LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis by Yihan Liu, Yuhua Wang, Long Cui, Runze Li, Dan Xiao, Dan Xiao

“…Mechanistically, OIP5-AS1 functioned as a molecular sponge for miR-429, regulating DOCK4 expression. Overexpression of miR-429 or knockdown of DOCK4 reversed the effects of OIP5-AS1 on macrophage polarization markers and restored macrophage migration.Conclusion:OIP5-AS1 modulates macrophage polarization through the miR-429/DOCK4 axis and inhibits LUAD cell progression. …”
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Cullin-3 and Regulatory Biomolecules Profiling in Vitiligo: Integrated Docking, Clinical, and In Silico Insights by Hidi A. A. Abdellatif, Mohamed Azab, Eman Hassan El-Sayed, Rwan M. M. M. Halim, Ahmad J. Milebary, Dhaifallah A. Alenizi, Manal S. Fawzy, Noha M. Abd El-Fadeal

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Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells by Ke-Ke Zhang, Meng Li, Yan-Hong Liao, Xiao-Tian Liu, Yong-Bo Bao, Yan Gong

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Evaluating ginkgetin from Ginkgo biloba as a novel agent for sleep promotion through molecular docking and in vivostudies by Mir Behrad Aghazadeh Ghadim, Ebrahim Salimi-Sabour, Alireza Shahriari, Mahdi Niazi, Farideh Bahrami

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Exploring the mechanism of proteinuria reduction by hydroxychloroquine in IgA nephropathy using network pharmacology and molecular mocking by Meiqi Lu, Yuxin Wang, Zheng Wan, Yixuan Chen, Mengshu Lin, Xiaoqi Deng, Xiaoxia Su, Qing Gao

“…HCQ targeted miR-130b-3p, thereby influencing the TLR/MyD88/NF-κB signaling pathway and modulating the expression of MMP2, IGF1, and PPARG. …”
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ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway by Mulin Liu, Jingyang Zhang, Siqi Zhu, Wenjun Jiang, Yu Yan, Qin Zheng, Shijun Li

“…Moreover, ALG3 was identified as a novel target of miR-142-5p. Four potential small molecule inhibitors of ALG3 were identified, with selumetinib emerging as a promising candidate. …”
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Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells by Zheng Wang, Mengqin Yuan, Lichao Yao, Zhiyu Xiong, Kai Dai, Pingji Liu, Ping Chen, Muhua Sun, Kan Shu, Yuchen Xia, Yingan Jiang

“…Furthermore, molecular docking simulations further identified optimal ETS1-GPX4 binding sites. …”
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Molecular mechanisms of acquired idiopathic generalized anhidrosis: differential gene expression and potential therapeutic targets by Sanjukta Dasgupta

“…Through the Drug Gene Interaction Database (DGIdb), ciprofibrate is identified as a potential therapeutic agent targeting the JUN gene. Molecular docking confirmed a strong binding affinity between ciprofibrate and JUN, suggesting ciprofibrate could modulate JUN activity and regulate AIGA symptoms. …”
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Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceu... by Hui Zang, Liuyan Wang, Yang Wu, Junfei Chang, Wanjun Liu

“…In addition, the mechanism of these hub genes was investigated through enrichment analysis, immune microenvironment analysis, regulatory network construction, and molecular docking. Results Ultimately, 1,430 DEGs, 4,577 key module genes, and 486 target genes of AM were intersected to derive 28 candidate genes. …”
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Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid by Chuan Wang, Chaode Cen, Huachuan Su, Yuhui Peng, Tao Wang, Jian Li, Fei Zhang, Wuxun Peng

“…Finally, it was verified that retinoic acid improved ONFH by hsa-miR-320a/GLB1 in vitro and in vivo. This study identifies CREBBP, GLB1, and PSAP as promising biomarkers for ONFH while underscoring their potential roles in lipid metabolism and immune modulation. …”
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Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis by Juledezi Hailati, Zhiqiang Liu, Lei Zhang, Muhuyati Wulasihan

“…Finally, we also found that PDCD4 dysregulation in cancers like ACC may increase AF risk through immune modulation, suggesting that targeting PDCD4 could benefit both AF and ACC patients.ConclusionsThis study demonstrates that PDCD4 modulates AF progression by regulating key genes and pathways involved in inflammation, fibrosis, and metabolic processes. …”
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