Spontaneous Uterine Perforation of Pyometra Presenting as Acute Abdomen by Toshihiro Kitai, Kentaro Okuno, Hiromi Ugaki, Yoshiko Komoto, Satoshi Fujimi, Masahiko Takemura

“…Although correct diagnosis, early intervention, and proper treatment can reduce morbidity and mortality of spontaneous perforation of pyometra, if severe infection occurs, this disease can be life threatening for immunocompromised hosts.…”
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Effectiveness of an Innovative Pulsed Electromagnetic Fields Stimulation in Healing of Untreatable Skin Ulcers in the Frail Elderly: Two Case Reports by Fabio Guerriero, Emanuele Botarelli, Gianni Mele, Lorenzo Polo, Daniele Zoncu, Paolo Renati, Carmelo Sgarlata, Marco Rollone, Giovannoi Ricevuti, Niccolò Maurizi, Matthew Francis, Mariangela Rondanelli, Simone Perna, Davide Guido, Piero Mannu

“…Specifically, chronic wounds result in significant morbidity and mortality and have a profound economic impact. …”
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Sensory Disturbance of the Lower Extremity after Sural Artery Flap Elevation by Kaoru Tada, Seigo Suganuma, Mika Nakada, Masashi Matsuta, Atsuro Murai, Hiroyuki Tsuchiya

“…Elevation of the sural artery flap with the sural nerve is associated with donor-site morbidities, such as postoperative sensory disturbance of the lower extremity. …”
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Concealed penis: A review of multilevel classification and surgical reconstruction techniques by Bo‐yu Xiang, Jing‐xuan Peng, Xue‐jun Shang, Xiong‐bing Zu, Dong‐jie Li

“…This condition has significant morbidity and a negative effect on certain aspects of the patient's quality of life, including but not limited to hygiene, micturition, self‐image and sexual function. …”
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Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“… Cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) remains a significant cause of morbidity and mortality. Post-hemorrhage cerebral vasospasm (PHCV) occurs through a complex pathophysiology, and numerous pharmacologic agents, including vasodilators, anti-inflammatories, and fibrinolytics, as well as endovascular techniques have been used to prevent and/or treat PHCV. …”
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Case reports of iatrogenic vascular injury in the trauma field: what is the same and what is different? by Youngwoong Kim, Kyunghak Choi, Seongho Choi, Min Ae Keum, Sungjeep Kim, Kyu-Hyouck Kyoung, Jihoon T Kim, Minsu Noh

“…IVI in trauma patients can be successfully managed, but significant morbidity can occur. If an IVI is suspected, immediate evaluation and management are required.…”
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A comprehensive review of the roles of T-cell immunity in preeclampsia by Xu Peng, Ibeh Chinwe Oluchi-Amaka, Joanne Kwak-Kim, Joanne Kwak-Kim, Xiuhua Yang

“…It is recognized as one of the “Great Obstetrical Syndromes” and principally contributes to maternal morbidity and mortality. PE has been associated with a range of immune disorders, including a preponderance of T helper (Th) 1 over Th2 cells and imbalanced levels of Th17 and T regulatory cells (Tregs). …”
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Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors by Hafiz Muhammad Aslam, Shumaila Muhammad Iqbal, Hira Shaikh, Faizan A. Faizee, Ambreen A. Merchant, Marwan Shaheen, Shahrukh K. Hashmi

“…Numerous reports pertinent to haploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in the morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more feasible and has meaningful implications in the situations where matched donors are infrequent.…”
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Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies by Chau Yee Ng, Chun-Bing Chen, Ming-Ying Wu, Jennifer Wu, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Ya-Ching Chang, Chun-Wei Lu

“…Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). …”
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Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis by Gernot Wagner, Gerald Gartlehner, Kylie Thaler, Dominic Ledinger, Johanna Feyertag, Irma Klerings, KM Saif-Ur-Rahman, Declan Devane, Kate Olsson, Karam Adel Ali, Sabine Vygen-Bonnet, Heini Salo, Dace Zavadska, Marta Grgič Vitek, Marje Oona, Robert Cunney, David Tuerlinckx, Frederikke Kristensen Lomholt, Isolde Sommer

“…Abstract Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccination in children and adults. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…Understanding the mechanism responsible for malaria relapse is paramount for successful treatment and reduction in morbidity and mortality. This case illustrates the importance of considering cytochrome mutations that affect drug efficacy in cases of relapsing malaria.…”
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Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele by Vardine Sahakyan, Enrico Pozzo, Robin Duelen, Jan Deprest, Maurilio Sampaolesi

“…This condition results in serious morbidity and increased mortality after birth. Folic acid significantly reduces, and conversely, folate antagonist methotrexate (MTX) and valproic acid (VPA) increase the occurrence of NTDs, including MMC. …”
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An Unusual Localization of Lunate in a Transcaphoid Volar Lunate Dislocation: Current Concepts by Grigorios Kastanis, George Velivasakis, Anna Pantouvaki, Manolis Spyrantis

“…Untreated or improperly treated, those injuries lead to serious morbidity and loss of function. Therefore, good functional prognosis with decreased percentage of complications can be achieved following early recognition and early open surgical ligamentous complex repair.…”
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Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature by V. Masciullo, S. Mainenti, D. Lorusso, P. A. Margariti, G. Scambia

“…We describe the second case reported of a patient developing a severe C. difficile colitis following chemotherapy without any recent antibiotic use and review the data of the literature, emphasizing the need to a prompt diagnosis and management that can significantly decrease the morbidity and life-threatening complications associated with this infection.…”
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Prematurity-Related Hypertension in Children and Adolescents by Karolina Poplawska, Karolina Dudek, Maja Koziarz, Dominik Cieniawski, Tomasz Drozdz, Sylwester Smialek, Dorota Drozdz, Przemko Kwinta

“…Due to the functional and structural immaturity of different organ systems, preterms have a higher rate of morbidity and mortality. The prevention and treatment of the complications of prematurity is a major challenge in perinatal health care. …”
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Knowledge and attitude factors as determinants of pregnant women’s participation in triple elimination program in North Bali by Sekarini Ni Nyoman Ayu Desy, Yanti Linda, Pratiwi Putu Irma

“…This low coverage, which increases the risk of morbidity and mortality, is the result of misconceptions about immunizations. …”
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Diagnostic, Treatment, and System Challenges in the Management of Recurrent Neuroleptic Malignant Syndrome on a General Medical Service by Karan Verma, Vivek Jayadeva, Raymond Serrano, Karthik Sivashanker

“…Neuroleptic malignant syndrome (NMS), an iatrogenic form of malignant catatonia, carries high morbidity and mortality rates especially in the context of delayed recognition and standard intervention protocol of lorazepam trial. …”
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Quality of Life in Endometrial Cancer Survivors: What Does Obesity Have to Do with It? by Amanda Nickles Fader, Heidi E. Frasure, Karen M. Gil, Nathan A. Berger, Vivian E. von Gruenigen

“…Most women with type I endometrial cancer (EC) are obese, increasing the risk of morbidity and mortality in this population. The study objective was to evaluate the impact of obesity on quality of life (QOL) and general health status in EC survivors with early-stage disease. …”
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Treatment of Habitual Patellar Dislocation in an Adult by Isolated Medial Patellofemoral Ligament Reconstruction by Yoann Bohu, Mathieu Thaunat, Nicolas Lefevre, Shahnaz Klouche, Serge Herman, Yves Catonné

“…Treatment is difficult, and often associated with significant morbidity. A 30-year-old man, construction worker, presented a habitual patellofemoral dislocation which was caused by direct trauma to the knee as a child. …”
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Elevated levels of neutrophils with a pro-inflammatory profile in Turner syndrome across karyotypes by Jesper Just, Lukas Ochsner Reynaud Ridder, Emma Bruun Johannsen, Jens Magnus Bernth Jensen, Mikkel Steen Petersen, Helene Viborg Christensen, Kenneth Kjærgaard, Jacob Redder, Simon Chang, Kirstine Stochholm, Anne Skakkebæk, Claus Højbjerg Gravholt

“…Abstract Turner syndrome (TS) presents with multiple karyotypes, including 45,X monosomy and variants such as isochromosomes and mosaicism, and is characterized by several co-morbidities, including metabolic conditions and autoimmunity. …”
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