Sécurité, complexité, imprévisibilité : apports et perspectives des travaux de Leplat  by Lucie Cuvelier, Françoise Decortis, Pierre Falzon

Get full text

Los contenidos culturales y educativos en la televisión peruana de señal abierta. Un análisis de la oferta televisiva en el año 2024 by Pedro Rodrigo de Jesús Falcón Sarango

Get full text

A produção dos representantes digitais: análise dos requisitos da digitalização de preservação e da digitalização de substituição by Dalton Garcia do Carmo, Cintia Chagas

Get full text

Des démarches capacitantes pour développer les compétences des managers by Brigitte Nivet, Johann Petit, Pierre Falzon

Get full text

Formulation of unavailable diagnostic haptens for the detection of contact allergy to topical medications in the Polish Baseline Series by Radosław Śpiewak, Aldona Maciejewska, Krzysztof Niwiński

Get full text

The Effect of Audible Joint Manipulation Sounds in the Upper Cervical Spine on Brain Wave and Autonomic Nervous System Activity by Dalton Whitman, Rob Sillevis, Matthew Frommelt

Get full text

France – Israel: consequences of the «October 7» by Alexander I. Shumilin

Subjects: Get full text

Bonte P., Porqueres i Gené E., Wilgaux J. (dir.), L’argument de la filiation aux fondements des sociétés européennes et méditerranéennes, Paris, Éditions de la Maison des sciences de l’homme, 2011, 473 p. by Émilie Barraud

Get full text

CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…Background Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels.Methods To address this issue, we have developed a 65-kDa multispecific antibody construct, CLN-978, with affinities tuned to optimize the killing of low-CD19 expressing tumor cells. …”
Get full text

Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis in Both Haematological Malignancies and Solid Tumours: The Extraordinary Case of MYEOV Gene by Spyros I. Papamichos, Dimitrios Margaritis, Ioannis Kotsianidis

“…This study focuses on MYEOV, an oncogene encoding for two protein isoforms, reported as causally involved in promoting cancer cell proliferation and metastasis in both haematological malignancies and solid tumours. First we document, via stringent in silico analysis, that MYEOV arose de novo in Catarrhini. …”
Get full text

The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malignant lymphoma undergoing chemotherapy: a systematic review of randomized controlled trials by Charlotte Groenset, Magnus N. Bech, Mary Jarden, Nina Høgdal, Martin Hutchings, Charlotte Suetta, Jan Christensen

“…Purpose: This study aims to identify and summarize evidence on the effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, health-related quality of life (HRQoL), feasibility of the interventions, in patients with malignant lymphoma undergoing chemotherapy. Methods: A systematic search was conducted in six electronic databases and trials registers on November 15, 2023. …”
Get full text

Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin by Anna Ugalde, Richard W. Tothill, Stephen Quinn, Hui-Li Wong, Owen Prall, Catherine Mitchell, Nilmini Wickramasinghe, Clare Fedele, Natalie Richards, Elizabeth Todio, Cindy Bryant, Louisa G. Collins, Sarah McLean, Hyun Soo Ko, Tim Akhurst, Christopher Steer, Bo Gao, Mark Wong, Chloe Georgiou, Narayan Karanth, Anna Kuchel, Louise Nott, Shamsudheen Padinharakam, Mark Shackleton, Ian M. Collins, Madhu Singh, Rachel Wong, Zee Wan Wong, Alexis Butler, Tharani Sivakumaran, Penelope Schofield, Linda Mileshkin

“…Abstract Background People with malignancy of undefined primary origin (MUO) have a poor prognosis and may undergo a protracted diagnostic workup causing patient distress and high cancer related costs. …”
Get full text

Editorial: Two decades of targeted therapies in hematology: new targets and novel combinations by Bruno António Cardoso, Bruno António Cardoso, Natalia Neparidze

Subjects: Get full text

THE NATIONAL ONCOLOGICAL PROGRAM IMPLEMENTATION – EXPERIENCE IN THE VLADIMIR REGION (TO THE 70TH ANNIVERSARY OF THE REGIONAL CLINICAL ONCOLOGICAL DISPENSARY) by A. G. Zirin, E. A. Rumyantseva, K. V. Chirkov, M. N. Bulanov, G. V. Shatalova, Yu. L. Timofeev, A. V. Basharin, I. A. Konyukhov, A. V. Sheiko

Subjects: Get full text

Le musée national des prisons à Fontainebleau, entretien avec Catherine Prade by Catherine Prade

Subjects: Get full text

MicroRNA-219 in the central nervous system: a potential theranostic approach by Nahal Shamaeizadeh, Mina Mirian

Subjects: “…brain malignancies…”
Get full text

Gate Dispatching in Tidal River Network Areas Based on EFDC Model by ZHANG Xianguo, WANG Huipeng, HUANG Miansong, ZHENG Lei, LIU Xiaofang

Subjects: “…treatment of black and malodorous water bodies…”
Get full text

Evaluation of Platelet Parameters in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma in a Background of Oral Submucous Fibrosis by Packiaraj Selvajothi Ranjitham, Subramanian Kuzhali, Muthu Ponnuswamy Sumathy, Santiago Gnandeepam

Subjects: “…oral submucous fibrosis turning malignant…”
Get full text

Case Report: Neonatal onset intractable diarrhea and hypoproteinemia due to intestinal malrotation and chronic midgut volvulus by Cuifang Zheng, Song Sun, Ying Gong, Shijian Miao, Kuiran Dong, Ying Huang

Subjects: Get full text

Volait Mercedes, Maisons de France au Caire. Le remploi de grands décors mamelouks et ottomans dans une architecture moderne.... by Jean Olivier GUILHOT

Get full text