GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation by Pengyu Duan, Xiaoyan Li, Yonghong Bi, Weiyu Feng, Zhehao Jin, Xiaoqian Zhang, Guanghui He, Da An, Zhibin Wen, Bing Zhang

“…Abstract Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) is an important cause of neurological impairment and leads to considerable morbidity and mortality. The stability of the blood-brain barrier (BBB) is crucial for minimizing secondary neurological damage and improving long-term prognosis. …”
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Health-related quality of life in children with presumptive TB by M.G. Anthony, L.S. Johnson, M. van Niekerk, A. Mfwaze, B. Bavuma, A.C. Hesseling, G. Hoddinott, M.M. van der Zalm

“…BACKGROUND: Respiratory illnesses, including pulmonary TB (PTB), cause significant morbidity. We aimed to understand the health-related quality of life (HRQoL) of children with presumptive PTB. …”
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Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease by Gennaro Clemente, Andrea Tringali, Agostino M. De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante

“…Two cases (11.1%) of gallbladder cancer associated with the Mirizzi syndrome were incidentally found: a patient underwent right hepatectomy and another patient was unresectable. The overall morbidity rate was 16.6%. There was no postoperative mortality. …”
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Greater residential greenness is associated with reduced epigenetic aging in adults by Andrey I. Egorov, Shannon M. Griffin, Jo Klein, Wei Guo, Jennifer N. Styles, Jason Kobylanski, Mark S. Murphy, Elizabeth Sams, Edward E. Hudgens, Timothy J. Wade

“…Epigenetic age acceleration (EAA) is a composite biomarker of biological aging based on DNA methylation measurements; it is predictive of morbidity and mortality. This cross-sectional study of 116 adult residents of a metropolitan area in central North Carolina investigated associations between exposure to residential green spaces and EAA using four previously developed epigenetic age formulas. …”
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Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation by Konradin F. Müskens, Winny N. R. Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A. deWitte, Marc Bierings, Caroline A. Lindemans, Stefan Nierkens, Mirjam E. Belderbos

“…Abstract Despite advances in allogeneic hematopoietic cell transplantation (HCT), poor graft function (PGF) remains an important complication with substantial morbidity and mortality. The investigation of preventive and therapeutic PGF treatments is hindered by inconsistencies in reported incidence and outcomes across studies, which may be explained by heterogeneity in PGF definition. …”
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Prevalence of Bacterial Urinary Tract Infections and Associated Factors among Patients Attending Hospitals in Bushenyi District, Uganda by Martin Odoki, Adamu Almustapha Aliero, Julius Tibyangye, Josephat Nyabayo Maniga, Eddie Wampande, Charles Drago Kato, Ezera Agwu, Joel Bazira

“…Urinary tract infections (UTIs) are one of the major causes of morbidity and comorbidities in patients with underlying conditions, and it accounts for the majority of the reasons for hospital visit globally. …”
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Molecular Detection and Genetic Characterization of Avian Leukosis Virus From Field Outbreaks in Bangladesh by Md. Golzar Hossain, Riman Pathan, SM Nazmul Hasan, Anandha Mozumder, Moslema Jahan Mou, Marjana Akter, Chandan Sikder, Riyan Al Islam Reshad, Roni Mia, Sukumar Saha, Tofazzal Islam, Sharmin Akter

“…ABSTRACT Avian leukosis is a significant viral disease affecting chicken populations globally, including Bangladesh, resulting in high mortality and morbidity rates and causing substantial economic losses in the commercial poultry industry. …”
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Implementation of 2% Chlorhexidine Bathing to Reduce Healthcare-Associated Infections Among Patients in the Intensive Care Unit by Hsu-Liang Chang, Tzu-Ying Liu, Po-Shou Huang, Chin-Hwan Chen, Chia-Wen Yen, Hui-Zhu Chen, Shin-Huei Kuo, Tun-Chieh Chen, Shang-Yi Lin, Po-Liang Lu

“…Healthcare-associated infections (HAIs) significantly increase morbidity, mortality, length of hospital stays, and costs, particularly among ICU patients. …”
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Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…<b>Results</b>: The study revealed that the NM_030777.4(SLC2A10):c.243C>G (p.Ser81Arg) mutation in SLC2A10 leads to mild outcomes of no mortality and less morbidity. Novel features such as a flat philtrum, bulbous noses, bilateral nasolacrimal duct obstruction, allergic conjunctivitis, latent nystagmus, café au lait spots, eczema, dermatitis, allergic reactions, bilateral temporomandibular joint cysts, bilateral syndactyly (toes), parapelvic cysts, kidney malrotation, vesicoureteral reflux, and nephrolithiasis were identified in our cohort. …”
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Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity by Zhe Zhang, Yimeng Xia, Yimeng Xia, Zhihong Wang, Yaxing Sun, Dan Pu, Yijia He, Ruixian Liu, Yanru Zhang, Yan Liu, Junzhi Yu, Shiyang Ning, Baisui Feng, Yaohe Wang, Na Wang

“…IntroductionLung cancer is the leading cause of cancer-related death worldwide, and its morbidity and mortality are increasing. Although low-dose CT lung cancer screening has been shown to reduce lung cancer mortality, its adoption rate is limited and the pace of its promotion is slow, highlighting the urgent need for more effective prevention measures. …”
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Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention by Xiao-Dan Wu, Wei Zhao, Quan-Wei Wang, Xin-Yu Yang, Jing-Yue Wang, Shuo Yan, Qian Tong

“…Abstract New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. …”
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Blood Pressure and Haematological Indices in Twelve Communities in Ashanti, Ghana by Jacob Plange-Rhule, Sally M. Kerry, John B. Eastwood, Frank B. Micah, Sampson Antwi, Francesco P. Cappuccio

“…Hypertension is the most important risk factor for cardiovascular mortality and morbidity in Sub-Saharan Africa. In western populations, high haemoglobin levels are associated with raised BP unlike in Sub-Saharan Africa where there is a paucity of data. …”
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In-Hospital Cardiac Arrest in the Cardiac Catheterization Laboratory: Effective Transition from an ICU- to CCU-Led Resuscitation Team by Rajat Sharma, Hilary Bews, Hardeep Mahal, Chantal Y. Asselin, Megan O’Brien, Lillian Koley, Brett Hiebert, John Ducas, Davinder S. Jassal

“…IHCA is a major public health concern with increased patient morbidity and mortality. A proportion of all IHCAs occurs in the CCL. …”
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Mechanisms Predisposing Penile Fracture and Long-Term Outcomes on Erectile and Voiding Functions by Leonardo O. Reis, Marcelo Cartapatti, Rafael Marmiroli, Eduardo Jeronimo de Oliveira Júnior, Ricardo Destro Saade, Adriano Fregonesi

“…Immediate surgical treatment warrants long-term very low morbidity.…”
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Lessons learnt from measures taken to prevent rabies introduction and spread into a long rabies free territory (case study of the Irkutsk Oblast) by I. V. Meltsov, A. M. Ablov, E. N. Shkolnikova, M. E. Koplik, P. A. Minchenko, T. V. Desyatova, I. D. Zarva, A. D. Botvinkin, A. Ye. Metlin

“…Rabies is endemic on the considerable part of the Russian Federation, and it is associated with current natural outbreaks of the infection. The highest animal morbidity rates are reported in the central and southern regions of the European part of Russia and in the southern part of Western Siberia. …”
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Investigating lung cancer microenvironment from cell segmentation of pathological image and its application in prognostic stratification by Xu Zhang, Zi-Han Zhang, Yong-Min Liu, Shi-Lei Zhao, Xu-Tong Zhao, Li-Zhi Zhang, Chun-Dong Gu, Yi Zhao

“…Abstract Lung cancer, particularly adenocarcinoma, ranks high in morbidity and mortality rates worldwide, with a relatively low five-year survival rate. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…Introduction Ageing is associated with a multitude of healthcare issues including dementia, depression, frailty, morbidity associated with chronic disease and high healthcare utilisation. …”
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Dichotomitin promotes osteoblast differentiation and improves osteoporosis by inhibiting oxidative stress by Meichun Han, Weibin Du, Lei Zhang, Zhenwei Wang, Shengqiang Fang, Yang Zheng, Renfu Quan

“…Abstract Objective Osteoporosis is a systemic disease with high morbidity and significant adverse effects. Increasing evidence supports the close relationship between oxidative stress and osteoporosis, suggesting that treatment with antioxidants may be a viable approach. …”
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Health inequities among persons with disabilities: a global scoping review by Emre Umucu, Andrew A. Vernon, Deyu Pan, Sang Qin, Guillermina Solis, Rebecca Campa, Beatrice Lee

“…In the course of our review, our team identified three overarching themes of health inequity, encompassing (a) access to healthcare and resources, (b) morbidity, mortality, &amp; risk factors, and (c) social determinants of health. …”
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Analytical hierarchy process as a tool supporting a decision-making for assessment of the risk of transboundary infectious animal disease introduction to the Russian Federation an... by N. V. Lebedev, A. S. Igolkin, K. N. Gruzdev, D. G. Spirin, M. A. Farukh, N. V. Ermilov, G. G. Eremin

“…The article assesses the validity of the possibilities and use of modern methods of analyzing and predicting the spread of animal morbidity, identifying cause-and-effect relationships and the extent of the spread of particularly dangerous animal diseases. …”
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