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Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy
Published 2025-02-01“…Among the promising new treatments are: blood-brain barrier (BBB)-penetrable enzyme replacement therapy (ERT), substrate reduction therapy, nonsense suppression therapy, and mRNA engineering. However, the most advanced treatments, that are currently under investigation are in-vivo and ex-vivo gene therapy. …”
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1663
Perceptions and reflections of embryo donation recipients: a qualitative follow-up study
Published 2025-01-01“…As respondents identified largely as Christian/Catholic, further studies are warranted to assess the perceptions of a more diverse and generalisable population of recipients and children born via embryo donation.…”
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Fabrication of Cu: ZnO thin film sensor for ethanol vapor detection
Published 2025-01-01“… For a long time, metal oxide semiconductor (MOS) based gas sensors have been widely used in domestic, commercial, and industrial sectors to detect harmful gases. …”
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1665
Outcomes following immunosuppressive therapy withdrawal after complete renal response in proliferative lupus nephritis
Published 2025-01-01“…In contrast, an IST duration exceeding 48 months prior to discontinuation (HR: 0.26), maintaining CRR for at least 48 months (HR: 0.32), achieving complete remission per DORIS (definition of remission in systemic lupus erythematosus) criteria at IST withdrawal (HR: 0.21) and gradual IST tapering (HR: 0.09) were associated with a reduced risk of RR.Following reintroduction of IST, 20 out of 29 patients (68.9%) achieved CRR, 5 (17.2%) achieved a partial response and 4 (13.8%) did not respond; of these, 3 patients (10.3%) progressed to end-stage renal disease.Conclusions Successful withdrawal of IST is possible in carefully selected patients with proliferative LN. If an RR occurs, most patients are able to remain in remission after resuming IST.…”
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Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach
Published 2021-01-01“…Although, recently, vaccines have been approved for the prevention of COVID-19, there is still an urgent need for the discovery of more efficacious and safer drugs especially from natural sources. …”
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Biological effectiveness of combined exposure to neutrons and gamma radiation applied in two orders of sequence: Relevance for biological dosimetry after nuclear emergencies
Published 2025-02-01“…Methods: Whole blood from 3 human donors was exposed to neutrons with an energy spectrum similar to that of the Hiroshima uranium bomb, to gamma radiation from a 60Co source and to a 50:50 combination of both radiations, given in two orders of sequence. …”
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Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient
Published 2016-01-01“…Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. …”
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Immunodeficiency, Centromeric Instability, and Facial Dysmorphism (ICF) Syndrome: How HSCT alters the impairment of the DNA methylation process
Published 2025-02-01“…Advances in molecular biology and genetics enabled insights into the DNA methylation machinery, which allowed us to gain a more precise understanding of the pathogenesis of ICF and also opened up opportunities for the development of new therapeutic options. …”
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Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache
Published 2025-02-01“…Obvious CSF dynamics disturbances were excluded in the remaining 29 patients (76.3%, mean of the median 24-hour ICP 3 mmHg ± 3SD). The only clinical feature that was more common in patients with abnormal ICP compared to patients with normal ICP results was audiovestibular disturbance, namely aural fullness or muffled hearing (67% versus 17%, p = 0.015). …”
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Results of work of the maternal child program. University Pediatric Hospital of Cienfuegos, 2021
Published 2022-07-01“…Hospital mortality increases by six more deaths compared to 2020, responding to the main cause of emergency care followed by Sepsis. …”
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Bacterial, fungal and parasitic co-infections in leprosy: A scoping review.
Published 2023-05-01“…<h4>Background</h4>In leprosy patients, the most commonly reported non-viral co-infections are Tuberculosis, Leishmaniasis, Chromoblastomycosis and Helminths. …”
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Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration
Published 2020-01-01Get full text
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Fabrication of Cu: ZnO thin film sensor for ethanol vapor detection
Published 2025-01-01“… For a long time, metal oxide semiconductor (MOS) based gas sensors have been widely used in domestic, commercial, and industrial sectors to detect harmful gases. …”
Get full text
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Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome
Published 2021-01-01Get full text
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Decentralized Identity Management for Internet of Things (IoT) Devices Using IOTA Blockchain Technology
Published 2025-01-01Subjects: Get full text
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Advanced Copper Oxide Chemical and Green Synthesis: Characterization and Antibacterial Evaluation
Published 2024-12-01Get full text
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Niños y adolescentes con enfermedades raras atendidos en consulta provincial de nutrición
Published 2019-02-01“…Los pacientes con las formas severas de desnutrición presentan una mayor expresividad de la sintomatología. …”
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