Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells by Fangming Xiu, Mile Stanojcic, Li Diao, Marc G. Jeschke

“…Innate immune system dysfunction via hyperglycemia is associated with a higher morbidity and mortality in critical illness. Along with others, we hypothesize that reduction in morbidity and mortality observed in patients receiving insulin treatment is partially due to its effect on the attenuation of the immune response. …”
Get full text

Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies by Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer

“…Chronic-recurrent infections with different pathogens leading to significant morbidity suggested combined immunodeficiency, CMC, or Mendelian susceptibility to mycobacterial diseases. …”
Get full text

Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study by Ivan Hand, Nahla Zaghloul, Lily Barash, Rudolph Parris, Ulrika Aden, Hsiu-Ling Li

“…A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. …”
Get full text

Vaccinating Adult Patients with Cirrhosis: Trends over a Decade in the United States by Abhijeet Waghray, Nisheet Waghray, Hicham Khallafi, K. V. Narayanan Menon

“…Ultimately, the use of electronic medical record (EMR) reminders improved communication between healthcare professionals and public health programs to increase awareness are fundamental to reducing morbidity, mortality, and health-care related costs of vaccine preventable diseases in patients with cirrhosis.…”
Get full text

Epidemiological and entomological profile of malaria in Huambo province. Angola, 2018 by Lourdes Elena Duany Badell, Clementino Sacanombo, Jovita Chocoputo Cachequele André, Mwadi Kapinga Kapinga, Jesús Ramón Joya Garcia, Joaquin Ukuessenje Isaac

“…<br /><strong>Conclusions:</strong> malaria is a health problem in Huambo, its burden is high and causes great morbidity and fatality rates in vulnerable groups such as pregnant women and children under five years of age.…”
Get full text

Preliminary Results of Hyperthermic Intraperitoneal Intraoperative Chemotherapy as an Adjuvant in Resectable Pancreatic Cancer by Antonios-Apostolos K. Tentes, Dimitrios Kyziridis, Stylianos Kakolyris, Nicolaos Pallas, Georgios Zorbas, Odysseas Korakianitis, Christos Mavroudis, Nicolaos Courcoutsakis, Panos Prasopoulos

“…The hospital mortality and morbidity rate was 9.5% and 33.3%, respectively. 5-year and median survival was 23% and 11 months, respectively. …”
Get full text

Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy by Mohammad Golriz, Omid Ghamarnejad, Elias Khajeh, Mohammadsadegh Sabagh, Markus Mieth, Katrin Hoffmann, Alexis Ulrich, Thilo Hackert, Karl Heinz Weiss, Peter Schirmacher, Markus W. Büchler, Arianeb Mehrabi

“…The association of preoperative platelet counts with posthepatectomy liver failure (PHLF), morbidity (based on Clavien-Dindo classification), and 30-day mortality was evaluated using multivariate analysis. …”
Get full text

Choledochoplasty with Gallbladder Wall Free Flap: A Novel Technique for Large Bile Duct Defects from Mirizzi Syndrome in High-Risk Patients—A Case Report and Literature Review by Louis F. Chai, Gary S. Xiao

“…These injuries can cause significant morbidity and mortality, and additional interventions further compound this, especially for high-risk patients. …”
Get full text

Neonatal Outcomes of Late-Preterm Birth Associated or Not with Intrauterine Growth Restriction by Cristiane Ortigosa Rocha, Roberto Eduardo Bittar, Marcelo Zugaib

“…To compare neonatal morbidity and mortality between late-preterm intrauterine growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) infants of the comparable gestational ages (GAs). …”
Get full text

Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa: Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Re... by Simbarashe Takuva, Mhairi Maskew, Alana T. Brennan, Ian Sanne, A. Patrick MacPhail, Mathew P. Fox

“…Since low hemoglobin is an established adverse prognostic marker, prompt identification of anemia may result in improved morbidity and mortality of patients initiating ART.…”
Get full text

Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonit... by Carlos Alberto Figueiredo Filho, Celia Maria Machado Barbosa de Castro, Guilherme Veras Mascena, Gustavo Ithamar Souto Maior, Tharcia Kiara Beserra Oliveira, Carlos Teixeira Brandt

“…Survival in the study-II group was higher than in study-I group (p = 0.0462). The morbidity score for abdominal and thoracic cavity was lower in the study-II group as compared with study-I group (p = 0.0001). …”
Get full text

Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…In cases where the kidney is involved, a nephrectomy can lead to significant morbidity, especially in patients with pre‐existing renal impairment. …”
Get full text

Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases by Marilena Durazzo, Arianna Ferro, Victor Manuel Navarro-Tableros, Andrea Gaido, Paolo Fornengo, Fiorella Altruda, Renato Romagnoli, Søren K. Moestrup, Pier Luigi Calvo, Sharmila Fagoonee

“…The fight against the increasing incidence of liver-related morbidity and mortality is challenged by a lack of clinically validated early-stage biomarkers and the limited availability of effective anti-fibrotic therapies. …”
Get full text

Impact of diet on cardiometabolic risk in patients with obstructive sleep apnea by Domenico Basta

“…Obstructive sleep apnea (OSA) is a serious condition associated with increased morbidity and mortality from cardiovascular disease (CVD). …”
Get full text

Malignant Tumours Mimicking Complicated Appendicitis and Discovered upon Follow-Up after Percutaneous Drainage: A Case of Two Patients by Sharandran Chandra Mohan, Krishna Mohan Gummalla, Martin Weng Chin H’ng

“…The conservative management of periappendiceal abscesses is gaining favour due to decreased morbidity and improved clinical outcomes for patients. …”
Get full text

Compartment Syndrome following Bothrops Snakebite Leads to Decompressive Fasciotomies by Murilo Sérgio Valente-Aguiar, Bruno Gonçalves da Costa e Silva, Teresa Magalhães, Ricardo Jorge Dinis-Oliveira

“…Snakebite envenoming is a neglected tropical disease with relevant morbidity and mortality. In this report, we illustrate the clinical course of a suspected Bothrops snakebite envenoming of a patient that evidenced severe pain, edema, pallor, regional lymphadenopathy, ecchymosis, myonecrosis, and bullous erythema in the right lower limb, specially around the fang marks. …”
Get full text

Adult-to-Adult Living Donor Liver Transplantation by Shimul A Shah, Gary A Levy, Lesley D Adcock, Gary Gallagher, David R Grant

“…With a multidisciplinary team focused on donor safety and experienced surgeons capable of performing complex resection/reconstruction procedures, donor morbidity is low and recipient outcomes are comparable with results of deceased donor transplantation.…”
Get full text

CIHR Canadian HIV Trials Network Co-Infection and Concurrent Diseases Core: Updated Canadian Guidelines for the Treatment of Hepatitis C Infection in HIV-hepatitis C Coinfected Adu... by Mark Hull, Stephen Shafran, Alice Tseng, Pierre Giguère, Marina B Klein, Curtis Cooper

“…BACKGROUND: Hepatitis C virus (HCV) coinfection occurs in 20% to 30% of Canadians living with HIV and is responsible for a heavy burden of morbidity and mortality. Management of HIV-HCV coinfection is more complex due to the accelerated progression of liver disease, the timing and nature of antiretroviral and HCV therapy, mental health and addictions management, socioeconomic obstacles and drug-drug interactions between new HCV direct-acting antiviral therapies and antiretroviral regimens.…”
Get full text

A Case of “Refractory” Neuropsychiatric Lupus Responsive to Anticoagulation by Rui Wu, Sun Hu

“…Neuropsychiatric disorder is a severe complication in 14% to 75% of systemic lupus erythematosus (SLE) patients, which can result in significant morbidity. A 15-year-old female SLE patient with coexistence of dural sinus thrombosis and intracerebral hemorrhage resistant to two pulses of high dose of glucocorticoid was treated with anticoagulation of the low-molecular-weight [LMW] heparin subcutaneously followed by warfarin. …”
Get full text

Management of Infectious Processes of the Pleural Space: A Review by Ankur Girdhar, Adil Shujaat, Abubakr Bajwa

“…There has been an increase in the morbidity and mortality associated with parapneumonic effusions and empyema. …”
Get full text