Staging model for amyotrophic lateral sclerosis in Singapore by Yuan Teck Tay, Josiah YH Chai, Kamilah Bte Shekh Jabin, Kexin Ang

“…In this retrospective cohort study, clinical milestones used for staging were identical to King’s staging: stage 1 corresponded to symptom onset; stage 2A corresponded to diagnosis; stage 2B corresponded to two central nervous system (CNS) regions; stage 3B corresponded to three CNS regions; stage 4A corresponded to requirement of supportive enteric feeding; and stage 4B corresponded to requirement of non-invasive ventilation, of which bulbar, diaphragmatic, upper and lower limb pyramidal involvements each constituted one CNS region. …”
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A Platform For Solar Energy An Alternative Source For Kabale District at Kabale University. by Amanya, Devis

“…The paper presents the main milestones of the developments performed in this important field of energy conversion. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…Overall, this study represents a major milestone in the ongoing efforts to improve our understanding and clinical management of rare diseases, a crucial area of medical research and care.…”
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Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary by Camilla Lomholt Kjersgaard, MD, Andreas Ernst, MD, PhD, Pernille Jul Clemmensen, MD, PhD, Lea Lykke Harrits Lunddorf, MD, PhD, Linn Håkonsen Arendt, MD, PhD, Nis Brix, MD, PhD, Onyebuchi A. Arah, MD, PhD, Mette Deleuran, MD, PhD, Cecilia Høst Ramlau-Hansen, MHSc, PhD

“…For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). …”
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Practical security of twin-field quantum key distribution with optical phase-locked loop under wavelength-switching attack by Qingquan Peng, Jiu-Peng Chen, Tianyi Xing, Dongyang Wang, Yizhi Wang, Yang Liu, Anqi Huang

“…Abstract The twin-field class quantum key distribution (TF-class QKD) has experimentally demonstrated the ability to surpass the fundamental rate-distance limit without requiring a quantum repeater, as a revolutional milestone. In TF-class QKD implementation, an optical phase-locked loop (OPLL) structure is commonly employed to generate a reference light with correlated phase, ensuring coherence of optical fields between Alice and Bob. …”
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Toward High-order Solar Corona Simulations: A High-order Hyperbolized Poisson Approach for Magnetic Field Initialization by Rayan Dhib, Firas Ben Ameur, Vatsalya Sharma, Andrea Lani, Stefaan Poedts

“…The described developments are a milestone for enabling high-order global solar corona simulations on 3D unstructured grids.…”
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NERVE 2.0: boosting the new enhanced reverse vaccinology environment via artificial intelligence and a user-friendly web interface by Andrea Conte, Nicola Gulmini, Francesco Costa, Matteo Cartura, Felix Bröhl, Francesco Patanè, Francesco Filippini

“…Abstract Background Vaccines development in this millennium started by the milestone work on Neisseria meningitidis B, reporting the invention of Reverse Vaccinology (RV), which allows to identify vaccine candidates (VCs) by screening bacterial pathogens genome or proteome through computational analyses. …”
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An Overview of Hybrid DC–DC Converters: From Seeds to Leaves by Yan Lu, Junwei Huang, Zhiguo Tong, Tingxu Hu, Wen-Liang Zeng, Mo Huang, Xiangyu Mao, Guigang Cai

“…We try to analyze and summarize their pros and cons, and to derive the evolution of the hybrid dc–dc converters, with milestone examples. Then, we share our observations, design intuitions, and suggestions to help the researchers and engineers to pick up and design a new SCI hybrid dc–dc converter.…”
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Clusters explaining the relation between menopause and self-reported periodontal disease: a cross-sectional study by Hani T. Fadel, Lujain A. Qarah, Manal O. Alharbi, Alla Al-Sharif, Doaa S. Al-Harkan, Saba Kassim, Osama Abu-Hammad, Najla Dar-Odeh

“…Background Menopause is an important milestone in the women’s life continuum and is associated with potentially adverse effects, including those related to oral health. …”
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Apocalypse Now: Dombey in the Twenty-First Century by Jennifer Gribble

“…The narrative injunction to Mr Dombey, ‘awake, doomed man,’ has a Carlylean, Miltonic and biblical source, but it also strikes a significant key-note for early twenty-first-century readers. …”
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The evolution of the Gulf Coopera-tion Council approaches to security issues after the Arab Spring by E. S. Melkumyan

“…This paper attempts to identify the key milestones, factors and trends that have shaped the GCC decision-making process in the security sphere over the past 10 years since the beginning of the Arab Spring. …”
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Effortless alkalinity analysis using AI and smartphone technology, no equipment needed, from freshwater to saltwater by Zachary Y. Han, Zihan Zheng, Alan Y. Han, Huichun Zhang

“…This AI-powered, equipment-free technology represents a significant milestone in water quality monitoring, deviating from the trend of developing increasingly advanced analytical techniques and serving as a foundation for developing similar methods across various water quality parameters and broader analytical applications.…”
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Increasing TB/HIV Case Notification through an Active Case-Finding Approach among Rural and Mining Communities in Northwest Tanzania by R. Abeid, C. Mergenthaler, V. Muzuka, A. Goodluck, T. Nkwabi, J. Bigio, Aguilera Vasquez N, T. Pande, F. Haraka, J. Creswell, T. Rahman, M. Straetemans

“…While Tanzania is among the high TB burden countries to reach the WHO’s End TB 2030 milestones, 41% of the people estimated to have had TB in 2020 were not diagnosed and notified. …”
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El subsidio por desempleo agrario en Granada (1984-1996): Bolsas de fraude y dinámica de la contienda política by Álvaro López Osuna, Antonio Robles Egea

“…Par ailleurs, en corrélation avec ce qui précède, est étudié le degré de protestation sociale suscitée par la judiciarisation des fraudes au PER.At the beginning of 1984 the socialist government of Felipe González approved the creation of the agricultural unemployment subsidy. This historic milestone, which together with the Rural Employment Plan and a specific Rural Training Plan established a Comprehensive System for the Protection of the rural environment, meant the establishment of minimum wage for temporal agricultural workers in Andalusia and Extremadura. …”
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Arrested Puberty in an Adolescent Male with Anorexia Nervosa Successfully Resumed with Multidisciplinary Care by Diana Simão Raimundo, Carolina Figueiredo, Ana Raposo, Bernardo Dias Pereira

“…The recognition of this rare condition in males allows a personalized approach to disordered puberty, with resumption of normal function of the hypothalamic-pituitary-gonadal axis and achievement of pubertal milestones.…”
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Threats and Mitigation Strategies for Electroencephalography-Based Person Authentication by Zaib Unnisa, Asadullah Tariq, Irfan Ud Din, Danish Shehzad, Mohamed Adel Serhani, Abdelkader N. Belkacem, Nadeem Sarwar

“…According to research findings, in February 2022, a significant milestone was achieved when the EEG signals of a deceased person were successfully captured for the first time in recorded history. …”
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Regional processes in Hungary - From PHARE to Smart specialisation by Viktória Józsa

“…The objective of this study is to present a qualitative framework to the evaluation of the period from 1990 to 2015 in Hungary, as a case study of the transition economies, with the identification of the most important milestones and tendencies of regionalization. The relevance of the research is supported by the recent elimination of the NUTS II (regional) level institutional system in the country, and the relocation of ESIF management to the NUTS III (county) level. …”
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From InSAR‐Derived Subsidence to Relative Sea‐Level Rise—A Call for Rigor by P. S. J. Minderhoud, M. Shirzaei, P. Teatini

“…Thiéblemont et al. (2024, https://doi.org/10.1029/2024ef004523) reached a remarkable milestone by providing a continental‐scale estimate of vertical land motion (VLM) across European coastal zones by utilizing European Ground Motion Service (EGMS) data, obtained from Interferometric Synthetic Aperture Radar (InSAR) data from Sentinel‐1 satellites. …”
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Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis. by Shruthi Bandyadka, Diane P V Lebo, Albert A Mondragon, Sandy B Serizier, Julian Kwan, Jeanne S Peterson, Alexandra Y Chasse, Victoria K Jenkins, Anoush Calikyan, Anthony J Ortega, Joshua D Campbell, Andrew Emili, Kimberly McCall

“…The death and clearance of nurse cells is a consequential milestone in Drosophila melanogaster oogenesis. In preparation for oviposition, the germline-derived nurse cells bequeath to the developing oocyte all their cytoplasmic contents and undergo programmed cell death. …”
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Together throughout the year: seasonal patterns of bacterial and eukaryotic microbial communities in a macrotidal estuary by Vincent Hervé, Jérôme Morelle, Josie Lambourdière, Pascal Jean Lopez, Pascal Claquin

“…Conclusions This molecular survey represents a milestone in the understanding of macrotidal estuary dynamics and the Seine ecosystem, through the identification of putative markers of ecosystem functioning. …”
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