Development of a Novel Clinical Classification for Radiation-induced Cystitis: The Portuguese Navy Radiation-induced Cystitis (PNRC) Scale by Tiago Ribeiro de Oliveira, Carla D’Espiney Amaro, Sérgio Henriques Pereira, Afonso Sousa Castro, Pedro Gomes Monteiro, João Cardoso Felício, Guilherme Bernardo, João Chambino, José Palma dos Reis, Chandra Shekhar Biyani

“…Background and objective: Radiation-induced cystitis (RIC) is an important consequence of pelvic radiotherapy that can cause high morbidity and, in extreme cases, mortality. The lack of a widely accepted classification system makes it difficult to compare treatment regimens. …”
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miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis by Han Li, Junyan Duan, Tongtong Zhang, Yingjie Fu, Yue Xu, Hongjun Miao, Xuhua Ge

“…Sepsis-associated acute kidney injury (S-AKI) is a common disease in pediatric intensive care units (ICU) with high morbidity and mortality. The newly discovered results indicate that microRNAs (miRNAs) play an important role in the diagnosis and treatment of S-AKI and can be used as markers for early diagnosis. …”
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Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy by Francesca Lombardi, Simone Belmonti, Alessia Sanfilippo, Alberto Borghetti, Valentina Iannone, Pierluigi Francesco Salvo, Massimiliano Fabbiani, Elena Visconti, Simona Di Giambenedetto

“…Abstract Background Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). …”
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Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study by Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Cristian Papara, Katja Bieber, David A. De Luca, Jan Philipp Klein, Marlene A. Ludwig, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Artem Vorobyev, Astrid Dempfle, Ralf J. Ludwig

“…IntroductionChronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. Thus, they are a major medical burden with a high unmet need. …”
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Catheter‐Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single‐Centre Retrospective Study by Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

“…It is responsible for significant morbidity and mortality and a costly long hospital stay. …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…BackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes. …”
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Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements by Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Silvia Urciuoli, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Nicola Di Daniele, Annalisa Romani

“…Nephropathic patients show elevated cardiovascular morbidity and mortality compared to the general population. …”
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CYSTIC DEGENERATION OF THE DUODENUM ASSOCIATED WITH CHRONIC PANCREATITIS by A. G. Kriger, A. V. Smirnov, S. V. Berelavichus, D. S. Gorin, N. N. Vetsheva, Ja. I. Nerestjuk, D. V. Kalinin, A. V. Glotov

“…Clinical presentation of DD was not related with etiology and showed typical symptoms of CP: abdominal pain occurred in 98.8% of patients, body weight loss – 61.7%, duodenal obstruction – 35.8%, biliary hypertension – 34.1%. The overall morbidity was 35.1%. Overall postoperative mortality was 1.37% (1 patient). 66% of patients had no clinical symptoms postoperatively, a significantimprovement – 32%, no effect – 2%.Conclusion. …”
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Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol by Cristina Ardura-Garcia, Max Bachmann, Alejandro Rodriguez, Philip Cooper, Michael Richard Perkin, Irina Chis Ster, Natalia Cristina Romero, Martha E Chico, Alvaro Cruz, Diana Morillo, Santiago Mena-Bucheli, Angélica Ochoa, Claudia Rodas, Augusto Maldonado, Karen Arteaga, Jessica Alchundia, Karla Solorzano, Camila Figueiredo

“…Asthma attacks are an important cause of emergency care attendance and long-term morbidity. We designed a prospective study, the Asthma Attacks study, to identify factors associated with recurrence of asthma attacks (or exacerbations) among children and adolescents attending emergency care in three Ecuadorian cities.Methods and analysis Prospective cohort study designed to identify risk factors associated with recurrence of asthma attacks in 450 children and adolescents aged 5–17 years attending emergency care in public hospitals in three Ecuadorian cities (Quito, Cuenca and Portoviejo). …”
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Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Alcohol abuse has recently become a serious health concern worldwide, and the incidence of alcoholic liver disease (ALD) is rapidly increasing with high morbidity and mortality. Ferroptosis is a newly recognized form of regulated cell death caused by the iron-dependent accumulation of lipid peroxidation. …”
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Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial by Run-Cong Nie, Shu-Qiang Yuan, Ya Ding, Yong-Ming Chen, Yuan-Fang Li, Cheng-Cai Liang, Mu-Yan Cai, Guo-Ming Chen, Wei Wang, Xiao-Wei Sun, De-Sheng Weng, Dan-Dan Li, Jing-Jing Zhao, Xiao-Jiang Chen, Yuan-Xiang Guan, Zhi-Min Liu, Yao Liang, Ma Luo, Jun Chi, Hai-Bo Qiu, Zhi-Wei Zhou, Xiao-Shi Zhang, Ying-Bo Chen

“…MPR, pathological complete response (pCR) of primary tumors and ypT0N0 rates were 50.0% (16/32, 95% CI: 31.9–68.1%), 28.1% (9/32, 95% CI: 13.7–46.7%) and 25.0% (8/32, 95% CI: 11.5–43.4%), respectively. The surgical morbidity rate was 15.6% (5/32), and no 30-day mortality was observed. …”
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Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…Therefore, exploring and intervention of the factors associated with risk for LVDD is of great importance in reducing the morbidity and mortality of cardiovascular disease (CVD) complications in CKD patients. …”
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Hamstring vs Peroneus Longus Tendon Autograft in Anterior Cruciate Ligament Reconstruction: A Comparative Study by Khadri M Khalid, Adarsh Vajrangi, Eswara Reddy, Nagesh Sherikar, Rakshith Chakravarthy Harish Yellappa, Ranganatha B Kurupati

“…To gauge donor site morbidity, we measured thigh circumference preoperatively and postoperatively. …”
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Study protocol for a randomised-controlled study on emotion regulation training for adolescents with major depression: the KONNI study by Ellen Greimel, Lisa Feldmann, Charlotte Piechaczek, Frans Oort, Jürgen Bartling, Martin Schulte-Rüther, Gerd Schulte-Körne

“…Introduction Major depression (MD) often has its onset during adolescence and is associated with significant morbidity and mortality. One important factor for the development and maintenance of adolescent MD are disturbances in emotion regulation and the underlying neural processes. …”
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). …”
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Psychophysiological components of the activities of operators of nuclear power plants as a factor of accidents in the conditions of the threat of social catastrophe by O.A. Shevchenko, O.V. Sheviakov, V.V. Kornienko, I.A. Burlakova, Y.A. Slavska, N.I. Zhyhaylo, V.V. Vakulik, I.S. Ostapenko, O.A. Gerasimchuk, E.Y. Doroshenko, V.V. Prykhodko, S.A. Chernihivska, O.M. Ivchenko, V.M. Tychonovych, S.B. Dorogan

“…The expected effect is an increase in the efficiency and quality of operator’s activity, the productivity and reliability of the performance of production tasks, an increase in professional longevity, a decrease in rate and occupationally-related morbidity of these specialists.…”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…IntroductionMetastasis is the major cause of thyroid cancer morbidity and mortality. However, the mechanisms are still poorly understood. …”
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Profiles of Killer Systems and Volatile Organic Compounds of Rowanberry and Rosehip-Inhabiting Yeasts Substantiate Implications for Biocontrol by Iglė Vepštaitė-Monstavičė, Juliana Lukša-Žebelovič, Violeta Apšegaitė, Raimondas Mozūraitis, Robertas Lisicinas, Ramunė Stanevičienė, Laima Blažytė-Čereškienė, Saulius Serva, Elena Servienė

“…This study addressed the biocontrol potential of yeasts, isolated from spontaneous fermentations of rosehips (<i>Rosa canina</i> L.) and rowanberries (<i>Sorbus aucuparia</i> L.), focusing on their killer phenotypes and VOCs production. …”
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Risk Factors of Bacteremia following Multiple Traumas by Hak-Jae Lee, Eol Choi, Nak-Joon Choi, Hyun-Woo Sun, Jae-Suk Lee, Jeong-Woo Lee, Tae-Yoon Kim, Yoon-Joong Jung, Suk-Kyung Hong

“…Bacteremia is a major nosocomial infection that frequently occurs in trauma patients, increasing morbidity and mortality. The aim of this study was to identify risk factors and to describe epidemiological patterns for early onset (EOB) and late onset (LOB) bacteremia after trauma. …”
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