Resistance to P. brasiliensis Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation by Felipe Fornias Sperandio, Gisele Pesquero Fernandes, Ana Carolina Silvério Cerqueira Mendes, Giulia Maria de Alencar Castro Bani, Vera Lucia Garcia Calich, Eva Burger

“…Paracoccidioidomycosis (PCM) is a systemic fungal infection, endemic in Brazil, that leads to severe morbidity and even mortality if not correctly treated. …”
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Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study by Mahshid Taherkhani, Farzaneh Montazerifar, Azita Hekmatdoost, Bahram Rashidkhani, Abolfazl Payandeh, Mansour Karajibani

“…Background: Preeclampsia may cause maternal and child morbidity and mortality. Evidence suggests that oxidative stress may be involved in the development of preeclampsia; however, the role of dietary total antioxidant capacity (DTAC) on preeclampsia risk has not yet been elucidated. …”
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Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…Specific Pathogen-Free (SPF) animals are bred and maintained to exclude pathogens associated with significant morbidity or mortality, which may pose a risk to research replicability. …”
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Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses by Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal

“…This protection was demonstrated by lower lung viral titers and reduced morbidity and mortality. <b>Conclusions:</b> The findings support further investigation of heterologous Ad vaccine platforms expressing SP + HA stem + AIP-C5. …”
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Forty years of HIV infection and AIDS in Taiwan: Reflection on the past and looking toward the future by Sung-Hsi Huang, Hsun-Yin Huang, Stephane Wen-Wei Ku, Po-Hsien Kuo, Kuan-Yin Lin, Guan-Jhou Chen, Chia-Chi Lee, Yen-Fang Huang, Chien-Ching Hung

“…Challenges remain to achieve HIV elimination and long-term successful management of HIV infection, which include stigma and discrimination, late presentation of HIV infection, and accelerated ageing with increasing rates of co-morbidities among people with HIV.…”
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Case report: Clinical characteristics and Genetical analysis of HSD11B2 in three Chinese children with apparent mineralocorticoid excess: a case series by Yuan Ding, Yuan Ding, Ming Cheng, Ming Cheng, Bingyan Cao, Bingyan Cao, Min Liu, Min Liu, Xuyun Hu, Xuyun Hu, Di Wu, Di Wu, Di Wu

“…Such measures are essential for the prevention or mitigation of target organ damage, as well as for the reduction of associated morbidity and mortality…”
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The current and future cancer burden in the Gulf Cooperation Council (GCC) countries by Saleh A. Alessy, Saleh A. Alqahtani, Jerome Vignat, Amid Abuhmaidan, Amani E. L. Basmi, Najla Al Lawati, Ameera Ali A‐Nooh, Wael Shelpai, Samar Alhomoud, Ali Al‐Zahrani, Freddie Bray, Ariana Znaor

“…Abstract Background Cancer is a leading cause of morbidity and mortality in the Gulf Cooperation Council (GCC) countries. …”
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Healthy at home for COPD: an integrated digital monitoring, treatment, and pulmonary rehabilitation intervention by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John P. Broach, Vik Kheterpal, Apurv Soni

“…Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality in the United States. Frequent exacerbations result in higher use of emergency services and hospitalizations, leading to poor patient outcomes and high costs. …”
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Cocaine-Induced Giant Bullous Emphysema by Steven Douedi, Vandan D. Upadhyaya, Ishan Patel, Usman Mazahir, Eric Costanzo, Mohammad A. Hossain

“…The purpose of this case presentation is to support early identification and treatment of GBE using bullectomy with VATS, improving outcomes and decreasing morbidity and mortality.…”
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Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients by Cyril Cyrus, Shahanas Chathoth, Chittibabu Vatte, Nafie Alrubaish, Othman Almuhanna, J. Francis Borgio, Samir Al-Mueilo, Fahd Al Muhanna, Amein K. Al Ali

“…End-stage renal disease (ESRD) is the result of hypertensive nephrosclerosis and chronic glomerular diseases and is associated with high morbidity and mortality. There are strong heritable components in the manifestation of the disease with a genetic predisposition to renal disorders, including focal segmental glomerulosclerosis and arterionephrosclerosis. …”
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NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus by Nektaria Papadopoulou-Marketou, Alexandra Margeli, Ioannis Papassotiriou, George P. Chrousos, Christina Kanaka-Gantenbein, Jeanette Wahlberg

“…Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. …”
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Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level by Xiaowen Jia, Rong Zhang, Jinzhu Guo, Hua Yue, Qiuxia Liu, Lipei Guo, Qunchang Zhang

“…Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model. …”
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Epidemiological and sociodemographic description of snakebite envenoming cases in Paraguay reported between 2015 and 2021 by Guillermo Sequera, Sofia Ardiles-Ruesjas, Edgar Sanabria, Victor Hugo Segovia Portillo, Lorena Jara Oroa, Viviana de Egea, Julio Alonso-Padilla, Irene Losada, María Jesús Pinazo

“…Blessed with large forested areas, its economy largely relies on agricultural production which increases the exposure of outdoor workers to the morbidity and mortality of SBE. Lack of sufficient and accurate epidemiological data highlights the importance of drawing an updated picture of SBE burden in the country.Methods We performed a retrospective descriptive study on secondary SBE data reported to the national surveillance system between 2015 and 2021. …”
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Cost-effectiveness of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression: analysis of a randomised controlled trial by David Reeves, Calvin Heal, Patrick Joseph Doherty, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies, Elizabeth Camacho

“…Cardiac rehabilitation (CR) is a complex intervention offered to patients with CVD, following a heart event, diagnosis or intervention, and it aims to reduce mortality and morbidity. The objective of this within-trial economic evaluation was to compare the cost-effectiveness of metacognitive therapy (MCT) plus usual care (UC) to UC, from a health and social care perspective in the UK.Methods A multicentre, single-blind, randomised controlled trial (ISRCTN74643496) was conducted in the UK involving 332 patients with CR with elevated symptoms of anxiety and/or depression and compared group-based MCT with UC. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…COVID-19 has caused widespread morbidity and mortality, with its effects extending to multiple organ systems. …”
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The mental health impact of COVID-19: the need for community interventions and collaboration for recovery by Nadarajah Rajeshkannan, Daya Somasundaram, Balachandran Kumarendran, Thirunavukarasu Kumanan, Ivan Dinesh Aloysius, Nalayini Sugirthan, Sivanantham Sasikumar, Nalayini Jegathesan

“…There were also positive effects such as better understanding of bio-knowledge, interventions and discoveries, online learning, gratitude toward health-care workers, increased community and family cohesion, reduction in road traffic accidents, and drop in other respiratory infections with their resultant morbidity and mortality. Conclusion: Given the widespread mental health consequences of the COVID-19 pandemic, a community-based approach is suggested while treating more severe mental disorders at the primary care or specialist level.…”
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UPDATE ON CYTOMEGALOVIRUS INFECTION MANAGEMENT IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS by José Luis Piñana, Estela Giménez, Lourdes Vázquez, María Ángeles Marcos, Manuel Guerreiro, Rafael Duarte, Ariadna Pérez, Carlos de Miguel, Ildefonso Espigado, Marta González-Vicent, María Suarez-Lledó, Irene García-Cadenas, Rodrigo Martino, Angel Cedillo, Monserrat Rovira, Rafael de la Cámara, David Navarro, Carlos Solano

“…Background: Cytomegalovirus (CMV) infection is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and in patients receiving novel hematological therapies. Its impact on morbidity and mortality necessitates effective management strategies. …”
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Developing and testing community-based tuberculosis (TB) screening intervention to increase TB referral, case detection and knowledge among sexual minority people in urban Banglade... by Mahbubur Rahman, Golam Sarwar, Masud Reza, Mohammad Niaz Morshed Khan, Gorkey Gourab, A K M Masud Rana, Shaan Muberra Khan, Samira Dishti Irfan, Shahriar Ahmed, Rupali Sisir Banu, Sayera Banu, Sharful Islam Khan

“…Findings of this experimental research are likely to provide new insights for programme managers and policy planners for adopting a similar approach in order to enhance TB referral, thus ultimately increasing TB case detections and reducing the likelihood of TB-related mortalities and morbidities, irrespective of HIV status.Methods and analysis This operational research will follow a quasi-experimental design, applying both qualitative and quantitative methods, in two drop-in centres in three phases. …”
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Impact of physician’s sex/gender on processes of care, and clinical outcomes in cardiac operative care: a systematic review by Louise Y Sun, Sylvain Boet, Amy Johnston, Katina Zheng, Mimi Deng, Fadi Mansour, Hussein Said, Cole Etherington

“…Studies were screened in duplicate by two pairs of independent reviewers.Outcome measures Processes of care, patient morbidity and patient mortality.Results The search yielded 2095 publications after duplicate removal, of which two were ultimately included. …”
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Prosaposin – A plausible biomarker in head and neck squamous cell carcinoma by Avradeep Datta, Rajandeep Kaur, Anshika Chauhan, Geeta Singh Boora, Himanshu Garg, Debajyoti Chatterjee, Jaimanti Bakshi, Sushmita Ghoshal, Arnab Pal

“…Objectives: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the leading cancers in developing countries with very high morbidity and mortality. One of the important reasons for the poor outcome is late diagnosis, which is majorly attributed to the non-availability of suitable diagnostic and prognostic biomarkers. …”
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