An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

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Applied machine learning for predicting the properties and carbon and phosphorus fate of pristine and engineered hydrochar by Shiyu Xie, Tao Zhang, Siming You, Santanu Mukherjee, Mingjun Pu, Qing Chen, Yaosheng Wang, Esmat F. Ali, Hamada Abdelrahman, Jörg Rinklebe, Sang Soo Lee, Sabry M. Shaheen

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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

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Study on optimization of extraction and purification processes for total flavonoids from Lycopi herba roots and their anti-proliferative effects on fibrous synoviocytes in human rh... by Jie Chen, Chunyang Jiang, Zhenyu Liu, Panpan Wang, Qiang Ma, Nong Zhou

“…Lycopi herba, a traditional Chinese medicinal plant, has long been valued for its aerial parts. however, its roots, which are often discarded as non-medicinal waste, actually contain flavonoid compounds that possess potential medicinal values such as anti-inflammatory, antioxidant, and anti-tumor activities. …”
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Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment by Yaling Dai, Yuhao Zhang, Minguang Yang, Huawei Lin, Yulu Liu, Wenshan Xu, Yanyi Ding, Jing Tao, Weilin Liu

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Application of Anchoring Technique in Unilateral Percutaneous Vertebroplasty for Neurologically Intact Kümmell’s Disease by Rongqing Qin, Xing Zhang, Hongpeng Liu, Bing Zhou, Pin Zhou, Chuanliang Hu

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Clinical Outcome of Achilles Tendon Rupture Repaired by a Modified Minimally Invasive Percutaneous Suturing by Qi X, Zheng D, Lei Z, Yu J, Qiu X, Chen Y

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Bupivacaine–fentanyl isobaric spinal anesthesia reduces the risk of ICU admission in elderly patients undergoing lower limb orthopedic surgery by Wenxun Liu, Shuzhen Bao, Jiaxin Chen, Yan Li, Yinghua Gu, Qingshan Ye, Kerong Hai

“…Trial registration: This study has been registered in the Chinese Clinical Trial Registry (ChiCTR2000033411).…”
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Ultrasound-Assisted Enzymatic Extraction of the Active Components from <i>Acanthopanax sessiliflorus</i> Stem and Bioactivity Comparison with <i>Acanthopanax senticosus</i> by Qiaomu You, Yanjun Ren, Jiaotong Li, Guangnian Zeng, Xiongfei Luo, Chunying Zheng, Zhonghua Tang

“…<i>Acanthopanax senticosus</i> (ASC) contains a variety of bioactive compounds and serves as an important traditional Chinese medicinal resource. However, its prolonged growth cycle and reliance on wild populations limit its practical use. …”
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Optimization of Enzymatic Hydrolysis Process, Structural Characterization and Antioxidant Activity Analysis of Gastrodia elata Polysaccharide by Yunfei HU, De ZHOU, Qinglan ZENG, Jinsong HE, Ming ZHAO, Qingyan TANG

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Effect of French Press Brewing on the Sensory Quality of Robusta Coffee Produced in Hainan by LIU Di, LAO Fei, DONG Wenjiang, YU Xinxin

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On the ionospheric response in the Taiwan region to Typhoon Meranti in September 2016 by Peng Chen, Mingzhu Xiong, Yibin Yao, Hao Chen, Fucai Tang, Liangcai Qiu, Yuchen Zhang

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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

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Retrospective study on the effect of adding heparin sodium saline at different time points on improving severe coagulation in dialyzers (不同时间点追加肝素钠盐水对透析器重度凝血改善作用的回顾性研究)... by LI Linyang (李林洋), WANG Xinhui (王新慧), LI Hao (李昊), HUANG Yanping (黄砚萍), YU Renhuan (余仁欢)

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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

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Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute hypoxemic respiratory failure: A prospective p... by Jingjing Wang, Changxing Chen, Zhanqi Zhao, Puyu Deng, Chenchen Zhang, Yu Zhang, Hui Lv, Daonan Chen, Hui Xie, Ruilan Wang

“…Electrical impedance tomography (EIT) measurements including center of ventilation (COV), global inhomogeneity (GI) index, and regional ventilation delay (RVD) index were performed in the supine position (T0), 30 min after the start of APP (T1), and 30 min returning to supine position after the APP (T2). …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…In the fully adjusted model, overall participants with eGFR <60 compared with those >90 mL/min/1.73 m2 were at significantly increased risk of dementia (HR, 95% CI: 1.73, 1.21-2.45). …”
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Development and Evaluation of a Hypertension Prediction Model for Community-Based Screening of Sleep-Disordered Breathing by Feng T, Shan G, Hu Y, He H, Pei G, Zhou R, Ou Q

“…Data collection included demographic information, clinical indicators, and results from type IV sleep monitors, which recorded oxygen desaturation index (ODI), average nocturnal oxygen saturation (MeanSpO2), and lowest recorded oxygen saturation (MinSpO2). Hypertension was diagnosed using blood pressure monitoring or self-reported antihypertensive medication use. …”
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The effect of Tai Chi on plasma homocysteine in 1176 adults: a propensity score matching-based study by Yingchun Gu, Juncai Bai, Yang Li, Ling Han, Dongwei Wang

“…In the Tai Chi group, the type of exercise was 24 simplified forms of Tai Chi, at least 3 times/week for 30–60 min/ time. The median duration of practice for Tai Chi group was 26.5 (11,41) years. …”
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