Insiden Malaria di Puskesmas Sungai Durian dan Puskesmas Talawi Kota Sawahlunto Bulan Oktober 2011 sampai Februari 2012 by Mareza Dwithania, Nuzulia Irawati, Rosfita Rasyid

“…<br />Kata kunci: Plasmodium, Anopheles, malaria<br />Abstract<br />Malaria is still a global health problem, including in Indonesia due to its high morbidity and mortality. The high incidence of malaria in an area can be influenced by the parasites, hospes, and vectors. …”
Get full text

Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southw... by Li Liu, Ziyi Yan, Fumei He, Jie Chen, Linghan Kuang, Xingxin Liu, Yali Cui, Xia Wang, Chenglin Miao, Hong Li, Yongmei Jiang

“…Abstract Background Staphylococcus aureus is one of the most common pathogens that colonizes human skin/mucous membranes, where it causes local infection that can progress to invasive infection, resulting in high morbidity and mortality worldwide. This study aimed to investigate the antibiotic susceptibility and molecular characteristics of invasive S. aureus in children and women in Southwest China from 2018 to 2023 to provide novel insights helpful in preventing and treating S. aureus infections. …”
Get full text

Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…While extending the duration of second stage can reduce primary cesarean delivery rates, it may increase maternal and neonatal morbidities as the duration progresses. We aimed to develop a personalized machine learning (ML) model to predict the possible second-stage duration. …”
Get full text

The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patient... by Chen-Yan Min, Yue Gao, Yuan Li, Yi-Ning Jiang, Ying-Kun Guo, Hua-Yan Xu, Rong Xu, Xi Liu, Li-Ting Shen, Zhi-Gang Yang

“…Background Ischemia with nonobstructive coronary arteries (INOCA) has high morbidity, mortality, and poor quality of life. Metabolic syndrome (MetS) is a complex of multiple cardiac metabolic risk factors, significantly increasing the risk of major adverse cardiovascular events in INOCA patients. …”
Get full text

Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients by Zhang Dai, Xuhong Lan, Minjing Cai, Yunhui Liao, Jingwen Zhang, Naifang Ye, Xinxin Lu, Jiajia Wang, Yun Xiao, Yan Zhang, Yihui Yao, Xianming Liang

“…A nomogram model for 30-day morbidity of candidemia was determined using the least absolute shrinkage and logistic regression analysis.ResultsThe incidence of candidemia increased in recent years (2020: 0.025%, 2021: 0.029%, 2023:0.022%). …”
Get full text

Pancreaticoduodenectomy in trauma patients with grade IV–V duodenal or pancreatic injuries: a post hoc analysis of an EAST multicenter trial by Jeffry Nahmias, Daniel N Holena, Bellal Joseph, Martin Schreiber, Lisa M Kodadek, Mayur Narayan, Grace Chang, Joe Patton, Abid Khan, Mark Seamon, Jessica H Beard, Michelle T Bover Manderski, Michael A Vella, Ryan Peter Dumas, Haytham Kaafarani, Alison A Smith, Rachel Leah Choron, Christopher Bargoud, Amanda L Teichman, Francesk Mulita, Christine T Trankiem, Hashim Ahmed, Aaron Anderson, Odessa Pulido, Caleb Mentzer, Jane Keating, Mira Ghneim, Reynold Henry, Dane R Scantling, Andrew Benjamin, Christopher W Foote, Carlos H Palacio, Randi N Smith, Meghan Jonikas, Dias Argandykov, Jason D Sciarretta, Joshua P Hazelton, Pascal Udekwu, Jordan Michael Kirsch, Charoo Piplani, Julia Kuzinar, Dustin Hanos, Iman N Afif, Navpreet Kaur Dhillon, Ashling Zhang, Rebekah Devasahayam, Oliver Gunter, Brandi Sun, Chloe S Cao, Jessica K Reynolds, Lauren A Hilt, Karla Echeverria-Rosario, Nathaniel S Fung, Caitlin A Fitzgerald, Jeremy H Levin, JaeHee Yoon, Jacqueline Blank, Christopher J McLaughlin, Rami Al-Aref, Daniel S Howard, Kate Dellonte, Brent Hopkins, Chloe Shell, Evan G Wong, Howard Lieberman, Walter A Ramsey, Collin H Stewart, Claudia Alvarez, John D Berne, Ivan Puente, Ilya Rakitin, Lindsey Perea, Jason Wade, Laura K Mann, Vasileios Mousafeiris, Shari Reid-Gruner, Erica Sais, Lilamarie Moko

“…We suggest that the role of PD should be limited to cases of massive destruction of the pancreatic head and ampullary complex, given the likely procedure-related morbidity and adverse outcomes when compared with non-PD management.Level of evidence IV, Multicenter retrospective comparative study.…”
Get full text

Geographically widespread and novel hemotropic mycoplasmas and bartonellae in Mexican free-tailed bats and sympatric North American bat species by Daniel J. Becker, Kristin E. Dyer, Lauren R. Lock, Beckett L. Olbrys, Shawn A. Pladas, Anushka A. Sukhadia, Bret Demory, Juliana Maria Nunes Batista, Micaela Pineda, Nancy B. Simmons, Amanda M. Adams, Winifred F. Frick, M. Teague O'Mara, Dmitriy V. Volokhov

“…However, bacterial pathogens can have significant impacts on both human health and bat morbidity and even mortality. Hemoplasmas and bartonellae are facultative intracellular bacteria of special interest in bats, given their high prevalence and substantial genetic diversity. …”
Get full text

Prediction Models of Severity in Acute Biliary Pancreatitis by Iulia Ratiu, Renata Bende, Camelia Nica, Oana Budii, Calin Burciu, Andreea Barbulescu, Tudor Moga, Bogdan Miutescu, Roxana Sirli, Mirela Danila, Alina Popescu, Felix Bende

“…While the overall mortality rate of acute pancreatitis is relatively low, ranging between 3 and 5% in most cases, severe forms can result in significantly higher morbidity and mortality. Therefore, early risk assessment is crucial for optimizing management and treatment. …”
Get full text

Pre-existing IgG antibodies to HCoVs NL63 and OC43 Spike increased during the pandemic and after COVID-19 vaccination by Zahra Hasan, Kiran Iqbal Masood, Marc Veldhoen, Shama Qaiser, Marta Alenquer, Mishgan Akhtar, Sadaf Balouch, Junaid Iqbal, Yaqub Wassan, Shahneel Hussain, Khalid Feroz, Sajid Muhammad, Atif Habib, Akbar Kanji, Erum Khan, Afsar Ali Mian, Rabia Hussain, Maria Joao Amorim, Zulfiqar A. Bhutta

“…There is little information regarding endemic human coronaviruses (HCOVs) from Pakistan, which experienced a relatively low COVID-19 morbidity and mortality. We investigated antibodies to SARS-CoV-2 and HCoVs NL63 and OC43, comparing sera from prepandemic controls (PPC) period with responses in healthy controls from the pandemic (HC 2021). …”
Get full text

Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC by Long Chen, Houzhi Yang, Xianfu Wei, Xianfu Wei, Jianchao Liu, Xiuxin Han, Chao Zhang, Yongheng Liu, Yan Zhang, Yao Xu, Yiqin Li, Guowen Wang, Jinyan Feng

“…BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. …”
Get full text

Baska Mask versus I-gel in Spontaneously Breathing Anaesthetised Patients: A Randomised Clinical Study by Bhagyavardhan Botta, Yogarajan Ramalingam, Grishma Robba, Tanya Elizabeth, Kala Balasubramanian, Selvamani Subramanian, Senthil Kumar Vannivedu Santhnam, Kavyasri Morampudi

“…Compared to endotracheal intubation, these SGADs provide haemodynamic stability and lesser airway morbidity. Now-a-days, second and third generation SGADs, differing in their design, have been used in clinical practice due to their better clinical performance. …”
Get full text

Spotted fever group rickettsiae in black rats, pets, and humans in Zungarococha community, A rural area in the surroundings of Iquitos, Peru by Cusi Ferradas, Guillermo Salvatierra, David Payahuanca, Winnie Contreras, Andrés M. López-Pérez, Therangika A. Hangawatte, Diana León, Bruno M. Ghersi, Ricardo Gamboa, Katia Manzanares Villanueva, Viviana Pinedo-Cancino, Risa Pesapane, Gabriela Salmón-Mulanovich, Andrés G. Lescano, Janet Foley

“…Rickettsiae are a family of ectoparasite-borne bacteria that can produce high morbidity and mortality among humans. There are scarce data on rickettsial ecology in rural areas of the Peruvian Amazon basin, where seroprevalence has not been determined, and the identities of animals acting as reservoirs of these bacteria are not known. …”
Get full text

Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…Abstract Infection with Influenza A virus (IAV) induces severe inflammatory responses and lung injury, contributing significantly to mortality and morbidity rates. Alterations in the microbial composition of the lungs and intestinal tract resulting from infection could influence disease progression and treatment outcomes. …”
Get full text

Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…Various resistance mechanisms complicate treatment, leading to increased morbidity and mortality. Despite numerous studies conducted in Gulf Health Council (GHC) countries, the molecular epidemiology of MDR K. pneumoniae remains not clearly defined. …”
Get full text

Characterization of the gut microbiota and systemic inflammation in HIV-exposed uninfected infants from a resource-limited setting at 6 weeks of age by P. Munjoma, A. Mazhandu, J. Wyss, S. Ulrich Jordi, L. Katsidzira, B. Yilmaz, B. Misselwitz, K. Duri

“…Objective: Infants born to mothers infected with human immunodeficiency virus (HIV) experience heightened morbidity and mortality, likely due to systemic immune dysregulation potentially linked to gut microbial dysbiosis. …”
Get full text

Incidence of severe maternal outcomes following armed conflict in East Gojjam zone, Amhara region, Ethiopia: using the sub-Saharan Africa maternal near-miss criteria by Tirusew Nigussie Kebede, Kidist Ayalew Abebe, Ambachew Getahun Malede, Abinet Sisay, Ayenew Yirdie, Worku Taye, Tebabere Moltot Kitaw, Bezawit Melak Fente, Mesfin Tadese, Tesfanesh Lemma Demisse, Mulualem Silesh, Solomon Hailemeskel Beshah, Getaneh Dejen Tiche, Michael Amera Tizazu, Moges Sisay Chekole, Birhan Tsegaw Taye

“…This concept assumes that severe maternal morbidity predicts mortality risk, enabling the analysis of risk factors for life-threatening outcomes and improving our understanding on the causes of maternal death. …”
Get full text

Sacubitril/valsartan in patients with heart failure with reduced ejection fraction with end‐stage of renal disease by Seonhwa Lee, Jaewon Oh, Hyoeun Kim, Jaehyung Ha, Kyeong‐hyeon Chun, Chan Joo Lee, Sungha Park, Sang‐Hak Lee, Seok‐Min Kang

“…Abstract Aims Sacubitril/valsartan (SV) reduced heart failure hospitalization and cardiovascular mortality compared with enalapril in the Prospective Comparison of ARNI with ACE‐I to Determine Impact on Global Mortality and Morbidity in Heart Failure trial. However, this trial excluded patients with end stage of renal disease (ESRD); thus, the efficacy and safety of SV in heart failure with reduced ejection fraction (HFrEF) with ESRD remains uncertain. …”
Get full text

High Detection Rates for Prostate-specific Membrane Antigen–avid Prostate Cancer Recurrence at Low Prostate-specific Antigen levels on Extended Axial Field-of-view Positron Emissio... by Sarah Thomas, Jason Callahan, Paul Conway, Daniel Moon, Hugh Morgan, Johanna Ingbritsen, Melissa Munro, Robert E. Ware, Phil Dundee, Rodney J. Hicks

“…However, more than one-third of these patients had disease exclusively outside the prostate bed, with implications for the efficacy and morbidity of current salvage radiotherapy approaches. …”
Get full text

Development of a one-step multiplex RT-qPCR method for rapid detection of bovine diarrhea viruses by Dequan Yang, Li Ma, Zhongping Yang, Xianchao Yang, Jian Wang, Houbin Ju, Chunguang Lu, Yonggang Weng, Heping Zhao, Haixiao Shen, Xin Li, Feifei Ge, Xiaoxu Wang, Xiujuan Wu, Meng Xiang, Guidan Feng, Congsheng Tang, Shixin Huang, Hongjin Zhao

“…IntroductionViral calf diarrhea poses a significant challenge to the cattle industry worldwide due to its high morbidity and mortality rates, leading to substantial economic losses. …”
Get full text

Antibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent <i>Klebsiella pneumoniae</i> Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa,... by Azra, Taj Ali Khan, Ihtisham Ul Haq, Woranich Hinthong, Susana Campino, Aisha Gohar, Noman Khan, Muhammad Kashif, Ihsan Ullah, Taane G. Clark

“…The coexistence of high levels of antibiotic resistance and virulence factors in these isolates poses a severe threat to public health, as it can lead to difficult-to-treat infections and increased morbidity and mortality.…”
Get full text