Stagnation Point Flow of CoFe2O4/TiO2-H2O-Casson Nanofluid past a Slippery Stretching/Shrinking Cylindrical Surface in a Darcy–Forchheimer Porous Medium by Kifle Adula Duguma, Oluwole Daniel Makinde, Lemi Guta Enyadene

“…Moreover, the nanofluid thermal performance is enhanced with nanoparticles volume fraction, Casson nanofluid parameter, and Biot number but lessened with porous medium permeability.…”
Get full text

Identification of Novel GCK and HNF4α Gene Variants in Japanese Pediatric Patients with Onset of Diabetes before 17 Years of Age by Rumi Katashima, Mari Matsumoto, Yuka Watanabe, Maki Moritani, Ichiro Yokota

“…Results. We identified 22 missense variants (3 novel variants) in 27 patients (60.0%) in the GCK, HNF4α, and HNF1α genes. …”
Get full text

Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity by Suleiman Al-Hammadi, Najla S. Alkuwaiti, Ghassan A. Ghatasheh, Huda Al Dhanhani, Hiba M. Shendi, Abdulghani S. Elomami, Farida Almarzooqi, Abdul-Kader Souid

“…He also had “X-linked agammaglobulinemia” (MIM#300755) due to hemizygous missense variant, NM_001287344.1 (BTK):c.80G > A, p.Gly27Asp (novel). …”
Get full text

The evolution of hospitals from Antiquity to the Renaissance by Francois P. Retief, Louise Cilliers

“…Hospices, originally called xenodochia, initially built to shelter pilgrims and messengers between various bishops, were under Christian control developed into hospitals in the modern sense of the word. …”
Get full text

GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

“…Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts.Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer’s and coronary artery disease (CAD). …”
Get full text

Comparative genomics analysis of the reason for 12C6+ heavy-ion irradiation in improving Fe3O4 nanoparticle yield of Acidithiobacillus ferrooxidans by Jiani Yang, Shuang Zhang, Lirong Geng, Dan Zhao, Siyu Xing, Xinyue Ji, Lei Yan

“…Comparative genome analysis detected 14 mutation sites, causing six synonymous mutations, one missense mutation, and one nonsense mutation. We further annotated the genes involved in the mutation, such as hcp, hsdM, yghU, K7B00_11365, and K7B00_11355, which are responsible for the substantial changes in the Fe3O4 nanoparticle yield of A. ferrooxidans. …”
Get full text

Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel by Erick B. Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu, Swapna Asuthkar

“…Here, we aim to explore the pathways altered in brain tissues of TRPM8-deficient mice using the expression and methylation profiles of messenger RNA (mRNA) and long non-coding RNA (lncRNA). …”
Get full text

Mutation in the COL2A1 gene is associated with acetabular dysplasia by Miaomiao Xin, Xin Guan, Xin Guan, Jiangfei Yang, Yi Li, Zhentao Man, Hongsheng Sun, Min Fu

“…NGS and Sanger sequencing identified a heterozygous missense mutation in the COL2A1 gene (ex13, c.823C &gt; T; p.Arg275Cys) in both the proband and his father, while this mutation was absent in the mother. …”
Get full text

Expanded screening for Fabry disease in patients with chronic kidney disease not on dialysis: a multicenter Italian experience by Yuri Battaglia, Federica Baciga, Meilad Shakkour, Savio Russo, Giulia Carnicella, Michela Erlati, Gemma Sartori, Giulia Tronconi, Renzo Mignani, Federico Pieruzzi, Paolo Colomba, Laura Scichilone, Michele Andreucci, Concetto Sessa, Giovanni Duro

“…One patient with three family members carrying a novel mutation (c.320 A > G, p.Q107R); one patient with three family members carrying a silent mutation (c.48 T > G, p.L16L) and two patients with a missense mutation (c.376A > G, p.S126G), were identified. …”
Get full text

mRNA technology as one of the promising platforms for the SARS-CoV-2 vaccine development by A. A. Ilyichev, L. A. Orlova, S. V. Sharabrin, L. I. Karpenko

“…This review considers one of the promising vaccine platforms based on messenger RNA. Until recent years, mRNA-vaccination was out of practical implementation due to high sensitivity to nuclease degradation and consequent instability of drugs based on mRNA. …”
Get full text

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

“…Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer’s disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing γ-secretase complex, ostensibly supporting the amyloid hypothesis of pathogenesis. …”
Get full text

The role of microRNAs in learning and long-term memory by L. N. Grinkevich

“…MicroRNAs are unique endogenous non-coding RNAs about 22 nucleotides in length; each can regulate translation of hundreds of messenger RNA targets, thereby controlling entire gene networks. …”
Get full text

Combating economic crime in Ukraine in 1946–1949 by V. A. Grechenko

“…The most common crimes were the following: 1) maliciously delaying the repair of agricultural machinery, allegedly due to the lack of spare parts and specialists; 2) theft of grain during its transportation and sowing by persons responsible for this (weighers, field crew leaders, guards); 3) theft of seeds and fuel by security guards; 4) theft and embezzlement of seeds by officials of collective and state farms and subsidiary farms; 5) theft of seed by reducing the seeding rate and theft of fuel due to lack of control over its consumption; 6) theft of seeds by employees of storage facilities with their subsequent resale at markets at speculative prices; 7) creation of surplus seeds by weighing, moistening, writing off for drying, and increasing waste during sorting. …”
Get full text

Assessment of Allometry in Environmental DNA and RNA Production From Ayu (Plecoglossus altivelis) in an Experimental Condition Using Mitochondrial and Nuclear Gene Markers by Toshiaki S. Jo, Yusuke Ozaki, Nao Matsuda, Hiroki Yamanaka

“…To address the knowledge gaps, we conducted a long‐term rearing experiment using ayu (Plecoglossus altivelis) to monitor the production of their eDNA and messenger and ribosomal eRNA in their growth from larvae to adults. …”
Get full text

Identification of robust and abundant reference transcripts for EV mRNA cargo normalization by Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey

“…To identify reference messenger RNA (mRNA) transcripts, we analyze oligo-dT primed RNA-sequencing data from EVs originating from twelve different cell sources isolated using differential centrifugation followed by ultrafiltration. …”
Get full text

Genome-wide identification of novel flagellar motility genes in Pseudomonas syringae pv. tomato DC3000 by Zichu Yang, Tyler Helmann, Maël Baudin, Maël Baudin, Maël Baudin, Karl J. Schreiber, Karl J. Schreiber, Zhongmeng Bao, Paul Stodghill, Paul Stodghill, Adam Deutschbauer, Adam Deutschbauer, Jennifer D. Lewis, Jennifer D. Lewis, Bryan Swingle, Bryan Swingle

“…We used the overexpression phenotype to screen for nonsense and missense mutants of PSPTO_4229 that no longer reduce swimming motility and found a pair of conserved arginine residues that are necessary for motility suppression. …”
Get full text

Purinergic Signaling Pathway in Human Olfactory Neuronal Precursor Cells by Héctor Solís-Chagoyán, Edgar Flores-Soto, Marcela Valdés-Tovar, Montserrat G. Cercós, Eduardo Calixto, Luis M. Montaño, Carlos Barajas-López, Bettina Sommer, Arnoldo Aquino-Gálvez, Citlali Trueta, Gloria A. Benítez-King

“…This purinergic-triggered release of biochemical messengers to the extracellular milieu might be involved in the paracrine signaling among hOE cells.…”
Get full text

Cultivation of Pleurotus ostreatus on Agricultural Wastes and Their Combination by Bulti Kumera Fufa, Belsti Atnkut Tadesse, Mestawot Merid Tulu

“…The substrates were chopped into small pieces, and 500 g of their dry mass alone and their combination was measured, packed in a polythene bag, moistened, and pasteurized. The cooled substrates were inoculated with a spoon of P. ostreatus spawn brought from Debre Berhan University. …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. …”
Get full text

Consolidation Attributes and Deformation Response of Soft Clay Reinforced with Vertical Scoria Drains under Road Embankment by Hailemariam Merka Gebretsadik, Damtew Tsige Melese, Adamu Beyene Negesa

“…Besides, incorporation of scoria drains lessens the pore pressure developed. The comparative analysis conducted on the effect of drain arrangement revealed that no considerable difference was witnessed in the performance of the square and triangular installation patterns even though the consolidation rate remains slightly faster in the case of the triangular installation pattern.…”
Get full text