Early warning systems for identifying severe maternal outcomes: findings from the WHO global maternal sepsis studyResearch in context by Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Mohammad Iqbal Aman, Bashir Noormal, Marisa Espinoza, Julia Pasquale, Charlotte Leroy, Kristien Roelens, Griet Vandenberghe, M. Christian Urlyss Agossou, Sourou Goufodji Keke, Christiane Tshabu Aguemon, Patricia Soledad Apaza Peralta, Víctor Conde Altamirano, Rosalinda Hernández Muñoz, José Guilherme Cecatti, Carolina Ribeiro do Valle, Vincent Batiene, Kadari Cisse, Henri Gautier Ouedraogo, Kannitha Cheang, Phirun Lam, Tung Rathavy, Elie Simo, Pierre-Marie Tebeu, Emah Irene Yakana, Javier Carvajal, María Fernanda Escobar, Paula Fernández, Lotte Berdiin Colmorn, Jens Langhoff-Roos, Wilson Mereci, Paola Vélez, Yasser Salah Eldin, Alaa Sultan, Alula M. Teklu, Dawit Worku, Richard Adanu, Philip Govule, Charles Noora Lwanga, William Enrique Arriaga Romero, María Guadalupe Flores Aceituno, Carolina Bustillo, Bredy Lara, Vijay Kumar, Vanita Suri, Sonia Trikha, Irene Cetin, Serena Donati, Carlo Personeni, Guldana Baimussanova, Saule Kabylova, Balgyn Sagyndykova, George Gwako, Alfred Osoti, Zahida Qureshi, Raisa Asylbasheva, Aigul Boobekova, Damira Seksenbaeva, Saad Eddine Itani, Meilė Minkauskienė, Diana Ramašauskaitė, Owen Chikhwaza, Luis Gadama, Eddie Malunga, Haoua Dembele, Hamadoun Sangho, Fanta Eliane Zerbo, Filiberto Dávila Serapio, Nazarea Herrera Maldonado, Juan I. Islas Castañeda, Tatiana Cauaus, Ala Curteanu, Victor Petrov, Yadamsuren Buyanjargal, Seded Khishgee, Bat-Erdene Lkhagvasuren, Amina Essolbi, Rachid Moulki, Zara Jaze, Arlete Mariano, Nafissa Bique Osman, Hla Mya Thway Einda, Thae Maung Maung, Khaing Nwe Tin, Tara Gurung, Amir Babu Shrestha, Sangeeta Shrestha, Kitty Bloemenkamp, Marcus J. Rijken, Thomas Van Den Akker, María Esther Estrada, Néstor J. Pavón Gómez, Olubukola Adesina, Chris Aimakhu, Bukola Fawole, Rizwana Chaudhri, Saima Hamid, M. Adnan Khan, María del Pilar Huatuco Hernández, Nelly M. Zavaleta Pimentel, Maria Lu Andal, Zenaida Dy Recidoro, Carolina Paula Martin, Mihaela Budianu, Lucian Pușcașiu, Léopold Diouf, Dembo Guirassy, Philippe Marc Moreira, Miroslav Borovsky, Ladislav Kovac, Alexandra Kristufkova, Sylvia Cebekhulu, Laura Cornelissen, Priya Soma-Pillay, Vicenç Cararach, Marta López, María José Vidal Benedé, Hemali Jayakody, Kapila Jayaratne, Dhammica Rowel, Wisal Nabag, Sara Omer, Victoria Tsoy, Urunbish Uzakova, Dilrabo Yunusova, Thitiporn Siriwachirachai, Thumwadee Tangsiriwatthana, Catherine Dunlop, Marian Knight, Jhon Roman, Gerardo Vitureira, Dinh Anh Tuan, Luong Ngoc Truong, Nghiem Thi Xuan Hanh, Mugove Madziyire, Thulani Magwali, Stephen Munjanja, Adama Baguiya, Mónica Chamillard, Bukola Fawole, Marian Knight, Seni Kouanda, Pisake Lumbiganon, Ashraf Nabhan, Ruta Nadisauskiene, Linda Bartlett, Fernando Bellissimo-Rodrigues, Shevin T. Jacob, Sadia Shakoor, Khalid Yunis, Liana Campodónico, Hugo Gamerro, Daniel Giordano, Fernando Althabe, A. Metin Gülmezoglu

“…Summary: Background: Infections and sepsis are leading causes of morbidity and mortality in women during pregnancy and the post-pregnancy period. …”
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Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) pose a significant challenge to global public health, characterized by high morbidity and mortality rates, particularly in immunocompromised patients. …”
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Exploring the pivotal variables of tongue diagnosis between patients with chronic kidney disease and health participants by Po-Chi Hsu, Po-Chi Hsu, Jia-Ming Chen, Jia-Ming Chen, Chia-Chu Chang, Yu-Jun Chang, Ping-Fang Chiu, John Y. Chiang, John Y. Chiang, Lun-Chien Lo, Lun-Chien Lo

“…IntroductionChronic kidney disease (CKD) is a significant global health problem associated with high morbidity and mortality rates. Traditional Chinese Medicine (TCM) utilizes tongue diagnosis to differentiate symptoms and predict prognosis. …”
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COVID-19-related stress, anxiety and vaccine hesitancy among healthcare workers in a tertiary hospital in South-Western Nigeria by Temitope Olumuyiwa Ojo, Tajudin Adesegun Adetunji, Stanley Chinedu Eneh, Baderinwa Opeyemi Akanji, Olusola Fajobi, Olanrewaju Elugbaju, Olanrewaju Ibikunle Ibigbami, Temilola Oladunmomi Owojuyigbe, Samuel Anu Olowookere, Olusegun Temitope Afolabi, Adedeji Ayodeji Onayade

“…Vaccination emerged as the most effective measure to curb the spread and reduce COVID-19 morbidity and mortality. However, vaccine hesitancy presents a challenge to achieving optimal vaccination coverage in Nigeria. …”
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Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil by Pamela Santos Azevedo, Isabella Zuppo Laper, Deborah Marta do Santos Oliveira, Adriano de Paula Sabino, Marina Morgado Garcia, Isabela Cristina Menezes de Freitas, Isabela Cristina Menezes de Freitas, Wallace Mateus Prata, Wallace Mateus Prata, Mariângela Leal Cherchiglia, Juliana Álvares-Teodoro, Juliana Álvares-Teodoro, Francisco de Assis Acurcio, Francisco de Assis Acurcio, Augusto Afonso Guerra Júnior, Augusto Afonso Guerra Júnior

“…There are few studies on FL in Brazil, so this study aims to evaluate the patient’s profile, morbidity and mortality treated by the Brazilian national health service (SUS) and evaluate risk factors associated with treatment failure.MethodsThis is a nationwide 16 years cohort with patients that underwent chemotherapy in the SUS (2000–2015). …”
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Association of ambient temperature with social isolation among the community-dwelling Chinese older adults: A cross-sectional study in Hong Kong by Eliza Lai-Yi Wong, Hong Qiu, Kin-Fai Ho, Annie Wai-Ling Cheung, Hera Leung, Frank Youhua Chen, Eng-Kiong Yeoh

“…Background: The adverse health impacts of ambient temperature have been well-documented, encompassing not only the mortality and morbidity burden but also mood and mental health disorders. …”
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Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function—FEEL Trial Results by Maria Emília Figueiredo Teixeira, Weimar Kunz Sebba Barroso, Andréa Araújo Brandão, Ana Luiza Lima Sousa, Roberto Esporcatte, Mário Henrique Elesbão de Borba, Ana Clara Neri Ávila Baleeiro, Beatriz Caldas Gonçalves, Enzo Inumaru, Enzo Mata de Sousa, Giovana Barros Leal, Henrique Soares de Araújo Pereira Farias, Juliana Alves de Souza, Lure Emilly Barreto da Silva, Matheus Canguçu de Paiva Queiroz, Frederico Rafael Moreira, Priscila Valverde de Oliveira Vitorino, John Eikelboom, Álvaro Avezum

“…Hypertension is a major cause of cardiovascular morbidity and mortality worldwide. Objectives: To evaluate whether a spirituality-based intervention, compared to a control group, can reduce blood pressure (BP) and improve endothelial function after 12 weeks in patients with mild or moderate hypertension (HTN). …”
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Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia by Betelhem Gezahegn, Ahmed Abdella, Fentahun Meseret, Ahmed Mohammed, Mulualem Keneni, Tesfaye Asfaw, Diribsa Tizazu, Assefa Desalew

“…BackgroundSepsis in the neonatal period is a major health challenge in neonatal medicine because of its potential for rapid progression to multi-organ dysfunction, leading to higher morbidity and mortality. Although efforts have been made to advance the outcomes of neonates admitted to hospitals, there is a paucity of data regarding neonatal sepsis treatment outcomes in the study setting. …”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…However, they are associated with a unique spectrum of side effects, called immune-related adverse events (irAEs), which can cause significant morbidity and quickly progress to severe or life-threatening events if not treated promptly. …”
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Prevalence and determinants of HIV among reproductive-age women (15–49 years) in Africa from 2010 to 2019: a multilevel analysis of demographic and health survey data by Alemu Gedefie, Amare Muche, Anissa Mohammed, Aznamariam Ayres, Dagnachew Melak, Eyob Tilahun Abeje, Fekade Demeke Bayou, Fekadeselassie Belege Getaneh, Lakew Asmare, Abel Endawkie

“…BackgroundHuman immunodeficiency virus (HIV) remains the leading cause of global morbidity and mortality. The incidence of HIV is disproportionately higher in Sub-Saharan regions, particularly the Southern African sub-region, which is the most affected region and accounts for 77% of all new HIV infections in the region. …”
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Lymphatic leaks – success of intranodal lymphangiogram first strategy by Alan Campbell, Diana Velazquez-Pimentel, Matthew Seager, Richard Hesketh, Julian Hague, Jowad Raja, Jocelyn Brookes, An Ngo, Miles Walkden, Anthie Papadopoulou, Daron Smith, Borzoueh Mohammadi, Ravi Barod, Mohammed Rashid Akhtar, Jimmy Kyaw Tun, Deborah Elise Low, Ian Daniel Renfrew, Tim Fotheringham, Conrad von Stempel

“…Abstract Background Lymphatic leaks are associated with significant mortality and morbidity. Intranodal lymphangiography (ILAG) involves the direct injection of ethiodised lipid into the hilum of lymph nodes. …”
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Development and validation of the age-associated dementia policy (AgeD-Pol) computer simulation model in the USA and Europe by Anand Viswanathan, Lee H Schwamm, Krishna P Reddy, Emily P Hyle, Fatma M Shebl, Kenneth A Freedberg, Julia H A Foote, Yiqi Qian, Shibani S Mukerji, Nattanicha Wattananimitgul, Ankur Pandya

“…Objective To develop and validate a novel, microsimulation model that accounts for the prevalence and incidence of age-associated dementias (AAD), disease progression and associated mortality.Design, data sources and outcome measures We developed the AAD policy (AgeD-Pol) model, a microsimulation model to simulate the natural history, morbidity and mortality associated with AAD. We populated the model with age-stratified and sex-stratified data on AAD prevalence, AAD incidence and mortality among people with AAD. …”
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Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion by Xin Huang, Huarong Ye, Yugang Hu, Yumeng Lei, Yi Tian, Xingyue Huang, Jun Zhang, Yao Zhang, Bin Gui, Qianhui Liu, Ge Zhang, Qing Deng

“…Abstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early and accurate diagnosis is crucial for effective treatment and prognosis. …”
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Efficacy of an intervention to increase therapeutic adherence in patients with secondary prevention for cardiovascular disease: a study protocol for a randomized controlled trial by Francisco Manuel Lidón-Muñoz, José Antonio Quesada, José Antonio Quesada, José Antonio Quesada, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Vicente Francisco Gil-Guillén, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán, Domingo Orozco-Beltrán

“…Therapeutic adherence is crucial, as the lack of it increases morbidity, mortality, reduces quality of life, and raises healthcare costs. …”
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The relationship between dietary branched-chain and aromatic amino acids with the regulation of leptin and FTO genes in adipose tissue of patients undergoing abdominal surgery by Farshad Teymoori, Hossein Farhadnejad, Mostafa Norouzzadeh, Mitra Kazemi Jahromi, Niloufar Saber, Ebrahim Mokhtari, Golaleh Asghari, Emad Yuzbashian, Parvin Mirmiran, Alireza Khalaj, Maryam Zarkesh, Mehdi Hedayati, Mohammadreza Vafa

“…In overweight-obese patients(body mass index = 25–34.9 kg/m2), the intake of BCAAs(β:-0.75,95%CI:-1.47,-0.03), valine(β:-0.78,95%CI:-1.51,-0.05), and tyrosine(β:-0.81,95%CI:-1.55,-0.06) was inversely associated with FTO gene expression in subcutaneous fat tissue in adjusted model. In morbidly obese patients(body mass index ≥ 35 kg/m2), a higher intake of total BCAAs(β:1.10,95%CI:0.07–2.13), leucine(β:1.07,95%CI:0.03–2.13), and isoleucine(β:1.49,95%CI:0.46–2.52) was associated with an increase of leptin gene expression in subcutaneous fat tissue. …”
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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction by Zhi-rong Luo, Han Li, Zhong-xin Xiao, Shui-jin Shao, Tian-tian Zhao, Yue Zhao, Fang-fang Mou, Bo Yu, Hai-dong Guo

“…Cardiovascular disease has been established as a major cause of morbidity and mortality worldwide, resulting in a huge burden to patients, families, and society. …”
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An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan by Rabea Basri, Muslim Bin Aqeel, Faryal Mehwish Awan, Sadiq Noor Khan, Ayesha Obaid, Rubina Parveen, Muhammad Mohsin, Wajeeha Akhtar, Abdal Hussain Shah, Tahira Sher Afghan, Amir Alam, Saira Khan, Anam Naz

“…Furthermore, the cumulative allele frequency of all susceptibility and protection-related variants was calculated in diverse ethnic groups and the relationship with mosquito-borne disease-associated morbidity and mortality was examined to determine whether results are consistent with founder effect in these populations. …”
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Methods to Adjust for Confounding in Test-Negative Design COVID-19 Effectiveness Studies: Simulation Study by Elizabeth AK Rowley, Patrick K Mitchell, Duck-Hye Yang, Ned Lewis, Brian E Dixon, Gabriela Vazquez-Benitez, William F Fadel, Inih J Essien, Allison L Naleway, Edward Stenehjem, Toan C Ong, Manjusha Gaglani, Karthik Natarajan, Peter Embi, Ryan E Wiegand, Ruth Link-Gelles, Mark W Tenforde, Bruce Fireman

“…These studies require methods that adjust for the confounding that arises when morbidities and demographics are associated with vaccination and the risk of outcome events. …”
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Prognostic signature of multimorbidity, geriatric syndromes and resources cluster in older in- and outpatients: a pooled secondary analysis with a 6-month follow-up by Thomas Benzing, Jill Stegemann, Anna Maria Affeldt, Luisa Mück, Anne Ferring, Laura Gerhards, Lena Pickert, Annika Bausch, Philipp Antczak, M Cristina Polidori

“…Additionally, two clusters were identified pertaining to the CIRS, encompassing sensory-vegetative and heart-kidney morbidity. Patients within the iatrogenic cluster exhibited significantly higher MPI and readmissions during follow-up compared with those outside this cluster (p<0.001). …”
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Protocolized approach saves the limb in peripheral arterial injury: A decade experience by Pratyusha Priyadarshini, Supreet Kaur, Komal Gupta, Abhinav Kumar, Junaid Alam, Dinesh Bagaria, Narender Choudhary, Amit Gupta, Sushma Sagar, Biplab Mishra, Subodh Kumar

“…Injury prevention, robust prehospital care, and rapid referral to specialized trauma center are few efficient measures, which can decrease the morbidity associated with vascular injury.…”
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