Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

Get full text

Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats by LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin

“…Hematoxylin-eosin (HE) was used to stain the renal histopathological section, and the microscope (×400) was used to observe the structural changes of renal tubules and glomerulus; the peroxidase method was used to detect the renal function indexes such as uric acid (UA), creatinine (Cre) and urea nitrogen (BUN); enzyme-linked immunosorbent assay (ELISA) method was used to determine the contents of interleukin-1β (IL-1β) in serum and kidney tissues; Western blot was used to detect the expressions of Caspase-1, IL-1β and glucose transporter 9 (GLUT-9) in the kidney tissues.Results① Pathological examination results: there was not obvious pathological changes were observed in the kidney tissues of the Control group; in the Model group, the renal tissue capsule was incomplete, the glomerulus was deformed and atrophic, and the renal tubules were disordered; in the Exercise group, the number of inflammatory cell infiltration was significantly decreased, the renal tubular structure was relatively intact, and the pathological changes such as cytoplasmic vacuolation of renal tubular epithelial cells were significantly decreased. ② UA, Cre and BUN content of serum: compared with the Control group, UA, BUN and Cre content in serum of the Model group and Exercise group was significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, UA, BUN and Cre content in serum of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05). ③ Serum and kidney IL-1β content: compared with the Control group, the expression of IL-1β in serum and kidney of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expression of IL-1β in serum and kidney of the Exercise group was significantly decreased (<italic>P</italic>&lt;0.05). ④ Expressions of Caspase-1, IL-1β and GLUT-9 protein: compared with the Control group, the expressions of Caspase-1, IL-1β and GLUT-9 protein in kidney tissues of the Model group and the Exercise group were significantly increased (<italic>P</italic>&lt;0.05); compared with the Model group, the expressions of Caspase-1, IL-1β, and GLUT-9 protein in kidney tissues of the Exercise group were significantly decreased (<italic>P</italic>&lt;0.05).ConclusionAerobic treadmill exercise can effectively reduce the level of uric acid and inflammatory response of hyperuricemia rats, and improve renal function, which may be related to the regulation of GLUT-9 protein expression.…”
Get full text

Effects of Electroacupuncture at Fengchi Acupoint on Myosatellite Cells and TLR4/MyD88/NF-κB Signaling Pathway in Chronic Cervical Muscle Injury Rats by HUANG Yuting, CHEN Jiayan, KAN Yu, FANG Yanping, WANG Jinwei, ZHENG Linyao, JING Xianghong, LIAO Jun

“…After intervention, the posterior cervical muscle tissue of rats in each group was collected and the morphological changes of posterior cervical muscle tissue were observed under electron microscope. The protein contents of PCNA, MyoD, TLR4, MyD88 and NF-κBp65 were detected by immunohistochemistry.Results1) Morphological detection: Compared with the blank group, ultrasonic diagnosis results of the model group showed that tissue of posterior cervical muscle of rats was discontinuous and thickness was significantly narrower. …”
Get full text

Dual‐Vibration‐Assisted Charge Transport Through Hexabenzocoronene in Single‐Molecule Junctions by Miao Zhang, Boyu Wang, Hongxing Jia, Xinmiao Xie, Jie Hao, Li Zhou, Pingwu Du, Jinying Wang, Chuancheng Jia, Xuefeng Guo

Get full text

Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…The in vitro cellular uptake was observed via fluorescence microscope and flow cytometry. In vitro cytotoxicity was evaluated using the CCK-8 assay, flow cytometry, and live/dead cell staining. …”
Get full text

Exploring the Diversity of Some Microorganisms from Lake Al-Asfar, KSA: The Good, the Bad, and the Pathogenic by Fatimah Al Tammar, Nermin El Semary, Munirah F. Aldayel, Duaa Althumairy, Gowhara Alfayad

“…The first bacterium is associated with special lipid metabolism and is hardly pathogenic. Several diverse microscopic forms of protists, mainly Protozoa and parasites, were identified, which included <i>Entamoeba histolytica</i>, <i>Balantidium coli</i>, <i>Ascaris lumbricoides</i>, <i>Amoeba</i>, <i>Paramecium</i>, <i>Euglena</i>, and <i>Gymnodinium</i> sp. …”
Get full text

Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly by Teodor Cerbulescu, Flavia Ignuta, Uma Shailendri Rayudu, Maliha Afra, Ovidiu Rosca, Adrian Vlad, Stana Loredana

Get full text

Gender Analysis, Milk Value Chain, Kabale Uganda. Kabale: Kabale University. by Tugume, Samuel

“…Efforts should be made to facilitate access to credit or microloans specifically for women to purchase dairy cows. …”
Get full text

Efficacy of a reduced-dosage PRRS MLV vaccine against a NADC34-like strain of porcine reproductive and respiratory syndrome virus by Xinyu Yan, Jiayu Liu, Fengxiong Yue, Yan Lin, Yan Li, Wensi Wu, Shan Zhao, Xiaobo Huang, Qin Zhao, Yiping Wen, Sanjie Cao, Senyan Du, Nanfang Zeng, Qigui Yan

“…From the perspective of clinical score, gross lung lesions, and microscopic lesions, immunization with MLV vaccine can indeed relieve symptoms and lesions caused by the virus, and 0.1 dosage vaccination has a better effect in these aspects. …”
Get full text

Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor by Ben-Max de Ruiter, Jan E. Freund, C. Dilara Savci-Heijink, Jons W. van Hattum, Marinka J. Remmelink, Theo M. de Reijke, Joyce Baard, Guido M. Kamphuis, D. Martijn de Bruin, Jorg R. Oddens

“…Confocal laser endomicroscopy (CLE), a probe-based optical technique for real-time microscopic evaluation, has shown promising accuracy for grading of UCB. …”
Get full text

Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…The stool samples were collected and microscopically examined for parasites using the formalin ethyl acetate sedimentation technique. …”
Get full text

Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration by Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo

“…Hematoxylin eosin (he) staining was used to observe the structural changes of cerebral cortical neurons and retina, and transmission electron microscope was used to observe the structural changes of mitochondria and synapses. …”
Get full text

Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway by Yuanyuan ZHANG, Xinyu JIANG, Xihai LI, Mingxia WU

“…After 12 weeks of electroacupuncture intervention, the articular cartilage and synovium were harvested, and the changes of histomorphology of articular cartilage were observed under light microscope by hematoxylin-eosin staining and toluidine blue staining. …”
Get full text

La dimensión educativa de los niños de familias bolivianas de la localidad de General Daniel Cerri by María Kraser, Cecilia Ockier

“…El objetivo de la ponencia se orienta respecto a la dimensión educativa en los niños de familias bolivianas a identificar, desde la óptica microsocial mediante el empleo de técnicas cualitativas, las implicancias de la educación formal en el mencionado colectivo de niños, centrando nuestro análisis en las falencias socio- económicas del núcleo familiar que limitan la plena inserción de los estudiantes en el contexto escolar local. …”
Get full text

Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain by XIANG Hongchun, ZHANG Hong, LI Jing, LONG Man, LI Man, CAI Guowei

“…The "up and down" method was used to measure paw withdrawal mechanical threshold (PWMT); the hematoxylin-eosin (HE) staining was used to observe pathological characteristics of DRG tissues; immunofluorescence staining was used to detect the percentage of MCP-1 and CD68 immunopositive area in DRG tissues; Western blot method was used to detect the protein expression level of CD68, MCP-1, iNOS and IL-1β in DRG tissues, and transmission electron microscope was used to observe the ultrastructure of macrophages in DRG tissues.Results(1) PWMT: compared with the control group at the same time, PWMT in the model group decreased significantly at the 8th, 11th, 13th and 15th days (<italic>P</italic>&lt;0.05); compared with the model group at the same time, PWMT in the EA group increased significantly at the 11th, 13th and 15th days, and the differences were statistically significant (<italic>P</italic>&lt;0.05). (2) Histopathological features of DRG tissues: the inflammatory cells are nearly round in shape and blue-purple in color. …”
Get full text

Reliability of non-invasive imaging methods in the evaluation of pancreatic parenchyma changes in tumors of the pancreaticoduodenal zone by M.M. Veligotskyy, S.E. Arutyunov, I.I. Yakovtsova, I.V. Ivakhno, O.M. Veligotskyi

“…Morphological studies were carried out on a Primo Star microscope (Carl Zeiss) using the AxioCam program (ERc 5s). …”
Get full text

Perbandingan Levofloxacin dengan Ciprofloxacin Peroral dalam Menurunkan Leukosituria Sebagai Profilaksis Isk pada Kateterisasi di RSUP. Dr. M. Djamil Padang by Marwazi Sofyan, Alvarino ., Erkadius3 .

“…After insertion of catheter, urinalysis was performed to determine that the lecocyte count was less than 10 per high power field of the microscope, and each group then received either Ciprofloxacin or Levofloxacin, 750 mg orally. …”
Get full text

Effect of Exercise Preconditioning on Autophagy and Apoptosis of Cardiomyocytes in Aged Rats with Myocardial Ischemia Reperfusion Injury by LI Hongyu, YIN Xia, WANG Yanxia, Li Yuting, ZHU Luwen, TANG Qiang

“…Cardiomyocyte autophagosomes were observed by transmission electron microscope (TEM); cardiomyocyte apoptosis was detected by TUNEL staining; Beclin-1, LC3-Ⅱ, Bax, Caspase-9, Bcl-2, Bcl-XL protein expression levels were detected by Western blot method.Results① TEM observation results: a small amount of autolysosomes were observed in the Con group; more autolysosomes and autophagy vesicles were observed in the IR group; a small amount of autolysosomes were observed in the EP+IPC group; a small number of autophagic vesicles were observed in the EP+IPC+saline group; there wasn't typical autophagic vesicles and lysosomes were observed in the EP+IPC+3-MA group. ② TUNEL positive cell ratio results: only a few TUNEL positive cells were found in the Con group. …”
Get full text

LA DIMENSIÓN EDUCATIVA DE LOS NIÑOS DE FAMILIAS BOLIVIANAS DE LA LOCALIDAD DE GENERAL DANIEL CERRI by María Kraser, Cecilia Ockier

“…El objetivo de la ponencia se orienta respecto a la dimensión educativa en los niños de familias bolivianas a identificar, desde la óptica microsocial mediante el empleo de técnicas cualitativas, las implicancias de la educación formal en el mencionado colectivo de niños, centrando nuestro análisis en las falencias socio-económicas del núcleo familiar que limitan la plena inserción de los estudiantes en el contexto escolar local. …”
Get full text

Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy by Shanshan Jiang, Bhaskar Gurram, Junfei Zhu, Shan Lei, Yifan Zhang, Ting He, Oya Tagit, Hui Fang, Peng Huang, Jing Lin

Get full text