Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells by Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

“…Gene expression pathway analysis using spatial transcriptomics also revealed the possibility of improving senescent cell-derived inflammation via mitochondrial function. …”
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Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine by Juliana Escher Toller-Kawahisa, Paula Ramos Viacava, Eva Margareta Palsson-McDermott, Daniele Carvalho Nascimento, Mariana Patricia Cervantes-Silva, Shane Myles O'Carroll, Alessia Zotta, Luis Eduardo Alves Damasceno, Gabriel Azevedo Públio, Pedro Forti, João Paulo Mesquita Luiz, Bruno Marcel Silva de Melo, Timna Varela Martins, Vitor Marcel Faça, Annie Curtis, Thiago Mattar Cunha, Fernando de Queiroz Cunha, Luke Anthony John O'Neill, José Carlos Alves-Filho

“…The tetramerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) induces the production of the anti-inflammatory cytokine interleukin (IL)-10 in vivo, but the underlying mechanism remains elusive. Here, we report that PKM2 activation with the pharmacological agent TEPP-46 increases IL-10 production in LPS-activated macrophages by metabolic reprogramming, leading to the production and release of ATP from glycolysis. …”
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DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer by Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kaihong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao-Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Tao Liu, Mark A. Baker, Rick F. Thorne, Xu Dong Zhang, Lei Jin

“…Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. …”
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PGC-1α activation to enhance macrophage immune function in mycobacterial infections. by Joel R Frandsen, Zhihong Yuan, Brahmchetna Bedi, Zohra Prasla, Seoung-Ryoung Choi, Prabagaran Narayanasamy, Ruxana T Sadikot

“…Their incidence and prevalence are rising worldwide, due in part to elevated antimicrobial resistance which complicates treatment and potential successful outcomes. …”
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DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging by Ricardo Gredilla

“…The results reviewed here support that mitochondrial DNA damage plays an important role in aging.…”
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Skeletal Muscle Mitochondria and Aging: A Review by Courtney M. Peterson, Darcy L. Johannsen, Eric Ravussin

“…These changes may in turn alter mitochondrial dynamics, such as fusion and fission rates, and mitochondrially induced apoptosis, which may also lead to net muscle fiber loss and age-related sarcopenia. …”
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Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. by Michael O Isei, Meredith Crockett, Emily Chen, Joel Rodwell-Bullock, Trae Carroll, Peter A Girardi, Keith Nehrke, Gail V W Johnson

“…Specifically, we show that phosphomimetic tau at Ser-396/404 (EC) or Thr-231/Ser-235 (EM) partly inhibits mitophagy induction by paraquat, a potent inducer of mitochondrial oxidative stress. …”
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Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury. by Peter Jung, Euntaik Ha, Meijuan Zhang, Carolyn Fall, Mindy Hwang, Emily Taylor, Samuel Stetkevich, Aditi Bhanot, Christopher G Wilson, Johnny D Figueroa, Andre Obenaus, Shannon Bragg, Beatriz Tone, Saburi Eliamani, Barbara Holshouser, Arlin B Blood, Taiming Liu

“…NO reacted with complex IV at the heme a3 site, decreased the oxidative stress of mitochondria challenged with anoxia and reoxygenation, and suppressed mitochondrial oxygen respiration.…”
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Evolutionary history and phylogeographic relationships of shrews from Sorex araneus group. by Paweł Mackiewicz, Magdalena Moska, Heliodor Wierzbicki, Przemysław Gagat, Dorota Mackiewicz

“…The results were compared with phylogenies based on chromosomal rearrangement data and put into temporal and spatial context using molecular dating and historical biogeography methods. …”
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Loss of Mfn1 but not Mfn2 enhances adipogenesis. by Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Liang Dong, Afreen Haider, Koini Lim, Panna Tandon, Fabio Scurria, James E N Minchin, Stephen O'Rahilly S, Daniel J Fazakerley, Julien Prudent, Robert K Semple, David B Savage

“…<h4>Methods</h4>We characterised adipocyte differentiation of wildtype (WT), Mfn1-/- and Mfn2-/- mouse embryonic fibroblasts (MEFs) and 3T3-L1 preadipocytes in which Mfn1 or 2 levels were reduced using siRNA.…”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. …”
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Defects in skeletal muscle subsarcolemmal mitochondria in a non-obese model of type 2 diabetes mellitus. by Nicola Lai, China Kummitha, Charles Hoppel

“…Contrary to popular belief, these data provide compelling evidence that mitochondrial function is unaffected in insulin-resistant skeletal muscle from T2DM non-obese rats.…”
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IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging by Jean-Paul Decuypere, Giovanni Monaco, Ludwig Missiaen, Humbert De Smedt, Jan B. Parys, Geert Bultynck

“…Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics and homeostasis through binding and modulation of the intracellular Ca2+-release and Ca2+-uptake mechanisms. During aging, oxidative stress becomes an additional factor that affects ER and mitochondrial function and thus their role in Ca2+ signaling. …”
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Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection-A scoping review. by Janelle Y Wai, Eilidh M Wood, Kylie K Hornaday, Donna M Slater

“…<h4>Results</h4>Twenty-seven studies reporting on molecular and/or cellular mechanisms of SARS-CoV-2 mediated placental outcomes were included in this review. …”
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SAHA inhibits lung fibroblast activation by increasing p66Shc expression epigenetically by Yiheng Dong, Jieting Peng, Xiangyu Zhang, Qiong Wang, Xing Lyu

“…Furthermore, chromatin immunoprecipitation (ChIP) assays demonstrated that SAHA enhanced active histone markers, H3K9Ac and H3K4Me3, in the p66Shc gene region. Conclusions SAHA alleviates lung fibroblast activation and migration by increasing p66Shc expression and mitochondrial ROS generation through epigenetic modifications of histone 3.…”
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Mitochondria and Ageing by Christiaan Leeuwenburgh, Reinald Pamplona, Alberto Sanz

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Comparative bioacoustics of multiple eastern versus western songbird pairs in North America reveals a gradient of song divergence. by Lan-Nhi Phung, David P L Toews

“…We found that there were strong differences in the songs between eastern and western taxa, though the magnitude of that difference was not correlated to a mitochondrial DNA-based estimates of divergence. …”
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Incidence of endosymbiont bacteria Wolbachia in cowpea weevil Callosobruchus maculatus Fabricius (Coleoptera, Chrysomelidae). by Bilal Rasool, Tahira Younis, Saba Zafar, Aqsa Parvaiz, Zeeshan Javed, Inshaal Rasool, Muhammad Shakeel

“…Phylogenetic analysis utilized mitochondrial COI and 12S rRNA genes to identify the host C. maculatus, while screening for Wolbachia was conducted using genes (wsp, coxA, and ftsZ) genes. …”
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Transformation of sperm structure in Octopus vulgaris: From spermatogenesis to spermatophoric release. by Hyeon Jin Kim, Jung Jun Park, Jung Sick Lee

“…The tail is divided into three parts: the mid-piece, principal-piece, and end-piece. The mid-piece forms a mitochondrial sheath with 7-8 mitochondria surrounding a "9+2" axoneme. …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…We investigated whether GV1001 could counteract doxorubicin-induced EndMT in endothelial cells and prevent atherosclerosis in a mouse model. …”
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