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  1. 681
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    Malignant Melanoma of the Urethra: A Rare Histologic Subdivision of Vulvar Cancer with a Poor Prognosis by Veronika Günther, I. Alkatout, C. Lez, S. Altarac, R. Fures, H. Cupic, Z. Persec, Z. Hrgovic, C. Mundhenke

    Published 2012-01-01
    “…Malignant melanoma of the urethra is a rare tumour that is difficult to diagnose and treat, resulting in a poor prognosis. …”
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    Article
  3. 683

    Decompressive Hemicraniectomy and Favorable Outcome in a Pediatric Patient with Malignant Middle Cerebral Artery Infarction by Ricardo Barrientos, Carlos Sisniega, Samanta Catueno, Robin Hougen, Ashley Hanna, Utpal Bhalala

    Published 2022-01-01
    “…We report a rare case of middle cerebral artery (MCA) stroke in a teenage girl with initial improvement, followed by progression to malignant MCA infarction, requiring an urgent decompressive hemicraniectomy (DHC). …”
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  4. 684

    Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma by Yufei Liang, Guoqi Zheng, Wenjie Yin, Hui Song, Chunying Li, Liang Tian, Dongliang Yang

    Published 2019-01-01
    “…The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods. 33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. …”
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  5. 685

    Clinical and Histopathologic Characteristics of Oral and Maxillofacial Malignancies: A 5-year Assessment in an Iranian Population by Saber Babazadeh, Shadi Saghafi Khadem, Zeinab Mousavi

    Published 2024-11-01
    “…Background: This study aimed to investigate the clinical and histopathological characteristics of oral and maxillofacial malignancies and their association with the 5-year survival rate of patients in an Iranian population.Methods and Materials: This cross-sectional study analyzed data from 99 patients diagnosed with an oral or maxillofacial malignancy. …”
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    Noninvasive Polypoid Malignant Mixed Mullerian Tumor of the Uterus: A Case Report and Literature Review by Leon Kaza, Leart Berdica, Teona Teona, Albina Ndoja

    Published 2025-01-01
    “…Introduction: Malignant mixed Müllerian tumors (MMMT), also known as carcinosarcomas, are rare and highly aggressive neoplasms of the uterus, accounting for less than 5% of all uterine malignancies. …”
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  10. 690

    Association of Chronic Pancreatitis and Malignant Main Duct IPMN: A Rare but Difficult Clinical Problem by Zoltán Berger, Hernán De La Fuente, Manuel Meneses, Fernanda Matamala, Makarena Sepúlveda, Claudia Rojas

    Published 2017-01-01
    “…Surgery and histology confirmed malignant IPMN with the typical image of chronic pancreatitis and intraductal stones in the vicinity. …”
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  13. 693

    Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy by Yu Chen, Xuan Wang, Jie Dai, Li Zhou, Xuefeng Xia, Jun Guo, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xuan Gao, Lirui Tang, Linzi Sun, Zhonghui Qi, Zelong Xu

    Published 2023-01-01
    “…Background Accumulating data suggest that mucosal melanoma, well known for its poor response to immune checkpoint blockade (ICB) and abysmal prognosis, is a heterogeneous subtype of melanoma with distinct genomic and clinical characteristics between different anatomic locations of the primary lesions. Primary malignant melanoma of the esophagus (PMME) is a rare, highly aggressive disease with a poorer prognosis compared with that of non-esophageal mucosal melanoma (NEMM). …”
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  14. 694

    The Effect of Thyroid Nodule Size and Characteristics on the Accuracy of Fine-Needle Aspiration Biopsy and the Risk of Malignancy by Mehmet Alperen Avcı, Can Akgün, Mustafa Gün, Selim Tamam, Meltem Türk

    Published 2024-10-01
    “…This study aims to examine the impact of thyroid nodule size and characteristics on malignancy risk and FNAB accuracy as evaluated by ultrasound. …”
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  15. 695

    Multiple Endocrine Neoplasia Type 1 with Concomitant Existence of Malignant Insulinoma: A Rare Finding by Randhir Sagar Yadav, Ashik Pokharel, Deepshikha Gaire, Shumneva Shrestha, Ashbita Pokharel, Sumita Pradhan, Prasan Bir Singh Kansakar

    Published 2021-01-01
    “…Insulinoma which has an incidence of 0.4% is a rare pancreatic neuroendocrine tumor. Malignant insulinoma is extremely rare, while primary hyperparathyroidism is a common occurrence in MEN1. …”
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  16. 696

    Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

    Published 2024-12-01
    “…Background Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating regulatory T cells (Treg cells) remain poorly understood.Methods Single-cell RNA sequencing analysis was employed to analyze the phenotypic and functional differences between TNFR2+ Treg cells and TNFR2− Treg cells. Malignant pleural effusion (MPE) from humans and mouse was used to investigate the potential mechanisms by which lactate regulates TNFR2 expression.Results Treg cells with high TNFR2 expression exhibited elevated levels of immune checkpoint molecules. …”
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  17. 697
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    Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria by Lana Nseir, Georget Mansour, Junior Makhoul, Luna Skaf, Mohammad Ziad Dahhan, Zuheir AlShehabi

    Published 2021-01-01
    “…Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42–58 years of age. …”
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