Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording by Giovanna Calandra-Buonaura, Pietro Guaraldi, Andrea Doria, Stefano Zanigni, Stefania Nassetti, Valentina Favoni, Sabina Cevoli, Federica Provini, Pietro Cortelli

“…This open-label pilot study aimed to objectively assess, by means of actigraphic recording, effect of rotigotine on sleep in PD patients with self-reported sleep complaints. 15 PD patients underwent one-week actigraphic recording before (T0) and during (T1) rotigotine treatment, which was titrated to the dose subjectively improving motor symptoms (4–8 mg/24 h). Sleep disturbances, daytime sleepiness, cognitive performance, QoL, and depression were also evaluated with questionnaires. …”
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Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…Results: Trigonelline (100 and 200 mg/kg) treatment effectively (P<0.05) mitigated SCI-induced changes in mechano-tactile sensation, allodynia, hyperalgesia, and motor nerve conduction velocity. …”
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Regulatory roles of eugenol in paraquat-altered SNCA/LZTS3/MAPT in the cerebellum of Wistar rats by Obinna Onwe Uchewa, Augustine Oseloka Ibegbu, Samuel Okoronkwo Okafor, Joseph Alo Nwafor, Ogugua Augustine Egwu

“…The low dose of eugenol was 200 mg/kg, the medium dose of eugenol was 400 mg/kg, and the high dose of eugenol was 600 mg/kg. …”
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Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study by Afnan AwadAllah Elgnainy, Mohammad Ismail Hamed, Wael Osman Mohamed, Nagwa Ali Sabri

“…Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. …”
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Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose by Maria Ballesta Méndez, Vincent van Pesch, Arnaud Capron, Philippe Hantson

“…Background. 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). …”
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The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…In the 72-hour post-stroke study, the animals were injected with 20mg/kg of PNU or vehicle subcutaneously immediately after reperfusion, followed by two additional doses of 10mg/kg of PNU or vehicle at 24 and 48 hours post-tMCAO. …”
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A Study to Compare the Analgesic Efficacy of Intrathecal Bupivacaine Alone with Intrathecal Bupivacaine Midazolam Combination in Patients Undergoing Elective Infraumbilical Surgery by Anirban Chattopadhyay, Souvik Maitra, Suvadeep Sen, Sulagna Bhattacharjee, Amitava Layek, Sugata Pal, Kakali Ghosh

“…Each patient in group “B” received hyperbaric bupivacaine 12.5 mg along with 0.4 mL of normal saline in the subarachnoid block, and patients of group “BM” received 12.5 mg hyperbaric bupivacaine along with preservative free midazolam 0.4 mL (2 mg). …”
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An Effective Phytoconstituent Aconitine: A Realistic Approach for the Treatment of Trigeminal Neuralgia by Dilek Çankal, Esra Küpeli Akkol, Yeliz Kılınç, Mert İlhan, Raffaele Capasso

“…A significant reduction in motor coordination was noted for the higher doses of aconitine which was similar with the 40 and 80 mg/kg doses of carbamazepine. …”
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Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis by Faisal Albaqami, Khawaja Waqas Ahmad, Fawad Ali Shah

“…Carvacrol was administered at a dose of 25 and 50 mg / kg once daily for fifteen days before haloperidol administration. …”
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Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…Parkinson’s disease (PD) is a gradually worsening neurodegenerative condition marked by the deterioration of dopaminergic neurons, motor dysfunction, and mitochondrial dysfunction. …”
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Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…By the end of Mn exposure, 10 mice were orally treated with 7.5 mg/kg L-DOPA. After 5 months of Mn mixture inhalation, striatal dopamine content decreased 71%, the SNc showed important reduction in the number of TH-immunopositive neurons, mice developed akinesia, postural instability, and action tremor; these motor alterations were reverted with L-DOPA treatment. …”
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Anthelmintic Activity of Crude Extract and Essential Oil of Tanacetum vulgare (Asteraceae) against Adult Worms of Schistosoma mansoni by Loyana Silva Godinho, Lara Soares Aleixo de Carvalho, Clarissa Campos Barbosa de Castro, Mirna Meana Dias, Priscila de Faria Pinto, Antônio Eduardo Miller Crotti, Pedro Luiz Silva Pinto, Josué de Moraes, Ademar A. Da Silva Filho

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Combining Ultrasound-Guided Popliteal Sciatic and Adductor Canal Block as a Lifesaver for High-Risk Patients Scheduled for Emergency Below Knee Surgery: A Case Series by Vijayalaxmi Biradar, Shweta Konnur, Abhay Sancheti

“…Adequate sensory and motor blockade required for surgery was achieved, with stable haemodynamic parameters throughout the procedure. …”
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Protocol of DEXPED trial: efficacy of intravenous dexamethasone, administered at the time of analgesic blocking of the lower limb, on postoperative pain in children: a randomised,... by Nathalie Thilly, Nicolas Vautrin, Yohann Bernard, François Wurtz, Claude Meistelman

“…The primary outcome is the total doses of opioid administered (in mg/kg of morphine equivalent) within 24 hours postoperatively. …”
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<i>Eugenia uniflora</i> Effects on the Depressive-like Behavior of MPTP-Exposed Female Rats: Apoptosis and α-Synuclein Modulation by Anne Suély Pinto Savall, Jhuly Dorneles De Mello, Eduarda Monteiro Fidelis, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Gustavo Petri Guerra, Marina Prigol, Robson Puntel, Jean Ramos Boldori, Cristiane Casagrande Denardin, Tuane Bazanella Sampaio, Simone Pinton

“…<b>Methods:</b> Rats received intranasal administration of MPTP or vehicle, followed by 14 days of oral administration of PFEU (300 or 2000 mg/kg, administered once daily) or vehicle. Depressive-like behavior was assessed using the splash and forced swimming tests, while motor ability was evaluated using the rotarod and open field tests. …”
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Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress by Badriyah S. Alotaibi, Uzma Saleem, Maryam Farrukh, Zunera Chaudhary, Nabia Anwar, Ifat Alsharif, Abdullah R. Alanzi, Tasahil S. Albishi, Fatima A. Jaber, Wedad Saeed Al-Qahtani, Muhammad Ajmal Shah

“…Methods: Haloperidol (1 mg/kg) was given to rats intraperitoneally for 3 weeks for induction of PD. …”
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Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice by Claudia Leticia Moreno Ávila, Jorge H. Limón-Pacheco, Magda Giordano, Verónica M. Rodríguez

“…Arsenic exposure has been associated with sensory, motor, memory, and learning alterations in humans and alterations in locomotor activity, behavioral tasks, and neurotransmitters systems in rodents. …”
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Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path... by Hart Mann Alain Youbi Mambou, Simon Pale, Orelien Sylvain Mtopi Bopda, Vanessa Tita Jugha, Nji Seraphin Ombel Musa, Tambong Ako Ojongnkpot, Bertrand Yuwong Wanyu, Raymond Bess Bila, Rashed N. Herqash, Abdelaaty A. Shahat, Germain Sotoing Taiwe

“…Mimosa pudica extracts (160 mg/kg) significantly increased the latency time to status epilepticus by 70.91%. …”
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Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients by Kota Hori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Aomi Kuzuhara, Takenori Hamada, Kouki Yoneda, Kenichiro Maekawa

“…The median change in CRP was 2.1 mg/dL (interquartile range, 1.1–3.8). Multivariate analysis revealed that improvements in mGPS (β=0.125, p=0.012) and CRP levels (β=0.108, p=0.108) were independently and positively associated with FIM-motor at discharge. …”
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Local anesthetic systemic toxicity after brachial plexus block with ropivacaine: a case report by A.G. Tutunnyk, N.V. Mynka, U.U. Kobelyatskyy

“…Brachial plexus nerve block was performed by interscalene access with introduction of 40 ml of 0.75% ropivacaine (300 mg). Twenty minutes after the injection, complete sensory/motor block was achieved. …”
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