GENOME POLITICS: STRATEGY AND TACTICS by Jonas Rubikas

“…The accuracy of these three-step processes is under the end-product selection control. For better realization of information in some cases the genome changes the usual way of expression, that is, the genome uses some tactical approaches: at the DNA level - restructuring of the genome (mating type in yeasts, sex determination in some flies and worms, V(D)J recombination in immunoglobulin genes in human B lymphocytes); at the RNA level - gene splicing, alternative and self splicing, RNA editing; at the protein level - protein splicing. …”
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Effect of Liquid Marble 3D Culture System on In Vitro Maturation and Embryo Development of Prepubertal Goat Oocytes by Andrea Podda, Linda Dujíčková, Federica Ariu, Giovanni Giuseppe Leoni, Dolors Izquierdo, Maria-Teresa Paramio, Luisa Bogliolo

“…After IVM, oocytes were parthenogenetically activated and cultured until the blastocyst stage. …”
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Covariation Between Microbiome Composition and Host Transcriptome in the Gut of Wild Drosophila melanogaster: A Re‐Analysis by Frances Llanwarne, Adam J. Dobson

“…Previous work in wild male D. melanogaster guts analysed paired measurements of (A) bacterial diversity and abundance, measured by 16S amplicon sequencing; and (B) the host gut transcriptome, but no signature of covariation was detected. Here, we re‐analyse those data comprehensively. We find orthogonal axes of microbial genera, which correspond to differential expression of host genes. …”
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Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway by Zhenming Tian, Han‐Jian Hu, Chun Cheung Chan, Tian Hu, Chaoyang Cai, Hong Li, Limin Rong, Gang‐Biao Jiang, Bin Liu

“…Abstract In the realm of neural regeneration post‐spinal cord injury, hydrogel scaffolds carrying induced neural stem cells (iNSCs) have demonstrated significant potential. However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. …”
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Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control by Yun Gao, Xiushan Yin, Xiaomeng Ren

“…They alleviate liver diseases by differentiating to hepatocyte-like cells, immunomodulation, homing to the injured site, regulating cell ferroptosis, regulating cell autophagy, paracrine effects, and MSC-mitochondrial transfer. In this review, we focus on the main resources of MSCs, underlying therapeutic mechanisms, clinical applications, and efforts made to improve MSC-based cell therapy efficiency.…”
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Iron metabolism in rheumatic diseases by Aliakbar Givian, Amin Azizan, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi

“…Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. …”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…Methods: Steatotic liver samples from human and Western diet (WD)-fed mice were employed for detecting Kcr levels. Mitochondrial function and mitochondria-ER interaction (MAM) relevant to ALR-Kcr modification was evaluated for hepatocyte lipid metabolism both in in vivo and in vitro experiments. …”
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Determination of genetic diversity between natural and cultured populations of Common Dentex (Dentex dentex) fish in the East Aegean Sea by Kayaci Ali, Can Mehmet Fatih, Güner Yusuf, Güleç Fatih

“…The mitochondrial Cytochrome Oxidase I (COI) gene was used to detect a total of 26 haplotypes. …”
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Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury by Beibei Wang, Jinsheng Zhang, Aijun Xu

“…In this study, we designed and synthesized siRNA sequences knocking down the rat Ndufs4 gene, constructed recombinant adenovirus Ndufs4 siRNA (Ad-Ndufs4 siRNA), and primarily verified the role of Ndufs4 in oxidative stress injury. …”
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Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness by DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong

“…Tenderness is one of the most important indicators to judge meat quality, and it is also the most important sensory index for consumers to choose meat. …”
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Comprehensive Analysis of the Proteome of <i>S. cerevisiae</i> Wild-Type and <i>pdr</i>5Δ Cells in Response to Bisphenol A (BPA) Exposure by Valentina Rossio, Joao A. Paulo

“…Proteomic analysis revealed that BPA induces widespread dose-dependent changes in protein abundance, including the upregulation of metabolic pathways such as arginine biosynthesis and the downregulation of mitochondrial proteins. Additionally, we observed markers of cellular stress induced by BPA by identifying multiple stress-induced proteins that were upregulated by this compound. …”
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Molecular architecture of the altered cortical complexity in autism by Makliya Mamat, Yiyong Chen, Wenwen Shen, Lin Li

“…Using fractal dimension as an index for quantifying cortical complexity, we identified significant regional alterations in ASD, within the left temporoparietal, left peripheral visual, right central visual, left somatomotor (including the insula), and left ventral attention networks. …”
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Recent results of molecularphylogenetic studies of endemic invertebrates inhabiting Lake Baikal by D. Yu. Sherbakov, M. V. Kovalenkova, O. O. Maikova

“…Another interesting feature is a practically absolute absence of evidence for co-evolution even of ecologically tightly connected organisms.…”
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The potential impact of glycine supplementation on the process of aging by Michalina Wójcikiewicz, Julia Kulbacka, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia-Ileczko, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“… Aging is a multifactorial process characterized by the progressive loss of cellular integrity, metabolic flexibility, mitochondrial function, and the gradual accumulation of oxidative and inflammatory damage. …”
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Perfluorooctanoic acid induces abnormal heart development via aryl hydrocarbon receptor-mediated oxidative stress and apoptosis in zebrafish larvae by Xueyi CHEN, Tianchi MA, Kang WANG, Tao CHEN, Yan JIANG

“…Total RNA was extracted from dissected hearts, and mRNA expression levels of oxidative stress-related genes (sod2, cat) and apoptosis-related gene (p53) were analyzed using quantitative PCR. …”
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Relatedness of White-Tailed Deer from Culling Efforts Within Chronic Wasting Disease Management Zones in Minnesota by Alberto Fameli, Christopher Jennelle, Jessie Edson, Erik Hildebrand, Michelle Carstensen, W. David Walter

“…We did not find evidence of genetic structure, suggesting that an outbreak in any of the management zones could naturally spread to the others. …”
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T-2 toxin induces senescence in human neuroblastoma SH-SY5Y cells by regulating the HIF-1α/p53/p21 pathway by Yating Wang, Xu Wang, Qinghua Wu

“…T-2 toxin rapidly triggered the expression of senescence-associated β-galactosidase, disrupted mitochondrial function, and altered the levels of Alzheimer’s disease-associated proteins (Tau, p-Tau, and APP). …”
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The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection by Xu Wang, Xu Wang, Xu Wang, Chunshu Rong, Ping Niu, Wei Leng, Gaihua Wang, Ziqiao He, Xin Qi, Dexi Zhao, Dexi Zhao, Jinhua Li

“…However, the role and mechanism of IAA neurotoxicity remain unclear. In this review, we comprehensively discuss the neurotoxic effects and mechanisms of IAA from the molecular level, cellular level and neurological manifestations. …”
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Clonorchis sinensis and Echinostoma hortense detected by endoscopy and molecular characterization: two case reports and update on diagnosis by Lijia Wen, Benhe Wang, Hui Zhang

“…To confirm the species, we designed primers targeting the ribosomal ITS (internal transcribed spacer) and mitochondrial COX-1 (cyclooxygenase-1) genes, followed by PCR amplification and sequencing. …”
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Earthworm (Oligochaeta, Lumbricidae) intraspecific genetic variation and polyploidy by S. V. Shekhovtsov, Ye. A. Derzhinsky, E. V. Golovanova

“…Vsevolodova-Perel and T.V. Malinina. The key to such a complex picture is probably the plasticity of reproductive modes in earthworms, which encompass diverse modes of sexual and asexual reproduction; also, it has been demonstrated that even high-ploidy forms can retain amphimixis.…”
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