Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine by Massimiliano Agostini, Erica Giacobbi, Francesca Servadei, Julia Bishof, Likas Funke, Giuseppe Sica, Valentina Rovella, Marco Carilli, Valerio Iacovelli, Yufang Shi, Jianquan Hou, Eleonora Candi, Gerry Melino, Giulio Cervelli, Manuel Scimeca, Alessandro Mauriello, Pierluigi Bove

“…The cancer hallmarks gene signatures highlight intriguing molecular aspects that characterize the biology of this tumor by both a high hypoxia and immune infiltration scores. Moreover, our analysis showed a slight increase in the Tumoral Mutational Burden, as well as an over-expression of the immune checkpoints. …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…Abstract Prostate cancer (PCa) is one of the most common cancers among men worldwide, and robot-assisted radical prostatectomy (RARP) is a widely used treatment for localized PCa. …”
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Comprehensive Assessment of the Risk of Symptomatic Embolism in Patients With Infective Endocarditis by Sebastian D. Santos‐Patarroyo, Juan A. Quintero‐Martinez, Brian D. Lahr, Supavit Chesdachai, Daniel C. DeSimone, Hector R. Villarraga, Hector I. Michelena, Larry M. Baddour

“…Our study aimed to define the short‐term risk of symptomatic embolization in patients with IE. …”
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Tilted Implants for Full-Arch Rehabilitations in Completely Edentulous Maxilla: A Retrospective Study by Nicolò Cavalli, Bruno Barbaro, Davide Spasari, Francesco Azzola, Alberto Ciatti, Luca Francetti

“…At each followup plaque level and bleeding scores were assessed and every complication was recorded. …”
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Comparative efficacy of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> composition and prucalopride in treatment of const... by V. T. Ivashkin, O. M. Drapkina, A. A. Sheptulin, O. S. Shifrin, Ye. A. Poluektova, S. Yu. Kuchumova

“…BOS was assessed by lactulose hydrogen breath test, quality of life — by The Short Form-36 (SF-36) questionnaire. Treatment was carried out for 28 days. …”
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The experience of bodily image for patients with left ventricular assist device by Irena Milaniak, Emilia Witkowska, Marta Cebula, Paulina Tomsia, Grzegorz Wasilewski, Izabela Górkiewicz-Kot, Sylwia Wiśniowska-Śmiałek, Michał Kaleta, Karol Wierzbicki, Karol Wierzbicki

“…Multiple regression analyses examined the associations between the research variable.ResultsThe mean Age of the participants was 59.64 (SD=9.63), and 96.3% were men. The mean scores were: Body Image Scale – 28.33 (SD=5,91); Acceptance of Illness Scale – 25.51 (SD=5.92); beliefs about pain control: internal factors – 15.85 (SD=4.96), the influence of physicians – 17.57 (SD=3.15), random events – 14.37(SD=3.32), NRS=2.80(SD=1.86), HADS anxiety – 5.33 (SD=4.12), HADS depression – 4.66 (SD=3.10), SF12MCS-45.49 (SD=6.48), SF-12PCS-41,33 (SD=6.48). …”
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Functional performance of patients with stroke during inpatient rehabilitation: a cross-sectional study of home and access visits by Melissa J. Krauss, Emily Somerville, Callista Poiter, Rebecca M. Bollinger, Brianna M. Holden, Gabrielle Blenden, Danielle Kretzer, Susan L. Stark

“…Both groups had significantly worse ICF scores at the home/access visit compared to IRF discharge for most activities. …”
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Prediction of reduced left ventricular ejection fraction using atrial fibrillation or flutter electrocardiograms: A machine-learning study by Soonil Kwon, SooMin Chung, So-Ryoung Lee, Kwangsoo Kim, Junmo Kim, Dahyeon Baek, Hyun-Lim Yang, Eue-Keun Choi, Seil Oh

“…Results A total of 15,683 patients were analyzed (mean age, 70.0 ± 11.7 years; 61.2% men), with 82.2% having LVEF ≥50% and 17.8% having LVEF < 50%. …”
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The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer by Adriana M. Coletta, Hyejung Lee, Sonam Puri, Sinead Culleton, Matthew F. Covington, Jeffrey T. Yap, Kelsey E. Maslana, Benjamin Haaland, Wallace Akerley

“…Results Our sample (n = 69) included men (52%) and women (48%), with a median age of 67.4‐years, history of smoking (67%), wild‐type genotype (75.4%), and a tumor histology of adenocarcinoma (68%). …”
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Gender-specific dual effects of physical activity on depression and mortality: a nine-year cohort study in Chinese adults aged 45 and above by Dan Shan, Dan Shan, Meina Yang, Meina Yang, Kunyan Zhou, Kunyan Zhou

“…This association was predominantly influenced by a significant increase in the risk of mild depression (a score of 10–14 on the CESD-10) (odds ratio [OR]: 1.76; 95% confidence interval [CI]: 1.29–2.42, p &lt; 0.001), with a more pronounced effect observed in women (OR: 1.83; 95% CI: 1.26–2.66, p = 0.002). …”
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Demographic disparities in access to COVID-19 clinical trial sites across the United States: a geospatial analysis by Raphael Cuomo, Tiana McMann, Qing Xu, Zhuoran Li, Joshua Yang, Julie Hsieh, Christine Lee, Milena Lolic, Richardae Araojo, Tim Mackey

“…The county-level, population-normalized count of study site locations, by type, was used as the outcome for national analysis, thereby enabling the determination of demographic associations with geospatial availability to enroll as a participant in a COVID-19 study. Z-scores of the Getis-Ord Gi statistic were used as the outcome for local analysis in order to account for areas close to those with clinical study sites. …”
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Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer by İsmail Tırnova, Maya Gasimova, Hatice Akay, Çağla Sarıtürk, Aslıhan Güven Mert, Özlem Yenidünya, Feza Yarbuğ Karakayalı

“…Controlling Nutritional Status (CONUT) Score was used to assess the nutritional status. …”
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Comprehensive assessment of a nationwide simulation-based course for artificial life support. by Mateusz Puslecki, Marek Dabrowski, Marcin Ligowski, Bishoy Zakhary, Ahmed S Said, Kollengode Ramanathan, Elaine Cooley, Lukasz Puslecki, Sebastian Stefaniak, Piotr Ziemak, Ilona Kiel-Puslecka, Agata Dabrowska, Tomasz Klosiewicz, Maciej Sip, Radoslaw Zalewski, Malgorzata Ladzinska, Wojciech Mrowczynski, Piotr Ladzinski, Lidia Szlanga, Konrad Baumgart, Piotr Kupidlowski, Lukasz Szarpak, Marek Jemielity, Bartlomiej Perek

“…<h4>Results</h4>There were 115 participants (60% men) predominantly in the age of 30-40 years. Majority of them (63%) were anesthesiologists or intensivists with more than 5-year clinical experience, but 54% had no previous ECMO experience. …”
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Translation, adaptation, and validation of the Care Coordination Instrument for cancer patients by Anne Werner, Anke Steckelberg, Alexandra Strobel, Andreas Wienke, Heike Schmidt, Dirk Vordermark, Patrick Michl, C. Benedikt Westphalen, Julia Lühnen

“…Significant factors on the care coordination score are treatment location (hospital vs. private practice oncologist M = -9.83 score points, p = 0.011) and gender (women vs. men M = 8.92 score points, p = 0.002). …”
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Telerehabilitation: A Practical Remote Alternative for Coaching and Monitoring Physical Kinetic Therapy in Patients with Mild and Moderate Disabling Parkinson’s Disease during the... by Aurelian Anghelescu

“…We studied 17 patients (5 women and 12 men), aged between 54-70 years (average 65.9 ± 4.87), with a disease history of 7.3 ± 3.6 (years), with mild or moderate disabling clinical forms, quantified by an average Hoehn and Yahr score of 2.3 ± 0.35 (limits 1.5-3). …”
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COGEVIS: A New Scale to Evaluate Cognition in Patients with Visual Deficiency by Claire Meyniel, Dalila Samri, Farah Stefano, Joel Crevoisier, Florence Bonté, Raffaella Migliaccio, Laure Delaby, Anne Bertrand, Marie Odile Habert, Bruno Dubois, Bahram Bodaghi, Stéphane Epelbaum

“…Cognitive impairment was diagnosed in 37.5% of participants. The COGEVIS score cutoff point to screen for cognitive impairment was 24 (maximum score of 30) with a sensitivity of 66.7% and a specificity of 95%. …”
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Effectiveness of an Impella Versus Intra‐Aortic Balloon Pump in Patients Who Received Extracorporeal Membrane Oxygenation by Yuji Nishimoto, Hiroyuki Ohbe, Jun Nakata, Toru Takiguchi, Mikio Nakajima, Yusuke Sasabuchi, Toshiaki Isogai, Hiroki Matsui, Yukihito Sato, Tetsuya Watanabe, Takahisa Yamada, Masatake Fukunami, Hideo Yasunaga

“…The mean age of patients was 65 years, 77% were men, and 57% had acute coronary syndrome. After propensity score matching, the patient characteristics were well balanced between the groups. …”
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Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register by Katarina Eeg-Olofsson, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson, Linus Schioler, Björn Zethelius, Nils Ekström, Jan Cederholm, Junmei Miao Jonasson

“…Covariance adjustment and propensity scores were used to adjust for several baseline risk factors and characteristics at Cox regression.Results Compared with metformin in monotherapy, HRs for fatal/non-fatal CVD and all-cause mortality with all other OHAs combined (approximately 80% sulphonylureas) in monotherapy were 1.02 (95% CI 0.93 to 1.12) and 1.13 (1.01 to 1.27), while 1.18 (1.07 to 1.29) and 1.34 (1.19 to 1.50) with insulin in monotherapy, adjusting using propensity scores. …”
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Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort) by Gilles Wandeler, Samuel Bosomprah, Cleophas Chimbetete, Belinda Varaidzo Chihota, Guy Muula, Carolyn Bolton-Moore, Tinei Shamu, Ardele Mandiriri, Esau Banda

“…We plan to enrich the work through conducting in-depth assessments on the determinants of cardiovascular, liver and kidney end-organ disease outcomes yearly. …”
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The effect of an app-based dietary education on dietary intake and cardiometabolic risk markers in people with type 2 diabetes: results from a randomized controlled trial by Linnea Sjöblom, Essi Hantikainen, Anna Dahlgren, Ylva Trolle Lagerros, Stephanie E. Bonn

“…Overall diet quality was estimated with a Nordic Nutrition Recommendation (NNR) score and specific dietary intake was estimated for 13 food groups/nutrients. …”
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