RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…In all, the RUBY format has attractive mAb-like attributes and offers the possibility to mitigate many of the development challenges linked to other bsAb formats, facilitating both high functionality and developability.…”
Get full text

In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies by Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot

Get full text

Virulence is not directly related to strain success in planta in Clavibacter nebraskensis by Molly Veregge, Cory D. Hirsch, Matthew J. Moscou, Liana Burghardt, Peter Tiffin, Devanshi Khokhani

Get full text

Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing by Daniele Merico, Nigel Sharfe, Harjit Dadi, Bhooma Thiruvahindrapuram, Jill de Rijke, Zakia Dahi, Mehdi Zarrei, Abdulrahman Al Ghamdi, Azhar Al Shaqaq, Linda Vong, Stephen W. Scherer, Chaim M. Roifman

Get full text

Human adenovirus species B knob proteins as immunogens for inducing cross-neutralizing antibody responses by Zhenwei Liu, Yuting Xian, Jixian Lan, Zhichao Zhou, Xiao Li, Rong Zhou, Dehui Chen, Xingui Tian

Get full text

Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria by Eve T. Beauchemin, Claire Hunter, Corinne F. Maurice

Get full text

Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

Get full text

Evolutionary and functional divergence of Sfx, a plasmid-encoded H-NS homolog, underlies the regulation of IncX plasmid conjugation by Avril Wang, Martha Cordova, William Wiley Navarre

Get full text

RETRACTED: Melanin Produced by Bordetella parapertussis Confers a Survival Advantage to the Bacterium during Host Infection by Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Fuminori Sugihara, Yasuhiko Horiguchi

Get full text

Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…ABSTRACT Type VI secretion system (T6SS) is utilized by many Gram-negative bacteria to eliminate competing bacterial species and manipulate host cells. …”
Get full text

Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

Get full text

A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications by Rousseau, Coralie, Demoulinger, Gautier, Rousvoal, Sylvie, Champeval, Delphine, Dolly, Maurane, Michel, Gurvan, Thomas, François, Markov, Gabriel V., Potin, Philippe, Dittami, Simon M., Prado, Soizic, Leblanc, Catherine, Le Guillard, Cécile

Get full text

Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation by Yitao Dai, Vitor Lourenzon, Laura P. Ióca, Dua Al-Smadi, Lydia Arnold, Ian McIntire, Roberto G. S. Berlinck, Alessandra S. Eustáquio

Get full text

Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

Get full text

Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection by Zeyu Liu, Xue Li, Xiaohong Li, Xingyu Yan, Yuan Tian, Yue Zhao, Kexin Liu, Pei Hao, Shuye Zhang, Chao Zhang

Get full text

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

Get full text

Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…ABSTRACT Many bacteria metabolize ethanolamine as a nutrient source through cytoplasmic organelles named bacterial microcompartments (BMCs). …”
Get full text

Driver lines for studying associative learning in Drosophila by Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard, He Yang, Ching-Po Yang, Claire Managan, Igor Siwanowicz, Tzumin Lee, Gerald M Rubin, Glenn C Turner, Yoshinori Aso

Get full text

3-Methyl-4-Nitrobenzoate Derivates as Antifungal Drug Candidates: Biological and In Silico Evaluation by Alana R. Ferreira, Yunierkis P. Castillo, Ana C. M. Andrade, Diego F. Nóbrega, João Paulo G. de Oliveira, Tamires C. Lima, Ricardo D. de Castro, Damião P. de Sousa

“…The Candida genus includes many opportunistic pathogens of great clinical importance, being commonly involved in several superficial and systemic human fungal infections. …”
Get full text

Effect of Rising Temperature on Lyme Disease: Ixodes scapularis Population Dynamics and Borrelia burgdorferi Transmission and Prevalence by Dorothy Wallace, Vardayani Ratti, Anita Kodali, Jonathan M. Winter, Matthew P. Ayres, Jonathan W. Chipman, Carissa F. Aoki, Erich C. Osterberg, Clara Silvanic, Trevor F. Partridge, Mariana J. Webb

Get full text