MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of... by Andrew Clegg, James Wason, Miles Witham, Nina Wilson, Claire J Steves, Helen C Hancock, Avan A P Sayer, Leanne Marsay, Claire McDonald, Thomas von Zglinicki, Katherine J Rennie, Penny Bradley, Stephen Connolly, Shaun Hiu, Laura Robertson, Laura Simms, Alison J Steel, Bryony Storey

“…Randomisation will be performed using a web-based minimisation system with a random element, balancing on sex and baseline walk speed. …”
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Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Structural and social barriers should be minimised to ensure healthcare provision for those affected. …”
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A comparative study between condensed polytetrafluoroethylene mesh versus other composite meshes in Endo-laparoscopic ventral herniorrhaphy by Meredeth Chin, James Lee Wai Kit, Sujith Wijerathne, Avelyn Aw, Daryl Chia Kai Ann, Sean Lee Kien Fatt, Tharun Ragupathi, Harry Ng Ho Man, Davide Lomanto

“…In intra-peritoneal onlay method (IPOM) a dual layer composite mesh with an absorbable barrier on the visceral surface is used for minimising bowel adhesions. Three most popular prosthetic mesh scaffolds are polypropylene (PP), polyester and expanded polytetrafluoroethylene (ePTFE). …”
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Contribution à l’analyse de la viabilité d’une petite population de gorilles, Gorilla beringei graueri (Hominidae, Primates), par modélisation et simulations de l’écosystème du Mon... by Jean‑Claude Kasolene Kyungu, Jean Mukulire Malekani, Lohandjola Nyamangombe

“…Ces résultats indiquent combien il est important et urgent de renforcer les mesures de stabilisation de cette petite population par le repeuplement de la forêt avec quelques nouvelles femelles afin de minimiser les risques d’extinction.…”
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Comparative analysis of techno-economic and techno-environmental approach to optimal sizing and dispatch of hybrid solar–battery systems by Luka Smajila, Silvia Trevisan, Farzin Golzar, Ketan Vaidya, Rafael Guedez

“…The research uses mixed-integer linear programming (MILP) to optimise the dispatch strategy, minimising both operational costs and CO2eq emissions. …”
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A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…Gene therapy should be presented as one of a range of treatment options; understanding its risks, uncertainties and benefits is key to managing expectations and minimising treatment remorse. Awareness of how different factor levels impact bleeding tendency and frequency would be helpful, as success of gene therapy cannot be determined by factor activity alone. …”
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Assessment in education: Current trends, problems and contradictions (review of scientific publications) by I. B. Shmigirilova, A. S. Rvanova, O. V. Grigorenko

“…An analysis of the pros and cons of international experience in the field of educational assessment can help scientists and practising teachers gain a more objective view of new approaches to the assessment of student learning outcomes, thereby contributing to the minimisation of the manifestation of possible risks in the development of assessment tools and procedures and their implementation in educational practice.…”
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Stiffness characteristics of the lower extremities in Women’s Chinese Basketball Association competition athletes: normative values and position differences by Dan Wang, Zhihai Wang, Mingming Yang, Kaiyuan Qu, Xinyu Mao, Xin Yang, Zhiye Zhang, Che Shao, Eamonn Delahunt, Eamonn Delahunt, Wenxuan Fang

“…Thus, there might be an ‘optimal’ stiffness value or range that allows for maximising athletic performance while simultaneously minimising risk of sports injury. Basketball players can be classified by position as centres, guards and forwards, with each position characterised by specific injury risks and exercise patterns. …”
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NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…Analysis in both phases will be using multilevel logistic regression incorporating random effects with respect to surgeon and adjusting for minimisation factors. Phase III secondary outcomes include protracted hypoparathyroidism, hypercalcaemia, complications, length of stay, readmissions and patient reported quality of life using the Short Form 36 Health Survey Questionnaire and Hypoparathyroid Patient Questionnaire instruments.Ethics and dissemination NIFTy is funded by National Institute for Health and Care Research Efficacy and Mechanism Evaluation Programme (Grant Ref: 17/11/27) and approved by a Research Ethics Committee (reference: 21/WA/0375) and Health Research Authority (HRA). …”
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Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…Enhanced Recovery After Surgery (ERAS) guidelines include the following patient-managed recommendations: early mobilisation, early eating and drinking, opioid minimisation and physiotherapy exercises. Low adherence rates to these recommendations suggest that patients need support to do these things. …”
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Safeguarding in Sport: The Performative Compliance of International Sports Federations by Carole Gomez, Lucie Schoch

“… Introduction For decades, cases of sexual abuse and harassment of athletes have been ignored or minimised due to silence, collusion, fear of reputational damage and ignorance (Mountjoy, 2016). …”
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Les Jeunes Tunisiens, une contre-expérience de la minoration ? Politisation des langues dans la presse francophone en Tunisie coloniale (1907-1912) by Sarra Zaïed

“…In addition, the Young Tunisians tried to escape the status of minimisation acquired during the establishment of the protectorate, and to reactivate a symbolic place in their speeches in the press. …”
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The Superiority of Removable Contact Splints in the Healing of Diabetic Foot during Postoperative Care by Vladimíra Fejfarová, Jaroslav Pavlů, Robert Bém, Veronika Wosková, Michal Dubský, Andrea Němcová, Alexandra Jirkovská, Bedřich Sixta, Karol Sutoris, Filip Thieme, David G. Armstrong, Eliška Vrátná, Jitka Hazdrová, Věra Lánská

“…This observational study suggests that removable contact splint combined with a wheelchair is better than a wheelchair with or without removable off-loading device for accelerating wound healing after surgical procedures; it also minimises overall postoperative complications, reducing the number of reamputations by up to 77% and the number of rehospitalizations by up to 66%.…”
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Robotic Surgery from a Gynaecological Oncology Perspective: A Global Gynaecological Oncology Surgical Outcomes Collaborative Led Study (GO SOAR3) by Faiza Gaba, Karen Ash, Oleg Blyuss, Dhivya Chandrasekaran, Marielle Nobbenhuis, Thomas Ind, Elly Brockbank, on behalf of the GO SOAR Collaborators

“…Conclusions: Whilst robotic surgery is considered a landmark innovation in surgery, it must be responsibly implemented through effective training and waste minimisation, which must be a key metric in measuring the success of robotic programmes.…”
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Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China by Linan Zeng, Lingli Zhang, Dan Yu, Huiqing Wang, Liang Huang, Siyu Li, Guo Cheng, Zhi-Jun Jia

“…Logistic regression results showed that PIP was more likely to occur in male patients (OR 1.128, 95% CI 1.059 to 1.202) and younger patients (<2 years old; OR 1.974; 95% CI 1.739 to 2.241), and in those with more comorbidities (≥11 types; OR 4.181; 95% CI 3.671 to 4.761), concomitant drugs (≥11 types; OR 22.250; 95% CI 14.468 to 34.223) or longer hospital stay (≥30 days; OR 8.130; 95% CI 6.727 to 9.827).Conclusions Medications for long-term hospitalised young children with multiple comorbidities should be minimised and optimised, to avoid PIP, reduce adverse drug reactions and ensure children’s medication safety. …”
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Utilisation des Anti-Inflammatoires Non Stéroïdiens chez les personnes âgées en rhumatologie au CHR-Tsévié (Togo) by VES Koffi-Tessio, E Fianyo, ML Diallo, S Oniankitan, A Adjolou, KC Tagbor, KA Nouvedji, M Ngakui, A Tsowou, C Deghela, K Kakpovi, P Houzou, O Oniankitan, M Mijiyawa

“…Les prescriptions d’AINS chez cette population doivent répondre à leurs besoins spécifiques tout en améliorant non seulement les résultats thérapeutiques mais, surtout, minimisant le risque iatrogène. …”
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Engagement féminin en Kabylie et intersection des revendications (1980-2001). Dominations, expériences et négociations identitaires by Margherita Rasulo

“…As subalterns within a minority group, the representatives of this movement are confronted by various processes of minimisation. Kabylia is a Berber-speaking region characterised by the tension between the perpetuation and renegotiation of social and symbolic structures. …”
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Recommendations for the diagnosis and treatment of anti-neutrophil cytoplasmic autoantibody associated vasculitis by Enrique Morales, Iñigo Rúa-Figueroa, José Luis Callejas Rubio, Ana Ávila Bernabéu, Ricardo Blanco Alonso, María C. Cid Xutgla, Gema Fernández Juárez, Natalia Mena-Vázquez, Juan José Ríos Blanco, Joaquín Manrique Escola, F. Javier Narváez García, Bernardo Sopeña, Luis F. Quintana Porras, Susana Romero-Yuste, Roser Solans Laqué

“…In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects.This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. …”
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Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…These actions highlight the importance of timely decision-making and coordinated family preparedness in minimising the effects of floods. ● Most respondents emphasized that the greatest contribution of early warning measures is in reducing human deaths and injuries, followed by reducing effects on livestock and easily movable household assets. …”
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ADMINISTRATIVE PREREQUISITES FOR FINANCIAL MANAGEMENT AND MARKETING OF SMALL BUSINESSES AT THE REGIONAL LEVEL by Natalia Koval, Oksana Kubai, Natalia Germaniuk

“…The likelihood of making mistakes must be minimised, as the consequences can have a significant impact on the company's financial health. …”
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