TMU/kg diet. …”
Get full text

Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…ObjectiveIschemic stroke represents a leading cause of disability and mortality worldwide, necessitating effective and complementary therapeutic strategies. …”
Get full text

Particulate matter emission in agricultural biomass residue combustion by M.G. Nugraha, A. Sharfan, V.S.Y. Prakoso, M. Hidayat, H. Saptoadi

“…Exposure to these pollutants poses substantial risks to human health, including respiratory illnesses, cardiovascular diseases, and premature mortality. This study aims to assess the environmental implications of biomass waste combustion in Yogyakarta, Indonesia. …”
Get full text