homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

“…In this nationwide prospective cohort study, we leveraged a Tasso-SST based self-blood collection and stabilization tool (homeRNA) to profile detailed kinetics of the presymptomatic to convalescence host immunity to contemporaneous respiratory pathogens. Methods: We enrolled non-symptomatic adults with recent exposure to ARIs who subsequently tested negative (exposed-uninfected) or positive for respiratory pathogens. …”
Get full text

Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…The study aimed to reveal the antiurolithiatic potential of two benzene sulfonamide derivatives (SBCl and SBF; A and B, respectively) against ethylene glycol-induced kidney stones. Methods: The rats were divided into two main groups: the first group consisted of 20 rats with induced kidney stones, and the second group included 15 control rats. …”
Get full text

Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…We hypothesized that complete cigarette-to-e-cigarette switching would improve respiratory symptoms compared to continued smoking. Methods: Longitudinal analysis of data from waves 2–6 (W2–W6; 2014–2021) of the Population Assessment of Tobacco and Health (PATH) Study, an observational cohort study that surveyed 5653 US adults ≥18 years without COPD/chronic bronchitis/emphysema. …”
Get full text

MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI by Wenbin Lu, Genshan Ma, Zulong Sheng, Qingjie Wang, Lijuan Chen, Junhua Qi, Ronghui Shi, Jingjing Ji, Zhenjun Ji, Qiming Dai

“…We aimed to investigate whether MSCs can contribute to the heterogeneity of Ly6Chigh monocytes differentiated into Ly6Clow monocytes and whether this regulation is related to nuclear receptor NR4A1. Methods. Ly6Chigh/low monocytes were first cocultured with MSCs. …”
Get full text

Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…Therefore, the current research was designed to evaluate the propranolol on the growth performance, antioxidant status, and the status of some hematological and biochemical parameters of broiler chickens under induced ascites. Materials and Methods: The experiment was carried out in a completely randomized design with four treatments in four replicates and 10 chickens in each replicate. …”
Get full text

Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling by Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan, Bo Fang

“…This study aims to investigate the regulation of transient receptor potential vanilloid 1 (TRPV1) and cyclin-dependent kinase 5 (CDK5) expression levels by miR-142-5p as a common upstream molecule, and to delve into the mature process of miR-142-5p from the perspective of N 6-methyladenosine (m6A) modification. Methods To assess the RNA levels of TRPV1, CDK5, miR-142-5p, pre-miR-142, and pri-miR-142, quantitative PCR with reverse transcription (RT–qPCR) was utilized. …”
Get full text

Response of Agronomic Characteristics and Yield of Garlic Plant (Allium sativum L.) to Different Levels of Planting Density and Nutrition by Hadi khavari, Masoud Rafiee

“…Research has shown that the growth and yield of this plant are largely influenced by the management of the supply of various nutrients. Materials and Methods This experiment was conducted as a factorial layout based on a randomized complete block design with three replications during the growing season of 2016- 2017 at the experimental field of Beiranshahr city of Khorramabad in Lorestan Province, Iran. …”
Get full text

Selection of Superior Sugar Beet Genotypes using the Analysis of Quantitative and Qualitative Traits by Mahdi Hassani, Ali Saremirad, Hamed Mansouri

“…The current study undertakes the comprehensive evaluation of sugar beet genotypes across various traits encompassing quantitative and qualitative performance, aiming to pinpoint and select superior genotypes for future breeding initiatives. Methods: This research was conducted on 49 meticulously chosen sugar beet genotypes, comprising 44 novel hybrids and five control varieties, encompassing three domestic and two foreign cultivars. …”
Get full text

STR profiling in a cohort of Saudi patients with acute leukemia by Husein A. Alhatim, PhD Student, Muhammad NH Abdullah, PhD, Suhaili A. Jamaludin, PhD, Armania B. Nurdin, PhD, Sayed A. Amer, PhD

“…Abstract: Objective: This study was aimed at characterizing whether the autosomal short tandem repeats (STRs) used in forensic identification might differ between leukemic blood samples and saliva samples. Methods: Blood and saliva samples were collected from 27 patients diagnosed with acute leukemia in Riyadh City, KSA. …”
Get full text

Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized c... by Ni-Na Hou, Meng-Yun Zhang, Yu-Wei Zhang, Hong-Jing Wu, Hong Luo, Heng Yang

“…We aimed to evaluate the intraoperative safety and efficacy of weak opioidized anesthesia with low-dose esketamine in the treatment of elderly patients with lumbar spinal stenosis undergoing total laminectomy with complete decompression and interbody implant fusion. Methods In total, 90 elderly patients were randomized into three groups: the esketamine HS group (0.2 mg/kg induction, 0.25 mg/(kg·h) infusion), the esketamine LS group (0.2 mg/kg induction, 0.125 mg/(kg·h) infusion), and the control group (group C receiving an equal volume of saline). …”
Get full text

Comparative Analysis of the Outcomes of Laparoscopic Right Hemicolectomy with D2 and D3 Lymphadenectomy in the Treatment of Patients with Right Colon Cancer by A. A. Nevolskikh, V. A. Avdeenko, Yu. Yu. Mikhaleva, T. P. Pochuev, P. V. Sokolov, R. F. Zibirov, I. P. Reznik, N. D. Silin, L. O. Petrov, S. A. Ivanov, A. D. Kaprin

“…Tsyb Medical Radiological Research Center.Materials and methods. Conducted from 2018 to 2023, the study included 174 patients with stage I–III RCC: in 106 patients, laparoscopic right hemicolectomy with D2 lymph node dissection was performed, in 68 patients — with D3 lymph node dissection. …”
Get full text

Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women by Stephen J Sharp, Kay-Tee Khaw, Robert Luben, Nita G Forouhi, Leila Finikarides, Islam Afzal, Marleen Lentjes

“…The effects of different dietary fats on lipid profiles, metabolic markers and health outcomes may vary not just according to the general classification of their main component fatty acids as saturated or unsaturated but possibly according to different profiles in individual fatty acids, processing methods as well as the foods in which they are consumed or dietary patterns. …”
Get full text

Perinatal mortality and other severe adverse outcomes following planned birth at 39 weeks versus expectant management in low-risk women: a population based cohort studyResearch in... by Kylie Crawford, Waldemar A. Carlo, Anthony Odibo, Aris Papageorghiou, William Tarnow-Mordi, Sailesh Kumar

“…We compared outcomes following planned birth at 39+0–39+6 weeks gestation (either by induction of labour or scheduled caesarean section) to expectant management. Methods: The population included low-risk, singleton pregnancies between 2000 and 2021 in Queensland, Australia. …”
Get full text

Direct maternal morbidity and the risk of pregnancy-related deaths, stillbirths, and neonatal deaths in South Asia and sub-Saharan Africa: A population-based prospective cohort stu... by Fahad Aftab, Imran Ahmed, Salahuddin Ahmed, Said Mohammed Ali, Seeba Amenga-Etego, Shabina Ariff, Rajiv Bahl, Abdullah H Baqui, Nazma Begum, Zulfiqar A Bhutta, Godfrey Biemba, Simon Cousens, Vinita Das, Saikat Deb, Usha Dhingra, Arup Dutta, Karen Edmond, Fabian Esamai, Amit Kumar Ghosh, Peter Gisore, Caroline Grogan, Davidson H Hamer, Julie Herlihy, Lisa Hurt, Muhammad Ilyas, Fyezah Jehan, Mohammed Hamad Juma, Michel Kalonji, Rasheda Khanam, Betty R Kirkwood, Aarti Kumar, Alok Kumar, Vishwajeet Kumar, Alexander Manu, Irene Marete, Usma Mehmood, Nicole Minckas, Shambhavi Mishra, Dipak K Mitra, Mamun Ibne Moin, Karim Muhammad, Sam Newton, Serge Ngaima, Andre Nguwo, Muhammad Imran Nisar, John Otomba, Mohammad Abdul Quaiyum, Sophie Sarrassat, Sunil Sazawal, Katherine E Semrau, Caitlin Shannon, Vinay Pratap Singh, Sajid Soofi, Seyi Soremekun, Atifa Mohammed Suleiman, Venantius Sunday, Thandassery R Dilip, Antoinette Tshefu, Yaqub Wasan, Kojo Yeboah-Antwi, Sachiyo Yoshida, Anita K Zaidi, Alliance for Maternal and Newborn Health Improvement (AMANHI) maternal morbidity study group

“…We aimed to generate prospective, reliable population-based data on the burden of major direct maternal morbidities in the antenatal, intrapartum, and postnatal periods and its association with maternal, foetal, and neonatal death in South Asia and sub-Saharan Africa.<h4>Methods and findings</h4>This is a prospective cohort study, conducted in 9 research sites in 8 countries of South Asia and sub-Saharan Africa. …”
Get full text

Path and Practice of Gap Management in National Parks: A Comparison Between China and the US and Inspirations Therefrom by Yun MA, Siyuan HE

“…Through a comparative approach, the research identifies key institutional factors shaping the management of these gaps and provides recommendations for improving China’s approach to gap management.MethodsThis research employs a combination of policy text analysis, historical analysis and comparative analysis to explore the concept and management of “gap” in national parks in both China and the US. …”
Get full text

Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function by Si-yu Wang, Yu-xin Wang, Lu-shun Guan, Ao Shen, Run-jie Huang, Shu-qiang Yuan, Yu-long Xiao, Li-shuai Wang, Dan Lei, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan

“…Therefore, our aim is to develop a prognostic model that predicts the prognosis of GC patients and initially explore the role of MEF2C in immunotherapy for GC. Methods Transcriptome sequence data of GC was obtained from The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO) and PRJEB25780 cohort for subsequent immune infiltration analysis, immune microenvironment analysis, consensus clustering analysis and feature selection for definition and classification of gene M and N. …”
Get full text

Association between traffic-related air pollution and risk of outpatient visits for dry eye disease in a megacity along the subtropical coast in South China by Fan Cao, Yue Chen, Yan-Chao Gui, Zi-Yue Fu, Zheng Lyu, Kou Liu, Li-Ming Tao, Zhi-Fan Chen, Hai-Feng Pan, Zheng-Xuan Jiang, Qian-Li Meng

“…This study aimed to investigate the associations between traffic-related air pollutants with risk of dry eye disease (DED) outpatient visits in a megacity (Guangzhou) along the subtropical coast in South China. Methods Daily data on DED outpatient visits and environmental variables from 1 January 2014 to 31 December 2020 in Guangzhou were obtained. …”
Get full text

Evidence-based ankle pump exercise in prevention of postoperative deep-vein thrombosis in patients with lower extremity fracture (踝泵运动预防下肢骨折患者围手术期深静脉血栓的循证实践)... by BAO Xiuhong (鲍秀红), ZHANG Fang (张芳), ZHU Yi (朱屹), SHAO Ye (邵烨)

“…Objective To summarized the best evidence-based practice of ankle pump exercise in prevention of postoperative deep-vein thrombosis (DVT) in patients with lower extremity fracture, and to evaluate its clinical application. Methods CNKI, Wanfang, VIP, Medlive, BMJ, Cochrane library, Embase, PubMed, RNAO, ESPEN, NGC and NICE were searched for clinical practice guidelines, systematic reviews and relevant papers from August 2012 to August 2012. …”
Get full text

Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis by Chuanxin Liu, Xiaobin Huang, Jiao Kong, Xuejiao Li, Yuming Wang, Fangfang Zhang, Jiajia Duan

“…This study aims to elucidate the mechanisms of PPT-induced hepatotoxicity using tandem quality tag (TMT) based quantitative proteomics and phosphoproteomics, providing potential targets and directions for developing new therapeutic strategies to facilitate the safe and rational use of podophyllotoxin in clinical settings. Methods: We employed a comprehensive assessment of PPT-induced hepatotoxicity based on the Toxicology Evidence Chain (TEC) concept, originally proposed by our research group in 2018. …”
Get full text

Cross-sectional study of the perceived wellbeing of children in palliative care by Daniel Toro-Pérez, Ester Camprodon-Rosanas, Catalina Bolancé, Montserrat Guillen, Sergi Navarro Vilarrubí, Joaquin T. Limonero

“…Objective: To describe the perceived wellbeing (pWB) and the psychological characteristics of young people with life-limiting and life-threatening conditions (LLTCs). Methods: We conducted a cross-sectional study in young people aged 8 years or older with collection of data on demographic and disease-related variables from the health records. …”
Get full text